Mutagenetix > Incidental Mutation

Incidental Mutation 'R5249:Dnah6'

398780

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

042820-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R5249 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

73017606-73221651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 73113488 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 2293 (R2293K)

Ref Sequence

ENSEMBL: ENSMUSP00000144791 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000064948
AA Change: R2293K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: R2293K

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000114038

SMART Domains

Protein: ENSMUSP00000109672
Gene: ENSMUSG00000052861

Domain	Start	End	E-Value	Type
Pfam:AAA_6	1	109	6.9e-45	PFAM
AAA	190	331	5.25e-1	SMART
low complexity region	407	417	N/A	INTRINSIC
AAA	533	686	1.01e-3	SMART
AAA	884	1042	3.08e0	SMART
low complexity region	1057	1068	N/A	INTRINSIC
low complexity region	1095	1106	N/A	INTRINSIC
Pfam:MT	1135	1267	1.1e-17	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000114040
AA Change: R2241K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: R2241K

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000204053
AA Change: R2293K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: R2293K

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Meta Mutation Damage Score

0.1832

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

98% (93/95)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 89 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	A	G	11: 23,575,483 (GRCm38)	*719Q	probably null	Het
2810403A07Rik	T	A	3: 88,696,725 (GRCm38)	I283N	probably damaging	Het
A4gnt	A	G	9: 99,620,231 (GRCm38)	H148R	probably damaging	Het
Acrbp	A	G	6: 125,060,922 (GRCm38)	D394G	probably damaging	Het
Adam18	T	C	8: 24,625,852 (GRCm38)	T609A	probably benign	Het
Adam25	T	A	8: 40,755,954 (GRCm38)	N752K	probably benign	Het
Ano6	A	C	15: 95,913,588 (GRCm38)	S176R	probably benign	Het
Ano7	T	C	1: 93,375,196 (GRCm38)	S19P	probably benign	Het
Ap1b1	A	G	11: 5,026,364 (GRCm38)	E437G	probably damaging	Het
Arfgap2	T	A	2: 91,265,637 (GRCm38)	C46*	probably null	Het
Arhgef26	T	A	3: 62,340,560 (GRCm38)	L355Q	probably damaging	Het
B4galnt4	C	T	7: 141,065,070 (GRCm38)	T219I	probably damaging	Het
Bap1	C	T	14: 31,257,286 (GRCm38)		probably benign	Het
Catip	T	G	1: 74,362,795 (GRCm38)	L43R	probably damaging	Het
Ccdc177	G	A	12: 80,758,508 (GRCm38)	R331C	unknown	Het
Cep85l	T	C	10: 53,319,594 (GRCm38)		probably null	Het
Cfap206	T	A	4: 34,714,502 (GRCm38)	Q398L	probably benign	Het
Clec18a	A	G	8: 111,073,736 (GRCm38)	C352R	probably damaging	Het
Clic6	A	T	16: 92,539,451 (GRCm38)	Y549F	probably damaging	Het
Cpne9	C	T	6: 113,293,073 (GRCm38)		probably benign	Het
Cyb5r3	A	C	15: 83,158,635 (GRCm38)		probably benign	Het
Dnmbp	C	A	19: 43,902,440 (GRCm38)	R296L	probably damaging	Het
Dtwd1	C	A	2: 126,154,774 (GRCm38)	Q60K	probably benign	Het
Esyt1	C	A	10: 128,516,574 (GRCm38)	V723L	probably benign	Het
Fam71f1	A	G	6: 29,323,897 (GRCm38)	D207G	probably damaging	Het
Fbxo42	T	C	4: 141,199,024 (GRCm38)	L339P	probably damaging	Het
Furin	A	T	7: 80,393,421 (GRCm38)	N347K	probably damaging	Het
Fzd7	T	C	1: 59,483,363 (GRCm38)	M135T	probably damaging	Het
Hlf	A	G	11: 90,387,806 (GRCm38)	M144T	probably benign	Het
Hyal5	C	T	6: 24,876,649 (GRCm38)	Q174*	probably null	Het
Kcnb1	T	A	2: 167,105,183 (GRCm38)	M582L	possibly damaging	Het
Kdm5d	T	C	Y: 916,692 (GRCm38)	Y391H	probably damaging	Het
Kif21b	C	T	1: 136,169,228 (GRCm38)	T1297M	probably damaging	Het
Krt8	T	G	15: 101,998,440 (GRCm38)	N317T	possibly damaging	Het
Lctl	G	T	9: 64,137,914 (GRCm38)	V372L	probably benign	Het
Lig1	C	T	7: 13,308,507 (GRCm38)	H822Y	possibly damaging	Het
Lrrc4b	A	G	7: 44,462,564 (GRCm38)	D620G	possibly damaging	Het
Mboat4	C	T	8: 34,115,121 (GRCm38)	H10Y	probably benign	Het
Med1	A	T	11: 98,157,240 (GRCm38)	M910K	probably benign	Het
Mia2	A	T	12: 59,108,125 (GRCm38)	D209V	probably damaging	Het
Mpp4	C	T	1: 59,144,858 (GRCm38)		probably benign	Het
Mrgprb1	A	T	7: 48,447,477 (GRCm38)	V229E	possibly damaging	Het
Mtor	T	A	4: 148,463,732 (GRCm38)	C485S	probably damaging	Het
Mx1	T	C	16: 97,457,428 (GRCm38)	D23G	probably damaging	Het
Myrfl	T	C	10: 116,783,233 (GRCm38)	D740G	probably benign	Het
Myt1l	G	A	12: 29,832,332 (GRCm38)	G509R	unknown	Het
Nav2	G	A	7: 49,535,913 (GRCm38)	V874I	probably damaging	Het
Ntrk3	A	T	7: 78,461,166 (GRCm38)	N262K	possibly damaging	Het
Olfr819	C	T	10: 129,966,209 (GRCm38)	A164T	probably benign	Het
Olfr916	A	G	9: 38,658,078 (GRCm38)	C105R	possibly damaging	Het
Opa1	A	T	16: 29,618,259 (GRCm38)	D699V	probably damaging	Het
Otud7a	A	G	7: 63,757,433 (GRCm38)	N495D	possibly damaging	Het
Pcsk9	T	C	4: 106,463,753 (GRCm38)	D53G	probably benign	Het
Pdcd5	A	G	7: 35,646,996 (GRCm38)		probably benign	Het
Phf21a	C	T	2: 92,228,477 (GRCm38)	P28L	probably damaging	Het
Pitpnm1	T	A	19: 4,108,130 (GRCm38)	D573E	probably damaging	Het
Ppp1r35	C	T	5: 137,779,144 (GRCm38)		probably benign	Het
Ptprq	T	C	10: 107,699,635 (GRCm38)	Q423R	probably damaging	Het
Pum1	A	T	4: 130,762,814 (GRCm38)	Y699F	probably benign	Het
Rabgef1	A	G	5: 130,213,000 (GRCm38)	D415G	probably benign	Het
Rapgef6	A	G	11: 54,523,117 (GRCm38)	E23G	probably benign	Het
Rpia	G	T	6: 70,783,579 (GRCm38)	C121*	probably null	Het
Serpinb13	T	A	1: 106,998,697 (GRCm38)	W201R	probably damaging	Het
Sh3bp4	T	C	1: 89,137,734 (GRCm38)	C17R	probably damaging	Het
Sh3d21	A	G	4: 126,162,065 (GRCm38)		probably benign	Het
Slamf6	A	C	1: 171,936,682 (GRCm38)	N214T	probably damaging	Het
Slc7a2	T	C	8: 40,908,093 (GRCm38)	Y365H	possibly damaging	Het
Sox18	T	C	2: 181,671,178 (GRCm38)		probably null	Het
Spink7	A	T	18: 62,592,436 (GRCm38)	F79I	possibly damaging	Het
Srpk3	C	T	X: 73,774,949 (GRCm38)	R82*	probably null	Het
Sspo	A	T	6: 48,493,310 (GRCm38)	H4561L	probably damaging	Het
Tcaf1	T	C	6: 42,676,859 (GRCm38)	K700R	probably benign	Het
Tcf25	G	T	8: 123,388,633 (GRCm38)	R203L	probably damaging	Het
Tcp11	T	C	17: 28,071,783 (GRCm38)	I201V	possibly damaging	Het
Tex2	T	C	11: 106,546,789 (GRCm38)	D685G	unknown	Het
Themis	G	T	10: 28,761,199 (GRCm38)	E100*	probably null	Het
Tmem52b	G	A	6: 129,514,258 (GRCm38)		probably null	Het
Tnr	C	T	1: 159,684,656 (GRCm38)		probably benign	Het
Tox3	T	C	8: 90,248,816 (GRCm38)	I396V	probably benign	Het
Tpm2	T	A	4: 43,514,828 (GRCm38)	E269V	probably benign	Het
Tulp1	C	T	17: 28,362,677 (GRCm38)		probably benign	Het
Tymp	GC	GCC	15: 89,374,364 (GRCm38)		probably null	Het
Ube2j2	A	C	4: 155,949,058 (GRCm38)	K30Q	possibly damaging	Het
Usp19	T	A	9: 108,492,608 (GRCm38)	M1K	probably null	Het
Vmn2r52	C	A	7: 10,176,270 (GRCm38)	R6L	probably benign	Het
Zbed4	G	A	15: 88,781,087 (GRCm38)	V453M	probably benign	Het
Zfp319	T	C	8: 95,328,471 (GRCm38)	E368G	probably benign	Het
Zfp366	A	C	13: 99,229,609 (GRCm38)	E426A	probably damaging	Het
Zfp687	A	T	3: 95,009,466 (GRCm38)	I783N	probably damaging	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,195,737 (GRCm38)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,086,207 (GRCm38)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,195,761 (GRCm38)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,212,434 (GRCm38)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,123,771 (GRCm38)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,156,350 (GRCm38)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,033,526 (GRCm38)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,083,157 (GRCm38)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,173,390 (GRCm38)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,074,781 (GRCm38)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,065,725 (GRCm38)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,173,456 (GRCm38)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,092,178 (GRCm38)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,074,748 (GRCm38)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,024,252 (GRCm38)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,075,802 (GRCm38)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,076,660 (GRCm38)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,188,377 (GRCm38)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,065,776 (GRCm38)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,135,801 (GRCm38)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,032,569 (GRCm38)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,060,143 (GRCm38)	missense	probably benign
IGL02126:Dnah6	APN	6	73,103,166 (GRCm38)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	73,017,797 (GRCm38)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,133,650 (GRCm38)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,168,911 (GRCm38)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,101,898 (GRCm38)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,076,640 (GRCm38)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,027,448 (GRCm38)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	73,021,227 (GRCm38)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,095,104 (GRCm38)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,121,823 (GRCm38)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,208,599 (GRCm38)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,138,715 (GRCm38)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,032,587 (GRCm38)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,149,140 (GRCm38)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,145,004 (GRCm38)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,041,054 (GRCm38)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,144,700 (GRCm38)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,053,647 (GRCm38)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,083,085 (GRCm38)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,075,850 (GRCm38)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,163,504 (GRCm38)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,065,755 (GRCm38)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,208,641 (GRCm38)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,101,880 (GRCm38)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,114,582 (GRCm38)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,060,260 (GRCm38)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,038,734 (GRCm38)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,188,535 (GRCm38)	splice site	probably benign
R0165:Dnah6	UTSW	6	73,021,323 (GRCm38)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,082,923 (GRCm38)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,159,115 (GRCm38)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,173,558 (GRCm38)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,069,399 (GRCm38)	splice site	probably benign
R0345:Dnah6	UTSW	6	73,021,257 (GRCm38)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,188,359 (GRCm38)	missense	probably benign
R0362:Dnah6	UTSW	6	73,208,609 (GRCm38)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,083,124 (GRCm38)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,044,774 (GRCm38)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	73,022,412 (GRCm38)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,123,811 (GRCm38)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,129,474 (GRCm38)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,212,622 (GRCm38)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,087,602 (GRCm38)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,035,293 (GRCm38)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,124,757 (GRCm38)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,159,193 (GRCm38)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,144,965 (GRCm38)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,159,135 (GRCm38)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,124,709 (GRCm38)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,208,545 (GRCm38)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,191,619 (GRCm38)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,027,442 (GRCm38)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,049,048 (GRCm38)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,151,553 (GRCm38)	missense	probably benign
R1557:Dnah6	UTSW	6	73,049,131 (GRCm38)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,076,600 (GRCm38)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,067,469 (GRCm38)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,144,963 (GRCm38)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,100,112 (GRCm38)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,044,752 (GRCm38)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,155,296 (GRCm38)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,205,732 (GRCm38)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,129,540 (GRCm38)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,044,761 (GRCm38)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,160,982 (GRCm38)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,024,958 (GRCm38)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,181,797 (GRCm38)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,100,088 (GRCm38)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,181,762 (GRCm38)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,084,721 (GRCm38)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,121,970 (GRCm38)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,095,044 (GRCm38)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,092,192 (GRCm38)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,067,466 (GRCm38)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,173,419 (GRCm38)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,027,422 (GRCm38)	missense	probably benign
R2041:Dnah6	UTSW	6	73,073,439 (GRCm38)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	73,021,182 (GRCm38)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,144,035 (GRCm38)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,049,166 (GRCm38)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,089,746 (GRCm38)	splice site	probably null
R2193:Dnah6	UTSW	6	73,138,640 (GRCm38)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,100,085 (GRCm38)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,113,581 (GRCm38)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	73,021,109 (GRCm38)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,156,421 (GRCm38)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,091,967 (GRCm38)	splice site	probably null
R2436:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,173,350 (GRCm38)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,032,633 (GRCm38)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,191,498 (GRCm38)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,127,927 (GRCm38)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,089,592 (GRCm38)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,129,448 (GRCm38)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,149,484 (GRCm38)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,118,026 (GRCm38)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,129,291 (GRCm38)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,191,479 (GRCm38)	missense	probably benign
R4486:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,178,416 (GRCm38)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,192,405 (GRCm38)	missense	probably benign
R4573:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,152,712 (GRCm38)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,129,660 (GRCm38)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,070,597 (GRCm38)	missense	probably benign
R4653:Dnah6	UTSW	6	73,073,457 (GRCm38)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,037,688 (GRCm38)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,192,422 (GRCm38)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,025,012 (GRCm38)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,129,530 (GRCm38)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,095,074 (GRCm38)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,089,668 (GRCm38)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	73,022,424 (GRCm38)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,044,762 (GRCm38)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,121,788 (GRCm38)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,192,676 (GRCm38)	intron	probably benign
R4948:Dnah6	UTSW	6	73,053,689 (GRCm38)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,188,383 (GRCm38)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,144,815 (GRCm38)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,044,691 (GRCm38)	missense	probably benign
R5044:Dnah6	UTSW	6	73,037,622 (GRCm38)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,181,761 (GRCm38)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,195,634 (GRCm38)	missense	probably benign
R5186:Dnah6	UTSW	6	73,067,427 (GRCm38)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,195,732 (GRCm38)	missense	possibly damaging	0.82
R5272:Dnah6	UTSW	6	73,127,861 (GRCm38)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,212,620 (GRCm38)	missense	probably benign
R5343:Dnah6	UTSW	6	73,212,616 (GRCm38)	missense	probably benign
R5375:Dnah6	UTSW	6	73,123,855 (GRCm38)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,037,615 (GRCm38)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,060,138 (GRCm38)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,075,734 (GRCm38)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,086,185 (GRCm38)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,092,157 (GRCm38)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,092,116 (GRCm38)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,190,419 (GRCm38)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,159,229 (GRCm38)	missense	probably benign
R5541:Dnah6	UTSW	6	73,192,988 (GRCm38)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,151,689 (GRCm38)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,149,525 (GRCm38)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	73,021,227 (GRCm38)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,060,279 (GRCm38)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,181,722 (GRCm38)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,086,166 (GRCm38)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,114,697 (GRCm38)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,188,494 (GRCm38)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,086,217 (GRCm38)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,191,605 (GRCm38)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,155,418 (GRCm38)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,074,586 (GRCm38)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,074,704 (GRCm38)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,044,732 (GRCm38)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,173,533 (GRCm38)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,053,695 (GRCm38)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,035,280 (GRCm38)	splice site	probably null
R6640:Dnah6	UTSW	6	73,024,293 (GRCm38)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,138,760 (GRCm38)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,037,549 (GRCm38)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,133,608 (GRCm38)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,133,542 (GRCm38)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,212,522 (GRCm38)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,181,755 (GRCm38)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,044,773 (GRCm38)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	73,021,178 (GRCm38)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,087,562 (GRCm38)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,135,680 (GRCm38)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,181,705 (GRCm38)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,173,545 (GRCm38)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,084,760 (GRCm38)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,144,722 (GRCm38)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,212,612 (GRCm38)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,192,317 (GRCm38)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,212,492 (GRCm38)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,127,904 (GRCm38)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,118,099 (GRCm38)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,027,440 (GRCm38)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,149,430 (GRCm38)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,092,168 (GRCm38)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,095,206 (GRCm38)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,124,759 (GRCm38)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,169,080 (GRCm38)	splice site	probably null
R7735:Dnah6	UTSW	6	73,069,429 (GRCm38)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,025,720 (GRCm38)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,127,919 (GRCm38)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,135,467 (GRCm38)	splice site	probably null
R8034:Dnah6	UTSW	6	73,129,225 (GRCm38)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,160,913 (GRCm38)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,025,786 (GRCm38)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,060,225 (GRCm38)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,037,566 (GRCm38)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,044,728 (GRCm38)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,168,827 (GRCm38)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,195,681 (GRCm38)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,076,599 (GRCm38)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,025,000 (GRCm38)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,074,651 (GRCm38)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,138,774 (GRCm38)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,178,457 (GRCm38)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,095,188 (GRCm38)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,168,867 (GRCm38)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,075,890 (GRCm38)	intron	probably benign
R8737:Dnah6	UTSW	6	73,067,445 (GRCm38)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,179,828 (GRCm38)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,065,773 (GRCm38)	missense	probably benign
R8809:Dnah6	UTSW	6	73,032,563 (GRCm38)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,127,954 (GRCm38)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,144,173 (GRCm38)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	73,021,148 (GRCm38)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,178,498 (GRCm38)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,144,751 (GRCm38)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,142,292 (GRCm38)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,084,657 (GRCm38)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,144,046 (GRCm38)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,067,486 (GRCm38)	missense	probably benign
R9106:Dnah6	UTSW	6	73,144,769 (GRCm38)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,060,203 (GRCm38)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,121,899 (GRCm38)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,144,941 (GRCm38)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,144,705 (GRCm38)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,027,514 (GRCm38)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,083,057 (GRCm38)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	73,021,278 (GRCm38)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,212,530 (GRCm38)	missense	probably benign
R9439:Dnah6	UTSW	6	73,035,347 (GRCm38)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,142,316 (GRCm38)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,138,767 (GRCm38)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,191,606 (GRCm38)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,101,889 (GRCm38)	missense	probably benign
RF020:Dnah6	UTSW	6	73,118,057 (GRCm38)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,178,518 (GRCm38)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,191,500 (GRCm38)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,037,673 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,133,559 (GRCm38)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,087,783 (GRCm38)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,032,526 (GRCm38)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	73,021,237 (GRCm38)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,155,272 (GRCm38)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,041,138 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGACATTAGCATTCTGTATGTCAAG -3'
(R):5'- GCACTTGGAAAACAATATCAAAACTGG -3'

Sequencing Primer
(F):5'- GCATTCTGTATGTCAAGTGATTACAG -3'
(R):5'- GACTTCCCAGAAGCAGTA -3'

Posted On

2016-07-06