Incidental Mutation 'R5173:Tas2r144'
ID 398891
Institutional Source Beutler Lab
Gene Symbol Tas2r144
Ensembl Gene ENSMUSG00000051917
Gene Name taste receptor, type 2, member 144
Synonyms mt2r33, Tas2r44
MMRRC Submission 042753-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5173 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 42192262-42193221 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 42193048 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 263 (F263I)
Ref Sequence ENSEMBL: ENSMUSP00000067734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063489]
AlphaFold Q7TQB8
Predicted Effect probably benign
Transcript: ENSMUST00000063489
AA Change: F263I

PolyPhen 2 Score 0.398 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000067734
Gene: ENSMUSG00000051917
AA Change: F263I

DomainStartEndE-ValueType
Pfam:TAS2R 12 314 9.6e-63 PFAM
Meta Mutation Damage Score 0.1919 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 AC A 11: 9,632,032 (GRCm39) probably null Het
Abca6 A T 11: 110,082,546 (GRCm39) F1142L probably benign Het
Ap1g1 T A 8: 110,577,764 (GRCm39) probably null Het
Apob T C 12: 8,058,238 (GRCm39) V2207A probably benign Het
Cenpp CAAACCTGAAAA CAAA 13: 49,618,258 (GRCm39) probably null Het
Chd3 A G 11: 69,260,069 (GRCm39) probably benign Het
Coch C A 12: 51,643,290 (GRCm39) Y103* probably null Het
Cul3 A T 1: 80,259,133 (GRCm39) D382E possibly damaging Het
Cul5 T C 9: 53,554,034 (GRCm39) T291A probably benign Het
Dab1 T C 4: 104,545,645 (GRCm39) probably null Het
Dmtf1 A G 5: 9,190,356 (GRCm39) probably benign Het
Dpp4 T C 2: 62,217,474 (GRCm39) Y41C probably damaging Het
Eif2ak4 A G 2: 118,238,841 (GRCm39) I45M probably damaging Het
Epn3 T C 11: 94,386,923 (GRCm39) K149R probably damaging Het
Flnc A G 6: 29,455,537 (GRCm39) E2029G probably damaging Het
Gm5799 A G 14: 43,782,116 (GRCm39) N96S probably damaging Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Grik5 T C 7: 24,762,319 (GRCm39) H224R possibly damaging Het
Lpar6 A T 14: 73,476,537 (GRCm39) E166V probably benign Het
Mical1 T C 10: 41,360,985 (GRCm39) L683P probably damaging Het
Mis18bp1 T C 12: 65,196,149 (GRCm39) I538M possibly damaging Het
Mobp A G 9: 119,997,311 (GRCm39) R77G possibly damaging Het
Muc21 G T 17: 35,931,633 (GRCm39) probably benign Het
Mylk A G 16: 34,797,383 (GRCm39) H1614R probably benign Het
Or2y16 T C 11: 49,334,713 (GRCm39) F12L probably benign Het
Or4p18 G A 2: 88,233,266 (GRCm39) T4I probably benign Het
Or7c19 T C 8: 85,957,205 (GRCm39) L27P probably damaging Het
Osbpl1a C T 18: 12,895,697 (GRCm39) V390I probably benign Het
Pcdha7 C A 18: 37,107,705 (GRCm39) D243E probably benign Het
Pi4ka A T 16: 17,168,770 (GRCm39) N653K possibly damaging Het
Plin5 T G 17: 56,422,548 (GRCm39) probably null Het
Plod1 A G 4: 148,000,758 (GRCm39) probably benign Het
Psd3 T C 8: 68,149,641 (GRCm39) K372E probably damaging Het
Psmd11 C T 11: 80,351,566 (GRCm39) T263I probably benign Het
Ptprt A T 2: 161,769,676 (GRCm39) N396K probably benign Het
Rab39 T C 9: 53,597,800 (GRCm39) E155G probably damaging Het
Rimbp2 T C 5: 128,874,712 (GRCm39) D293G probably benign Het
Rnf220 T C 4: 117,146,471 (GRCm39) probably benign Het
Rnmt C T 18: 68,454,430 (GRCm39) probably benign Het
Slc10a1 T A 12: 81,002,802 (GRCm39) I279F probably damaging Het
Sp140l1 G A 1: 85,078,288 (GRCm39) R54* probably null Het
Taar6 A G 10: 23,861,250 (GRCm39) Y99H probably damaging Het
Tex15 T A 8: 34,061,768 (GRCm39) N399K possibly damaging Het
Tlr9 T A 9: 106,103,151 (GRCm39) V814D possibly damaging Het
Tmem53 T A 4: 117,122,908 (GRCm39) probably benign Het
Ubap2l T C 3: 89,928,337 (GRCm39) I511V possibly damaging Het
Vmn2r60 T C 7: 41,844,935 (GRCm39) M766T probably damaging Het
Zfp462 T C 4: 55,011,115 (GRCm39) V1027A probably damaging Het
Other mutations in Tas2r144
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02349:Tas2r144 APN 6 42,193,010 (GRCm39) missense probably benign 0.26
IGL02644:Tas2r144 APN 6 42,192,787 (GRCm39) missense possibly damaging 0.89
IGL02816:Tas2r144 APN 6 42,192,539 (GRCm39) missense probably benign 0.03
R0375:Tas2r144 UTSW 6 42,193,058 (GRCm39) missense possibly damaging 0.92
R1526:Tas2r144 UTSW 6 42,192,674 (GRCm39) missense probably benign
R1543:Tas2r144 UTSW 6 42,192,537 (GRCm39) missense probably benign 0.00
R1678:Tas2r144 UTSW 6 42,192,490 (GRCm39) missense probably benign 0.44
R1868:Tas2r144 UTSW 6 42,192,936 (GRCm39) missense probably benign 0.01
R1880:Tas2r144 UTSW 6 42,193,004 (GRCm39) missense probably benign 0.02
R4060:Tas2r144 UTSW 6 42,192,563 (GRCm39) missense possibly damaging 0.82
R6108:Tas2r144 UTSW 6 42,192,691 (GRCm39) missense possibly damaging 0.88
R6249:Tas2r144 UTSW 6 42,192,291 (GRCm39) nonsense probably null
R6533:Tas2r144 UTSW 6 42,192,280 (GRCm39) missense probably benign
R6850:Tas2r144 UTSW 6 42,192,857 (GRCm39) missense possibly damaging 0.71
R7237:Tas2r144 UTSW 6 42,192,800 (GRCm39) missense probably damaging 0.99
R7296:Tas2r144 UTSW 6 42,192,373 (GRCm39) missense probably damaging 1.00
R7431:Tas2r144 UTSW 6 42,192,908 (GRCm39) missense probably damaging 1.00
R8206:Tas2r144 UTSW 6 42,192,325 (GRCm39) missense probably damaging 0.98
R9341:Tas2r144 UTSW 6 42,193,066 (GRCm39) missense probably benign 0.03
R9343:Tas2r144 UTSW 6 42,193,066 (GRCm39) missense probably benign 0.03
R9640:Tas2r144 UTSW 6 42,192,428 (GRCm39) missense probably benign 0.00
X0067:Tas2r144 UTSW 6 42,193,099 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGATCAATGTACTCAGCCTAGC -3'
(R):5'- ACTTCCAGGTTCCAGTTACTG -3'

Sequencing Primer
(F):5'- CAGCCTAGCTTTCTTGTATTATATGG -3'
(R):5'- CCAGTTACTGGTTCTACCTTTTAAG -3'
Posted On 2016-07-06