Incidental Mutation 'R5173:Mobp'
ID 398911
Institutional Source Beutler Lab
Gene Symbol Mobp
Ensembl Gene ENSMUSG00000032517
Gene Name myelin-associated oligodendrocytic basic protein
Synonyms MOBP155
MMRRC Submission 042753-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R5173 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 119978773-120010550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119997311 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 77 (R77G)
Ref Sequence ENSEMBL: ENSMUSP00000071084 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068698] [ENSMUST00000093773] [ENSMUST00000111627] [ENSMUST00000174193] [ENSMUST00000214943] [ENSMUST00000215512]
AlphaFold Q9D2P8
Predicted Effect possibly damaging
Transcript: ENSMUST00000068698
AA Change: R77G

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000071084
Gene: ENSMUSG00000032517
AA Change: R77G

DomainStartEndE-ValueType
Pfam:FYVE_2 1 75 6.4e-13 PFAM
low complexity region 82 99 N/A INTRINSIC
low complexity region 102 151 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000093773
SMART Domains Protein: ENSMUSP00000091287
Gene: ENSMUSG00000032517

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111627
SMART Domains Protein: ENSMUSP00000107254
Gene: ENSMUSG00000032517

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174193
SMART Domains Protein: ENSMUSP00000134410
Gene: ENSMUSG00000032517

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214008
Predicted Effect probably benign
Transcript: ENSMUST00000214943
Predicted Effect probably benign
Transcript: ENSMUST00000215512
Meta Mutation Damage Score 0.0620 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 100% (50/50)
MGI Phenotype PHENOTYPE: Mice homozygous for one null allele show abnormal myelin arrangements but do not exhibit an overt behavorial phenotype. Mice homozygous for another allele have normal myelin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 AC A 11: 9,632,032 (GRCm39) probably null Het
Abca6 A T 11: 110,082,546 (GRCm39) F1142L probably benign Het
Ap1g1 T A 8: 110,577,764 (GRCm39) probably null Het
Apob T C 12: 8,058,238 (GRCm39) V2207A probably benign Het
Cenpp CAAACCTGAAAA CAAA 13: 49,618,258 (GRCm39) probably null Het
Chd3 A G 11: 69,260,069 (GRCm39) probably benign Het
Coch C A 12: 51,643,290 (GRCm39) Y103* probably null Het
Cul3 A T 1: 80,259,133 (GRCm39) D382E possibly damaging Het
Cul5 T C 9: 53,554,034 (GRCm39) T291A probably benign Het
Dab1 T C 4: 104,545,645 (GRCm39) probably null Het
Dmtf1 A G 5: 9,190,356 (GRCm39) probably benign Het
Dpp4 T C 2: 62,217,474 (GRCm39) Y41C probably damaging Het
Eif2ak4 A G 2: 118,238,841 (GRCm39) I45M probably damaging Het
Epn3 T C 11: 94,386,923 (GRCm39) K149R probably damaging Het
Flnc A G 6: 29,455,537 (GRCm39) E2029G probably damaging Het
Gm5799 A G 14: 43,782,116 (GRCm39) N96S probably damaging Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Grik5 T C 7: 24,762,319 (GRCm39) H224R possibly damaging Het
Lpar6 A T 14: 73,476,537 (GRCm39) E166V probably benign Het
Mical1 T C 10: 41,360,985 (GRCm39) L683P probably damaging Het
Mis18bp1 T C 12: 65,196,149 (GRCm39) I538M possibly damaging Het
Muc21 G T 17: 35,931,633 (GRCm39) probably benign Het
Mylk A G 16: 34,797,383 (GRCm39) H1614R probably benign Het
Or2y16 T C 11: 49,334,713 (GRCm39) F12L probably benign Het
Or4p18 G A 2: 88,233,266 (GRCm39) T4I probably benign Het
Or7c19 T C 8: 85,957,205 (GRCm39) L27P probably damaging Het
Osbpl1a C T 18: 12,895,697 (GRCm39) V390I probably benign Het
Pcdha7 C A 18: 37,107,705 (GRCm39) D243E probably benign Het
Pi4ka A T 16: 17,168,770 (GRCm39) N653K possibly damaging Het
Plin5 T G 17: 56,422,548 (GRCm39) probably null Het
Plod1 A G 4: 148,000,758 (GRCm39) probably benign Het
Psd3 T C 8: 68,149,641 (GRCm39) K372E probably damaging Het
Psmd11 C T 11: 80,351,566 (GRCm39) T263I probably benign Het
Ptprt A T 2: 161,769,676 (GRCm39) N396K probably benign Het
Rab39 T C 9: 53,597,800 (GRCm39) E155G probably damaging Het
Rimbp2 T C 5: 128,874,712 (GRCm39) D293G probably benign Het
Rnf220 T C 4: 117,146,471 (GRCm39) probably benign Het
Rnmt C T 18: 68,454,430 (GRCm39) probably benign Het
Slc10a1 T A 12: 81,002,802 (GRCm39) I279F probably damaging Het
Sp140l1 G A 1: 85,078,288 (GRCm39) R54* probably null Het
Taar6 A G 10: 23,861,250 (GRCm39) Y99H probably damaging Het
Tas2r144 T A 6: 42,193,048 (GRCm39) F263I probably benign Het
Tex15 T A 8: 34,061,768 (GRCm39) N399K possibly damaging Het
Tlr9 T A 9: 106,103,151 (GRCm39) V814D possibly damaging Het
Tmem53 T A 4: 117,122,908 (GRCm39) probably benign Het
Ubap2l T C 3: 89,928,337 (GRCm39) I511V possibly damaging Het
Vmn2r60 T C 7: 41,844,935 (GRCm39) M766T probably damaging Het
Zfp462 T C 4: 55,011,115 (GRCm39) V1027A probably damaging Het
Other mutations in Mobp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01155:Mobp APN 9 119,997,300 (GRCm39) missense probably benign 0.08
IGL01730:Mobp APN 9 119,996,992 (GRCm39) missense probably damaging 1.00
IGL02078:Mobp APN 9 119,996,980 (GRCm39) missense probably damaging 1.00
IGL02470:Mobp APN 9 119,997,072 (GRCm39) missense probably benign 0.18
P0041:Mobp UTSW 9 119,997,083 (GRCm39) utr 3 prime probably benign
R3794:Mobp UTSW 9 119,997,033 (GRCm39) nonsense probably null
R3890:Mobp UTSW 9 119,997,022 (GRCm39) missense probably damaging 1.00
R5255:Mobp UTSW 9 119,997,419 (GRCm39) unclassified probably benign
R5549:Mobp UTSW 9 119,996,876 (GRCm39) missense probably damaging 1.00
R5870:Mobp UTSW 9 119,996,919 (GRCm39) missense probably damaging 0.98
R6128:Mobp UTSW 9 119,997,392 (GRCm39) unclassified probably benign
R7267:Mobp UTSW 9 119,996,914 (GRCm39) missense probably damaging 1.00
R9260:Mobp UTSW 9 119,997,572 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCCTGTTAGGAAGGTTCTGGAG -3'
(R):5'- AGCCATCTAAAGTGAGGACCG -3'

Sequencing Primer
(F):5'- TTCTGGAGGGCGAGCAG -3'
(R):5'- CCCCATGTTAGTACTTGCAGAGAG -3'
Posted On 2016-07-06