Incidental Mutation 'R5178:Vmn1r87'
ID 399471
Institutional Source Beutler Lab
Gene Symbol Vmn1r87
Ensembl Gene ENSMUSG00000070815
Gene Name vomeronasal 1 receptor 87
Synonyms V1rk1
MMRRC Submission 042758-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R5178 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 12865398-12866285 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 12865792 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 165 (A165E)
Ref Sequence ENSEMBL: ENSMUSP00000154184 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094827] [ENSMUST00000211249] [ENSMUST00000227443] [ENSMUST00000228800]
AlphaFold Q8R255
Predicted Effect possibly damaging
Transcript: ENSMUST00000094827
AA Change: A165E

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000092422
Gene: ENSMUSG00000070815
AA Change: A165E

DomainStartEndE-ValueType
Pfam:TAS2R 1 285 1.2e-11 PFAM
Pfam:V1R 14 280 1.8e-36 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000211249
AA Change: A165E

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227443
AA Change: A165E

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228800
AA Change: A165E

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abt1 G T 13: 23,606,819 (GRCm39) A94E possibly damaging Het
Carmil2 G T 8: 106,423,521 (GRCm39) G1207V probably damaging Het
Cndp2 A T 18: 84,693,153 (GRCm39) N202K probably benign Het
Cyp2c66 A G 19: 39,159,473 (GRCm39) Y308C probably damaging Het
Dhx29 T G 13: 113,069,134 (GRCm39) S155A possibly damaging Het
Dnah7b T G 1: 46,397,376 (GRCm39) F3936V possibly damaging Het
Dsg1b G A 18: 20,530,560 (GRCm39) G405E probably damaging Het
Exo5 A T 4: 120,778,734 (GRCm39) probably null Het
Fam171b T C 2: 83,710,331 (GRCm39) F668L probably damaging Het
Gemin5 A T 11: 58,037,344 (GRCm39) S624T probably benign Het
Gpc2 C A 5: 138,273,867 (GRCm39) V444L possibly damaging Het
Hephl1 T A 9: 14,997,468 (GRCm39) K399N probably damaging Het
Lair1 G A 7: 4,013,488 (GRCm39) T82I possibly damaging Het
Lhx1 G T 11: 84,411,214 (GRCm39) A155E possibly damaging Het
Maip1 G A 1: 57,454,849 (GRCm39) D278N probably benign Het
Mcm4 T A 16: 15,453,167 (GRCm39) D174V probably benign Het
Mcph1 T A 8: 18,657,342 (GRCm39) D60E probably damaging Het
Mmp17 T A 5: 129,672,122 (GRCm39) W132R probably damaging Het
Or4p7 C T 2: 88,221,819 (GRCm39) T76I possibly damaging Het
Or7e174 T A 9: 20,012,488 (GRCm39) C144* probably null Het
Pds5a T C 5: 65,821,218 (GRCm39) T169A probably damaging Het
Pfkm A G 15: 98,029,396 (GRCm39) N697D probably benign Het
Pira1 T A 7: 3,742,396 (GRCm39) K44* probably null Het
Ppwd1 A T 13: 104,356,943 (GRCm39) S191T probably benign Het
Ranbp2 T A 10: 58,312,607 (GRCm39) M1109K probably benign Het
Robo4 T C 9: 37,319,256 (GRCm39) W535R probably damaging Het
Rsf1 A G 7: 97,311,079 (GRCm39) D603G possibly damaging Het
Slc22a26 T C 19: 7,767,540 (GRCm39) T289A possibly damaging Het
Sp2 A G 11: 96,846,664 (GRCm39) F554L probably benign Het
Sp4 A G 12: 118,225,624 (GRCm39) V580A possibly damaging Het
Tbc1d19 T A 5: 54,046,667 (GRCm39) S413T possibly damaging Het
Tecta T C 9: 42,286,481 (GRCm39) D725G probably damaging Het
Tmem200a T A 10: 25,870,277 (GRCm39) Q4H probably benign Het
Tpx2 T A 2: 152,717,469 (GRCm39) I122N probably benign Het
Trgc4 A G 13: 19,528,932 (GRCm39) probably benign Het
Ube4b T C 4: 149,427,449 (GRCm39) M900V probably damaging Het
Vmn2r95 A G 17: 18,660,337 (GRCm39) T250A probably benign Het
Wasf1 G A 10: 40,813,672 (GRCm39) R518H unknown Het
Zfhx2 A T 14: 55,312,232 (GRCm39) F154Y probably benign Het
Zfp729a A G 13: 67,785,764 (GRCm39) probably null Het
Zfp976 A G 7: 42,261,925 (GRCm39) probably null Het
Other mutations in Vmn1r87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01400:Vmn1r87 APN 7 12,866,230 (GRCm39) missense probably damaging 1.00
IGL01577:Vmn1r87 APN 7 12,865,775 (GRCm39) missense probably benign 0.00
IGL02972:Vmn1r87 APN 7 12,866,256 (GRCm39) nonsense probably null
IGL03246:Vmn1r87 APN 7 12,866,288 (GRCm39) utr 5 prime probably benign
PIT4142001:Vmn1r87 UTSW 7 12,866,112 (GRCm39) missense probably benign 0.00
R0153:Vmn1r87 UTSW 7 12,866,211 (GRCm39) missense probably damaging 1.00
R0502:Vmn1r87 UTSW 7 12,865,583 (GRCm39) missense probably damaging 1.00
R0658:Vmn1r87 UTSW 7 12,865,756 (GRCm39) missense probably damaging 1.00
R1589:Vmn1r87 UTSW 7 12,865,703 (GRCm39) missense possibly damaging 0.46
R1731:Vmn1r87 UTSW 7 12,865,703 (GRCm39) missense possibly damaging 0.46
R2027:Vmn1r87 UTSW 7 12,865,823 (GRCm39) missense probably damaging 0.99
R2044:Vmn1r87 UTSW 7 12,865,748 (GRCm39) missense probably benign 0.02
R3124:Vmn1r87 UTSW 7 12,865,493 (GRCm39) missense probably damaging 1.00
R4208:Vmn1r87 UTSW 7 12,866,185 (GRCm39) missense probably benign 0.37
R4731:Vmn1r87 UTSW 7 12,866,254 (GRCm39) missense possibly damaging 0.92
R4732:Vmn1r87 UTSW 7 12,866,254 (GRCm39) missense possibly damaging 0.92
R4733:Vmn1r87 UTSW 7 12,866,254 (GRCm39) missense possibly damaging 0.92
R5079:Vmn1r87 UTSW 7 12,866,253 (GRCm39) missense probably benign 0.01
R5125:Vmn1r87 UTSW 7 12,865,792 (GRCm39) missense possibly damaging 0.79
R6599:Vmn1r87 UTSW 7 12,865,886 (GRCm39) nonsense probably null
R7067:Vmn1r87 UTSW 7 12,865,849 (GRCm39) missense probably benign 0.02
R7560:Vmn1r87 UTSW 7 12,865,745 (GRCm39) missense probably damaging 1.00
R7574:Vmn1r87 UTSW 7 12,865,613 (GRCm39) missense probably benign 0.01
R7910:Vmn1r87 UTSW 7 12,865,832 (GRCm39) missense probably damaging 1.00
R8040:Vmn1r87 UTSW 7 12,866,086 (GRCm39) missense possibly damaging 0.87
R8220:Vmn1r87 UTSW 7 12,865,427 (GRCm39) missense possibly damaging 0.72
R9690:Vmn1r87 UTSW 7 12,866,263 (GRCm39) missense probably benign 0.01
X0028:Vmn1r87 UTSW 7 12,865,910 (GRCm39) missense possibly damaging 0.52
Predicted Primers PCR Primer
(F):5'- TCCAATACTGGGTTGCTCTTGG -3'
(R):5'- GTGGGCATGGCTTAAATCCAAG -3'

Sequencing Primer
(F):5'- TCTTGGGTTGGTAAAGTGAATAGAAG -3'
(R):5'- GCTTAAATCCAAGCTTGAGTCATGC -3'
Posted On 2016-07-06