Incidental Mutation 'R5178:Or7e174'
ID 399480
Institutional Source Beutler Lab
Gene Symbol Or7e174
Ensembl Gene ENSMUSG00000044106
Gene Name olfactory receptor family 7 subfamily E member 174
Synonyms MOR145-4, GA_x6K02T2PVTD-13841888-13842802, Olfr868
MMRRC Submission 042758-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R5178 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 20009922-20012986 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 20012488 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 144 (C144*)
Ref Sequence ENSEMBL: ENSMUSP00000148302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000212767] [ENSMUST00000212999]
AlphaFold Q8VFI8
Predicted Effect probably null
Transcript: ENSMUST00000050227
AA Change: C144*
SMART Domains Protein: ENSMUSP00000050040
Gene: ENSMUSG00000044106
AA Change: C144*

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 3.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 38 288 3.6e-7 PFAM
Pfam:7tm_1 44 293 4.8e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000212767
AA Change: C144*
Predicted Effect probably null
Transcript: ENSMUST00000212999
AA Change: C144*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215566
Meta Mutation Damage Score 0.9657 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abt1 G T 13: 23,606,819 (GRCm39) A94E possibly damaging Het
Carmil2 G T 8: 106,423,521 (GRCm39) G1207V probably damaging Het
Cndp2 A T 18: 84,693,153 (GRCm39) N202K probably benign Het
Cyp2c66 A G 19: 39,159,473 (GRCm39) Y308C probably damaging Het
Dhx29 T G 13: 113,069,134 (GRCm39) S155A possibly damaging Het
Dnah7b T G 1: 46,397,376 (GRCm39) F3936V possibly damaging Het
Dsg1b G A 18: 20,530,560 (GRCm39) G405E probably damaging Het
Exo5 A T 4: 120,778,734 (GRCm39) probably null Het
Fam171b T C 2: 83,710,331 (GRCm39) F668L probably damaging Het
Gemin5 A T 11: 58,037,344 (GRCm39) S624T probably benign Het
Gpc2 C A 5: 138,273,867 (GRCm39) V444L possibly damaging Het
Hephl1 T A 9: 14,997,468 (GRCm39) K399N probably damaging Het
Lair1 G A 7: 4,013,488 (GRCm39) T82I possibly damaging Het
Lhx1 G T 11: 84,411,214 (GRCm39) A155E possibly damaging Het
Maip1 G A 1: 57,454,849 (GRCm39) D278N probably benign Het
Mcm4 T A 16: 15,453,167 (GRCm39) D174V probably benign Het
Mcph1 T A 8: 18,657,342 (GRCm39) D60E probably damaging Het
Mmp17 T A 5: 129,672,122 (GRCm39) W132R probably damaging Het
Or4p7 C T 2: 88,221,819 (GRCm39) T76I possibly damaging Het
Pds5a T C 5: 65,821,218 (GRCm39) T169A probably damaging Het
Pfkm A G 15: 98,029,396 (GRCm39) N697D probably benign Het
Pira1 T A 7: 3,742,396 (GRCm39) K44* probably null Het
Ppwd1 A T 13: 104,356,943 (GRCm39) S191T probably benign Het
Ranbp2 T A 10: 58,312,607 (GRCm39) M1109K probably benign Het
Robo4 T C 9: 37,319,256 (GRCm39) W535R probably damaging Het
Rsf1 A G 7: 97,311,079 (GRCm39) D603G possibly damaging Het
Slc22a26 T C 19: 7,767,540 (GRCm39) T289A possibly damaging Het
Sp2 A G 11: 96,846,664 (GRCm39) F554L probably benign Het
Sp4 A G 12: 118,225,624 (GRCm39) V580A possibly damaging Het
Tbc1d19 T A 5: 54,046,667 (GRCm39) S413T possibly damaging Het
Tecta T C 9: 42,286,481 (GRCm39) D725G probably damaging Het
Tmem200a T A 10: 25,870,277 (GRCm39) Q4H probably benign Het
Tpx2 T A 2: 152,717,469 (GRCm39) I122N probably benign Het
Trgc4 A G 13: 19,528,932 (GRCm39) probably benign Het
Ube4b T C 4: 149,427,449 (GRCm39) M900V probably damaging Het
Vmn1r87 G T 7: 12,865,792 (GRCm39) A165E possibly damaging Het
Vmn2r95 A G 17: 18,660,337 (GRCm39) T250A probably benign Het
Wasf1 G A 10: 40,813,672 (GRCm39) R518H unknown Het
Zfhx2 A T 14: 55,312,232 (GRCm39) F154Y probably benign Het
Zfp729a A G 13: 67,785,764 (GRCm39) probably null Het
Zfp976 A G 7: 42,261,925 (GRCm39) probably null Het
Other mutations in Or7e174
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02647:Or7e174 APN 9 20,012,505 (GRCm39) missense probably benign 0.02
IGL03080:Or7e174 APN 9 20,012,705 (GRCm39) missense probably damaging 0.99
R0421:Or7e174 UTSW 9 20,012,771 (GRCm39) missense probably damaging 1.00
R0422:Or7e174 UTSW 9 20,012,744 (GRCm39) nonsense probably null
R1108:Or7e174 UTSW 9 20,012,121 (GRCm39) missense probably benign 0.01
R1386:Or7e174 UTSW 9 20,012,878 (GRCm39) missense probably benign 0.09
R1693:Or7e174 UTSW 9 20,012,883 (GRCm39) missense probably benign 0.21
R1732:Or7e174 UTSW 9 20,012,796 (GRCm39) missense probably damaging 1.00
R2006:Or7e174 UTSW 9 20,012,165 (GRCm39) missense probably benign 0.03
R4556:Or7e174 UTSW 9 20,012,619 (GRCm39) missense possibly damaging 0.63
R4602:Or7e174 UTSW 9 20,012,540 (GRCm39) missense probably benign 0.07
R5125:Or7e174 UTSW 9 20,012,488 (GRCm39) nonsense probably null
R7324:Or7e174 UTSW 9 20,012,726 (GRCm39) missense possibly damaging 0.83
R7358:Or7e174 UTSW 9 20,012,169 (GRCm39) missense probably damaging 1.00
R7536:Or7e174 UTSW 9 20,012,826 (GRCm39) missense probably damaging 0.99
R7539:Or7e174 UTSW 9 20,012,915 (GRCm39) missense probably benign 0.12
R7572:Or7e174 UTSW 9 20,012,154 (GRCm39) missense probably damaging 1.00
R7946:Or7e174 UTSW 9 20,012,780 (GRCm39) missense probably damaging 1.00
R8805:Or7e174 UTSW 9 20,012,580 (GRCm39) missense probably benign 0.21
Predicted Primers PCR Primer
(F):5'- GCTTCAAATCCACAGTCCAGTC -3'
(R):5'- TATACCTCCCACTTGAAGAGGTG -3'

Sequencing Primer
(F):5'- AGTCCAGTCATATCCTACGTGGG -3'
(R):5'- CCCACTTGAAGAGGTGATTCTCAG -3'
Posted On 2016-07-06