Incidental Mutation 'R5255:Vmn1r218'
ID 399515
Institutional Source Beutler Lab
Gene Symbol Vmn1r218
Ensembl Gene ENSMUSG00000115020
Gene Name vomeronasal 1 receptor 218
Synonyms V1ri5
MMRRC Submission 042826-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R5255 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 23133155-23146112 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23136711 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 76 (D76V)
Ref Sequence ENSEMBL: ENSMUSP00000154543 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074992] [ENSMUST00000226692] [ENSMUST00000227050] [ENSMUST00000227160] [ENSMUST00000227741]
AlphaFold Q8R261
Predicted Effect possibly damaging
Transcript: ENSMUST00000074992
AA Change: D76V

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000074519
Gene: ENSMUSG00000115020
AA Change: D76V

DomainStartEndE-ValueType
Pfam:TAS2R 1 288 2e-7 PFAM
Pfam:V1R 33 297 5.4e-41 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226692
AA Change: D76V

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227050
AA Change: D76V

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000227160
Predicted Effect probably benign
Transcript: ENSMUST00000227741
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228348
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921501E09Rik A T 17: 33,066,765 (GRCm38) C354* probably null Het
Abcf1 A T 17: 35,959,737 (GRCm38) probably null Het
Abr T A 11: 76,455,683 (GRCm38) E434V probably damaging Het
Acaca T A 11: 84,311,307 (GRCm38) L197Q probably damaging Het
Acot10 A G 15: 20,665,932 (GRCm38) I241T probably benign Het
Acp6 T C 3: 97,167,996 (GRCm38) V182A probably benign Het
Ahnak2 G A 12: 112,773,378 (GRCm38) T1420I possibly damaging Het
Akr1c6 A T 13: 4,447,019 (GRCm38) K153N probably benign Het
Ank3 T C 10: 69,885,200 (GRCm38) L600P probably damaging Het
Arhgef1 G A 7: 24,925,022 (GRCm38) A824T probably damaging Het
B230307C23Rik T A 16: 98,008,691 (GRCm38) N22K possibly damaging Het
Btn1a1 A G 13: 23,464,154 (GRCm38) probably benign Het
Cenpf G A 1: 189,672,627 (GRCm38) T352I possibly damaging Het
Ces4a C A 8: 105,142,489 (GRCm38) F185L probably benign Het
Clybl A C 14: 122,384,279 (GRCm38) E293A probably benign Het
Cobl A G 11: 12,375,825 (GRCm38) W217R probably damaging Het
D430041D05Rik T C 2: 104,256,600 (GRCm38) N677S probably benign Het
Ddx51 C A 5: 110,656,042 (GRCm38) T390N possibly damaging Het
Drd5 T G 5: 38,319,967 (GRCm38) V101G probably damaging Het
Elmo3 C T 8: 105,307,353 (GRCm38) P244L probably benign Het
Esrrg G A 1: 188,146,358 (GRCm38) R189H probably damaging Het
Fxr2 A G 11: 69,643,841 (GRCm38) T183A probably benign Het
Gjd4 T C 18: 9,280,613 (GRCm38) H155R probably benign Het
Hivep2 T A 10: 14,131,267 (GRCm38) probably null Het
Ints10 T C 8: 68,793,972 (GRCm38) probably benign Het
Kank4 T C 4: 98,778,972 (GRCm38) T413A probably benign Het
Mapkbp1 T C 2: 120,017,254 (GRCm38) V568A probably damaging Het
Mobp A G 9: 120,168,353 (GRCm38) probably benign Het
Mpst A G 15: 78,410,508 (GRCm38) S147G probably benign Het
Myo5b A T 18: 74,662,670 (GRCm38) Y559F possibly damaging Het
Nceh1 T C 3: 27,183,139 (GRCm38) I21T probably damaging Het
Olfr1303 T C 2: 111,814,178 (GRCm38) K183E probably benign Het
Ralgps1 A T 2: 33,276,159 (GRCm38) V126E probably damaging Het
Rnls A G 19: 33,382,423 (GRCm38) V115A probably damaging Het
Scn1a A T 2: 66,277,669 (GRCm38) V1554D probably damaging Het
Slc16a11 T A 11: 70,215,432 (GRCm38) D165E probably damaging Het
Slc16a5 A G 11: 115,462,675 (GRCm38) T23A probably benign Het
Slc22a30 G A 19: 8,344,393 (GRCm38) Q436* probably null Het
Slc3a1 A T 17: 85,028,453 (GRCm38) probably null Het
Slitrk6 A T 14: 110,749,753 (GRCm38) *841K probably null Het
Syngr1 A G 15: 80,091,446 (GRCm38) Y18C possibly damaging Het
Tarbp1 T G 8: 126,428,970 (GRCm38) D1343A probably benign Het
Vac14 T A 8: 110,634,329 (GRCm38) I177N probably damaging Het
Wdr75 T A 1: 45,799,117 (GRCm38) I62N probably damaging Het
Zfp12 A T 5: 143,240,379 (GRCm38) I68L probably null Het
Zswim8 T A 14: 20,721,651 (GRCm38) Y1551N probably damaging Het
Other mutations in Vmn1r218
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02014:Vmn1r218 APN 13 23,136,831 (GRCm38) missense probably damaging 0.97
IGL02670:Vmn1r218 APN 13 23,137,004 (GRCm38) missense probably benign 0.01
IGL03085:Vmn1r218 APN 13 23,137,311 (GRCm38) missense possibly damaging 0.76
IGL03334:Vmn1r218 APN 13 23,136,618 (GRCm38) missense probably damaging 1.00
R0049:Vmn1r218 UTSW 13 23,137,055 (GRCm38) nonsense probably null
R0049:Vmn1r218 UTSW 13 23,137,055 (GRCm38) nonsense probably null
R1387:Vmn1r218 UTSW 13 23,137,308 (GRCm38) missense probably damaging 1.00
R1959:Vmn1r218 UTSW 13 23,136,513 (GRCm38) missense probably damaging 0.96
R3713:Vmn1r218 UTSW 13 23,136,911 (GRCm38) missense probably damaging 1.00
R3714:Vmn1r218 UTSW 13 23,136,911 (GRCm38) missense probably damaging 1.00
R4037:Vmn1r218 UTSW 13 23,136,801 (GRCm38) missense possibly damaging 0.91
R4038:Vmn1r218 UTSW 13 23,136,801 (GRCm38) missense possibly damaging 0.91
R4039:Vmn1r218 UTSW 13 23,136,801 (GRCm38) missense possibly damaging 0.91
R4432:Vmn1r218 UTSW 13 23,137,242 (GRCm38) missense possibly damaging 0.87
R5521:Vmn1r218 UTSW 13 23,136,573 (GRCm38) missense probably benign 0.01
R7384:Vmn1r218 UTSW 13 23,136,725 (GRCm38) missense probably benign 0.00
R7565:Vmn1r218 UTSW 13 23,136,660 (GRCm38) missense probably benign 0.05
R8178:Vmn1r218 UTSW 13 23,137,302 (GRCm38) missense probably benign 0.08
R8536:Vmn1r218 UTSW 13 23,137,365 (GRCm38) missense probably benign 0.00
R9225:Vmn1r218 UTSW 13 23,136,654 (GRCm38) missense probably benign 0.04
R9609:Vmn1r218 UTSW 13 23,136,669 (GRCm38) missense probably benign 0.01
R9734:Vmn1r218 UTSW 13 23,136,864 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTCTAGCTGGACCTGGAG -3'
(R):5'- GCAAGTTGGAGCTTATGAGAAC -3'

Sequencing Primer
(F):5'- CTGGACCTGGAGTTGTAGGAAATATC -3'
(R):5'- GGAGCTTATGAGAACATTAACAATCC -3'
Posted On 2016-07-06