Mutagenetix > Incidental Mutation

Incidental Mutation 'R5180:Taar7a'

399736

Institutional Source

Beutler Lab

Gene Symbol

Taar7a

Ensembl Gene

ENSMUSG00000095647

Gene Name

trace amine-associated receptor 7A

Synonyms

Taar7a, LOC215856

MMRRC Submission

042760-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

R5180 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23868303-23869379 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23869046 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 112 (C112R)

Ref Sequence

ENSEMBL: ENSMUSP00000077616 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078532]

AlphaFold

Q5QD12

Predicted Effect

probably damaging
Transcript: ENSMUST00000078532
AA Change: C112R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: C112R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	54	344	9.2e-10	PFAM
Pfam:7TM_GPCR_Srx	56	261	5.2e-9	PFAM
Pfam:7tm_1	64	326	3.2e-58	PFAM

Meta Mutation Damage Score

0.6957

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.2%

Validation Efficiency

97% (60/62)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,416,510 (GRCm39)	T4091A	probably benign	Het
Adgrv1	G	A	13: 81,431,535 (GRCm39)		probably benign	Het
Ago3	C	T	4: 126,261,544 (GRCm39)	V435I	probably benign	Het
Akap10	C	T	11: 61,807,015 (GRCm39)	A72T	probably damaging	Het
Ampd2	G	T	3: 107,986,358 (GRCm39)	Q273K	probably benign	Het
Ankrd35	C	A	3: 96,587,789 (GRCm39)	H109Q	probably damaging	Het
Atpaf2	A	G	11: 60,296,695 (GRCm39)	L153S	possibly damaging	Het
C1qtnf7	G	A	5: 43,773,156 (GRCm39)	V152M	probably benign	Het
Ccnb1	C	G	13: 100,918,283 (GRCm39)	Q121H	possibly damaging	Het
Cep295	C	T	9: 15,243,416 (GRCm39)	C1680Y	probably benign	Het
Cyp4f15	A	T	17: 32,909,714 (GRCm39)	I104F	probably benign	Het
Daam1	A	G	12: 71,993,899 (GRCm39)	N434S	unknown	Het
Dab2ip	C	T	2: 35,610,503 (GRCm39)	P782L	possibly damaging	Het
Dhx34	C	A	7: 15,939,405 (GRCm39)	G663*	probably null	Het
Dnah7a	T	C	1: 53,462,446 (GRCm39)	D3715G	probably damaging	Het
Dnajc11	C	T	4: 152,054,396 (GRCm39)	R201C	probably damaging	Het
Erf	A	T	7: 24,945,690 (GRCm39)	I27N	probably damaging	Het
Fbxl7	T	A	15: 26,543,507 (GRCm39)	Y380F	probably damaging	Het
Gm3336	A	G	8: 71,173,110 (GRCm39)		probably benign	Het
Gm4787	G	C	12: 81,424,604 (GRCm39)	T518S	probably benign	Het
Gm5134	T	C	10: 75,812,200 (GRCm39)	Y152H	probably damaging	Het
Gm6899	A	G	11: 26,543,795 (GRCm39)		probably benign	Het
Gna11	T	C	10: 81,380,707 (GRCm39)	K19E	probably benign	Het
Gpr15	C	A	16: 58,538,248 (GRCm39)	L280F	probably benign	Het
Grhl3	T	A	4: 135,286,415 (GRCm39)	K89*	probably null	Het
Ino80d	C	A	1: 63,125,488 (GRCm39)		probably benign	Het
Irak3	T	G	10: 119,981,687 (GRCm39)	K406T	probably damaging	Het
Kif15	G	A	9: 122,828,275 (GRCm39)	C634Y	probably damaging	Het
Lin9	T	A	1: 180,496,763 (GRCm39)	L351I	probably benign	Het
Macrod2	A	T	2: 140,237,636 (GRCm39)	E14V	probably damaging	Het
Matn3	T	A	12: 9,005,374 (GRCm39)	D261E	probably benign	Het
Mdga1	A	T	17: 30,076,710 (GRCm39)		probably benign	Het
Natd1	G	T	11: 60,804,482 (GRCm39)	R24S	probably benign	Het
Ncapd3	T	A	9: 26,962,941 (GRCm39)	D415E	possibly damaging	Het
Or5b101	A	T	19: 13,004,776 (GRCm39)	S306T	probably benign	Het
Parp9	T	A	16: 35,774,106 (GRCm39)	Y81*	probably null	Het
Pde4d	A	G	13: 109,877,007 (GRCm39)	N73S	probably benign	Het
Pigb	A	T	9: 72,941,872 (GRCm39)	I129N	probably damaging	Het
Plxnb1	C	A	9: 108,940,761 (GRCm39)		probably null	Het
Ppfibp1	G	T	6: 146,928,819 (GRCm39)	R813L	probably damaging	Het
Ramp3	T	A	11: 6,608,619 (GRCm39)	L16Q	unknown	Het
Slc35a4	T	C	18: 36,815,688 (GRCm39)	S173P	probably benign	Het
Slc41a1	T	C	1: 131,772,115 (GRCm39)	V415A	probably damaging	Het
Smarcc2	CCAGCAGCAGCAGCAGCAGC	CCAGCAGCAGCAGCAGC	10: 128,323,231 (GRCm39)		probably benign	Het
Snph	G	A	2: 151,442,307 (GRCm39)	R43W	probably benign	Het
Sptan1	A	T	2: 29,883,736 (GRCm39)		probably benign	Het
Supt20	C	A	3: 54,616,506 (GRCm39)	H254Q	probably benign	Het
Tbc1d4	T	C	14: 101,745,008 (GRCm39)	Y206C	probably damaging	Het
Tecta	A	G	9: 42,248,504 (GRCm39)	V1961A	probably damaging	Het
Tgfbr1	T	A	4: 47,383,948 (GRCm39)	Y30*	probably null	Het
Tmem71	C	T	15: 66,427,063 (GRCm39)	S44N	probably benign	Het
Tnfrsf1b	C	A	4: 144,954,067 (GRCm39)	C94F	probably damaging	Het
Ttn	A	G	2: 76,579,740 (GRCm39)	Y23718H	probably damaging	Het
Ube2i	T	C	17: 25,484,268 (GRCm39)		probably benign	Het
Vmn2r16	G	T	5: 109,478,391 (GRCm39)	V49F	probably benign	Het
Vps45	A	G	3: 95,953,683 (GRCm39)	I223T	possibly damaging	Het
Zfp955a	T	C	17: 33,461,592 (GRCm39)	Y180C	probably benign	Het
Zhx1	C	G	15: 57,917,470 (GRCm39)	G259R	probably damaging	Het
Zscan18	T	A	7: 12,509,216 (GRCm39)		probably benign	Het

Other mutations in Taar7a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00476:Taar7a	APN	10	23,868,294 (GRCm39)	unclassified	probably benign
IGL02408:Taar7a	APN	10	23,868,500 (GRCm39)	missense	probably benign
PIT4434001:Taar7a	UTSW	10	23,869,319 (GRCm39)	missense	probably benign
R0422:Taar7a	UTSW	10	23,869,172 (GRCm39)	missense	probably benign	0.02
R1029:Taar7a	UTSW	10	23,868,439 (GRCm39)	missense	possibly damaging	0.65
R1742:Taar7a	UTSW	10	23,869,117 (GRCm39)	missense	probably damaging	0.98
R2104:Taar7a	UTSW	10	23,868,959 (GRCm39)	missense	probably damaging	0.99
R2421:Taar7a	UTSW	10	23,868,415 (GRCm39)	missense	probably damaging	1.00
R3907:Taar7a	UTSW	10	23,868,457 (GRCm39)	missense	probably benign	0.25
R4021:Taar7a	UTSW	10	23,869,284 (GRCm39)	missense	probably benign	0.00
R5486:Taar7a	UTSW	10	23,868,356 (GRCm39)	missense	probably benign	0.00
R5507:Taar7a	UTSW	10	23,868,529 (GRCm39)	missense	probably damaging	0.98
R5587:Taar7a	UTSW	10	23,868,726 (GRCm39)	missense	probably benign	0.00
R5766:Taar7a	UTSW	10	23,869,260 (GRCm39)	missense	probably benign	0.01
R5861:Taar7a	UTSW	10	23,868,337 (GRCm39)	missense	probably benign
R7201:Taar7a	UTSW	10	23,868,358 (GRCm39)	missense	probably benign	0.04
R7506:Taar7a	UTSW	10	23,868,892 (GRCm39)	missense	possibly damaging	0.50
R8810:Taar7a	UTSW	10	23,869,279 (GRCm39)	missense	probably benign	0.20
R9015:Taar7a	UTSW	10	23,868,733 (GRCm39)	missense	probably damaging	0.97
R9172:Taar7a	UTSW	10	23,868,677 (GRCm39)	missense	probably benign	0.16
R9686:Taar7a	UTSW	10	23,869,309 (GRCm39)	missense	probably benign	0.01
R9717:Taar7a	UTSW	10	23,868,799 (GRCm39)	missense	probably benign	0.01
R9720:Taar7a	UTSW	10	23,868,733 (GRCm39)	missense	probably benign	0.10
X0064:Taar7a	UTSW	10	23,868,515 (GRCm39)	missense	probably damaging	1.00
Z1177:Taar7a	UTSW	10	23,868,790 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- ATGCACTTGCCAGAAACAGAAG -3'
(R):5'- CTGAACAGGTCCTGTGTCAG -3'

Sequencing Primer
(F):5'- CACTTGCCAGAAACAGAAGCAGTG -3'
(R):5'- TGTGTCAGGAGCCCATACTC -3'

Posted On

2016-07-06