Incidental Mutation 'R5257:Mslnl'
| ID |
399832 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mslnl
|
| Ensembl Gene |
ENSMUSG00000041062 |
| Gene Name |
mesothelin-like |
| Synonyms |
|
| MMRRC Submission |
042855-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5257 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
25736040-25748330 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 25746165 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 502
(Y502H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
[ENSMUST00000075884]
|
| AlphaFold |
Q8C160 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047098
AA Change: Y502H
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: Y502H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
|
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075884
|
| SMART Domains |
Protein: ENSMUSP00000075279
Gene: ENSMUSG00000063011
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Mesothelin
|
1 |
624 |
N/A |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000102319
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.5%
|
| Validation Efficiency |
97% (63/65) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
T |
11: 9,249,684 (GRCm38) |
T128S |
possibly damaging |
Het |
| Abca16 |
T |
G |
7: 120,436,769 (GRCm38) |
|
probably null |
Het |
| Acpp |
T |
C |
9: 104,309,475 (GRCm38) |
I266V |
probably benign |
Het |
| Afg3l2 |
G |
T |
18: 67,421,259 (GRCm38) |
L458M |
probably damaging |
Het |
| Asf1b |
C |
T |
8: 83,969,267 (GRCm38) |
T179I |
probably benign |
Het |
| Astn1 |
A |
G |
1: 158,612,532 (GRCm38) |
K890R |
probably damaging |
Het |
| Card11 |
G |
A |
5: 140,876,425 (GRCm38) |
P1039L |
possibly damaging |
Het |
| Chsy3 |
A |
G |
18: 59,409,794 (GRCm38) |
E668G |
possibly damaging |
Het |
| Cnot8 |
T |
A |
11: 58,117,522 (GRCm38) |
N271K |
possibly damaging |
Het |
| Dcaf5 |
G |
T |
12: 80,397,719 (GRCm38) |
P200H |
probably damaging |
Het |
| Dkk4 |
C |
A |
8: 22,627,015 (GRCm38) |
L215I |
probably damaging |
Het |
| Dnhd1 |
C |
T |
7: 105,674,037 (GRCm38) |
T584I |
probably benign |
Het |
| Dock3 |
T |
C |
9: 106,996,925 (GRCm38) |
Y449C |
probably damaging |
Het |
| Dsg1a |
A |
G |
18: 20,320,931 (GRCm38) |
D31G |
probably damaging |
Het |
| Fgfr1op |
T |
C |
17: 8,172,943 (GRCm38) |
S152P |
probably benign |
Het |
| Foxi2 |
C |
T |
7: 135,410,527 (GRCm38) |
T48M |
probably benign |
Het |
| Gdf3 |
T |
C |
6: 122,606,386 (GRCm38) |
M341V |
probably damaging |
Het |
| Gm21738 |
A |
G |
14: 19,415,942 (GRCm38) |
L199S |
probably benign |
Het |
| Gm4787 |
G |
C |
12: 81,377,830 (GRCm38) |
T518S |
probably benign |
Het |
| Igkv4-80 |
T |
A |
6: 69,016,827 (GRCm38) |
T27S |
probably benign |
Het |
| Ipo9 |
A |
T |
1: 135,385,435 (GRCm38) |
C1019S |
probably damaging |
Het |
| Klk14 |
G |
A |
7: 43,692,077 (GRCm38) |
C51Y |
probably damaging |
Het |
| Ktn1 |
T |
A |
14: 47,667,363 (GRCm38) |
H199Q |
probably benign |
Het |
| Kyat3 |
A |
G |
3: 142,734,576 (GRCm38) |
M354V |
probably benign |
Het |
| Lbhd1 |
A |
G |
19: 8,884,089 (GRCm38) |
|
probably benign |
Het |
| Llgl1 |
G |
C |
11: 60,711,563 (GRCm38) |
|
probably null |
Het |
| Lyzl6 |
T |
A |
11: 103,635,073 (GRCm38) |
I74F |
probably damaging |
Het |
| Mfsd4b2 |
T |
A |
10: 39,922,021 (GRCm38) |
M113L |
probably benign |
Het |
| Nckap5 |
A |
G |
1: 126,024,508 (GRCm38) |
S1372P |
probably damaging |
Het |
| Nle1 |
T |
C |
11: 82,904,946 (GRCm38) |
D225G |
probably damaging |
Het |
| Olfr221 |
T |
C |
14: 52,035,884 (GRCm38) |
T76A |
possibly damaging |
Het |
| P2rx7 |
A |
G |
5: 122,681,003 (GRCm38) |
E496G |
probably damaging |
Het |
| Padi4 |
C |
T |
4: 140,746,204 (GRCm38) |
V641M |
probably benign |
Het |
| Phf11d |
T |
C |
14: 59,352,711 (GRCm38) |
I221V |
possibly damaging |
Het |
| Pla2g2c |
G |
A |
4: 138,731,545 (GRCm38) |
|
probably benign |
Het |
| Prdm16 |
A |
T |
4: 154,367,214 (GRCm38) |
D179E |
possibly damaging |
Het |
| Psca |
A |
T |
15: 74,716,391 (GRCm38) |
I56F |
probably damaging |
Het |
| Ptrhd1 |
A |
G |
12: 4,236,481 (GRCm38) |
Y124C |
probably damaging |
Het |
| Sardh |
T |
C |
2: 27,244,259 (GRCm38) |
T82A |
probably damaging |
Het |
| Sesn1 |
C |
T |
10: 41,894,988 (GRCm38) |
P172S |
probably benign |
Het |
| Setd4 |
T |
C |
16: 93,596,333 (GRCm38) |
T57A |
probably damaging |
Het |
| Skint5 |
T |
C |
4: 113,577,662 (GRCm38) |
T1037A |
unknown |
Het |
| Slc18a3 |
T |
C |
14: 32,463,820 (GRCm38) |
D202G |
probably damaging |
Het |
| Slc44a5 |
G |
A |
3: 154,243,123 (GRCm38) |
C176Y |
probably damaging |
Het |
| Slc6a5 |
G |
A |
7: 49,929,992 (GRCm38) |
V373M |
probably damaging |
Het |
| Sorbs3 |
T |
C |
14: 70,185,034 (GRCm38) |
I523V |
probably benign |
Het |
| Sspo |
T |
C |
6: 48,476,494 (GRCm38) |
V2872A |
probably damaging |
Het |
| Stard9 |
T |
A |
2: 120,699,343 (GRCm38) |
L2027H |
probably damaging |
Het |
| Tex2 |
T |
A |
11: 106,567,759 (GRCm38) |
|
probably benign |
Het |
| Tfdp1 |
C |
T |
8: 13,369,529 (GRCm38) |
T86M |
possibly damaging |
Het |
| Ttc6 |
A |
T |
12: 57,702,275 (GRCm38) |
D1331V |
possibly damaging |
Het |
| Vps13b |
A |
G |
15: 35,794,421 (GRCm38) |
T2326A |
possibly damaging |
Het |
| Wnk1 |
A |
G |
6: 120,037,188 (GRCm38) |
S149P |
probably benign |
Het |
| Zfp521 |
G |
A |
18: 13,846,978 (GRCm38) |
S126F |
probably damaging |
Het |
| Zfp958 |
A |
T |
8: 4,628,456 (GRCm38) |
E160D |
probably benign |
Het |
|
| Other mutations in Mslnl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01621:Mslnl
|
APN |
17 |
25,743,667 (GRCm38) |
unclassified |
probably benign |
|
|
IGL01629:Mslnl
|
APN |
17 |
25,744,775 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02084:Mslnl
|
APN |
17 |
25,746,151 (GRCm38) |
missense |
probably benign |
0.07 |
|
IGL02408:Mslnl
|
APN |
17 |
25,747,998 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL02726:Mslnl
|
APN |
17 |
25,744,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL03387:Mslnl
|
APN |
17 |
25,744,077 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0561:Mslnl
|
UTSW |
17 |
25,743,203 (GRCm38) |
nonsense |
probably null |
|
|
R0881:Mslnl
|
UTSW |
17 |
25,742,965 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1295:Mslnl
|
UTSW |
17 |
25,743,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1296:Mslnl
|
UTSW |
17 |
25,743,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1629:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1630:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1631:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1632:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1794:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1850:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1866:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1876:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1914:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2166:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2241:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2243:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2247:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2282:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2284:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2852:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2877:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2878:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2919:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2920:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3026:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3405:Mslnl
|
UTSW |
17 |
25,746,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3406:Mslnl
|
UTSW |
17 |
25,746,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3411:Mslnl
|
UTSW |
17 |
25,744,517 (GRCm38) |
missense |
probably benign |
0.05 |
|
R3434:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3546:Mslnl
|
UTSW |
17 |
25,744,969 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3612:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3729:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3730:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3802:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3804:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3894:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3895:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4454:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4455:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4456:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4457:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4561:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4562:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4564:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4600:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4601:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4610:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4704:Mslnl
|
UTSW |
17 |
25,738,978 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R5155:Mslnl
|
UTSW |
17 |
25,738,968 (GRCm38) |
nonsense |
probably null |
|
|
R5456:Mslnl
|
UTSW |
17 |
25,743,159 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5645:Mslnl
|
UTSW |
17 |
25,737,842 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6007:Mslnl
|
UTSW |
17 |
25,746,775 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6083:Mslnl
|
UTSW |
17 |
25,737,902 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6142:Mslnl
|
UTSW |
17 |
25,744,557 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6761:Mslnl
|
UTSW |
17 |
25,746,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7058:Mslnl
|
UTSW |
17 |
25,743,212 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7156:Mslnl
|
UTSW |
17 |
25,743,210 (GRCm38) |
missense |
probably benign |
0.20 |
|
R7467:Mslnl
|
UTSW |
17 |
25,736,921 (GRCm38) |
start codon destroyed |
probably benign |
0.33 |
|
R7687:Mslnl
|
UTSW |
17 |
25,743,183 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7807:Mslnl
|
UTSW |
17 |
25,746,777 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8682:Mslnl
|
UTSW |
17 |
25,746,988 (GRCm38) |
missense |
probably benign |
|
|
R8735:Mslnl
|
UTSW |
17 |
25,745,088 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8742:Mslnl
|
UTSW |
17 |
25,745,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9208:Mslnl
|
UTSW |
17 |
25,742,720 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9264:Mslnl
|
UTSW |
17 |
25,742,532 (GRCm38) |
intron |
probably benign |
|
|
RF007:Mslnl
|
UTSW |
17 |
25,743,228 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- TATACAGAGGGCAAGCACTTTAAAG -3'
(R):5'- TGTCCATGGAGATGTTGGCC -3'
Sequencing Primer
(F):5'- CACTTTAAAGGATGGAGGATACAC -3'
(R):5'- CCTGTGCCAGGTATTGAAGTTCC -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation