Incidental Mutation 'R5269:Gon4l'
ID 400035
Institutional Source Beutler Lab
Gene Symbol Gon4l
Ensembl Gene ENSMUSG00000054199
Gene Name gon-4 like
Synonyms 1500041I23Rik, 2610100B20Rik
MMRRC Submission 042834-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.903) question?
Stock # R5269 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 88742531-88817406 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 88802835 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 1149 (I1149L)
Ref Sequence ENSEMBL: ENSMUSP00000103122 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081695] [ENSMUST00000090942] [ENSMUST00000107498]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000081695
AA Change: I1149L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000080397
Gene: ENSMUSG00000054199
AA Change: I1149L

DomainStartEndE-ValueType
low complexity region 16 29 N/A INTRINSIC
low complexity region 104 115 N/A INTRINSIC
low complexity region 150 163 N/A INTRINSIC
low complexity region 240 256 N/A INTRINSIC
low complexity region 348 377 N/A INTRINSIC
low complexity region 432 439 N/A INTRINSIC
low complexity region 527 542 N/A INTRINSIC
low complexity region 683 696 N/A INTRINSIC
Blast:SANT 813 865 1e-23 BLAST
low complexity region 961 975 N/A INTRINSIC
low complexity region 1311 1329 N/A INTRINSIC
low complexity region 1418 1434 N/A INTRINSIC
low complexity region 1452 1497 N/A INTRINSIC
low complexity region 1507 1541 N/A INTRINSIC
Pfam:PAH 1652 1700 8.8e-9 PFAM
low complexity region 1800 1811 N/A INTRINSIC
coiled coil region 1919 1943 N/A INTRINSIC
low complexity region 2085 2094 N/A INTRINSIC
SANT 2153 2204 2.2e-1 SMART
low complexity region 2207 2222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000090942
AA Change: I1150L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088461
Gene: ENSMUSG00000054199
AA Change: I1150L

DomainStartEndE-ValueType
low complexity region 16 29 N/A INTRINSIC
low complexity region 104 115 N/A INTRINSIC
low complexity region 150 163 N/A INTRINSIC
low complexity region 241 257 N/A INTRINSIC
low complexity region 349 378 N/A INTRINSIC
low complexity region 433 440 N/A INTRINSIC
low complexity region 528 543 N/A INTRINSIC
low complexity region 684 697 N/A INTRINSIC
Blast:SANT 814 866 2e-23 BLAST
low complexity region 962 976 N/A INTRINSIC
low complexity region 1312 1330 N/A INTRINSIC
low complexity region 1419 1435 N/A INTRINSIC
low complexity region 1453 1498 N/A INTRINSIC
low complexity region 1508 1542 N/A INTRINSIC
Pfam:PAH 1654 1700 2.1e-8 PFAM
low complexity region 1801 1812 N/A INTRINSIC
coiled coil region 1920 1944 N/A INTRINSIC
low complexity region 2086 2095 N/A INTRINSIC
SANT 2154 2205 2.2e-1 SMART
low complexity region 2208 2223 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107498
AA Change: I1149L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000103122
Gene: ENSMUSG00000054199
AA Change: I1149L

DomainStartEndE-ValueType
low complexity region 16 29 N/A INTRINSIC
low complexity region 104 115 N/A INTRINSIC
low complexity region 150 163 N/A INTRINSIC
low complexity region 240 256 N/A INTRINSIC
low complexity region 348 377 N/A INTRINSIC
low complexity region 432 439 N/A INTRINSIC
low complexity region 527 542 N/A INTRINSIC
low complexity region 683 696 N/A INTRINSIC
Blast:SANT 813 865 1e-23 BLAST
low complexity region 961 975 N/A INTRINSIC
low complexity region 1311 1329 N/A INTRINSIC
low complexity region 1418 1434 N/A INTRINSIC
low complexity region 1452 1497 N/A INTRINSIC
low complexity region 1507 1541 N/A INTRINSIC
Pfam:PAH 1652 1700 8.8e-9 PFAM
low complexity region 1800 1811 N/A INTRINSIC
coiled coil region 1919 1943 N/A INTRINSIC
low complexity region 2085 2094 N/A INTRINSIC
SANT 2153 2204 2.2e-1 SMART
low complexity region 2207 2222 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198113
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198251
Predicted Effect probably benign
Transcript: ENSMUST00000212694
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.9%
Validation Efficiency 100% (71/71)
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit arrested B cell development at the early pro-B cell stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,595,717 (GRCm39) S357P possibly damaging Het
Adam39 A G 8: 41,279,018 (GRCm39) I470V probably benign Het
Agrn A T 4: 156,253,447 (GRCm39) C1708S probably benign Het
Agtpbp1 A G 13: 59,621,557 (GRCm39) I42T probably damaging Het
Akap6 T C 12: 53,186,626 (GRCm39) C1347R probably damaging Het
Antxr1 A G 6: 87,157,165 (GRCm39) L452P probably damaging Het
Arhgef33 T A 17: 80,677,704 (GRCm39) V417D probably damaging Het
Brca2 A G 5: 150,462,688 (GRCm39) I817M possibly damaging Het
Casp4 A T 9: 5,321,521 (GRCm39) probably benign Het
Cdh20 T C 1: 104,861,882 (GRCm39) Y21H possibly damaging Het
Cdr2 C T 7: 120,557,557 (GRCm39) V323M possibly damaging Het
Cebpa G A 7: 34,819,283 (GRCm39) R147H probably benign Het
Cetn4 C A 3: 37,364,118 (GRCm39) E31* probably null Het
Cobll1 G A 2: 64,964,115 (GRCm39) Q189* probably null Het
Colec12 A G 18: 9,846,825 (GRCm39) T74A possibly damaging Het
Crisp4 A G 1: 18,198,934 (GRCm39) S124P probably damaging Het
Eddm3b T A 14: 51,354,178 (GRCm39) D55E probably damaging Het
Elmo1 C A 13: 20,633,656 (GRCm39) N439K probably benign Het
Fabp12 T C 3: 10,315,167 (GRCm39) N60S probably benign Het
Fat2 T A 11: 55,178,704 (GRCm39) H1452L probably benign Het
Flacc1 A G 1: 58,730,919 (GRCm39) S46P possibly damaging Het
Flrt2 T C 12: 95,746,712 (GRCm39) V350A possibly damaging Het
Ganab T C 19: 8,889,301 (GRCm39) F626S probably damaging Het
Ghr T C 15: 3,349,561 (GRCm39) Y539C probably benign Het
Gm6871 T C 7: 41,197,525 (GRCm39) T112A probably damaging Het
Gm7133 T A 1: 97,110,848 (GRCm39) noncoding transcript Het
Greb1l G A 18: 10,511,409 (GRCm39) D45N probably benign Het
H2-K2 A G 17: 34,215,989 (GRCm39) probably benign Het
Herc2 C T 7: 55,818,618 (GRCm39) R2770* probably null Het
Insyn2b G A 11: 34,352,788 (GRCm39) E277K probably damaging Het
Itsn2 A G 12: 4,683,553 (GRCm39) probably benign Het
Klb A G 5: 65,506,140 (GRCm39) D129G probably damaging Het
Klf1 A G 8: 85,629,969 (GRCm39) I265V probably benign Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Map3k10 T C 7: 27,357,957 (GRCm39) E607G probably benign Het
Melk C T 4: 44,363,730 (GRCm39) T592M probably damaging Het
Mroh6 A G 15: 75,757,639 (GRCm39) L457P probably damaging Het
Mrpl21 T A 19: 3,337,012 (GRCm39) C128S probably damaging Het
Or51f23 T C 7: 102,453,327 (GRCm39) V214A probably benign Het
Paqr4 G T 17: 23,957,187 (GRCm39) H105Q probably damaging Het
Pcdhga10 A G 18: 37,881,747 (GRCm39) I503V probably benign Het
Pds5a T C 5: 65,821,271 (GRCm39) N151S probably damaging Het
Pif1 A G 9: 65,499,111 (GRCm39) T444A possibly damaging Het
Ppp2r3d T C 9: 101,031,064 (GRCm39) R851G probably damaging Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Ros1 T G 10: 51,927,104 (GRCm39) Q2172P probably damaging Het
Rpe65 A G 3: 159,309,984 (GRCm39) T86A probably benign Het
Rpl18a G A 8: 71,348,932 (GRCm39) R15C possibly damaging Het
Sh3tc2 A G 18: 62,108,684 (GRCm39) K258R probably benign Het
Ska3 T A 14: 58,059,573 (GRCm39) E84V possibly damaging Het
Slc25a40 T A 5: 8,497,409 (GRCm39) probably null Het
Slf1 A T 13: 77,252,700 (GRCm39) S274T probably benign Het
Spata21 A T 4: 140,830,332 (GRCm39) Q267H probably damaging Het
Strbp A T 2: 37,517,455 (GRCm39) W207R possibly damaging Het
Taf6l T C 19: 8,752,326 (GRCm39) E454G probably damaging Het
Tcam1 C A 11: 106,176,353 (GRCm39) L360I probably benign Het
Tnxb G A 17: 34,922,582 (GRCm39) R2465H possibly damaging Het
Trim66 T A 7: 109,056,797 (GRCm39) Y1120F probably benign Het
Trp53 T A 11: 69,480,031 (GRCm39) M243K probably damaging Het
Ttl T A 2: 128,910,831 (GRCm39) C72S probably damaging Het
Ttn A G 2: 76,539,240 (GRCm39) V34582A probably benign Het
Uqcrh T C 4: 115,927,101 (GRCm39) T31A possibly damaging Het
Usp40 A G 1: 87,923,504 (GRCm39) C256R probably benign Het
Vmn1r168 A G 7: 23,240,839 (GRCm39) E232G probably benign Het
Wdr72 A T 9: 74,064,653 (GRCm39) I562F probably damaging Het
Wnt4 A G 4: 137,005,061 (GRCm39) N24S probably benign Het
Other mutations in Gon4l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Gon4l APN 3 88,764,492 (GRCm39) missense probably damaging 1.00
IGL02002:Gon4l APN 3 88,802,643 (GRCm39) missense possibly damaging 0.46
IGL02065:Gon4l APN 3 88,764,517 (GRCm39) missense probably null 1.00
IGL02283:Gon4l APN 3 88,802,671 (GRCm39) missense probably damaging 0.99
IGL02669:Gon4l APN 3 88,802,806 (GRCm39) missense probably damaging 1.00
IGL03222:Gon4l APN 3 88,802,950 (GRCm39) missense possibly damaging 0.56
IGL03385:Gon4l APN 3 88,814,850 (GRCm39) missense probably benign 0.10
PIT4581001:Gon4l UTSW 3 88,802,821 (GRCm39) missense probably damaging 1.00
R0020:Gon4l UTSW 3 88,766,244 (GRCm39) missense probably damaging 1.00
R0115:Gon4l UTSW 3 88,802,989 (GRCm39) missense probably damaging 1.00
R0173:Gon4l UTSW 3 88,765,710 (GRCm39) missense probably damaging 1.00
R0270:Gon4l UTSW 3 88,765,707 (GRCm39) missense probably damaging 1.00
R0961:Gon4l UTSW 3 88,805,403 (GRCm39) splice site probably benign
R1017:Gon4l UTSW 3 88,765,803 (GRCm39) missense probably benign 0.15
R1163:Gon4l UTSW 3 88,799,842 (GRCm39) missense probably damaging 1.00
R1729:Gon4l UTSW 3 88,810,405 (GRCm39) missense probably damaging 1.00
R1764:Gon4l UTSW 3 88,799,906 (GRCm39) missense probably damaging 1.00
R1861:Gon4l UTSW 3 88,802,794 (GRCm39) missense probably damaging 1.00
R2141:Gon4l UTSW 3 88,794,902 (GRCm39) missense possibly damaging 0.66
R2347:Gon4l UTSW 3 88,770,824 (GRCm39) missense probably damaging 1.00
R2402:Gon4l UTSW 3 88,766,350 (GRCm39) missense probably damaging 1.00
R2842:Gon4l UTSW 3 88,802,794 (GRCm39) missense probably damaging 1.00
R4375:Gon4l UTSW 3 88,814,694 (GRCm39) missense probably benign 0.00
R4376:Gon4l UTSW 3 88,814,694 (GRCm39) missense probably benign 0.00
R4377:Gon4l UTSW 3 88,814,694 (GRCm39) missense probably benign 0.00
R4569:Gon4l UTSW 3 88,817,397 (GRCm39) intron probably benign
R4650:Gon4l UTSW 3 88,770,859 (GRCm39) missense possibly damaging 0.94
R4859:Gon4l UTSW 3 88,802,655 (GRCm39) missense probably benign 0.00
R4901:Gon4l UTSW 3 88,815,458 (GRCm39) missense possibly damaging 0.50
R4998:Gon4l UTSW 3 88,807,305 (GRCm39) missense probably damaging 1.00
R5059:Gon4l UTSW 3 88,807,319 (GRCm39) missense probably benign 0.00
R5217:Gon4l UTSW 3 88,794,882 (GRCm39) missense probably damaging 1.00
R5279:Gon4l UTSW 3 88,794,944 (GRCm39) missense probably benign
R5283:Gon4l UTSW 3 88,794,897 (GRCm39) missense probably damaging 1.00
R5386:Gon4l UTSW 3 88,765,803 (GRCm39) missense probably benign 0.15
R5433:Gon4l UTSW 3 88,803,532 (GRCm39) missense possibly damaging 0.93
R5583:Gon4l UTSW 3 88,807,278 (GRCm39) missense probably damaging 1.00
R5695:Gon4l UTSW 3 88,803,523 (GRCm39) frame shift probably null
R5921:Gon4l UTSW 3 88,817,254 (GRCm39) intron probably benign
R6003:Gon4l UTSW 3 88,803,400 (GRCm39) missense probably damaging 0.99
R6063:Gon4l UTSW 3 88,807,306 (GRCm39) missense probably damaging 1.00
R6217:Gon4l UTSW 3 88,799,968 (GRCm39) missense possibly damaging 0.62
R6273:Gon4l UTSW 3 88,763,156 (GRCm39) missense probably damaging 1.00
R6280:Gon4l UTSW 3 88,798,195 (GRCm39) missense probably damaging 1.00
R6790:Gon4l UTSW 3 88,766,305 (GRCm39) missense probably damaging 1.00
R6829:Gon4l UTSW 3 88,787,413 (GRCm39) missense possibly damaging 0.96
R6891:Gon4l UTSW 3 88,766,173 (GRCm39) splice site probably null
R7128:Gon4l UTSW 3 88,802,999 (GRCm39) missense possibly damaging 0.94
R7315:Gon4l UTSW 3 88,802,486 (GRCm39) missense probably benign 0.00
R7355:Gon4l UTSW 3 88,770,827 (GRCm39) missense probably damaging 1.00
R7426:Gon4l UTSW 3 88,814,829 (GRCm39) missense probably benign
R7635:Gon4l UTSW 3 88,802,413 (GRCm39) missense probably benign 0.03
R7643:Gon4l UTSW 3 88,810,114 (GRCm39) missense probably damaging 1.00
R7715:Gon4l UTSW 3 88,815,313 (GRCm39) missense probably benign
R7773:Gon4l UTSW 3 88,803,102 (GRCm39) missense probably benign 0.00
R8090:Gon4l UTSW 3 88,799,931 (GRCm39) missense probably damaging 1.00
R8224:Gon4l UTSW 3 88,802,449 (GRCm39) missense probably damaging 1.00
R8260:Gon4l UTSW 3 88,799,937 (GRCm39) missense probably damaging 0.98
R8434:Gon4l UTSW 3 88,762,086 (GRCm39) missense probably damaging 1.00
R8732:Gon4l UTSW 3 88,807,291 (GRCm39) missense possibly damaging 0.95
R8812:Gon4l UTSW 3 88,802,314 (GRCm39) missense possibly damaging 0.86
R9132:Gon4l UTSW 3 88,815,484 (GRCm39) missense probably benign 0.29
R9161:Gon4l UTSW 3 88,808,955 (GRCm39) missense probably damaging 1.00
R9187:Gon4l UTSW 3 88,786,618 (GRCm39) missense probably benign 0.10
R9212:Gon4l UTSW 3 88,803,730 (GRCm39) missense probably benign 0.01
R9338:Gon4l UTSW 3 88,809,019 (GRCm39) missense probably benign 0.00
R9387:Gon4l UTSW 3 88,802,260 (GRCm39) missense probably benign 0.00
R9416:Gon4l UTSW 3 88,803,538 (GRCm39) missense probably benign 0.00
R9607:Gon4l UTSW 3 88,765,751 (GRCm39) missense probably damaging 0.99
Z1177:Gon4l UTSW 3 88,766,343 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2016-07-06