Incidental Mutation 'R5195:Crk'
ID 400147
Institutional Source Beutler Lab
Gene Symbol Crk
Ensembl Gene ENSMUSG00000017776
Gene Name v-crk avian sarcoma virus CT10 oncogene homolog
Synonyms Crk-III, Crk-II, Crk-I, Crko, proto-oncogene c-crk
MMRRC Submission 042771-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5195 (G1)
Quality Score 128
Status Validated
Chromosome 11
Chromosomal Location 75570085-75597734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 75570289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 14 (Y14N)
Ref Sequence ENSEMBL: ENSMUSP00000104063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017920] [ENSMUST00000093115] [ENSMUST00000108425] [ENSMUST00000108426]
AlphaFold Q64010
Predicted Effect probably damaging
Transcript: ENSMUST00000017920
AA Change: Y14N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000017920
Gene: ENSMUSG00000017776
AA Change: Y14N

DomainStartEndE-ValueType
SH2 11 110 4.98e-28 SMART
SH3 135 191 1.82e-19 SMART
SH3 238 295 6.86e-6 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000093115
AA Change: Y14N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000090803
Gene: ENSMUSG00000017776
AA Change: Y14N

DomainStartEndE-ValueType
SH2 11 110 4.98e-28 SMART
SH3 135 191 1.82e-19 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108425
AA Change: Y14N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104063
Gene: ENSMUSG00000017776
AA Change: Y14N

DomainStartEndE-ValueType
SH2 11 110 4.98e-28 SMART
SH3 135 191 1.82e-19 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108426
AA Change: Y14N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104064
Gene: ENSMUSG00000017776
AA Change: Y14N

DomainStartEndE-ValueType
SH2 11 72 7.29e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000147718
SMART Domains Protein: ENSMUSP00000116527
Gene: ENSMUSG00000017776

DomainStartEndE-ValueType
SH2 1 71 1.31e0 SMART
SH3 96 152 1.82e-19 SMART
Meta Mutation Damage Score 0.9374 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 97% (72/74)
MGI Phenotype FUNCTION: This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
PHENOTYPE: Mice homozygous for an isoform specific knockout do not exhibit any obvious abnormalities. Mice homozygous of a null allele of both isoforms exhibit fetal and perinatal lethality associated with abnormal cardiovascular morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apoo-ps T C 13: 107,551,053 (GRCm39) noncoding transcript Het
Arhgef40 T A 14: 52,227,269 (GRCm39) S438T possibly damaging Het
Barhl2 A G 5: 106,601,305 (GRCm39) L358P possibly damaging Het
Bicra G A 7: 15,713,878 (GRCm39) P775S possibly damaging Het
Ccdc78 T A 17: 26,008,962 (GRCm39) probably null Het
Ccnb1-ps T A 7: 41,755,522 (GRCm39) noncoding transcript Het
Cct6a A T 5: 129,871,718 (GRCm39) noncoding transcript Het
Cep120 T A 18: 53,854,770 (GRCm39) H455L probably damaging Het
Cobl C T 11: 12,203,565 (GRCm39) V964I probably benign Het
Cpt1a A T 19: 3,433,800 (GRCm39) I761F possibly damaging Het
Deup1 A T 9: 15,486,487 (GRCm39) Y398N possibly damaging Het
Efcab15 T C 11: 103,089,794 (GRCm39) Y381C probably damaging Het
Epha3 C T 16: 63,366,510 (GRCm39) G980D possibly damaging Het
Fanca A G 8: 124,030,684 (GRCm39) probably benign Het
Gbp4 T A 5: 105,267,398 (GRCm39) D507V probably benign Het
Gtf2i A T 5: 134,273,686 (GRCm39) L740* probably null Het
Hmgn2 C A 4: 133,694,597 (GRCm39) A8S probably benign Het
Hook2 A T 8: 85,721,405 (GRCm39) N252I probably damaging Het
Igkv19-93 T A 6: 68,713,510 (GRCm39) T39S probably damaging Het
Inpp5j A C 11: 3,449,889 (GRCm39) probably null Het
Insyn2a A T 7: 134,486,145 (GRCm39) F469I probably damaging Het
Kbtbd3 G C 9: 4,316,905 (GRCm39) E19Q possibly damaging Het
Kcns2 G A 15: 34,839,677 (GRCm39) A347T possibly damaging Het
Klhl31 A G 9: 77,557,572 (GRCm39) E96G possibly damaging Het
Kptn A G 7: 15,857,028 (GRCm39) Y172C probably damaging Het
Krt86 T A 15: 101,374,814 (GRCm39) M328K probably benign Het
Lama1 A G 17: 68,071,795 (GRCm39) D894G probably benign Het
Lars2 T C 9: 123,282,375 (GRCm39) V653A probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lhcgr A T 17: 89,050,374 (GRCm39) V384D probably damaging Het
Malrd1 C T 2: 16,155,621 (GRCm39) T2010M unknown Het
Maml2 T A 9: 13,532,410 (GRCm39) N541K probably damaging Het
Med24 T C 11: 98,601,107 (GRCm39) K585R possibly damaging Het
Muc20 G A 16: 32,614,846 (GRCm39) S177L unknown Het
Mylk T A 16: 34,799,585 (GRCm39) F1658L probably damaging Het
Obscn C T 11: 58,951,676 (GRCm39) V4392I possibly damaging Het
Or10d5 A G 9: 39,861,975 (GRCm39) S31P probably benign Het
Or11g2 T C 14: 50,856,243 (GRCm39) L188P probably damaging Het
Pcnx2 A T 8: 126,528,288 (GRCm39) F1311I possibly damaging Het
Pcsk1 T C 13: 75,274,974 (GRCm39) L521P probably damaging Het
Pde4a A G 9: 21,115,629 (GRCm39) T445A possibly damaging Het
Pgam5 A T 5: 110,413,854 (GRCm39) L103* probably null Het
Pkd2 G A 5: 104,634,547 (GRCm39) R526Q probably benign Het
Polr2a T C 11: 69,634,905 (GRCm39) Y618C probably damaging Het
Pramel16 T A 4: 143,677,450 (GRCm39) E43V probably damaging Het
Pramel5 T A 4: 143,998,311 (GRCm39) M311L probably benign Het
Rbbp8 T C 18: 11,855,208 (GRCm39) F478L probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryk T C 9: 102,744,812 (GRCm39) V122A probably benign Het
Sik3 G T 9: 46,120,142 (GRCm39) probably null Het
Slc22a30 G A 19: 8,321,757 (GRCm39) Q436* probably null Het
Slc35e4 T A 11: 3,862,872 (GRCm39) I106F possibly damaging Het
Slc41a3 T C 6: 90,610,653 (GRCm39) S172P probably damaging Het
Snrnp70 T A 7: 45,044,134 (GRCm39) K32N probably damaging Het
Spag17 T C 3: 100,008,704 (GRCm39) Y1945H probably benign Het
St7 A G 6: 17,743,636 (GRCm39) probably benign Het
Stab1 C A 14: 30,862,478 (GRCm39) probably benign Het
Taf13 G A 3: 108,488,390 (GRCm39) R91Q probably damaging Het
Tmem200a T C 10: 25,954,854 (GRCm39) probably benign Het
Tnc A T 4: 63,885,489 (GRCm39) L1871Q probably damaging Het
Toe1 T C 4: 116,661,852 (GRCm39) H439R probably damaging Het
Trpm1 T C 7: 63,887,441 (GRCm39) V893A possibly damaging Het
Ubr3 G A 2: 69,786,378 (GRCm39) A831T probably benign Het
Wdr89 C T 12: 75,680,062 (GRCm39) R64Q probably benign Het
Zbed5 G T 5: 129,931,019 (GRCm39) V323F probably benign Het
Zeb2 T C 2: 44,891,647 (GRCm39) R287G probably damaging Het
Other mutations in Crk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02223:Crk APN 11 75,594,205 (GRCm39) missense probably damaging 0.99
IGL02266:Crk APN 11 75,570,415 (GRCm39) missense probably damaging 1.00
R0282:Crk UTSW 11 75,594,195 (GRCm39) missense probably damaging 1.00
R1956:Crk UTSW 11 75,583,496 (GRCm39) missense possibly damaging 0.83
R2864:Crk UTSW 11 75,594,211 (GRCm39) missense probably damaging 1.00
R8556:Crk UTSW 11 75,583,347 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TTAGACCTAGACTCCGCCTC -3'
(R):5'- AGCTTGCTCAGAAGACAGC -3'

Sequencing Primer
(F):5'- TAGAGGGCGCGTCATTTCC -3'
(R):5'- TGCAGCAGACCAGGGTTCTAC -3'
Posted On 2016-07-06