Incidental Mutation 'R5271:Or4c15b'
ID 400262
Institutional Source Beutler Lab
Gene Symbol Or4c15b
Ensembl Gene ENSMUSG00000075095
Gene Name olfactory receptor family 4 subfamily C member 15B
Synonyms Olfr1229, GA_x6K02T2Q125-50727797-50726862, MOR233-19, MOR233-22
MMRRC Submission 042861-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5271 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89112540-89113475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89113297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 60 (F60Y)
Ref Sequence ENSEMBL: ENSMUSP00000150344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099788] [ENSMUST00000213883] [ENSMUST00000214593]
AlphaFold Q7TQZ9
Predicted Effect probably benign
Transcript: ENSMUST00000099788
AA Change: F60Y

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000097376
Gene: ENSMUSG00000075095
AA Change: F60Y

DomainStartEndE-ValueType
Pfam:7tm_1 39 286 2.9e-29 PFAM
Pfam:7tm_4 138 279 1.7e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111549
AA Change: F81Y

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000107174
Gene: ENSMUSG00000075095
AA Change: F81Y

DomainStartEndE-ValueType
transmembrane domain 2 19 N/A INTRINSIC
Pfam:7tm_4 49 324 9.6e-51 PFAM
Pfam:7tm_1 60 307 7.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213883
AA Change: F60Y

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000214593
AA Change: F60Y

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.1126 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency 97% (65/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik T C 3: 124,373,496 (GRCm39) K33R possibly damaging Het
4632415L05Rik C T 3: 19,949,311 (GRCm39) noncoding transcript Het
4930542C16Rik A C 14: 24,665,598 (GRCm39) noncoding transcript Het
Adprh A T 16: 38,266,416 (GRCm39) L242* probably null Het
Anapc1 G A 2: 128,527,905 (GRCm39) Q18* probably null Het
Bfar T C 16: 13,510,261 (GRCm39) probably benign Het
Bmp1 T C 14: 70,745,568 (GRCm39) I206V probably benign Het
Cc2d1b T A 4: 108,480,826 (GRCm39) probably benign Het
Clock A G 5: 76,389,801 (GRCm39) I349T probably damaging Het
Cox11 A G 11: 90,534,558 (GRCm39) Y60C probably damaging Het
Cyp1a1 G A 9: 57,610,121 (GRCm39) V512M probably benign Het
Dcdc2a T C 13: 25,371,671 (GRCm39) F311S probably benign Het
Dnase1l3 T C 14: 7,993,843 (GRCm38) D48G probably damaging Het
Engase G T 11: 118,372,223 (GRCm39) A172S probably damaging Het
F2 T C 2: 91,465,466 (GRCm39) probably benign Het
Galnt2l A G 8: 122,997,872 (GRCm39) probably benign Het
Gcc2 T C 10: 58,105,517 (GRCm39) V215A possibly damaging Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Gm20671 T C 5: 32,977,303 (GRCm39) K1817R possibly damaging Het
Gm20939 T A 17: 95,184,583 (GRCm39) Y410* probably null Het
Gm27013 T C 6: 130,653,878 (GRCm39) Y528C probably damaging Het
Il23r T C 6: 67,400,680 (GRCm39) H550R probably benign Het
Iqgap1 A T 7: 80,383,896 (GRCm39) V1056E probably damaging Het
Lrit3 T A 3: 129,581,950 (GRCm39) Y679F probably damaging Het
Megf8 A T 7: 25,041,131 (GRCm39) E1120V probably damaging Het
Mta1 A G 12: 113,095,577 (GRCm39) E518G probably damaging Het
Myo9a A G 9: 59,814,665 (GRCm39) I2200M probably damaging Het
Ncoa7 T C 10: 30,598,725 (GRCm39) H66R probably benign Het
Ncor1 A G 11: 62,231,371 (GRCm39) V812A probably damaging Het
Ndnf T C 6: 65,680,650 (GRCm39) Y310H possibly damaging Het
Ndst1 G A 18: 60,838,204 (GRCm39) T347I probably benign Het
Or10a3m T C 7: 108,313,424 (GRCm39) L276S probably damaging Het
Pcdhb10 C A 18: 37,546,222 (GRCm39) Q433K probably benign Het
Pcdhb18 G A 18: 37,624,649 (GRCm39) V660M possibly damaging Het
Pds5b T A 5: 150,646,818 (GRCm39) N202K possibly damaging Het
Pira12 A T 7: 3,900,566 (GRCm39) Y61* probably null Het
Polk T C 13: 96,620,047 (GRCm39) S718G probably benign Het
Ptpdc1 T C 13: 48,744,174 (GRCm39) D149G probably damaging Het
Rb1cc1 T A 1: 6,319,417 (GRCm39) C35* probably null Het
Samd9l C T 6: 3,376,156 (GRCm39) M368I probably benign Het
Shroom3 T C 5: 93,110,107 (GRCm39) M1739T probably damaging Het
Slc18a3 A G 14: 32,185,705 (GRCm39) L226P probably damaging Het
St7l A T 3: 104,775,376 (GRCm39) Y84F probably damaging Het
Svil A T 18: 5,062,329 (GRCm39) N392I probably benign Het
Syngr1 T A 15: 79,982,240 (GRCm39) M9K probably benign Het
Taar2 T C 10: 23,816,930 (GRCm39) S157P probably damaging Het
Tagap1 G T 17: 7,223,495 (GRCm39) Y400* probably null Het
Tbc1d8 T A 1: 39,412,848 (GRCm39) E976V probably damaging Het
Tmem163 G A 1: 127,419,289 (GRCm39) probably benign Het
Tnfaip2 A G 12: 111,414,894 (GRCm39) probably benign Het
Ttn C T 2: 76,536,861 (GRCm39) S34988N possibly damaging Het
Tubg1 T G 11: 101,011,064 (GRCm39) N15K probably damaging Het
Unc93a2 T C 17: 7,637,081 (GRCm39) N149S possibly damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Zap70 T A 1: 36,820,446 (GRCm39) V547D probably damaging Het
Zfp146 G T 7: 29,861,900 (GRCm39) N47K probably benign Het
Znrf1 T G 8: 112,335,976 (GRCm39) M159R probably benign Het
Other mutations in Or4c15b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02982:Or4c15b APN 2 89,113,453 (GRCm39) missense probably damaging 0.98
R1535:Or4c15b UTSW 2 89,113,401 (GRCm39) missense probably benign 0.14
R1610:Or4c15b UTSW 2 89,113,165 (GRCm39) missense probably damaging 1.00
R3896:Or4c15b UTSW 2 89,113,441 (GRCm39) missense possibly damaging 0.78
R4516:Or4c15b UTSW 2 89,113,187 (GRCm39) missense probably benign 0.05
R4922:Or4c15b UTSW 2 89,112,811 (GRCm39) missense possibly damaging 0.93
R4990:Or4c15b UTSW 2 89,113,671 (GRCm39) splice site probably null
R5267:Or4c15b UTSW 2 89,112,574 (GRCm39) nonsense probably null
R5514:Or4c15b UTSW 2 89,112,817 (GRCm39) missense probably damaging 1.00
R5621:Or4c15b UTSW 2 89,112,697 (GRCm39) missense probably damaging 0.97
R7154:Or4c15b UTSW 2 89,113,204 (GRCm39) missense probably damaging 1.00
R7992:Or4c15b UTSW 2 89,113,082 (GRCm39) missense probably benign 0.01
R9028:Or4c15b UTSW 2 89,112,676 (GRCm39) missense probably damaging 1.00
Z1176:Or4c15b UTSW 2 89,113,241 (GRCm39) frame shift probably null
Z1176:Or4c15b UTSW 2 89,112,881 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCAAATAGCAACATAGCGGTC -3'
(R):5'- GGCATTCATCTTTTCCTTGGAAAC -3'

Sequencing Primer
(F):5'- TCATAGGCCATGGCTGACAG -3'
(R):5'- CTTTTCCTTGGAAACCATGCAAAAC -3'
Posted On 2016-07-06