Mutagenetix > Incidental Mutations

Incidental Mutation 'R5198:Vmn2r63'

400471

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r63

Ensembl Gene

ENSMUSG00000090751

Gene Name

vomeronasal 2, receptor 63

Synonyms

EG435975

MMRRC Submission

042774-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R5198 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

42903251-42933789 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 42903745 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 696 (V696L)

Ref Sequence

ENSEMBL: ENSMUSP00000129089 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000163803]

Predicted Effect

probably benign
Transcript: ENSMUST00000163803
AA Change: V696L

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: V696L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	3.5e-43	PFAM
Pfam:NCD3G	514	567	5.1e-23	PFAM
Pfam:7tm_3	600	835	3.5e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

98% (54/55)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931423N10Rik	G	A	2: 23,212,461	C121Y	probably damaging	Het
Abcc9	A	G	6: 142,626,000	V1121A	probably benign	Het
Adamtsl3	A	C	7: 82,611,798	K1647Q	possibly damaging	Het
Adgrb1	A	T	15: 74,543,701	Q710L	probably null	Het
Alox12	T	C	11: 70,254,417	E110G	probably damaging	Het
Cep152	T	A	2: 125,587,624	M738L	probably benign	Het
Cma2	T	C	14: 55,972,075	V38A	probably benign	Het
Dlc1	C	T	8: 36,938,398	G79D	probably damaging	Het
Dmpk	C	G	7: 19,088,019	L301V	probably benign	Het
Dus3l	A	G	17: 56,769,574	I585V	probably benign	Het
Etl4	A	G	2: 20,713,387	Y313C	probably damaging	Het
Fbxw15	C	A	9: 109,558,174	S251I	probably benign	Het
Gata4	G	A	14: 63,200,451	S417L	probably benign	Het
Gdpd5	T	A	7: 99,438,308	Y60N	probably damaging	Het
Gm17669	T	C	18: 67,562,556	M57T	probably benign	Het
Gpr39	A	T	1: 125,677,436	I34F	probably benign	Het
Iffo2	T	A	4: 139,575,217	D90E	probably benign	Het
Il17c	A	G	8: 122,422,369	D84G	possibly damaging	Het
Itih3	T	C	14: 30,912,649	T134A	probably benign	Het
Lama2	G	A	10: 27,347,003	A429V	probably damaging	Het
Muc6	G	T	7: 141,638,772	T1996N	possibly damaging	Het
Mug1	G	A	6: 121,874,562	R806H	probably damaging	Het
Naaa	G	A	5: 92,268,045	R65*	probably null	Het
Nacc2	C	T	2: 26,060,334	M463I	probably benign	Het
Nemf	A	G	12: 69,356,047	S72P	probably damaging	Het
Nudt7	G	A	8: 114,135,445		probably null	Het
Olfr1272	T	C	2: 90,296,393	Q156R	probably damaging	Het
Olfr625-ps1	T	C	7: 103,682,729	S4P	probably benign	Het
Otx1	C	A	11: 21,997,037	A91S	probably damaging	Het
Pacs1	T	C	19: 5,139,297	D757G	probably benign	Het
Pkd2	A	C	5: 104,483,092	I461L	probably benign	Het
Pramel5	T	G	4: 144,273,494		probably benign	Het
Ptgdr	G	C	14: 44,858,843	F137L	probably damaging	Het
Pum1	T	A	4: 130,779,879	C1085*	probably null	Het
Rfx3	T	C	19: 27,830,776	D189G	probably damaging	Het
Rlf	T	A	4: 121,148,553	K1077*	probably null	Het
Slc25a30	C	A	14: 75,769,616	D147Y	probably benign	Het
Smap2	T	C	4: 121,016,787	E22G	possibly damaging	Het
Szt2	T	C	4: 118,388,322	T1098A	probably benign	Het
Tbcc	T	C	17: 46,890,862	F58S	probably damaging	Het
Tekt3	G	A	11: 63,070,308	R101H	probably damaging	Het
Vcan	T	A	13: 89,690,872	E2184D	probably damaging	Het
Vkorc1	T	C	7: 127,894,588	E18G	probably benign	Het
Vmn1r68	T	C	7: 10,527,796	H125R	probably benign	Het
Wdr59	G	A	8: 111,481,988	H421Y	probably benign	Het
Xkr7	T	C	2: 153,054,953	Y576H	probably damaging	Het
Zfp112	T	C	7: 24,124,856	V83A	possibly damaging	Het
Zfp616	G	A	11: 74,083,510	V293I	probably benign	Het

Other mutations in Vmn2r63

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01399:Vmn2r63	APN	7	42904119	missense	probably damaging	0.99
IGL01765:Vmn2r63	APN	7	42903364	missense	probably benign
IGL02203:Vmn2r63	APN	7	42904008	missense	probably benign	0.01
IGL02825:Vmn2r63	APN	7	42926850	critical splice donor site	probably null
IGL03155:Vmn2r63	APN	7	42903454	missense	probably damaging	1.00
IGL03260:Vmn2r63	APN	7	42929192	missense	probably damaging	1.00
IGL03411:Vmn2r63	APN	7	42927944	missense	probably benign	0.42
PIT4280001:Vmn2r63	UTSW	7	42903985	missense	probably damaging	1.00
R0066:Vmn2r63	UTSW	7	42927090	splice site	probably benign
R0328:Vmn2r63	UTSW	7	42903275	missense	probably benign	0.09
R0344:Vmn2r63	UTSW	7	42903618	missense	probably damaging	0.98
R0554:Vmn2r63	UTSW	7	42933705	nonsense	probably null
R0555:Vmn2r63	UTSW	7	42928528	nonsense	probably null
R0685:Vmn2r63	UTSW	7	42928010	missense	probably benign	0.13
R0751:Vmn2r63	UTSW	7	42928035	missense	probably damaging	1.00
R1349:Vmn2r63	UTSW	7	42929218	missense	possibly damaging	0.95
R1372:Vmn2r63	UTSW	7	42929218	missense	possibly damaging	0.95
R1416:Vmn2r63	UTSW	7	42927915	missense	probably benign	0.00
R1502:Vmn2r63	UTSW	7	42928591	missense	possibly damaging	0.62
R1563:Vmn2r63	UTSW	7	42904126	missense	probably benign	0.00
R1652:Vmn2r63	UTSW	7	42928211	missense	probably benign	0.32
R1693:Vmn2r63	UTSW	7	42928319	missense	probably benign
R1698:Vmn2r63	UTSW	7	42933614	missense	probably benign
R1753:Vmn2r63	UTSW	7	42928245	nonsense	probably null
R2136:Vmn2r63	UTSW	7	42926873	missense	probably damaging	0.99
R2175:Vmn2r63	UTSW	7	42933580	critical splice donor site	probably null
R2261:Vmn2r63	UTSW	7	42928607	missense	probably benign	0.02
R2262:Vmn2r63	UTSW	7	42928607	missense	probably benign	0.02
R2263:Vmn2r63	UTSW	7	42928607	missense	probably benign	0.02
R3413:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R3426:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R3427:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R3802:Vmn2r63	UTSW	7	42903405	missense	probably damaging	0.99
R4319:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R4321:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R4323:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R4346:Vmn2r63	UTSW	7	42928113	missense	possibly damaging	0.67
R4568:Vmn2r63	UTSW	7	42933826	splice site	probably null
R4649:Vmn2r63	UTSW	7	42903690	missense	possibly damaging	0.79
R4653:Vmn2r63	UTSW	7	42903690	missense	possibly damaging	0.79
R4679:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4734:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4741:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4748:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4806:Vmn2r63	UTSW	7	42926890	missense	probably benign	0.34
R4933:Vmn2r63	UTSW	7	42903978	missense	probably damaging	1.00
R5399:Vmn2r63	UTSW	7	42928277	missense	probably benign
R5400:Vmn2r63	UTSW	7	42928211	missense	probably benign	0.32
R6158:Vmn2r63	UTSW	7	42933680	missense	probably damaging	1.00
R6185:Vmn2r63	UTSW	7	42929011	missense	probably damaging	0.98
R6267:Vmn2r63	UTSW	7	42928635	splice site	probably null
R6362:Vmn2r63	UTSW	7	42903297	missense	probably benign
R6706:Vmn2r63	UTSW	7	42928577	missense	probably damaging	1.00
R6764:Vmn2r63	UTSW	7	42903271	missense	probably damaging	0.97
R7104:Vmn2r63	UTSW	7	42928535	missense	possibly damaging	0.67
R7503:Vmn2r63	UTSW	7	42933590	missense	probably benign	0.02
R7506:Vmn2r63	UTSW	7	42926967	missense	probably damaging	1.00
R7525:Vmn2r63	UTSW	7	42926982	missense	possibly damaging	0.52
R7658:Vmn2r63	UTSW	7	42925269	missense	probably damaging	1.00
R7663:Vmn2r63	UTSW	7	42927042	missense	probably benign	0.00
R7702:Vmn2r63	UTSW	7	42928129	missense	possibly damaging	0.46
R7918:Vmn2r63	UTSW	7	42903531	missense	probably damaging	1.00
Z1088:Vmn2r63	UTSW	7	42928559	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- CAGATTCCTGGATAAGAAGGCC -3'
(R):5'- TTGCTTGCTCTACATTGGGC -3'

Sequencing Primer
(F):5'- ATGGTATAGCTCCCAAGTGC -3'
(R):5'- TGCTCTACATTGGGCAGCCC -3'

Posted On

2016-07-06