Mutagenetix > Incidental Mutations

Incidental Mutation 'R5198:Olfr625-ps1'

400479

Institutional Source

Beutler Lab

Gene Symbol

Olfr625-ps1

Ensembl Gene

ENSMUSG00000073943

Gene Name

olfactory receptor 625, pseudogene 1

Synonyms

MOR31-15P, GA_x6K02T2PBJ9-6416276-6417237

MMRRC Submission

042774-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R5198 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

103682720-103683685 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 103682729 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 4 (S4P)

Ref Sequence

ENSEMBL: ENSMUSP00000095797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098195] [ENSMUST00000190218]

Predicted Effect

probably benign
Transcript: ENSMUST00000098195
AA Change: S4P

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000095797
Gene: ENSMUSG00000073943
AA Change: S4P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	317	8.1e-110	PFAM
Pfam:7TM_GPCR_Srsx	41	225	3.6e-9	PFAM
Pfam:7tm_1	47	299	1.6e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000190218

SMART Domains

Protein: ENSMUSP00000140044
Gene: ENSMUSG00000073943

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	31	214	7e-8	PFAM
Pfam:7tm_1	37	289	2.8e-26	PFAM
Pfam:7tm_4	136	282	2.7e-28	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.1%

Validation Efficiency

98% (54/55)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931423N10Rik	G	A	2: 23,212,461	C121Y	probably damaging	Het
Abcc9	A	G	6: 142,626,000	V1121A	probably benign	Het
Adamtsl3	A	C	7: 82,611,798	K1647Q	possibly damaging	Het
Adgrb1	A	T	15: 74,543,701	Q710L	probably null	Het
Alox12	T	C	11: 70,254,417	E110G	probably damaging	Het
Cep152	T	A	2: 125,587,624	M738L	probably benign	Het
Cma2	T	C	14: 55,972,075	V38A	probably benign	Het
Dlc1	C	T	8: 36,938,398	G79D	probably damaging	Het
Dmpk	C	G	7: 19,088,019	L301V	probably benign	Het
Dus3l	A	G	17: 56,769,574	I585V	probably benign	Het
Etl4	A	G	2: 20,713,387	Y313C	probably damaging	Het
Fbxw15	C	A	9: 109,558,174	S251I	probably benign	Het
Gata4	G	A	14: 63,200,451	S417L	probably benign	Het
Gdpd5	T	A	7: 99,438,308	Y60N	probably damaging	Het
Gm17669	T	C	18: 67,562,556	M57T	probably benign	Het
Gpr39	A	T	1: 125,677,436	I34F	probably benign	Het
Iffo2	T	A	4: 139,575,217	D90E	probably benign	Het
Il17c	A	G	8: 122,422,369	D84G	possibly damaging	Het
Itih3	T	C	14: 30,912,649	T134A	probably benign	Het
Lama2	G	A	10: 27,347,003	A429V	probably damaging	Het
Muc6	G	T	7: 141,638,772	T1996N	possibly damaging	Het
Mug1	G	A	6: 121,874,562	R806H	probably damaging	Het
Naaa	G	A	5: 92,268,045	R65*	probably null	Het
Nacc2	C	T	2: 26,060,334	M463I	probably benign	Het
Nemf	A	G	12: 69,356,047	S72P	probably damaging	Het
Nudt7	G	A	8: 114,135,445		probably null	Het
Olfr1272	T	C	2: 90,296,393	Q156R	probably damaging	Het
Otx1	C	A	11: 21,997,037	A91S	probably damaging	Het
Pacs1	T	C	19: 5,139,297	D757G	probably benign	Het
Pkd2	A	C	5: 104,483,092	I461L	probably benign	Het
Pramel5	T	G	4: 144,273,494		probably benign	Het
Ptgdr	G	C	14: 44,858,843	F137L	probably damaging	Het
Pum1	T	A	4: 130,779,879	C1085*	probably null	Het
Rfx3	T	C	19: 27,830,776	D189G	probably damaging	Het
Rlf	T	A	4: 121,148,553	K1077*	probably null	Het
Slc25a30	C	A	14: 75,769,616	D147Y	probably benign	Het
Smap2	T	C	4: 121,016,787	E22G	possibly damaging	Het
Szt2	T	C	4: 118,388,322	T1098A	probably benign	Het
Tbcc	T	C	17: 46,890,862	F58S	probably damaging	Het
Tekt3	G	A	11: 63,070,308	R101H	probably damaging	Het
Vcan	T	A	13: 89,690,872	E2184D	probably damaging	Het
Vkorc1	T	C	7: 127,894,588	E18G	probably benign	Het
Vmn1r68	T	C	7: 10,527,796	H125R	probably benign	Het
Vmn2r63	C	A	7: 42,903,745	V696L	probably benign	Het
Wdr59	G	A	8: 111,481,988	H421Y	probably benign	Het
Xkr7	T	C	2: 153,054,953	Y576H	probably damaging	Het
Zfp112	T	C	7: 24,124,856	V83A	possibly damaging	Het
Zfp616	G	A	11: 74,083,510	V293I	probably benign	Het

Other mutations in Olfr625-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02547:Olfr625-ps1	APN	7	103682766	missense	probably benign	0.01
R1160:Olfr625-ps1	UTSW	7	103682861	missense	possibly damaging	0.50
R1508:Olfr625-ps1	UTSW	7	103683471	missense	possibly damaging	0.50
R1766:Olfr625-ps1	UTSW	7	103682861	missense	possibly damaging	0.50
R1901:Olfr625-ps1	UTSW	7	103683543	missense	probably damaging	0.98
R2116:Olfr625-ps1	UTSW	7	103683312	missense	probably damaging	1.00
R4701:Olfr625-ps1	UTSW	7	103683062	missense	probably damaging	1.00
R4995:Olfr625-ps1	UTSW	7	103683367	missense	probably damaging	1.00
R5750:Olfr625-ps1	UTSW	7	103683155	missense	possibly damaging	0.95
R5776:Olfr625-ps1	UTSW	7	103683039	missense	probably damaging	1.00
R5905:Olfr625-ps1	UTSW	7	103683574	missense	probably damaging	1.00
R5933:Olfr625-ps1	UTSW	7	103683473	missense	probably damaging	1.00
R6488:Olfr625-ps1	UTSW	7	103683078	missense	probably damaging	0.98
R7846:Olfr625-ps1	UTSW	7	103683200	missense	probably benign	0.03
R7878:Olfr625-ps1	UTSW	7	103683264	missense	probably damaging	1.00
RF040:Olfr625-ps1	UTSW	7	103682938	frame shift	probably null
Z1088:Olfr625-ps1	UTSW	7	103683186	missense	probably benign	0.01
Z1176:Olfr625-ps1	UTSW	7	103683105	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- GCAAAGCCTACCAGAGACTCTG -3'
(R):5'- AGATATCAGCAAGTGCCAACATAG -3'

Sequencing Primer
(F):5'- GCCAACTGTGAGTATCAC -3'
(R):5'- GGTTCATGAAGGCTGCATTCAG -3'

Posted On

2016-07-06