Mutagenetix > Incidental Mutations

Incidental Mutation 'R5238:Vmn1r158'

400500

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r158

Ensembl Gene

ENSMUSG00000094700

Gene Name

vomeronasal 1 receptor 158

Synonyms

Gm16455

MMRRC Submission

042809-MU

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.567) question?

Stock #

R5238 (G1)

Quality Score

195

Status

Not validated

Chromosome

Chromosomal Location

22789859-22790782 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22790374 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 137 (M137L)

Ref Sequence

ENSEMBL: ENSMUSP00000133990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174643]

Predicted Effect

probably benign
Transcript: ENSMUST00000174643
AA Change: M137L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133990
Gene: ENSMUSG00000094700
AA Change: M137L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	39	290	5.5e-9	PFAM
Pfam:V1R	41	298	3.2e-17	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd12b	T	A	12: 70,163,368		probably null	Het
Adamtsl5	C	T	10: 80,345,358	G63D	probably damaging	Het
Armc9	T	A	1: 86,199,847	M68K	probably benign	Het
Atad2	A	C	15: 58,108,337	H381Q	possibly damaging	Het
Bclaf1	T	G	10: 20,332,384		probably benign	Het
Cbwd1	G	T	19: 24,920,630	T382K	probably damaging	Het
Ccdc188	A	G	16: 18,219,174	E238G	probably damaging	Het
Cldn19	G	T	4: 119,255,733	C54F	probably damaging	Het
Clip1	T	C	5: 123,647,883	D246G	probably damaging	Het
Col20a1	T	C	2: 180,998,586	V512A	probably damaging	Het
Cyfip1	G	T	7: 55,892,031	A355S	probably benign	Het
Dffa	T	G	4: 149,104,303	L18R	probably benign	Het
Dnah8	G	A	17: 30,790,917	E3761K	probably damaging	Het
Dusp10	A	G	1: 184,037,013	T59A	possibly damaging	Het
Eed	T	C	7: 89,976,965	S67G	probably benign	Het
Fam181a	C	T	12: 103,316,133	A99V	probably benign	Het
Gm12185	G	A	11: 48,908,217	T483I	possibly damaging	Het
Htr3b	A	T	9: 48,937,242	C234*	probably null	Het
Kidins220	C	A	12: 25,003,010	T433K	probably benign	Het
Man2a1	T	C	17: 64,636,507	Y186H	probably damaging	Het
Mcm9	G	T	10: 53,629,997	S60R	possibly damaging	Het
Mst1r	T	A	9: 107,907,574	C144S	probably damaging	Het
Nckap5	A	G	1: 126,027,724	C364R	probably damaging	Het
Nptx2	T	C	5: 144,556,231	I376T	probably damaging	Het
Olfr237-ps1	T	C	6: 43,154,027	S241P	probably damaging	Het
Otogl	A	T	10: 107,768,973	C2191S	probably damaging	Het
Plxdc2	T	A	2: 16,650,215	F208L	probably damaging	Het
Robo3	A	C	9: 37,416,879	Y1339D	probably damaging	Het
Rsph9	G	T	17: 46,135,082	Y42*	probably null	Het
Slc39a1	T	A	3: 90,249,395	L86Q	probably null	Het
Slfn8	T	C	11: 83,013,388	D392G	probably damaging	Het
Tiprl	A	G	1: 165,215,768	V263A	probably benign	Het
Tmub2	A	G	11: 102,284,994		probably benign	Het
Trpm1	T	A	7: 64,268,954	F681I	probably damaging	Het
Ttn	A	T	2: 76,811,243	L5176Q	possibly damaging	Het
Uba3	A	T	6: 97,201,935	C68*	probably null	Het
Vmn1r50	C	T	6: 90,107,483	A70V	possibly damaging	Het
Wwc1	T	C	11: 35,875,896	K511E	probably benign	Het
Zfp600	T	C	4: 146,195,171		probably null	Het

Other mutations in Vmn1r158

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01147:Vmn1r158	APN	7	22790779	missense	probably benign	0.01
R1173:Vmn1r158	UTSW	7	22790445	missense	probably benign	0.19
R1574:Vmn1r158	UTSW	7	22790347	missense	probably damaging	1.00
R1574:Vmn1r158	UTSW	7	22790347	missense	probably damaging	1.00
R1725:Vmn1r158	UTSW	7	22790647	missense	probably benign	0.08
R1777:Vmn1r158	UTSW	7	22790430	missense	probably damaging	1.00
R1813:Vmn1r158	UTSW	7	22790718	missense	probably damaging	1.00
R1896:Vmn1r158	UTSW	7	22790718	missense	probably damaging	1.00
R2077:Vmn1r158	UTSW	7	22790390	missense	probably benign	0.03
R3749:Vmn1r158	UTSW	7	22790214	missense	probably damaging	1.00
R4872:Vmn1r158	UTSW	7	22790754	missense	possibly damaging	0.94
R6500:Vmn1r158	UTSW	7	22790653	missense	possibly damaging	0.89
R6511:Vmn1r158	UTSW	7	22790691	missense	probably benign	0.00
R6581:Vmn1r158	UTSW	7	22790040	missense	possibly damaging	0.69
R6751:Vmn1r158	UTSW	7	22789881	missense	probably damaging	0.96
R7168:Vmn1r158	UTSW	7	22790676	missense	possibly damaging	0.82
R7337:Vmn1r158	UTSW	7	22790224	missense	probably benign	0.00
R7747:Vmn1r158	UTSW	7	22790300	missense	probably benign	0.15
R7902:Vmn1r158	UTSW	7	22790008	missense	possibly damaging	0.67
R8328:Vmn1r158	UTSW	7	22790062	missense	probably damaging	1.00
R8400:Vmn1r158	UTSW	7	22789880	nonsense	probably null
Z1177:Vmn1r158	UTSW	7	22790458	missense	possibly damaging	0.46

Predicted Primers

PCR Primer
(F):5'- TGGCATCATAGGCAAACTGC -3'
(R):5'- ACAGGTGATTTTAAGCCACATGG -3'

Sequencing Primer
(F):5'- CTGCAAGAGGACAGTGCCTAC -3'
(R):5'- CCAAACAACATGATGGCTTTTGCTC -3'

Posted On

2016-07-06