Mutagenetix > Incidental Mutation

Incidental Mutation 'R5200:Vmn2r97'

400730

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R5200 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19134584-19168333 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 19148615 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 170 (P170L)

Ref Sequence

ENSEMBL: ENSMUSP00000156141 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably damaging
Transcript: ENSMUST00000168710
AA Change: P170L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: P170L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000232219
AA Change: P170L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232325

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.3%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap9	T	C	5: 4,010,734 (GRCm39)	V497A	probably benign	Het
Alx3	T	C	3: 107,507,980 (GRCm39)	F163S	possibly damaging	Het
Ankmy1	T	C	1: 92,798,014 (GRCm39)	R997G	probably benign	Het
Arfgef2	T	C	2: 166,702,604 (GRCm39)	S848P	probably benign	Het
Atp11b	A	G	3: 35,891,156 (GRCm39)	I810V	probably benign	Het
C1ql4	T	G	15: 98,982,718 (GRCm39)	I212L	probably benign	Het
Cep63	T	C	9: 102,475,387 (GRCm39)	Y443C	probably benign	Het
Cfap45	C	T	1: 172,372,696 (GRCm39)	Q464*	probably null	Het
Clcn3	T	C	8: 61,376,039 (GRCm39)	K618R	probably damaging	Het
Dmpk	C	G	7: 18,821,944 (GRCm39)	L301V	probably benign	Het
Dnaaf4	T	C	9: 72,879,713 (GRCm39)	S418P	probably damaging	Het
H2-M10.2	T	G	17: 36,595,641 (GRCm39)	R216S	probably benign	Het
Hook1	A	G	4: 95,881,367 (GRCm39)	D113G	probably damaging	Het
Ift122	A	G	6: 115,897,340 (GRCm39)	E914G	probably damaging	Het
Insr	A	G	8: 3,248,059 (GRCm39)		probably null	Het
Itpr2	A	T	6: 146,045,605 (GRCm39)		probably null	Het
Myo6	C	T	9: 80,183,656 (GRCm39)	Q684*	probably null	Het
Nrde2	T	A	12: 100,096,756 (GRCm39)	I1015F	possibly damaging	Het
Or12e9	T	A	2: 87,202,446 (GRCm39)	V190E	probably damaging	Het
Or2d4	G	A	7: 106,544,187 (GRCm39)	T7I	possibly damaging	Het
Otx1	C	A	11: 21,947,037 (GRCm39)	A91S	probably damaging	Het
Pappa	A	T	4: 65,074,076 (GRCm39)	N210I	probably damaging	Het
Pax4	G	A	6: 28,445,138 (GRCm39)	P179L	probably damaging	Het
Pcx	G	A	19: 4,668,532 (GRCm39)	D656N	probably damaging	Het
Pms1	T	A	1: 53,245,916 (GRCm39)	H541L	probably benign	Het
Pten	C	T	19: 32,777,291 (GRCm39)	P95L	probably damaging	Het
Rsrc2	G	A	5: 123,877,562 (GRCm39)	R140*	probably null	Het
Shc3	T	C	13: 51,670,601 (GRCm39)	M49V	probably damaging	Het
Snap91	C	G	9: 86,697,497 (GRCm39)	K288N	probably damaging	Het
Spag17	C	T	3: 99,970,787 (GRCm39)	Q1324*	probably null	Het
Tasor	A	G	14: 27,151,183 (GRCm39)	E53G	probably benign	Het
Tfr2	A	G	5: 137,569,242 (GRCm39)		probably benign	Het
Tgfbrap1	A	T	1: 43,114,803 (GRCm39)	I99K	probably damaging	Het
Tmem38a	T	A	8: 73,333,878 (GRCm39)	V119E	probably damaging	Het
Tmtc4	T	G	14: 123,182,969 (GRCm39)	D243A	probably benign	Het
Tnc	A	T	4: 63,889,515 (GRCm39)	S1755T	probably damaging	Het
Trim67	T	C	8: 125,551,589 (GRCm39)	S590P	probably damaging	Het
Ttn	T	A	2: 76,590,287 (GRCm39)	T12814S	probably damaging	Het
Uspl1	T	A	5: 149,150,923 (GRCm39)	S708T	probably benign	Het
Vmn2r69	A	T	7: 85,055,717 (GRCm39)	F807Y	probably damaging	Het
Zfp612	C	T	8: 110,816,532 (GRCm39)	Q580*	probably null	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	19,167,921 (GRCm39)	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	19,149,490 (GRCm39)	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	19,168,073 (GRCm39)	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	19,149,286 (GRCm39)	nonsense	probably null
IGL02429:Vmn2r97	APN	17	19,150,596 (GRCm39)	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	19,149,432 (GRCm39)	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	19,149,947 (GRCm39)	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	19,168,298 (GRCm39)	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	19,149,668 (GRCm39)	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	19,148,438 (GRCm39)	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	19,167,900 (GRCm39)	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	19,149,878 (GRCm39)	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	19,167,930 (GRCm39)	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	19,134,734 (GRCm39)	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	19,167,665 (GRCm39)	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	19,148,440 (GRCm39)	nonsense	probably null
R1546:Vmn2r97	UTSW	17	19,168,110 (GRCm39)	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	19,149,397 (GRCm39)	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	19,167,648 (GRCm39)	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	19,149,593 (GRCm39)	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	19,160,500 (GRCm39)	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	19,149,944 (GRCm39)	missense	unknown
R2106:Vmn2r97	UTSW	17	19,168,100 (GRCm39)	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2153:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2154:Vmn2r97	UTSW	17	19,167,584 (GRCm39)	nonsense	probably null
R2516:Vmn2r97	UTSW	17	19,167,814 (GRCm39)	missense	probably benign
R3739:Vmn2r97	UTSW	17	19,148,413 (GRCm39)	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	19,149,890 (GRCm39)	missense	probably benign
R3885:Vmn2r97	UTSW	17	19,148,596 (GRCm39)	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	19,167,873 (GRCm39)	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	19,148,332 (GRCm39)	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	19,167,542 (GRCm39)	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	19,168,337 (GRCm39)	intron	probably benign
R4439:Vmn2r97	UTSW	17	19,150,616 (GRCm39)	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	19,149,550 (GRCm39)	missense	probably benign
R4948:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	19,160,436 (GRCm39)	nonsense	probably null
R5029:Vmn2r97	UTSW	17	19,168,173 (GRCm39)	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	19,148,617 (GRCm39)	nonsense	probably null
R5637:Vmn2r97	UTSW	17	19,167,628 (GRCm39)	nonsense	probably null
R5765:Vmn2r97	UTSW	17	19,167,442 (GRCm39)	nonsense	probably null
R5885:Vmn2r97	UTSW	17	19,168,035 (GRCm39)	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	19,167,861 (GRCm39)	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	19,150,566 (GRCm39)	nonsense	probably null
R6818:Vmn2r97	UTSW	17	19,168,193 (GRCm39)	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	19,167,756 (GRCm39)	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	19,134,663 (GRCm39)	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	19,134,629 (GRCm39)	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	19,150,548 (GRCm39)	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	19,148,470 (GRCm39)	missense	probably benign
R7862:Vmn2r97	UTSW	17	19,167,416 (GRCm39)	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	19,149,326 (GRCm39)	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	19,149,802 (GRCm39)	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	19,150,662 (GRCm39)	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	19,167,854 (GRCm39)	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	19,134,802 (GRCm39)	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	19,168,104 (GRCm39)	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	19,160,472 (GRCm39)	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	19,149,607 (GRCm39)	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	19,134,585 (GRCm39)	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	19,149,640 (GRCm39)	missense	probably benign
R9252:Vmn2r97	UTSW	17	19,167,849 (GRCm39)	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	19,134,762 (GRCm39)	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	19,149,368 (GRCm39)	missense	probably benign
R9422:Vmn2r97	UTSW	17	19,149,333 (GRCm39)	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	19,149,227 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	19,149,919 (GRCm39)	missense	probably benign
R9601:Vmn2r97	UTSW	17	19,134,770 (GRCm39)	missense	probably benign
R9672:Vmn2r97	UTSW	17	19,149,442 (GRCm39)	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	19,168,221 (GRCm39)	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	19,167,561 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTGCAATTTGCCATTGAGGAGATC -3'
(R):5'- GAACTTACCTGGCTTCATTTACTGC -3'

Sequencing Primer
(F):5'- CTACAATGTCAGATTCACTGGGAAG -3'
(R):5'- GAAACCTGGATTGAACTCT -3'

Posted On

2016-07-06