Incidental Mutation 'R5241:Tas2r123'
ID |
400816 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tas2r123
|
Ensembl Gene |
ENSMUSG00000057381 |
Gene Name |
taste receptor, type 2, member 123 |
Synonyms |
mt2r55, mGR23, STC 9-2, T2R23, Tas2r23 |
MMRRC Submission |
042812-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.052)
|
Stock # |
R5241 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
132824105-132825106 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 132824181 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 26
(I26T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000071615
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071696]
|
AlphaFold |
P59528 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000071696
AA Change: I26T
PolyPhen 2
Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000071615 Gene: ENSMUSG00000057381 AA Change: I26T
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
7 |
322 |
4.6e-79 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 91.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A930033H14Rik |
A |
G |
10: 69,048,581 (GRCm39) |
|
probably null |
Het |
Adgrb3 |
T |
C |
1: 25,150,871 (GRCm39) |
T881A |
possibly damaging |
Het |
Adgrv1 |
A |
T |
13: 81,637,048 (GRCm39) |
C3464* |
probably null |
Het |
Afp |
A |
G |
5: 90,649,473 (GRCm39) |
M347V |
probably benign |
Het |
Apc2 |
A |
G |
10: 80,148,068 (GRCm39) |
T1041A |
probably benign |
Het |
Atl1 |
T |
C |
12: 70,005,887 (GRCm39) |
S398P |
possibly damaging |
Het |
Atp8b4 |
G |
A |
2: 126,225,646 (GRCm39) |
P528L |
probably benign |
Het |
Bahcc1 |
C |
A |
11: 120,162,229 (GRCm39) |
P176T |
probably damaging |
Het |
Bsnd |
A |
G |
4: 106,345,182 (GRCm39) |
V88A |
probably benign |
Het |
Dnah7c |
T |
A |
1: 46,569,660 (GRCm39) |
F687Y |
probably benign |
Het |
Dok6 |
T |
C |
18: 89,616,913 (GRCm39) |
I23M |
possibly damaging |
Het |
Fcgbp |
A |
T |
7: 27,784,624 (GRCm39) |
D228V |
probably damaging |
Het |
Gatad2a |
G |
A |
8: 70,370,667 (GRCm39) |
Q107* |
probably null |
Het |
Glis3 |
G |
T |
19: 28,327,423 (GRCm39) |
T663K |
probably benign |
Het |
Gm10784 |
T |
A |
13: 50,099,129 (GRCm39) |
|
noncoding transcript |
Het |
Gsdmc2 |
C |
T |
15: 63,696,743 (GRCm39) |
R476H |
probably benign |
Het |
Gsdmc3 |
A |
G |
15: 63,735,995 (GRCm39) |
S202P |
possibly damaging |
Het |
Map3k8 |
T |
C |
18: 4,340,750 (GRCm39) |
E188G |
probably damaging |
Het |
Mccc1 |
T |
A |
3: 36,028,345 (GRCm39) |
Q487L |
probably benign |
Het |
Msantd1 |
A |
G |
5: 35,078,813 (GRCm39) |
D116G |
probably damaging |
Het |
Myh1 |
T |
A |
11: 67,095,275 (GRCm39) |
S212T |
probably benign |
Het |
Nr1h4 |
A |
G |
10: 89,319,351 (GRCm39) |
Y158H |
probably damaging |
Het |
Or4p19 |
T |
C |
2: 88,242,442 (GRCm39) |
T187A |
possibly damaging |
Het |
Or51f1e |
T |
C |
7: 102,747,524 (GRCm39) |
V192A |
probably benign |
Het |
Or6k8-ps1 |
T |
A |
1: 173,979,667 (GRCm39) |
I195N |
probably benign |
Het |
Pcnt |
A |
T |
10: 76,269,451 (GRCm39) |
H272Q |
probably benign |
Het |
Pdia5 |
T |
C |
16: 35,250,145 (GRCm39) |
N242S |
probably benign |
Het |
Pkd1l2 |
A |
T |
8: 117,761,857 (GRCm39) |
D1441E |
probably damaging |
Het |
Runx2 |
G |
T |
17: 44,950,664 (GRCm39) |
Y203* |
probably null |
Het |
Sdr9c7 |
T |
G |
10: 127,745,659 (GRCm39) |
I257S |
probably benign |
Het |
Slitrk1 |
A |
G |
14: 109,150,444 (GRCm39) |
M89T |
probably benign |
Het |
St14 |
G |
T |
9: 31,011,714 (GRCm39) |
C397* |
probably null |
Het |
Tmem144 |
A |
T |
3: 79,721,431 (GRCm39) |
M329K |
probably benign |
Het |
Tmem252 |
T |
C |
19: 24,651,491 (GRCm39) |
M20T |
probably benign |
Het |
Umodl1 |
T |
C |
17: 31,203,066 (GRCm39) |
V473A |
probably benign |
Het |
Wdr70 |
A |
G |
15: 8,108,700 (GRCm39) |
C149R |
probably benign |
Het |
Xirp2 |
C |
T |
2: 67,312,704 (GRCm39) |
R58* |
probably null |
Het |
Zer1 |
A |
C |
2: 29,994,982 (GRCm39) |
L471R |
probably damaging |
Het |
Zfp101 |
C |
T |
17: 33,601,210 (GRCm39) |
C182Y |
probably benign |
Het |
|
Other mutations in Tas2r123 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01021:Tas2r123
|
APN |
6 |
132,824,369 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01547:Tas2r123
|
APN |
6 |
132,824,421 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02576:Tas2r123
|
APN |
6 |
132,824,703 (GRCm39) |
missense |
possibly damaging |
0.96 |
IGL03303:Tas2r123
|
APN |
6 |
132,824,401 (GRCm39) |
missense |
probably damaging |
1.00 |
G1patch:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
R0068:Tas2r123
|
UTSW |
6 |
132,824,955 (GRCm39) |
missense |
possibly damaging |
0.66 |
R0068:Tas2r123
|
UTSW |
6 |
132,824,955 (GRCm39) |
missense |
possibly damaging |
0.66 |
R0110:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably benign |
0.01 |
R0364:Tas2r123
|
UTSW |
6 |
132,824,644 (GRCm39) |
missense |
probably benign |
|
R0415:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
R0469:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably benign |
0.01 |
R1791:Tas2r123
|
UTSW |
6 |
132,824,528 (GRCm39) |
missense |
probably damaging |
1.00 |
R1976:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably damaging |
0.96 |
R2328:Tas2r123
|
UTSW |
6 |
132,824,279 (GRCm39) |
missense |
probably benign |
0.02 |
R4282:Tas2r123
|
UTSW |
6 |
132,825,008 (GRCm39) |
missense |
possibly damaging |
0.75 |
R4283:Tas2r123
|
UTSW |
6 |
132,825,008 (GRCm39) |
missense |
possibly damaging |
0.75 |
R4939:Tas2r123
|
UTSW |
6 |
132,824,808 (GRCm39) |
missense |
probably benign |
0.32 |
R5079:Tas2r123
|
UTSW |
6 |
132,824,681 (GRCm39) |
missense |
probably benign |
0.01 |
R5288:Tas2r123
|
UTSW |
6 |
132,824,190 (GRCm39) |
missense |
probably benign |
0.17 |
R5851:Tas2r123
|
UTSW |
6 |
132,824,271 (GRCm39) |
missense |
probably damaging |
1.00 |
R6725:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
R6895:Tas2r123
|
UTSW |
6 |
132,824,133 (GRCm39) |
missense |
probably benign |
|
R7017:Tas2r123
|
UTSW |
6 |
132,824,513 (GRCm39) |
missense |
probably benign |
0.00 |
R7183:Tas2r123
|
UTSW |
6 |
132,824,661 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8972:Tas2r123
|
UTSW |
6 |
132,824,333 (GRCm39) |
missense |
probably benign |
0.30 |
R9321:Tas2r123
|
UTSW |
6 |
132,825,095 (GRCm39) |
missense |
probably benign |
|
|
Predicted Primers |
PCR Primer
(F):5'- CAAACCCAAGATTTTCATGGAGG -3'
(R):5'- CTGATCTCCTAGGCAAATGTGG -3'
Sequencing Primer
(F):5'- CCCAAGATTTTCATGGAGGAATTATG -3'
(R):5'- TCCTAGGCAAATGTGGGCACAG -3'
|
Posted On |
2016-07-06 |