Incidental Mutation 'R5244:Vmn2r101'
ID 401081
Institutional Source Beutler Lab
Gene Symbol Vmn2r101
Ensembl Gene ENSMUSG00000094892
Gene Name vomeronasal 2, receptor 101
Synonyms EG627576
MMRRC Submission 042815-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R5244 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 19797493-19832579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19831788 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 595 (S595P)
Ref Sequence ENSEMBL: ENSMUSP00000131583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171914]
AlphaFold E9PZS9
Predicted Effect probably damaging
Transcript: ENSMUST00000171914
AA Change: S595P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: S595P

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 466 1.6e-36 PFAM
Pfam:NCD3G 509 562 6.4e-22 PFAM
Pfam:7tm_3 595 830 1.4e-51 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 97% (63/65)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930550C14Rik G T 9: 53,323,098 (GRCm39) G45W probably damaging Het
Abca13 C T 11: 9,225,081 (GRCm39) T520I probably benign Het
Adamtsl3 C T 7: 82,247,277 (GRCm39) P485L probably benign Het
Bbof1 A C 12: 84,476,847 (GRCm39) E492A possibly damaging Het
Capn11 T C 17: 45,944,818 (GRCm39) E483G probably damaging Het
Cbs C T 17: 31,836,134 (GRCm39) G438D probably damaging Het
Chil6 A G 3: 106,297,290 (GRCm39) Y284H probably damaging Het
Cops4 C A 5: 100,681,241 (GRCm39) Q131K probably benign Het
Cul4a T C 8: 13,196,566 (GRCm39) I740T probably damaging Het
Cyfip1 C T 7: 55,574,947 (GRCm39) T1066I probably damaging Het
Dnah7b T C 1: 46,273,018 (GRCm39) L2382P probably damaging Het
Ehd3 A T 17: 74,136,995 (GRCm39) H388L probably benign Het
Fam13a G T 6: 58,930,459 (GRCm39) Y484* probably null Het
Gm5117 A G 8: 32,228,305 (GRCm39) noncoding transcript Het
Gulp1 G A 1: 44,827,613 (GRCm39) D260N probably damaging Het
Hhipl1 T A 12: 108,278,393 (GRCm39) N240K probably damaging Het
Hydin A T 8: 111,259,451 (GRCm39) E2474D possibly damaging Het
Ifi207 C T 1: 173,557,503 (GRCm39) V412I probably benign Het
Ighv9-4 T C 12: 114,263,871 (GRCm39) I21V probably benign Het
Kcnh1 A T 1: 191,907,184 (GRCm39) T79S probably benign Het
Kpna6 A G 4: 129,549,221 (GRCm39) probably null Het
Lnpk C T 2: 74,362,232 (GRCm39) G262D probably damaging Het
Lsm7 T C 10: 80,688,907 (GRCm39) E66G probably benign Het
Mbd3l1 T A 9: 18,395,933 (GRCm39) C19* probably null Het
Mfsd6l T A 11: 68,448,001 (GRCm39) L284Q possibly damaging Het
Naip5 C T 13: 100,382,170 (GRCm39) V180I probably benign Het
Or2ag1b T A 7: 106,288,396 (GRCm39) I181F probably benign Het
Or2j6 A T 7: 139,980,051 (GRCm39) C303S probably benign Het
Or4k39 T A 2: 111,238,899 (GRCm39) noncoding transcript Het
Or6d13 T A 6: 116,518,187 (GRCm39) Y258N probably damaging Het
Or7g22 A T 9: 19,049,147 (GRCm39) N286I probably damaging Het
Or8g20 T G 9: 39,395,808 (GRCm39) H247P probably damaging Het
Or8u10 C G 2: 85,915,300 (GRCm39) A274P probably damaging Het
Pck1 T A 2: 172,996,656 (GRCm39) I190N possibly damaging Het
Pfkfb3 T A 2: 11,489,660 (GRCm39) I209F probably damaging Het
Phc1 A G 6: 122,298,938 (GRCm39) S677P probably damaging Het
Pirb G A 7: 3,719,062 (GRCm39) A609V probably benign Het
Plag1 A T 4: 3,903,887 (GRCm39) S435T probably benign Het
Plscr2 C G 9: 92,173,102 (GRCm39) L215V probably benign Het
Pnma8a A G 7: 16,695,248 (GRCm39) S368G probably damaging Het
Polr2b A G 5: 77,490,847 (GRCm39) probably benign Het
Pthlh T C 6: 147,158,651 (GRCm39) Y103C probably damaging Het
Ptprq A G 10: 107,422,556 (GRCm39) V1612A possibly damaging Het
Rprd2 T A 3: 95,697,494 (GRCm39) I85L possibly damaging Het
Slc27a2 T C 2: 126,420,775 (GRCm39) V422A probably benign Het
Slc29a1 T C 17: 45,899,339 (GRCm39) probably benign Het
Slc36a4 A T 9: 15,645,574 (GRCm39) I334F probably benign Het
Slc4a10 T A 2: 62,119,069 (GRCm39) S761R probably damaging Het
Spa17 T A 9: 37,523,285 (GRCm39) M1L probably damaging Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Het
Stk19 A G 17: 35,051,046 (GRCm39) L72P probably damaging Het
Trhde T C 10: 114,636,986 (GRCm39) M74V probably benign Het
Trim37 C T 11: 87,109,083 (GRCm39) H937Y probably benign Het
Ttc7b A G 12: 100,314,269 (GRCm39) L46P probably damaging Het
Ttll4 T C 1: 74,735,607 (GRCm39) V1005A probably benign Het
Ugt2b36 T C 5: 87,239,765 (GRCm39) T207A probably damaging Het
Unc13c C T 9: 73,433,233 (GRCm39) probably null Het
Vmn1r221 T C 13: 23,401,808 (GRCm39) noncoding transcript Het
Wnt10a T C 1: 74,842,454 (GRCm39) L310P probably damaging Het
Yif1b G A 7: 28,943,866 (GRCm39) A115T probably damaging Het
Zfp219 C A 14: 52,245,999 (GRCm39) R331L possibly damaging Het
Other mutations in Vmn2r101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01121:Vmn2r101 APN 17 19,809,936 (GRCm39) missense probably damaging 0.99
IGL02125:Vmn2r101 APN 17 19,809,963 (GRCm39) missense possibly damaging 0.95
IGL02300:Vmn2r101 APN 17 19,832,199 (GRCm39) missense probably damaging 1.00
IGL02682:Vmn2r101 APN 17 19,832,507 (GRCm39) missense possibly damaging 0.82
IGL02825:Vmn2r101 APN 17 19,810,132 (GRCm39) missense probably benign 0.00
IGL02862:Vmn2r101 APN 17 19,831,867 (GRCm39) missense probably damaging 1.00
IGL02943:Vmn2r101 APN 17 19,831,666 (GRCm39) missense probably damaging 0.99
R0371:Vmn2r101 UTSW 17 19,810,394 (GRCm39) missense probably benign 0.07
R0462:Vmn2r101 UTSW 17 19,810,431 (GRCm39) missense probably benign 0.04
R0492:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R0654:Vmn2r101 UTSW 17 19,810,373 (GRCm39) missense probably benign 0.01
R1120:Vmn2r101 UTSW 17 19,797,723 (GRCm39) splice site probably benign
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1676:Vmn2r101 UTSW 17 19,832,184 (GRCm39) missense probably benign 0.00
R2023:Vmn2r101 UTSW 17 19,810,368 (GRCm39) nonsense probably null
R2149:Vmn2r101 UTSW 17 19,809,225 (GRCm39) missense probably benign 0.00
R2350:Vmn2r101 UTSW 17 19,810,045 (GRCm39) missense probably benign 0.01
R2760:Vmn2r101 UTSW 17 19,809,901 (GRCm39) missense probably benign 0.14
R3085:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3086:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3719:Vmn2r101 UTSW 17 19,809,811 (GRCm39) missense possibly damaging 0.50
R3771:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R3773:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R4225:Vmn2r101 UTSW 17 19,831,951 (GRCm39) missense probably damaging 1.00
R4248:Vmn2r101 UTSW 17 19,809,376 (GRCm39) missense probably damaging 1.00
R4290:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4291:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4293:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r101 UTSW 17 19,810,423 (GRCm39) missense probably damaging 1.00
R4721:Vmn2r101 UTSW 17 19,832,287 (GRCm39) missense probably damaging 0.99
R4829:Vmn2r101 UTSW 17 19,832,229 (GRCm39) missense probably benign 0.03
R5022:Vmn2r101 UTSW 17 19,831,649 (GRCm39) critical splice acceptor site probably null
R5110:Vmn2r101 UTSW 17 19,831,897 (GRCm39) missense possibly damaging 0.92
R5397:Vmn2r101 UTSW 17 19,809,104 (GRCm39) missense probably damaging 1.00
R5875:Vmn2r101 UTSW 17 19,809,092 (GRCm39) missense probably damaging 0.99
R5944:Vmn2r101 UTSW 17 19,809,769 (GRCm39) missense probably benign 0.00
R6216:Vmn2r101 UTSW 17 19,811,267 (GRCm39) missense probably benign 0.00
R6334:Vmn2r101 UTSW 17 19,810,112 (GRCm39) missense possibly damaging 0.83
R6512:Vmn2r101 UTSW 17 19,809,146 (GRCm39) missense probably damaging 1.00
R6607:Vmn2r101 UTSW 17 19,832,296 (GRCm39) missense probably damaging 1.00
R6965:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R7101:Vmn2r101 UTSW 17 19,809,350 (GRCm39) missense probably null 0.14
R7183:Vmn2r101 UTSW 17 19,832,440 (GRCm39) missense probably damaging 1.00
R7344:Vmn2r101 UTSW 17 19,832,059 (GRCm39) missense probably benign 0.38
R7375:Vmn2r101 UTSW 17 19,831,652 (GRCm39) missense probably damaging 1.00
R7574:Vmn2r101 UTSW 17 19,831,899 (GRCm39) missense possibly damaging 0.91
R7575:Vmn2r101 UTSW 17 19,831,654 (GRCm39) missense probably benign 0.01
R7592:Vmn2r101 UTSW 17 19,811,443 (GRCm39) splice site probably null
R7626:Vmn2r101 UTSW 17 19,832,192 (GRCm39) nonsense probably null
R7715:Vmn2r101 UTSW 17 19,832,177 (GRCm39) missense probably damaging 1.00
R7730:Vmn2r101 UTSW 17 19,831,950 (GRCm39) missense possibly damaging 0.81
R8078:Vmn2r101 UTSW 17 19,810,507 (GRCm39) missense probably benign 0.07
R8228:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R8283:Vmn2r101 UTSW 17 19,832,253 (GRCm39) missense probably damaging 1.00
R8712:Vmn2r101 UTSW 17 19,811,397 (GRCm39) missense probably benign 0.24
R8765:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R9091:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9092:Vmn2r101 UTSW 17 19,809,807 (GRCm39) missense probably benign 0.07
R9113:Vmn2r101 UTSW 17 19,811,288 (GRCm39) missense possibly damaging 0.56
R9158:Vmn2r101 UTSW 17 19,809,161 (GRCm39) missense probably benign 0.00
R9168:Vmn2r101 UTSW 17 19,809,138 (GRCm39) missense probably damaging 1.00
R9235:Vmn2r101 UTSW 17 19,810,238 (GRCm39) missense probably damaging 0.99
R9270:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9290:Vmn2r101 UTSW 17 19,811,395 (GRCm39) missense probably benign 0.05
R9296:Vmn2r101 UTSW 17 19,810,047 (GRCm39) missense probably damaging 0.98
R9602:Vmn2r101 UTSW 17 19,831,780 (GRCm39) nonsense probably null
R9706:Vmn2r101 UTSW 17 19,809,925 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r101 UTSW 17 19,809,237 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- GGACTCCTGTTTTCATGATAACC -3'
(R):5'- CTTTGGCCAACACAGTAGCAAG -3'

Sequencing Primer
(F):5'- CCTATATTTCTGACCAGATGTTTACC -3'
(R):5'- TAACTGCAAAGGTAGTCTGCTG -3'
Posted On 2016-07-06