Mutagenetix > Incidental Mutation

Incidental Mutation 'R5258:Or5d37'

401221

Institutional Source

Beutler Lab

Gene Symbol

Or5d37

Ensembl Gene

ENSMUSG00000075136

Gene Name

olfactory receptor family 5 subfamily D member 37

Synonyms

GA_x6K02T2Q125-49585842-49584862, Olfr1164, MOR174-11

MMRRC Submission

042828-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R5258 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

87923199-87924310 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 87923762 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 173 (Y173N)

Ref Sequence

ENSEMBL: ENSMUSP00000097422 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099834]

AlphaFold

A2AVT5

Predicted Effect

probably benign
Transcript: ENSMUST00000099834
AA Change: Y173N

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000097422
Gene: ENSMUSG00000075136
AA Change: Y173N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	43	320	3.8e-47	PFAM
Pfam:7tm_1	53	302	2.9e-15	PFAM

Meta Mutation Damage Score

0.0721

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.4%

Validation Efficiency

98% (55/56)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	A	14: 32,385,266 (GRCm39)	D233V	probably damaging	Het
Abca13	A	T	11: 9,199,684 (GRCm39)	T128S	possibly damaging	Het
Abca16	T	G	7: 120,035,992 (GRCm39)		probably null	Het
Abcc8	T	C	7: 45,757,811 (GRCm39)	I1313V	probably benign	Het
Abcc8	C	T	7: 45,806,572 (GRCm39)	V379I	probably benign	Het
Acp3	T	C	9: 104,186,674 (GRCm39)	I266V	probably benign	Het
Asf1b	C	T	8: 84,695,896 (GRCm39)	T179I	probably benign	Het
B3gnt7	A	G	1: 86,233,287 (GRCm39)	K61E	possibly damaging	Het
Card11	G	A	5: 140,862,180 (GRCm39)	P1039L	possibly damaging	Het
Cd1d2	C	G	3: 86,894,954 (GRCm39)	R147G	possibly damaging	Het
Cfap68	T	C	9: 50,675,633 (GRCm39)		probably benign	Het
Cfap69	T	C	5: 5,654,271 (GRCm39)		probably null	Het
Ddx46	T	C	13: 55,800,837 (GRCm39)	F331L	possibly damaging	Het
Dkk4	C	A	8: 23,117,031 (GRCm39)	L215I	probably damaging	Het
Dnhd1	C	T	7: 105,323,244 (GRCm39)	T584I	probably benign	Het
Dock3	T	C	9: 106,874,124 (GRCm39)	Y449C	probably damaging	Het
Foxi2	C	T	7: 135,012,256 (GRCm39)	T48M	probably benign	Het
Gm12887	T	C	4: 121,472,897 (GRCm39)	K82E	probably benign	Het
Gm4787	G	C	12: 81,424,604 (GRCm39)	T518S	probably benign	Het
Igkv4-80	T	A	6: 68,993,811 (GRCm39)	T27S	probably benign	Het
Invs	A	G	4: 48,396,374 (GRCm39)	D349G	possibly damaging	Het
Lbhd1	A	G	19: 8,861,453 (GRCm39)		probably benign	Het
Lipo3	T	A	19: 33,591,243 (GRCm39)		probably benign	Het
Llgl1	G	C	11: 60,602,389 (GRCm39)		probably null	Het
Lyzl6	T	A	11: 103,525,899 (GRCm39)	I74F	probably damaging	Het
Map3k6	T	C	4: 132,974,953 (GRCm39)	V662A	possibly damaging	Het
Megf8	T	A	7: 25,047,751 (GRCm39)	F1645I	possibly damaging	Het
Mfsd4b2	T	A	10: 39,798,017 (GRCm39)	M113L	probably benign	Het
Mib1	G	A	18: 10,795,856 (GRCm39)		probably null	Het
Mrps6	T	A	16: 91,896,543 (GRCm39)	V36E	probably damaging	Het
Nhsl1	C	A	10: 18,400,070 (GRCm39)	S432*	probably null	Het
Nle1	T	C	11: 82,795,772 (GRCm39)	D225G	probably damaging	Het
Nlrp4c	T	A	7: 6,069,622 (GRCm39)	S508T	probably benign	Het
Or1e16	AGCGGTCGTAGGC	AGC	11: 73,286,480 (GRCm39)		probably null	Het
P2rx7	A	G	5: 122,819,066 (GRCm39)	E496G	probably damaging	Het
Prdm16	A	T	4: 154,451,671 (GRCm39)	D179E	possibly damaging	Het
Psca	A	T	15: 74,588,240 (GRCm39)	I56F	probably damaging	Het
Ptprg	A	G	14: 12,142,431 (GRCm38)	T361A	probably benign	Het
Ptrhd1	A	G	12: 4,286,481 (GRCm39)	Y124C	probably damaging	Het
Sesn1	C	T	10: 41,770,984 (GRCm39)	P172S	probably benign	Het
Sspo	T	C	6: 48,453,428 (GRCm39)	V2872A	probably damaging	Het
Stard9	T	A	2: 120,529,824 (GRCm39)	L2027H	probably damaging	Het
Tas2r114	T	A	6: 131,666,504 (GRCm39)	I175F	probably benign	Het
Tex2	T	A	11: 106,458,585 (GRCm39)		probably benign	Het
Tfdp1	C	T	8: 13,419,529 (GRCm39)	T86M	possibly damaging	Het
Trav14-1	C	T	14: 53,791,730 (GRCm39)	H27Y	probably benign	Het
Trim24	A	T	6: 37,896,335 (GRCm39)	Q264L	probably benign	Het
Vmn2r90	A	G	17: 17,933,114 (GRCm39)	I225V	probably benign	Het
Vps13b	A	G	15: 35,794,567 (GRCm39)	T2326A	possibly damaging	Het
Zfp354b	A	C	11: 50,813,917 (GRCm39)	I336S	probably benign	Het
Zfp407	C	T	18: 84,334,051 (GRCm39)	V1761I	probably damaging	Het
Zfp958	A	T	8: 4,678,456 (GRCm39)	E160D	probably benign	Het

Other mutations in Or5d37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01522:Or5d37	APN	2	87,923,360 (GRCm39)	missense	possibly damaging	0.48
IGL02894:Or5d37	APN	2	87,924,107 (GRCm39)	missense	possibly damaging	0.79
IGL02977:Or5d37	APN	2	87,923,915 (GRCm39)	missense	probably benign
R0234:Or5d37	UTSW	2	87,923,366 (GRCm39)	nonsense	probably null
R0234:Or5d37	UTSW	2	87,923,366 (GRCm39)	nonsense	probably null
R0480:Or5d37	UTSW	2	87,923,972 (GRCm39)	missense	probably benign
R0644:Or5d37	UTSW	2	87,923,633 (GRCm39)	missense	probably benign	0.02
R1479:Or5d37	UTSW	2	87,923,630 (GRCm39)	missense	probably benign	0.05
R2047:Or5d37	UTSW	2	87,924,237 (GRCm39)	missense	probably benign	0.01
R2311:Or5d37	UTSW	2	87,924,178 (GRCm39)	missense	probably benign	0.00
R2973:Or5d37	UTSW	2	87,923,458 (GRCm39)	missense	probably benign	0.00
R3683:Or5d37	UTSW	2	87,923,603 (GRCm39)	missense	probably damaging	1.00
R3685:Or5d37	UTSW	2	87,923,603 (GRCm39)	missense	probably damaging	1.00
R4258:Or5d37	UTSW	2	87,923,362 (GRCm39)	missense	probably damaging	1.00
R4811:Or5d37	UTSW	2	87,923,876 (GRCm39)	missense	probably benign	0.08
R4970:Or5d37	UTSW	2	87,923,353 (GRCm39)	missense	probably damaging	1.00
R5112:Or5d37	UTSW	2	87,923,353 (GRCm39)	missense	probably damaging	1.00
R5884:Or5d37	UTSW	2	87,924,140 (GRCm39)	missense	probably damaging	1.00
R6329:Or5d37	UTSW	2	87,924,008 (GRCm39)	missense	probably damaging	1.00
R6597:Or5d37	UTSW	2	87,923,413 (GRCm39)	missense	probably damaging	1.00
R7018:Or5d37	UTSW	2	87,923,600 (GRCm39)	missense	probably benign	0.00
R7055:Or5d37	UTSW	2	87,924,045 (GRCm39)	missense	probably damaging	1.00
R7314:Or5d37	UTSW	2	87,923,458 (GRCm39)	missense	probably benign	0.00
R7350:Or5d37	UTSW	2	87,923,542 (GRCm39)	missense	probably benign	0.01
R7527:Or5d37	UTSW	2	87,923,954 (GRCm39)	missense	probably damaging	1.00
R8003:Or5d37	UTSW	2	87,923,589 (GRCm39)	nonsense	probably null
R8814:Or5d37	UTSW	2	87,923,315 (GRCm39)	missense	probably benign
R9072:Or5d37	UTSW	2	87,924,172 (GRCm39)	missense	probably benign	0.25
R9073:Or5d37	UTSW	2	87,924,172 (GRCm39)	missense	probably benign	0.25
R9189:Or5d37	UTSW	2	87,924,194 (GRCm39)	missense	probably damaging	1.00
R9276:Or5d37	UTSW	2	87,923,806 (GRCm39)	missense	probably benign
R9284:Or5d37	UTSW	2	87,924,278 (GRCm39)	start codon destroyed	probably benign
Z1176:Or5d37	UTSW	2	87,923,678 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GGGAATTTTGATGACAGTGACAAC -3'
(R):5'- CTTTGAAGGATGCATGGCTC -3'

Sequencing Primer
(F):5'- ACTGAAGGAGGTGTCTGA -3'
(R):5'- GAAGGATGCATGGCTCAATATTTTC -3'

Posted On

2016-07-06