|Institutional Source||Beutler Lab|
|Gene Name||prostate stem cell antigen|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5258 (G1)|
|Chromosomal Location||74714839-74717069 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 74716391 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 56 (I56F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000023265 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000023265] [ENSMUST00000070923]|
|Predicted Effect||probably damaging
AA Change: I56F
PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
AA Change: I56F
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.6467|
|Coding Region Coverage||
|Validation Efficiency||98% (55/56)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Homozygous null mice are viable and fertile and show no significant differences in spontaneous or radiation-induced primary epithelial tumor formation relative to wild-type littermates. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Psca||
(F):5'- TCCAGCCAGACATCAAAGCTTTG -3'
(R):5'- TCACAATCGGGCTATGGTAGG -3'
(F):5'- GACATCAAAGCTTTGCTCACC -3'
(R):5'- TCTCCCAGAGCCTACAGACGG -3'