Incidental Mutation 'R5261:Or5ak25'
ID 401418
Institutional Source Beutler Lab
Gene Symbol Or5ak25
Ensembl Gene ENSMUSG00000075218
Gene Name olfactory receptor family 5 subfamily AK member 25
Synonyms MOR203-3, GA_x6K02T2Q125-46915844-46914897, Olfr995
MMRRC Submission 042830-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # R5261 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85268553-85269500 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85269241 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 87 (V87A)
Ref Sequence ENSEMBL: ENSMUSP00000149952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099924] [ENSMUST00000214679] [ENSMUST00000216933] [ENSMUST00000217218]
AlphaFold Q8VF74
Predicted Effect probably benign
Transcript: ENSMUST00000099924
AA Change: V87A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097508
Gene: ENSMUSG00000075218
AA Change: V87A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-50 PFAM
Pfam:7tm_1 41 290 2.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214679
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215758
Predicted Effect probably benign
Transcript: ENSMUST00000216933
AA Change: V87A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217218
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.5%
  • 20x: 93.1%
Validation Efficiency 96% (64/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik C G 2: 152,282,777 (GRCm39) P211A probably damaging Het
Ambra1 G A 2: 91,715,951 (GRCm39) V761M probably damaging Het
Amfr T A 8: 94,702,798 (GRCm39) probably null Het
Asphd1 C A 7: 126,545,287 (GRCm39) A357S probably benign Het
Brd3 C A 2: 27,353,931 (GRCm39) Q60H probably damaging Het
Cd96 T A 16: 45,890,016 (GRCm39) M336L probably benign Het
Cep152 T A 2: 125,406,125 (GRCm39) H1469L probably benign Het
Coro1a G T 7: 126,299,816 (GRCm39) probably null Het
D630045J12Rik A T 6: 38,171,555 (GRCm39) L871Q probably benign Het
Depdc5 C T 5: 33,095,635 (GRCm39) P824L probably damaging Het
Enpep T G 3: 129,099,075 (GRCm39) D467A probably damaging Het
Extl2 G A 3: 115,821,013 (GRCm39) A273T probably benign Het
Foxi3 T A 6: 70,937,500 (GRCm39) F218Y probably damaging Het
Golga2 A G 2: 32,194,166 (GRCm39) M521V probably benign Het
Gpr142 T A 11: 114,695,168 (GRCm39) N44K probably damaging Het
Gtf2ird2 A G 5: 134,245,061 (GRCm39) I440V probably benign Het
Gucy1b2 T A 14: 62,642,028 (GRCm39) K698I probably damaging Het
Hspa1b T C 17: 35,177,983 (GRCm39) M1V probably null Het
Ints9 T A 14: 65,245,521 (GRCm39) Y260N probably benign Het
Khdc3 T G 9: 73,010,768 (GRCm39) V182G possibly damaging Het
Ky A G 9: 102,414,798 (GRCm39) probably null Het
Map2k1 T A 9: 64,098,843 (GRCm39) I263F probably damaging Het
Or13a18 A C 7: 140,190,576 (GRCm39) I166L probably benign Het
Or2t47 T C 11: 58,442,877 (GRCm39) S63G probably benign Het
Otogl T A 10: 107,613,453 (GRCm39) H2004L probably benign Het
Palmd T C 3: 116,717,009 (GRCm39) H496R probably benign Het
Papolb C G 5: 142,515,409 (GRCm39) R78P possibly damaging Het
Pcdh10 G A 3: 45,336,247 (GRCm39) G854R probably damaging Het
Pdcd11 A G 19: 47,101,976 (GRCm39) I1054V probably benign Het
Pik3ap1 A T 19: 41,364,545 (GRCm39) L58Q probably damaging Het
Ppp2ca A G 11: 51,989,937 (GRCm39) K21R probably benign Het
Prmt5 A C 14: 54,745,373 (GRCm39) I598S probably damaging Het
Pycr1 T A 11: 120,532,050 (GRCm39) I239F probably damaging Het
R3hdm2 C T 10: 127,334,285 (GRCm39) R896C probably damaging Het
Rev3l C T 10: 39,722,725 (GRCm39) P699S probably damaging Het
Samd1 CGAGGAGGAGGAGGAGGAGGA CGAGGAGGAGGAGGAGGA 8: 84,725,625 (GRCm39) probably benign Het
Sel1l A T 12: 91,791,658 (GRCm39) M351K possibly damaging Het
Sesn2 A G 4: 132,226,617 (GRCm39) L159P probably damaging Het
Slc35f4 T A 14: 49,540,946 (GRCm39) probably benign Het
Slc3a1 C A 17: 85,359,403 (GRCm39) N409K probably damaging Het
Slc45a2 C T 15: 11,027,871 (GRCm39) T480I probably damaging Het
Slco1c1 T C 6: 141,492,502 (GRCm39) F246S probably damaging Het
Socs2 T G 10: 95,228,681 (GRCm39) I190L unknown Het
Srsf1 T A 11: 87,938,684 (GRCm39) I7N possibly damaging Het
Stox1 T A 10: 62,503,620 (GRCm39) H145L probably damaging Het
Trap1 A T 16: 3,874,286 (GRCm39) I243N probably damaging Het
Trav7-3 T C 14: 53,681,207 (GRCm39) I83T probably benign Het
Trmt9b T C 8: 36,979,078 (GRCm39) I227T probably benign Het
Tuft1 A T 3: 94,546,712 (GRCm39) I42K possibly damaging Het
Umps A G 16: 33,787,344 (GRCm39) V3A probably benign Het
Vim A C 2: 13,579,643 (GRCm39) E134A probably null Het
Vmn1r28 C A 6: 58,242,524 (GRCm39) H122Q probably benign Het
Vps51 T G 19: 6,121,063 (GRCm39) E283D probably benign Het
Vsig10l T A 7: 43,120,274 (GRCm39) V760D probably damaging Het
Xrn1 A G 9: 95,927,596 (GRCm39) D1460G probably benign Het
Zfp282 A G 6: 47,874,824 (GRCm39) D343G probably damaging Het
Zfp35 A G 18: 24,136,778 (GRCm39) H374R probably damaging Het
Other mutations in Or5ak25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02102:Or5ak25 APN 2 85,268,611 (GRCm39) missense probably damaging 1.00
IGL02540:Or5ak25 APN 2 85,269,259 (GRCm39) missense probably benign 0.05
IGL02687:Or5ak25 APN 2 85,268,930 (GRCm39) missense possibly damaging 0.93
IGL02713:Or5ak25 APN 2 85,268,981 (GRCm39) missense probably damaging 0.99
R0318:Or5ak25 UTSW 2 85,268,581 (GRCm39) missense possibly damaging 0.91
R0463:Or5ak25 UTSW 2 85,268,630 (GRCm39) missense probably damaging 1.00
R0638:Or5ak25 UTSW 2 85,268,845 (GRCm39) missense probably benign 0.03
R1668:Or5ak25 UTSW 2 85,269,220 (GRCm39) missense probably benign 0.00
R1718:Or5ak25 UTSW 2 85,269,149 (GRCm39) missense probably benign 0.39
R4981:Or5ak25 UTSW 2 85,268,813 (GRCm39) missense probably damaging 1.00
R7036:Or5ak25 UTSW 2 85,268,774 (GRCm39) missense probably damaging 1.00
R7899:Or5ak25 UTSW 2 85,268,741 (GRCm39) missense probably benign 0.39
R8209:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8226:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R8803:Or5ak25 UTSW 2 85,268,981 (GRCm39) missense probably damaging 0.99
R9037:Or5ak25 UTSW 2 85,269,139 (GRCm39) missense possibly damaging 0.88
R9541:Or5ak25 UTSW 2 85,269,025 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- CTGAACACAAACTTGTCGAGAC -3'
(R):5'- ACTGACTTCTATCTTCTGGGATTTG -3'

Sequencing Primer
(F):5'- CAAACTTGTCGAGACATGATTATGGG -3'
(R):5'- AATACTCAGAGTATCCTCTTCGTTG -3'
Posted On 2016-07-06