Incidental Mutation 'R5261:Vmn1r28'
ID |
401433 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r28
|
Ensembl Gene |
ENSMUSG00000115705 |
Gene Name |
vomeronasal 1 receptor 28 |
Synonyms |
V1rc25 |
MMRRC Submission |
042830-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.133)
|
Stock # |
R5261 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
58239279-58243645 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 58242524 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Histidine to Glutamine
at position 122
(H122Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000153785
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176874]
[ENSMUST00000226813]
[ENSMUST00000227805]
[ENSMUST00000228678]
|
AlphaFold |
Q8R2C9 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000176874
AA Change: H122Q
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
SMART Domains |
Protein: ENSMUSP00000135311 Gene: ENSMUSG00000094291 AA Change: H122Q
Domain | Start | End | E-Value | Type |
Pfam:V1R
|
28 |
293 |
8.4e-59 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000226813
AA Change: H122Q
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227805
AA Change: H122Q
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228678
AA Change: H122Q
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.5%
- 20x: 93.1%
|
Validation Efficiency |
96% (64/67) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 57 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
6820408C15Rik |
C |
G |
2: 152,282,777 (GRCm39) |
P211A |
probably damaging |
Het |
Ambra1 |
G |
A |
2: 91,715,951 (GRCm39) |
V761M |
probably damaging |
Het |
Amfr |
T |
A |
8: 94,702,798 (GRCm39) |
|
probably null |
Het |
Asphd1 |
C |
A |
7: 126,545,287 (GRCm39) |
A357S |
probably benign |
Het |
Brd3 |
C |
A |
2: 27,353,931 (GRCm39) |
Q60H |
probably damaging |
Het |
Cd96 |
T |
A |
16: 45,890,016 (GRCm39) |
M336L |
probably benign |
Het |
Cep152 |
T |
A |
2: 125,406,125 (GRCm39) |
H1469L |
probably benign |
Het |
Coro1a |
G |
T |
7: 126,299,816 (GRCm39) |
|
probably null |
Het |
D630045J12Rik |
A |
T |
6: 38,171,555 (GRCm39) |
L871Q |
probably benign |
Het |
Depdc5 |
C |
T |
5: 33,095,635 (GRCm39) |
P824L |
probably damaging |
Het |
Enpep |
T |
G |
3: 129,099,075 (GRCm39) |
D467A |
probably damaging |
Het |
Extl2 |
G |
A |
3: 115,821,013 (GRCm39) |
A273T |
probably benign |
Het |
Foxi3 |
T |
A |
6: 70,937,500 (GRCm39) |
F218Y |
probably damaging |
Het |
Golga2 |
A |
G |
2: 32,194,166 (GRCm39) |
M521V |
probably benign |
Het |
Gpr142 |
T |
A |
11: 114,695,168 (GRCm39) |
N44K |
probably damaging |
Het |
Gtf2ird2 |
A |
G |
5: 134,245,061 (GRCm39) |
I440V |
probably benign |
Het |
Gucy1b2 |
T |
A |
14: 62,642,028 (GRCm39) |
K698I |
probably damaging |
Het |
Hspa1b |
T |
C |
17: 35,177,983 (GRCm39) |
M1V |
probably null |
Het |
Ints9 |
T |
A |
14: 65,245,521 (GRCm39) |
Y260N |
probably benign |
Het |
Khdc3 |
T |
G |
9: 73,010,768 (GRCm39) |
V182G |
possibly damaging |
Het |
Ky |
A |
G |
9: 102,414,798 (GRCm39) |
|
probably null |
Het |
Map2k1 |
T |
A |
9: 64,098,843 (GRCm39) |
I263F |
probably damaging |
Het |
Or13a18 |
A |
C |
7: 140,190,576 (GRCm39) |
I166L |
probably benign |
Het |
Or2t47 |
T |
C |
11: 58,442,877 (GRCm39) |
S63G |
probably benign |
Het |
Or5ak25 |
A |
G |
2: 85,269,241 (GRCm39) |
V87A |
probably benign |
Het |
Otogl |
T |
A |
10: 107,613,453 (GRCm39) |
H2004L |
probably benign |
Het |
Palmd |
T |
C |
3: 116,717,009 (GRCm39) |
H496R |
probably benign |
Het |
Papolb |
C |
G |
5: 142,515,409 (GRCm39) |
R78P |
possibly damaging |
Het |
Pcdh10 |
G |
A |
3: 45,336,247 (GRCm39) |
G854R |
probably damaging |
Het |
Pdcd11 |
A |
G |
19: 47,101,976 (GRCm39) |
I1054V |
probably benign |
Het |
Pik3ap1 |
A |
T |
19: 41,364,545 (GRCm39) |
L58Q |
probably damaging |
Het |
Ppp2ca |
A |
G |
11: 51,989,937 (GRCm39) |
K21R |
probably benign |
Het |
Prmt5 |
A |
C |
14: 54,745,373 (GRCm39) |
I598S |
probably damaging |
Het |
Pycr1 |
T |
A |
11: 120,532,050 (GRCm39) |
I239F |
probably damaging |
Het |
R3hdm2 |
C |
T |
10: 127,334,285 (GRCm39) |
R896C |
probably damaging |
Het |
Rev3l |
C |
T |
10: 39,722,725 (GRCm39) |
P699S |
probably damaging |
Het |
Samd1 |
CGAGGAGGAGGAGGAGGAGGA |
CGAGGAGGAGGAGGAGGA |
8: 84,725,625 (GRCm39) |
|
probably benign |
Het |
Sel1l |
A |
T |
12: 91,791,658 (GRCm39) |
M351K |
possibly damaging |
Het |
Sesn2 |
A |
G |
4: 132,226,617 (GRCm39) |
L159P |
probably damaging |
Het |
Slc35f4 |
T |
A |
14: 49,540,946 (GRCm39) |
|
probably benign |
Het |
Slc3a1 |
C |
A |
17: 85,359,403 (GRCm39) |
N409K |
probably damaging |
Het |
Slc45a2 |
C |
T |
15: 11,027,871 (GRCm39) |
T480I |
probably damaging |
Het |
Slco1c1 |
T |
C |
6: 141,492,502 (GRCm39) |
F246S |
probably damaging |
Het |
Socs2 |
T |
G |
10: 95,228,681 (GRCm39) |
I190L |
unknown |
Het |
Srsf1 |
T |
A |
11: 87,938,684 (GRCm39) |
I7N |
possibly damaging |
Het |
Stox1 |
T |
A |
10: 62,503,620 (GRCm39) |
H145L |
probably damaging |
Het |
Trap1 |
A |
T |
16: 3,874,286 (GRCm39) |
I243N |
probably damaging |
Het |
Trav7-3 |
T |
C |
14: 53,681,207 (GRCm39) |
I83T |
probably benign |
Het |
Trmt9b |
T |
C |
8: 36,979,078 (GRCm39) |
I227T |
probably benign |
Het |
Tuft1 |
A |
T |
3: 94,546,712 (GRCm39) |
I42K |
possibly damaging |
Het |
Umps |
A |
G |
16: 33,787,344 (GRCm39) |
V3A |
probably benign |
Het |
Vim |
A |
C |
2: 13,579,643 (GRCm39) |
E134A |
probably null |
Het |
Vps51 |
T |
G |
19: 6,121,063 (GRCm39) |
E283D |
probably benign |
Het |
Vsig10l |
T |
A |
7: 43,120,274 (GRCm39) |
V760D |
probably damaging |
Het |
Xrn1 |
A |
G |
9: 95,927,596 (GRCm39) |
D1460G |
probably benign |
Het |
Zfp282 |
A |
G |
6: 47,874,824 (GRCm39) |
D343G |
probably damaging |
Het |
Zfp35 |
A |
G |
18: 24,136,778 (GRCm39) |
H374R |
probably damaging |
Het |
|
Other mutations in Vmn1r28 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01365:Vmn1r28
|
APN |
6 |
58,242,176 (GRCm39) |
missense |
possibly damaging |
0.76 |
IGL01712:Vmn1r28
|
APN |
6 |
58,242,393 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01788:Vmn1r28
|
APN |
6 |
58,242,522 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02629:Vmn1r28
|
APN |
6 |
58,242,801 (GRCm39) |
missense |
probably benign |
0.00 |
R0001:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0009:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0040:Vmn1r28
|
UTSW |
6 |
58,242,879 (GRCm39) |
missense |
probably damaging |
1.00 |
R0078:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0079:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0081:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0164:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0165:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0166:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0167:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0172:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0173:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0284:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0288:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R0704:Vmn1r28
|
UTSW |
6 |
58,242,702 (GRCm39) |
missense |
probably benign |
0.00 |
R1143:Vmn1r28
|
UTSW |
6 |
58,242,727 (GRCm39) |
missense |
probably benign |
0.00 |
R1225:Vmn1r28
|
UTSW |
6 |
58,242,951 (GRCm39) |
nonsense |
probably null |
|
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
R1464:Vmn1r28
|
UTSW |
6 |
58,242,217 (GRCm39) |
missense |
probably benign |
0.05 |
R1836:Vmn1r28
|
UTSW |
6 |
58,242,237 (GRCm39) |
missense |
probably damaging |
0.98 |
R1882:Vmn1r28
|
UTSW |
6 |
58,242,963 (GRCm39) |
missense |
probably benign |
|
R1905:Vmn1r28
|
UTSW |
6 |
58,242,912 (GRCm39) |
missense |
probably benign |
0.01 |
R4912:Vmn1r28
|
UTSW |
6 |
58,242,525 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5071:Vmn1r28
|
UTSW |
6 |
58,242,894 (GRCm39) |
missense |
probably benign |
0.25 |
R5113:Vmn1r28
|
UTSW |
6 |
58,242,843 (GRCm39) |
missense |
probably benign |
0.12 |
R5265:Vmn1r28
|
UTSW |
6 |
58,242,949 (GRCm39) |
missense |
probably damaging |
0.98 |
R5839:Vmn1r28
|
UTSW |
6 |
58,242,280 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6180:Vmn1r28
|
UTSW |
6 |
58,242,476 (GRCm39) |
missense |
probably damaging |
0.99 |
R6643:Vmn1r28
|
UTSW |
6 |
58,242,945 (GRCm39) |
missense |
probably benign |
0.17 |
R6884:Vmn1r28
|
UTSW |
6 |
58,242,633 (GRCm39) |
missense |
probably benign |
0.03 |
R7393:Vmn1r28
|
UTSW |
6 |
58,242,574 (GRCm39) |
missense |
possibly damaging |
0.81 |
R7471:Vmn1r28
|
UTSW |
6 |
58,242,850 (GRCm39) |
nonsense |
probably null |
|
R7738:Vmn1r28
|
UTSW |
6 |
58,243,039 (GRCm39) |
missense |
probably benign |
0.00 |
R7961:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
R8009:Vmn1r28
|
UTSW |
6 |
58,242,178 (GRCm39) |
missense |
probably benign |
|
R8156:Vmn1r28
|
UTSW |
6 |
58,242,183 (GRCm39) |
missense |
probably damaging |
1.00 |
R8167:Vmn1r28
|
UTSW |
6 |
58,243,052 (GRCm39) |
missense |
noncoding transcript |
|
R8879:Vmn1r28
|
UTSW |
6 |
58,242,669 (GRCm39) |
missense |
probably benign |
0.05 |
R9639:Vmn1r28
|
UTSW |
6 |
58,242,996 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TCCTCAGTGAAGGAGATAACTTGC -3'
(R):5'- AATACATCCCTGGCGATTATCAC -3'
Sequencing Primer
(F):5'- AGGAGATAACTTGCTTGCAAAC -3'
(R):5'- CACTGTTAAAATCGATCCCCTGATG -3'
|
Posted On |
2016-07-06 |