Incidental Mutation 'R5263:Mrgprb5'
ID 401551
Institutional Source Beutler Lab
Gene Symbol Mrgprb5
Ensembl Gene ENSMUSG00000070551
Gene Name MAS-related GPR, member B5
Synonyms MrgB5
MMRRC Submission 042831-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R5263 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 47817765-47818733 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 47817937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 266 (V266A)
Ref Sequence ENSEMBL: ENSMUSP00000091953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094389]
AlphaFold Q91ZB9
Predicted Effect probably damaging
Transcript: ENSMUST00000094389
AA Change: V266A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000091953
Gene: ENSMUSG00000070551
AA Change: V266A

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 38 217 1.4e-8 PFAM
Pfam:7tm_1 47 210 1.7e-7 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh4 G T 3: 138,133,816 (GRCm39) V309L probably benign Het
Agmo T C 12: 37,407,680 (GRCm39) V188A probably benign Het
Aqr A G 2: 113,947,059 (GRCm39) M1041T probably damaging Het
Arhgef4 T A 1: 34,764,078 (GRCm39) S1111R possibly damaging Het
Ascc3 A C 10: 50,592,757 (GRCm39) E1144D probably benign Het
Cct3 T C 3: 88,228,672 (GRCm39) probably null Het
Cd209f T C 8: 4,154,506 (GRCm39) T114A probably benign Het
Cgnl1 G A 9: 71,539,936 (GRCm39) Q1103* probably null Het
Cop1 G A 1: 159,152,507 (GRCm39) D586N probably damaging Het
Dcaf5 A G 12: 80,395,120 (GRCm39) S350P probably damaging Het
Dhx29 T C 13: 113,084,755 (GRCm39) C658R probably damaging Het
Dync1i1 G A 6: 5,969,446 (GRCm39) V424I possibly damaging Het
Gfap C T 11: 102,787,756 (GRCm39) R63Q probably damaging Het
Gm10563 CTTT CTTTATTT 4: 155,698,940 (GRCm39) probably null Het
Gprc6a C A 10: 51,502,900 (GRCm39) G321V probably damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Izumo1r A G 9: 14,812,976 (GRCm39) C99R probably damaging Het
Lrp1b T C 2: 41,850,691 (GRCm39) D102G probably damaging Het
Mettl4 G A 17: 95,047,937 (GRCm39) Q235* probably null Het
Mmrn2 A G 14: 34,121,541 (GRCm39) T804A probably benign Het
Ntng1 T C 3: 109,842,188 (GRCm39) D195G probably damaging Het
Pld4 T C 12: 112,731,465 (GRCm39) L206P probably damaging Het
Polr3a T C 14: 24,505,009 (GRCm39) I1084V possibly damaging Het
Prkd1 A G 12: 50,435,089 (GRCm39) L546P probably damaging Het
Rhob A T 12: 8,549,232 (GRCm39) M134K probably benign Het
Ryr3 A G 2: 112,548,347 (GRCm39) S3087P possibly damaging Het
Sema6c T C 3: 95,080,463 (GRCm39) L887P probably benign Het
Sltm T C 9: 70,492,081 (GRCm39) S648P unknown Het
Sucnr1 A G 3: 59,994,190 (GRCm39) I239M possibly damaging Het
Tgtp2 T A 11: 48,950,090 (GRCm39) M161L probably damaging Het
Trpm7 A G 2: 126,663,137 (GRCm39) V1037A probably benign Het
Vmn2r13 A T 5: 109,321,841 (GRCm39) H285Q probably benign Het
Zfp971 T A 2: 177,675,555 (GRCm39) C385S probably damaging Het
Zfpm2 T A 15: 40,962,791 (GRCm39) V283E probably benign Het
Zranb1 CTGATGATGATG CTGATGATGATGATG 7: 132,584,556 (GRCm39) probably benign Het
Other mutations in Mrgprb5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01516:Mrgprb5 APN 7 47,818,132 (GRCm39) missense probably damaging 1.00
IGL01662:Mrgprb5 APN 7 47,818,172 (GRCm39) missense probably benign 0.02
IGL01752:Mrgprb5 APN 7 47,818,415 (GRCm39) missense probably benign 0.22
IGL02117:Mrgprb5 APN 7 47,818,742 (GRCm39) utr 5 prime probably benign
IGL02866:Mrgprb5 APN 7 47,817,914 (GRCm39) missense probably damaging 0.99
IGL03382:Mrgprb5 APN 7 47,818,442 (GRCm39) missense probably benign 0.01
R0545:Mrgprb5 UTSW 7 47,818,633 (GRCm39) missense probably benign 0.08
R1389:Mrgprb5 UTSW 7 47,818,078 (GRCm39) missense probably damaging 1.00
R1939:Mrgprb5 UTSW 7 47,818,686 (GRCm39) missense probably benign 0.00
R2277:Mrgprb5 UTSW 7 47,818,579 (GRCm39) missense probably damaging 1.00
R2367:Mrgprb5 UTSW 7 47,818,347 (GRCm39) nonsense probably null
R2912:Mrgprb5 UTSW 7 47,817,815 (GRCm39) missense probably benign
R2968:Mrgprb5 UTSW 7 47,818,317 (GRCm39) missense probably damaging 0.98
R2969:Mrgprb5 UTSW 7 47,818,317 (GRCm39) missense probably damaging 0.98
R2970:Mrgprb5 UTSW 7 47,818,317 (GRCm39) missense probably damaging 0.98
R3499:Mrgprb5 UTSW 7 47,818,661 (GRCm39) missense probably benign 0.04
R3828:Mrgprb5 UTSW 7 47,817,839 (GRCm39) missense probably benign 0.01
R4590:Mrgprb5 UTSW 7 47,817,809 (GRCm39) missense probably benign 0.16
R4719:Mrgprb5 UTSW 7 47,818,526 (GRCm39) missense probably damaging 1.00
R5264:Mrgprb5 UTSW 7 47,817,796 (GRCm39) missense probably benign 0.10
R5644:Mrgprb5 UTSW 7 47,817,955 (GRCm39) missense probably benign 0.00
R6485:Mrgprb5 UTSW 7 47,818,525 (GRCm39) missense probably damaging 0.99
R6713:Mrgprb5 UTSW 7 47,818,537 (GRCm39) missense probably damaging 0.98
R7112:Mrgprb5 UTSW 7 47,818,655 (GRCm39) missense probably benign
R7176:Mrgprb5 UTSW 7 47,818,059 (GRCm39) missense possibly damaging 0.68
R7446:Mrgprb5 UTSW 7 47,818,252 (GRCm39) missense possibly damaging 0.65
R7640:Mrgprb5 UTSW 7 47,818,007 (GRCm39) missense probably benign 0.00
R7831:Mrgprb5 UTSW 7 47,817,997 (GRCm39) missense probably benign 0.05
R9041:Mrgprb5 UTSW 7 47,818,509 (GRCm39) missense probably damaging 1.00
R9314:Mrgprb5 UTSW 7 47,818,174 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TGTCTGATCAAAGACTCACTCAAC -3'
(R):5'- GCCCTGTTGGTCAAGATGATC -3'

Sequencing Primer
(F):5'- TGATCAAAGACTCACTCAACTACTG -3'
(R):5'- TGGTCAAGATGATCTGTGGATC -3'
Posted On 2016-07-06