Incidental Mutation 'R5264:Or51a39'
ID 401600
Institutional Source Beutler Lab
Gene Symbol Or51a39
Ensembl Gene ENSMUSG00000066273
Gene Name olfactory receptor family 51 subfamily A member 39
Synonyms MTPCR33, MOR11-2, GA_x6K02T2PBJ9-5431102-5430146, Olfr33
MMRRC Submission 042832-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R5264 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102362662-102363618 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102363558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 21 (T21A)
Ref Sequence ENSEMBL: ENSMUSP00000149588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084817] [ENSMUST00000094124] [ENSMUST00000216312]
AlphaFold Q8VGX7
Predicted Effect probably benign
Transcript: ENSMUST00000084817
AA Change: T21A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000081877
Gene: ENSMUSG00000066273
AA Change: T21A

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 2.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 211 7.5e-11 PFAM
Pfam:7tm_1 47 299 2.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094124
SMART Domains Protein: ENSMUSP00000091674
Gene: ENSMUSG00000070423

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 6.2e-117 PFAM
Pfam:7TM_GPCR_Srsx 37 308 2.4e-7 PFAM
Pfam:7tm_1 43 293 2.4e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210002
Predicted Effect probably benign
Transcript: ENSMUST00000216312
AA Change: T21A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.8%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ckap2l A T 2: 129,127,299 (GRCm39) M293K probably benign Het
Col4a4 C T 1: 82,471,312 (GRCm39) G681E unknown Het
Dnai7 A G 6: 145,127,502 (GRCm39) V469A probably benign Het
Efcab7 G A 4: 99,735,372 (GRCm39) R132H probably benign Het
Elovl4 T C 9: 83,662,817 (GRCm39) T239A probably benign Het
Fank1 A G 7: 133,481,621 (GRCm39) D240G probably damaging Het
Fbln5 T A 12: 101,723,703 (GRCm39) M346L possibly damaging Het
Fbxl21 T C 13: 56,680,136 (GRCm39) F174L probably benign Het
Gns A G 10: 121,216,090 (GRCm39) D279G probably benign Het
Hmcn1 A G 1: 150,555,265 (GRCm39) V2502A probably benign Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Large2 A G 2: 92,205,088 (GRCm39) probably benign Het
Lrrc8b A T 5: 105,628,118 (GRCm39) I155F probably damaging Het
Morc2b T C 17: 33,357,353 (GRCm39) I140V probably benign Het
Mrgprb5 G A 7: 47,817,796 (GRCm39) S313L probably benign Het
Nectin4 A T 1: 171,211,273 (GRCm39) T266S probably benign Het
Nsd1 C T 13: 55,395,159 (GRCm39) A1023V possibly damaging Het
Paqr8 A G 1: 21,005,332 (GRCm39) H162R possibly damaging Het
Pclo G A 5: 14,726,937 (GRCm39) probably benign Het
Phactr4 T C 4: 132,098,293 (GRCm39) D325G probably damaging Het
Plcg2 A T 8: 118,361,532 (GRCm39) E1255V possibly damaging Het
Polr3a T C 14: 24,505,009 (GRCm39) I1084V possibly damaging Het
Polr3b A T 10: 84,503,280 (GRCm39) Q399L probably benign Het
Ppp1r35 G A 5: 137,778,286 (GRCm39) probably benign Het
Psd3 A T 8: 68,166,377 (GRCm39) D919E probably benign Het
Ptgs2 A G 1: 149,978,481 (GRCm39) T198A possibly damaging Het
Ptpn14 T C 1: 189,564,997 (GRCm39) probably null Het
Ptprk A G 10: 28,461,582 (GRCm39) Y39C probably damaging Het
R3hdm4 A G 10: 79,749,175 (GRCm39) Y75H probably benign Het
Rsph4a A G 10: 33,785,379 (GRCm39) Y430C probably damaging Het
Samd12 C T 15: 53,723,669 (GRCm39) C8Y probably damaging Het
Sema3e A C 5: 14,276,662 (GRCm39) L314F probably damaging Het
Sis A G 3: 72,857,089 (GRCm39) F401L probably damaging Het
Smoc1 T A 12: 81,151,474 (GRCm39) S64T probably damaging Het
Socs5 T A 17: 87,441,769 (GRCm39) H236Q probably damaging Het
Spaca1 C A 4: 34,049,863 (GRCm39) R45L possibly damaging Het
Spag6 A G 2: 18,750,324 (GRCm39) K457E probably benign Het
Stat2 T A 10: 128,116,934 (GRCm39) probably null Het
Tcp11l2 A G 10: 84,449,524 (GRCm39) I496M probably damaging Het
Ttll4 A G 1: 74,725,535 (GRCm39) I648V possibly damaging Het
Vmn2r67 T C 7: 84,801,453 (GRCm39) Y161C probably damaging Het
Wnt5b A T 6: 119,410,813 (GRCm39) V171E probably damaging Het
Zfp236 T C 18: 82,648,219 (GRCm39) K933E probably damaging Het
Zfp236 T C 18: 82,676,198 (GRCm39) E373G probably damaging Het
Zfp617 A G 8: 72,686,885 (GRCm39) Y405C probably damaging Het
Zranb1 CTGATGATGATG CTGATGATGATGATG 7: 132,584,556 (GRCm39) probably benign Het
Other mutations in Or51a39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02064:Or51a39 APN 7 102,362,808 (GRCm39) missense probably damaging 1.00
IGL02349:Or51a39 APN 7 102,363,333 (GRCm39) missense probably damaging 0.99
IGL02739:Or51a39 APN 7 102,363,521 (GRCm39) missense possibly damaging 0.58
IGL03110:Or51a39 APN 7 102,363,090 (GRCm39) missense probably damaging 1.00
IGL03014:Or51a39 UTSW 7 102,362,753 (GRCm39) missense probably null 0.91
R0158:Or51a39 UTSW 7 102,363,162 (GRCm39) missense probably benign 0.03
R1455:Or51a39 UTSW 7 102,363,205 (GRCm39) nonsense probably null
R1996:Or51a39 UTSW 7 102,362,999 (GRCm39) missense probably damaging 1.00
R2032:Or51a39 UTSW 7 102,363,083 (GRCm39) missense probably benign 0.00
R2152:Or51a39 UTSW 7 102,362,788 (GRCm39) missense probably benign 0.01
R4852:Or51a39 UTSW 7 102,362,750 (GRCm39) missense probably damaging 0.99
R4965:Or51a39 UTSW 7 102,362,702 (GRCm39) missense probably damaging 1.00
R5464:Or51a39 UTSW 7 102,362,889 (GRCm39) missense probably benign
R6680:Or51a39 UTSW 7 102,363,522 (GRCm39) missense possibly damaging 0.70
R7195:Or51a39 UTSW 7 102,362,873 (GRCm39) missense possibly damaging 0.74
R7373:Or51a39 UTSW 7 102,363,306 (GRCm39) missense possibly damaging 0.53
R7391:Or51a39 UTSW 7 102,363,189 (GRCm39) missense probably benign 0.02
R7872:Or51a39 UTSW 7 102,363,389 (GRCm39) missense probably benign 0.01
R7948:Or51a39 UTSW 7 102,362,895 (GRCm39) missense probably benign 0.00
R8097:Or51a39 UTSW 7 102,363,197 (GRCm39) missense possibly damaging 0.53
R8969:Or51a39 UTSW 7 102,363,558 (GRCm39) missense probably benign 0.00
R9349:Or51a39 UTSW 7 102,362,875 (GRCm39) nonsense probably null
R9589:Or51a39 UTSW 7 102,363,372 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATCACTTAGGGCTAGCATGG -3'
(R):5'- TGAGCAGAACCAACTTGTTACC -3'

Sequencing Primer
(F):5'- CTAGCATGGACAGAAAGTAGTACATG -3'
(R):5'- CACATCTCCTGGGAATGA -3'
Posted On 2016-07-06