|Institutional Source||Beutler Lab|
|Gene Name||suppressor of cytokine signaling 5|
|Synonyms||Cish5, 1810018L08Rik, SOCS-5|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5264 (G1)|
|Chromosomal Location||87107679-87137583 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 87134341 bp|
|Amino Acid Change||Histidine to Glutamine at position 236 (H236Q)|
|Ref Sequence||ENSEMBL: ENSMUSP00000038591 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041369]|
|Predicted Effect||probably damaging
AA Change: H236Q
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: H236Q
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||98% (54/55)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are viable and fertile with normal immune system morphology and function. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Socs5||
(F):5'- CATGGACAGCGTTTCTAGCC -3'
(R):5'- ACAATGGGTTGACCTGTGC -3'
(F):5'- TTTCTAGCCGCGCGGTC -3'
(R):5'- TGACCTGTGCAGTAGCTTCAAAG -3'