Incidental Mutation 'R5267:Atp8a1'
ID |
401756 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Atp8a1
|
Ensembl Gene |
ENSMUSG00000037685 |
Gene Name |
ATPase phospholipid transporting 8A1 |
Synonyms |
Atp3a2, B230107D19Rik |
MMRRC Submission |
042859-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R5267 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
67775483-68004777 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 67919887 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Isoleucine
at position 393
(T393I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000144465
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037380]
[ENSMUST00000072971]
[ENSMUST00000135930]
[ENSMUST00000200955]
|
AlphaFold |
P70704 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000037380
AA Change: T393I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000042215 Gene: ENSMUSG00000037685 AA Change: T393I
Domain | Start | End | E-Value | Type |
Pfam:PhoLip_ATPase_N
|
38 |
101 |
9.8e-27 |
PFAM |
Pfam:E1-E2_ATPase
|
106 |
371 |
3e-11 |
PFAM |
Pfam:HAD
|
406 |
810 |
3.8e-23 |
PFAM |
Pfam:Cation_ATPase
|
485 |
585 |
6e-14 |
PFAM |
Pfam:PhoLip_ATPase_C
|
827 |
1079 |
8.2e-82 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000072971
AA Change: T393I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000072738 Gene: ENSMUSG00000037685 AA Change: T393I
Domain | Start | End | E-Value | Type |
Pfam:E1-E2_ATPase
|
104 |
375 |
2.1e-22 |
PFAM |
Pfam:Hydrolase
|
403 |
798 |
2.2e-14 |
PFAM |
Pfam:HAD
|
406 |
795 |
3e-18 |
PFAM |
Pfam:Hydrolase_like2
|
470 |
570 |
4.5e-14 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000135930
AA Change: T393I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000118379 Gene: ENSMUSG00000037685 AA Change: T393I
Domain | Start | End | E-Value | Type |
Pfam:PhoLip_ATPase_N
|
38 |
101 |
1.1e-26 |
PFAM |
Pfam:E1-E2_ATPase
|
106 |
371 |
8.6e-14 |
PFAM |
Pfam:HAD
|
406 |
795 |
3.6e-23 |
PFAM |
Pfam:Cation_ATPase
|
470 |
570 |
1.2e-13 |
PFAM |
Pfam:PhoLip_ATPase_C
|
812 |
1064 |
8.4e-82 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152433
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155911
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000200955
AA Change: T393I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000144465 Gene: ENSMUSG00000037685 AA Change: T393I
Domain | Start | End | E-Value | Type |
Pfam:PhoLip_ATPase_N
|
38 |
101 |
7.5e-25 |
PFAM |
Pfam:E1-E2_ATPase
|
106 |
371 |
3.7e-13 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201074
|
Meta Mutation Damage Score |
0.8218 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.8%
|
Validation Efficiency |
98% (86/88) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] PHENOTYPE: Homozygous mutant mice are viable, fertile and phenotypically normal. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 79 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca12 |
T |
A |
1: 71,374,933 (GRCm39) |
|
probably benign |
Het |
Adam15 |
T |
G |
3: 89,257,206 (GRCm39) |
|
probably benign |
Het |
Albfm1 |
T |
C |
5: 90,732,716 (GRCm39) |
F509S |
probably damaging |
Het |
Atp12a |
T |
C |
14: 56,621,668 (GRCm39) |
S768P |
probably damaging |
Het |
B4galnt4 |
T |
G |
7: 140,650,524 (GRCm39) |
I3S |
probably damaging |
Het |
Bfsp1 |
G |
A |
2: 143,668,971 (GRCm39) |
T536I |
probably benign |
Het |
Brsk1 |
G |
T |
7: 4,707,708 (GRCm39) |
W284L |
probably damaging |
Het |
Cadm3 |
A |
T |
1: 173,164,669 (GRCm39) |
D370E |
probably damaging |
Het |
Cadps2 |
A |
G |
6: 23,626,667 (GRCm39) |
I207T |
possibly damaging |
Het |
Calr4 |
A |
C |
4: 109,101,273 (GRCm39) |
T52P |
probably damaging |
Het |
Catsperg2 |
G |
A |
7: 29,416,491 (GRCm39) |
T307M |
probably damaging |
Het |
Ckap5 |
T |
A |
2: 91,422,097 (GRCm39) |
N1166K |
probably null |
Het |
Clca4a |
G |
A |
3: 144,659,573 (GRCm39) |
T761I |
probably damaging |
Het |
Cnksr3 |
A |
T |
10: 7,076,633 (GRCm39) |
|
probably null |
Het |
Diaph3 |
A |
G |
14: 86,893,989 (GRCm39) |
S7P |
probably benign |
Het |
Dnah7a |
G |
A |
1: 53,518,851 (GRCm39) |
P2969S |
probably damaging |
Het |
Dnai2 |
A |
T |
11: 114,631,293 (GRCm39) |
T221S |
probably benign |
Het |
Dsc2 |
A |
G |
18: 20,167,640 (GRCm39) |
|
probably null |
Het |
Eif4g1 |
A |
G |
16: 20,504,283 (GRCm39) |
N789S |
probably damaging |
Het |
Fn1 |
C |
T |
1: 71,668,863 (GRCm39) |
R694H |
probably damaging |
Het |
Gm5478 |
G |
A |
15: 101,552,837 (GRCm39) |
R365C |
probably damaging |
Het |
Gm5591 |
A |
T |
7: 38,218,338 (GRCm39) |
M845K |
possibly damaging |
Het |
Gm5800 |
A |
T |
14: 51,951,294 (GRCm39) |
|
probably null |
Het |
Gprc5c |
G |
T |
11: 114,755,093 (GRCm39) |
V257L |
possibly damaging |
Het |
H2-Q2 |
A |
T |
17: 35,562,155 (GRCm39) |
Y134F |
probably benign |
Het |
Hcfc1r1 |
A |
G |
17: 23,893,648 (GRCm39) |
R76G |
possibly damaging |
Het |
Hectd4 |
T |
C |
5: 121,482,887 (GRCm39) |
I3146T |
probably benign |
Het |
Herc1 |
G |
T |
9: 66,369,091 (GRCm39) |
L2928F |
probably damaging |
Het |
Hmx3 |
C |
T |
7: 131,145,898 (GRCm39) |
A202V |
probably benign |
Het |
Ikzf3 |
A |
T |
11: 98,381,406 (GRCm39) |
M58K |
probably benign |
Het |
Il20ra |
A |
G |
10: 19,625,107 (GRCm39) |
T129A |
probably damaging |
Het |
Il21 |
T |
C |
3: 37,281,946 (GRCm39) |
H66R |
probably benign |
Het |
Kcnh5 |
A |
T |
12: 75,134,190 (GRCm39) |
M453K |
probably damaging |
Het |
Kdf1 |
C |
G |
4: 133,256,258 (GRCm39) |
A325G |
probably damaging |
Het |
Klhl10 |
C |
T |
11: 100,338,047 (GRCm39) |
A262V |
probably benign |
Het |
Krt81 |
T |
A |
15: 101,357,340 (GRCm39) |
N464I |
probably benign |
Het |
Ksr1 |
A |
T |
11: 78,911,251 (GRCm39) |
I698N |
probably damaging |
Het |
Lrp2 |
A |
G |
2: 69,379,322 (GRCm39) |
V130A |
possibly damaging |
Het |
Mcm2 |
T |
C |
6: 88,874,432 (GRCm39) |
T25A |
probably benign |
Het |
Mrps18c |
T |
A |
5: 100,950,960 (GRCm39) |
Y93* |
probably null |
Het |
Mycl |
C |
T |
4: 122,894,289 (GRCm39) |
A363V |
probably damaging |
Het |
Mylk2 |
C |
A |
2: 152,755,469 (GRCm39) |
A211E |
probably benign |
Het |
Myo5a |
G |
A |
9: 75,059,292 (GRCm39) |
D507N |
probably damaging |
Het |
Myo7b |
A |
G |
18: 32,131,787 (GRCm39) |
F470L |
probably damaging |
Het |
Oas1a |
A |
T |
5: 121,037,284 (GRCm39) |
C248S |
probably benign |
Het |
Or2ag2b |
T |
C |
7: 106,418,015 (GRCm39) |
S242P |
probably damaging |
Het |
Or4c15b |
C |
T |
2: 89,112,574 (GRCm39) |
W301* |
probably null |
Het |
Or51aa2 |
T |
C |
7: 103,188,031 (GRCm39) |
I137V |
probably benign |
Het |
Or5b116 |
A |
G |
19: 13,422,475 (GRCm39) |
Y33C |
probably damaging |
Het |
Or5m9b |
T |
A |
2: 85,905,882 (GRCm39) |
V266E |
probably benign |
Het |
Or5p67 |
A |
G |
7: 107,922,185 (GRCm39) |
S233P |
probably damaging |
Het |
Or8d1 |
G |
A |
9: 38,767,101 (GRCm39) |
V248M |
probably damaging |
Het |
Otub1 |
C |
A |
19: 7,177,357 (GRCm39) |
G67C |
probably damaging |
Het |
Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
Paqr8 |
A |
G |
1: 21,004,920 (GRCm39) |
I25V |
probably benign |
Het |
Pcdh1 |
A |
G |
18: 38,325,252 (GRCm39) |
Y897H |
probably damaging |
Het |
Pde4d |
T |
G |
13: 109,397,343 (GRCm39) |
|
probably benign |
Het |
Pdzd8 |
C |
A |
19: 59,289,458 (GRCm39) |
K647N |
probably damaging |
Het |
Pnkp |
C |
T |
7: 44,511,827 (GRCm39) |
S113L |
probably damaging |
Het |
Praf2 |
T |
C |
X: 7,596,641 (GRCm39) |
|
probably benign |
Het |
Pramel29 |
A |
T |
4: 143,939,575 (GRCm39) |
|
probably benign |
Het |
Psg25 |
A |
T |
7: 18,258,711 (GRCm39) |
Y322N |
possibly damaging |
Het |
Rxrg |
A |
G |
1: 167,463,335 (GRCm39) |
E402G |
probably damaging |
Het |
Selenok |
T |
A |
14: 29,692,022 (GRCm39) |
V20E |
probably benign |
Het |
Sipa1 |
G |
A |
19: 5,705,786 (GRCm39) |
T394I |
probably benign |
Het |
Spag17 |
A |
T |
3: 99,969,264 (GRCm39) |
N1247I |
probably damaging |
Het |
Spata31d1c |
A |
G |
13: 65,183,718 (GRCm39) |
D420G |
probably damaging |
Het |
Syk |
A |
G |
13: 52,795,962 (GRCm39) |
K519R |
probably benign |
Het |
Syne2 |
A |
T |
12: 75,985,515 (GRCm39) |
E1654D |
possibly damaging |
Het |
Tha1 |
A |
C |
11: 117,760,502 (GRCm39) |
S241A |
probably damaging |
Het |
Thsd7a |
T |
A |
6: 12,379,601 (GRCm39) |
E941V |
probably damaging |
Het |
Tjp1 |
T |
C |
7: 64,972,797 (GRCm39) |
T548A |
probably damaging |
Het |
Tube1 |
C |
A |
10: 39,020,552 (GRCm39) |
D210E |
probably benign |
Het |
Vmn1r183 |
T |
A |
7: 23,754,971 (GRCm39) |
I258N |
possibly damaging |
Het |
Vmn1r89 |
A |
T |
7: 12,954,140 (GRCm39) |
N292I |
probably damaging |
Het |
Vmp1 |
C |
A |
11: 86,554,377 (GRCm39) |
V79L |
probably benign |
Het |
Zfp182 |
T |
A |
X: 20,902,605 (GRCm39) |
D125V |
possibly damaging |
Het |
Zfp975 |
T |
G |
7: 42,311,654 (GRCm39) |
T320P |
probably damaging |
Het |
Znrf1 |
G |
A |
8: 112,263,899 (GRCm39) |
A43T |
probably benign |
Het |
|
Other mutations in Atp8a1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00776:Atp8a1
|
APN |
5 |
67,906,486 (GRCm39) |
missense |
probably benign |
0.20 |
IGL00778:Atp8a1
|
APN |
5 |
67,817,246 (GRCm39) |
missense |
possibly damaging |
0.58 |
IGL01068:Atp8a1
|
APN |
5 |
67,824,680 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01152:Atp8a1
|
APN |
5 |
68,004,549 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01572:Atp8a1
|
APN |
5 |
67,824,994 (GRCm39) |
missense |
probably benign |
|
IGL01608:Atp8a1
|
APN |
5 |
67,970,479 (GRCm39) |
nonsense |
probably null |
|
IGL02171:Atp8a1
|
APN |
5 |
67,895,808 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02330:Atp8a1
|
APN |
5 |
67,970,520 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02381:Atp8a1
|
APN |
5 |
67,863,338 (GRCm39) |
missense |
probably benign |
|
IGL02420:Atp8a1
|
APN |
5 |
67,840,126 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02440:Atp8a1
|
APN |
5 |
67,824,777 (GRCm39) |
splice site |
probably benign |
|
IGL02598:Atp8a1
|
APN |
5 |
67,840,099 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03259:Atp8a1
|
APN |
5 |
67,781,349 (GRCm39) |
splice site |
probably null |
|
IGL03336:Atp8a1
|
APN |
5 |
67,887,150 (GRCm39) |
nonsense |
probably null |
|
IGL03380:Atp8a1
|
APN |
5 |
67,889,529 (GRCm39) |
missense |
probably benign |
0.25 |
PIT4131001:Atp8a1
|
UTSW |
5 |
67,779,945 (GRCm39) |
nonsense |
probably null |
|
PIT4445001:Atp8a1
|
UTSW |
5 |
67,780,003 (GRCm39) |
missense |
|
|
R0208:Atp8a1
|
UTSW |
5 |
67,932,064 (GRCm39) |
critical splice donor site |
probably null |
|
R0276:Atp8a1
|
UTSW |
5 |
67,944,016 (GRCm39) |
splice site |
probably benign |
|
R0279:Atp8a1
|
UTSW |
5 |
67,970,435 (GRCm39) |
splice site |
probably null |
|
R0329:Atp8a1
|
UTSW |
5 |
67,969,416 (GRCm39) |
splice site |
probably benign |
|
R0603:Atp8a1
|
UTSW |
5 |
67,914,039 (GRCm39) |
critical splice acceptor site |
probably null |
|
R0715:Atp8a1
|
UTSW |
5 |
67,932,068 (GRCm39) |
missense |
probably benign |
0.00 |
R0763:Atp8a1
|
UTSW |
5 |
67,817,226 (GRCm39) |
missense |
probably benign |
|
R1296:Atp8a1
|
UTSW |
5 |
67,780,049 (GRCm39) |
splice site |
probably benign |
|
R1631:Atp8a1
|
UTSW |
5 |
67,906,395 (GRCm39) |
splice site |
probably null |
|
R1764:Atp8a1
|
UTSW |
5 |
67,788,910 (GRCm39) |
missense |
probably benign |
0.14 |
R1771:Atp8a1
|
UTSW |
5 |
67,805,074 (GRCm39) |
missense |
probably damaging |
1.00 |
R1885:Atp8a1
|
UTSW |
5 |
67,904,661 (GRCm39) |
missense |
possibly damaging |
0.82 |
R1897:Atp8a1
|
UTSW |
5 |
67,895,772 (GRCm39) |
missense |
probably damaging |
1.00 |
R1968:Atp8a1
|
UTSW |
5 |
67,825,000 (GRCm39) |
missense |
probably benign |
0.05 |
R2965:Atp8a1
|
UTSW |
5 |
67,805,049 (GRCm39) |
missense |
probably benign |
0.28 |
R2966:Atp8a1
|
UTSW |
5 |
67,805,049 (GRCm39) |
missense |
probably benign |
0.28 |
R4247:Atp8a1
|
UTSW |
5 |
67,824,917 (GRCm39) |
missense |
probably damaging |
1.00 |
R4353:Atp8a1
|
UTSW |
5 |
67,926,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R4400:Atp8a1
|
UTSW |
5 |
67,922,221 (GRCm39) |
missense |
probably benign |
0.13 |
R4426:Atp8a1
|
UTSW |
5 |
67,932,171 (GRCm39) |
missense |
probably benign |
0.22 |
R4523:Atp8a1
|
UTSW |
5 |
67,824,943 (GRCm39) |
missense |
probably benign |
0.00 |
R4576:Atp8a1
|
UTSW |
5 |
67,973,158 (GRCm39) |
intron |
probably benign |
|
R4622:Atp8a1
|
UTSW |
5 |
67,840,056 (GRCm39) |
intron |
probably benign |
|
R4639:Atp8a1
|
UTSW |
5 |
67,813,317 (GRCm39) |
missense |
probably benign |
0.36 |
R4664:Atp8a1
|
UTSW |
5 |
67,919,929 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4732:Atp8a1
|
UTSW |
5 |
67,970,463 (GRCm39) |
missense |
probably benign |
0.07 |
R4733:Atp8a1
|
UTSW |
5 |
67,970,463 (GRCm39) |
missense |
probably benign |
0.07 |
R5071:Atp8a1
|
UTSW |
5 |
67,973,066 (GRCm39) |
missense |
probably benign |
0.29 |
R5314:Atp8a1
|
UTSW |
5 |
67,863,248 (GRCm39) |
critical splice donor site |
probably null |
|
R5424:Atp8a1
|
UTSW |
5 |
67,969,443 (GRCm39) |
missense |
probably damaging |
1.00 |
R5588:Atp8a1
|
UTSW |
5 |
67,972,027 (GRCm39) |
missense |
probably damaging |
1.00 |
R5698:Atp8a1
|
UTSW |
5 |
67,924,496 (GRCm39) |
missense |
probably benign |
0.14 |
R5815:Atp8a1
|
UTSW |
5 |
67,906,414 (GRCm39) |
missense |
probably benign |
0.00 |
R5977:Atp8a1
|
UTSW |
5 |
67,904,628 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6285:Atp8a1
|
UTSW |
5 |
67,824,950 (GRCm39) |
missense |
possibly damaging |
0.68 |
R6341:Atp8a1
|
UTSW |
5 |
67,840,270 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6736:Atp8a1
|
UTSW |
5 |
67,824,960 (GRCm39) |
missense |
probably damaging |
1.00 |
R6746:Atp8a1
|
UTSW |
5 |
67,908,392 (GRCm39) |
missense |
probably benign |
0.00 |
R6887:Atp8a1
|
UTSW |
5 |
67,895,794 (GRCm39) |
missense |
probably benign |
0.21 |
R6946:Atp8a1
|
UTSW |
5 |
67,779,968 (GRCm39) |
missense |
possibly damaging |
0.50 |
R6970:Atp8a1
|
UTSW |
5 |
67,895,805 (GRCm39) |
missense |
probably damaging |
1.00 |
R7035:Atp8a1
|
UTSW |
5 |
67,938,373 (GRCm39) |
missense |
probably benign |
0.00 |
R7218:Atp8a1
|
UTSW |
5 |
67,860,324 (GRCm39) |
missense |
|
|
R7278:Atp8a1
|
UTSW |
5 |
67,781,380 (GRCm39) |
missense |
|
|
R7530:Atp8a1
|
UTSW |
5 |
67,902,971 (GRCm39) |
missense |
|
|
R7548:Atp8a1
|
UTSW |
5 |
67,973,071 (GRCm39) |
nonsense |
probably null |
|
R7594:Atp8a1
|
UTSW |
5 |
67,808,935 (GRCm39) |
missense |
|
|
R7722:Atp8a1
|
UTSW |
5 |
67,780,041 (GRCm39) |
critical splice acceptor site |
probably null |
|
R8152:Atp8a1
|
UTSW |
5 |
67,919,925 (GRCm39) |
missense |
|
|
R9015:Atp8a1
|
UTSW |
5 |
67,887,250 (GRCm39) |
missense |
|
|
R9052:Atp8a1
|
UTSW |
5 |
67,936,301 (GRCm39) |
critical splice donor site |
probably null |
|
R9086:Atp8a1
|
UTSW |
5 |
67,932,159 (GRCm39) |
missense |
|
|
R9169:Atp8a1
|
UTSW |
5 |
67,824,944 (GRCm39) |
missense |
|
|
R9183:Atp8a1
|
UTSW |
5 |
67,924,378 (GRCm39) |
missense |
|
|
R9245:Atp8a1
|
UTSW |
5 |
67,779,977 (GRCm39) |
missense |
unknown |
|
R9401:Atp8a1
|
UTSW |
5 |
67,906,492 (GRCm39) |
missense |
|
|
R9607:Atp8a1
|
UTSW |
5 |
67,817,250 (GRCm39) |
missense |
|
|
R9664:Atp8a1
|
UTSW |
5 |
67,889,524 (GRCm39) |
missense |
|
|
X0019:Atp8a1
|
UTSW |
5 |
67,906,484 (GRCm39) |
missense |
probably benign |
0.22 |
|
Predicted Primers |
PCR Primer
(F):5'- CTGTGTGCCATGCATCAACAAAC -3'
(R):5'- ACTTTTCCGGACCGTCACAC -3'
Sequencing Primer
(F):5'- TGCCATGCATCAACAAACGTATTTAC -3'
(R):5'- CAGGGACCTAGGGTGGTTACAC -3'
|
Posted On |
2016-07-06 |