Incidental Mutation 'R4805:Krt24'
ID 401885
Institutional Source Beutler Lab
Gene Symbol Krt24
Ensembl Gene ENSMUSG00000020913
Gene Name keratin 24
Synonyms 2310058N18Rik, 2310075C18Rik
MMRRC Submission 041999-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.156) question?
Stock # R4805 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 99170785-99176088 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 99174452 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 205 (I205N)
Ref Sequence ENSEMBL: ENSMUSP00000017255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017255]
AlphaFold A1L317
Predicted Effect possibly damaging
Transcript: ENSMUST00000017255
AA Change: I205N

PolyPhen 2 Score 0.529 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000017255
Gene: ENSMUSG00000020913
AA Change: I205N

DomainStartEndE-ValueType
Filament 140 456 5.23e-157 SMART
Meta Mutation Damage Score 0.4653 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency 99% (69/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T A 15: 81,950,628 (GRCm39) Y1508* probably null Het
4931414P19Rik T C 14: 54,832,911 (GRCm39) E88G probably benign Het
Acaa1b A G 9: 118,986,014 (GRCm39) S17P probably benign Het
Arhgef7 G A 8: 11,881,552 (GRCm39) E565K probably damaging Het
Arl6ip1 AAAATAAATAAATAAATAAATAAATA AAAATAAATAAATAAATAAATAAATAAATA 7: 117,721,122 (GRCm39) probably benign Het
Bpnt1 T A 1: 185,077,504 (GRCm39) probably null Het
Ccnt1 C T 15: 98,442,189 (GRCm39) V360I probably benign Het
Chd4 T C 6: 125,105,908 (GRCm39) S1829P possibly damaging Het
Dennd1b A T 1: 138,981,122 (GRCm39) N112I probably damaging Het
Fat2 A T 11: 55,174,805 (GRCm39) D1969E probably benign Het
Flywch1 A C 17: 23,979,591 (GRCm39) D394E probably benign Het
Gal3st4 T A 5: 138,263,733 (GRCm39) probably null Het
Gm14403 T C 2: 177,200,492 (GRCm39) L146P probably damaging Het
Gm5283 G T 3: 17,285,123 (GRCm39) noncoding transcript Het
Gpr161 T A 1: 165,134,029 (GRCm39) L97Q probably damaging Het
Gstm2 A T 3: 107,892,411 (GRCm39) M105K possibly damaging Het
Hecw2 A G 1: 53,880,018 (GRCm39) Y1264H probably damaging Het
Ifi206 T A 1: 173,308,952 (GRCm39) Q348L possibly damaging Het
Ighv1-83 A T 12: 115,927,489 (GRCm39) M87K possibly damaging Het
Ighv2-7 A T 12: 113,771,154 (GRCm39) S44T probably damaging Het
Ipo7 T A 7: 109,650,691 (GRCm39) N884K probably benign Het
Itga2b T C 11: 102,358,692 (GRCm39) N75S probably benign Het
Krt20 A G 11: 99,319,811 (GRCm39) V431A unknown Het
Lmo2 T C 2: 103,811,407 (GRCm39) Y147H probably damaging Het
Lrrc31 A T 3: 30,745,446 (GRCm39) L67* probably null Het
Lrrc37a A G 11: 103,395,135 (GRCm39) F97L probably benign Het
Mapkap1 G A 2: 34,487,434 (GRCm39) probably null Het
Mgat4d T G 8: 84,084,787 (GRCm39) probably null Het
Mrgprb3 C T 7: 48,293,054 (GRCm39) V166I probably benign Het
Myh11 T A 16: 14,052,329 (GRCm39) Q379L possibly damaging Het
Myh7 T C 14: 55,222,590 (GRCm39) S782G probably benign Het
Nobox T C 6: 43,282,053 (GRCm39) D340G probably damaging Het
Ntn4 C T 10: 93,480,362 (GRCm39) R29C probably damaging Het
Or2t29 G A 11: 58,433,396 (GRCm39) T315I probably benign Het
Or5b101 T A 19: 13,005,661 (GRCm39) I11F probably benign Het
Pikfyve T A 1: 65,307,959 (GRCm39) I1845N probably damaging Het
Pramel15 A G 4: 144,103,590 (GRCm39) Y179H probably benign Het
Rad21l T G 2: 151,509,927 (GRCm39) H58P probably damaging Het
Scnn1g T C 7: 121,345,825 (GRCm39) L316S probably damaging Het
Serpina5 G A 12: 104,068,460 (GRCm39) V174I probably damaging Het
Shank1 T C 7: 43,993,135 (GRCm39) S788P unknown Het
Shisal1 T A 15: 84,301,397 (GRCm39) H82L probably damaging Het
Snap47 A G 11: 59,319,343 (GRCm39) V265A possibly damaging Het
Steap3 T A 1: 120,171,616 (GRCm39) H163L probably benign Het
Sycp2 T C 2: 178,035,754 (GRCm39) probably benign Het
Tet2 A G 3: 133,173,076 (GRCm39) F1729L probably benign Het
Thsd7b T C 1: 130,116,276 (GRCm39) V1343A probably benign Het
Thumpd2 G A 17: 81,334,130 (GRCm39) T486I probably damaging Het
Ttc41 G T 10: 86,565,662 (GRCm39) M405I possibly damaging Het
Ttn T C 2: 76,577,873 (GRCm39) D24340G probably damaging Het
Vmn1r10 T G 6: 57,090,602 (GRCm39) F65V possibly damaging Het
Vmn2r118 G T 17: 55,899,581 (GRCm39) D774E probably damaging Het
Vmn2r13 C T 5: 109,304,331 (GRCm39) C700Y probably damaging Het
Wsb1 A C 11: 79,131,217 (GRCm39) M393R possibly damaging Het
Zmat3 A G 3: 32,397,504 (GRCm39) Y214H probably benign Het
Zswim3 C T 2: 164,662,099 (GRCm39) T193I possibly damaging Het
Other mutations in Krt24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01907:Krt24 APN 11 99,176,030 (GRCm39) missense unknown
R0128:Krt24 UTSW 11 99,171,093 (GRCm39) missense probably damaging 0.98
R0561:Krt24 UTSW 11 99,175,439 (GRCm39) missense probably damaging 1.00
R1668:Krt24 UTSW 11 99,175,444 (GRCm39) missense probably benign 0.16
R2018:Krt24 UTSW 11 99,173,277 (GRCm39) missense probably damaging 1.00
R2307:Krt24 UTSW 11 99,175,456 (GRCm39) missense possibly damaging 0.48
R3114:Krt24 UTSW 11 99,173,262 (GRCm39) missense possibly damaging 0.85
R3115:Krt24 UTSW 11 99,173,262 (GRCm39) missense possibly damaging 0.85
R3116:Krt24 UTSW 11 99,173,262 (GRCm39) missense possibly damaging 0.85
R3979:Krt24 UTSW 11 99,173,596 (GRCm39) missense probably benign 0.23
R5347:Krt24 UTSW 11 99,173,556 (GRCm39) missense probably damaging 1.00
R5858:Krt24 UTSW 11 99,175,591 (GRCm39) missense probably damaging 1.00
R8369:Krt24 UTSW 11 99,173,534 (GRCm39) nonsense probably null
R9587:Krt24 UTSW 11 99,174,453 (GRCm39) missense probably damaging 1.00
X0028:Krt24 UTSW 11 99,171,859 (GRCm39) nonsense probably null
Z1176:Krt24 UTSW 11 99,175,712 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACCGACCAAGCTCTCTCCTG -3'
(R):5'- TACCCCAACAATTATGGAAGCTG -3'

Sequencing Primer
(F):5'- TTATTTAGGTCACCATCCCCCAAAGG -3'
(R):5'- AAGCTGTTTCCTATTGCAGAGAG -3'
Posted On 2016-07-15