Incidental Mutation 'R5207:Or6b2'
ID 402061
Institutional Source Beutler Lab
Gene Symbol Or6b2
Ensembl Gene ENSMUSG00000067064
Gene Name olfactory receptor family 6 subfamily B member 2
Synonyms Olfr1416, GA_x6K02T2R7CC-81277975-81278913, MOR103-3
MMRRC Submission 042782-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R5207 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 92407403-92408341 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 92407594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 250 (F250I)
Ref Sequence ENSEMBL: ENSMUSP00000149576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086837] [ENSMUST00000214928]
AlphaFold Q8VGU4
Predicted Effect probably benign
Transcript: ENSMUST00000086837
AA Change: F250I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000084048
Gene: ENSMUSG00000067064
AA Change: F250I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-53 PFAM
Pfam:7tm_1 41 290 6.7e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203760
AA Change: F250I
SMART Domains Protein: ENSMUSP00000145466
Gene: ENSMUSG00000067064
AA Change: F250I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-53 PFAM
Pfam:7tm_1 41 290 6.7e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214928
AA Change: F250I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 97% (60/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 A T 1: 179,621,159 (GRCm39) probably benign Het
Alg6 C T 4: 99,607,431 (GRCm39) L15F possibly damaging Het
Allc T A 12: 28,605,325 (GRCm39) M325L probably benign Het
Ap3b2 T C 7: 81,126,517 (GRCm39) N361S possibly damaging Het
Bmp8b A G 4: 123,009,714 (GRCm39) probably benign Het
Borcs6 A T 11: 68,951,674 (GRCm39) T351S probably damaging Het
Ccar1 T C 10: 62,589,060 (GRCm39) R808G unknown Het
Celsr3 A T 9: 108,709,958 (GRCm39) T1480S probably benign Het
Chdh C T 14: 29,753,318 (GRCm39) P76S probably damaging Het
Chmp7 T C 14: 69,969,755 (GRCm39) S62G probably benign Het
Cldn23 A T 8: 36,293,182 (GRCm39) V102E probably damaging Het
Csn2 G A 5: 87,842,821 (GRCm39) Q69* probably null Het
Ctrc A C 4: 141,567,695 (GRCm39) I136S probably damaging Het
Cysltr2 A C 14: 73,266,951 (GRCm39) L253R probably damaging Het
Ddr2 G A 1: 169,812,530 (GRCm39) T654M probably damaging Het
Derl2 G T 11: 70,910,073 (GRCm39) probably null Het
Dnai7 A T 6: 145,124,794 (GRCm39) D510E probably damaging Het
Dock5 T C 14: 68,013,733 (GRCm39) S1330G probably benign Het
Emp3 T C 7: 45,569,373 (GRCm39) N56S probably benign Het
Fam161a A T 11: 22,970,583 (GRCm39) K195* probably null Het
Ficd T A 5: 113,875,072 (GRCm39) V47E probably benign Het
Garin3 T C 11: 46,295,990 (GRCm39) S121P probably benign Het
Gbp10 T C 5: 105,372,575 (GRCm39) T123A probably benign Het
Gdf7 C T 12: 8,348,371 (GRCm39) A309T unknown Het
Gm14486 G T 2: 30,548,572 (GRCm39) noncoding transcript Het
Herc1 T A 9: 66,307,151 (GRCm39) C990* probably null Het
Itgb4 T C 11: 115,897,365 (GRCm39) V1530A probably damaging Het
Itpka G A 2: 119,580,974 (GRCm39) R374H probably damaging Het
Lacc1 T A 14: 77,271,594 (GRCm39) probably null Het
Med23 A T 10: 24,771,734 (GRCm39) K225* probably null Het
Mrgpra3 T A 7: 47,239,909 (GRCm39) T6S probably benign Het
Mroh7 T A 4: 106,578,583 (GRCm39) N32Y probably damaging Het
Mrps2 A G 2: 28,359,763 (GRCm39) R207G probably damaging Het
Mup20 A C 4: 61,969,823 (GRCm39) probably null Het
Nagpa A G 16: 5,017,478 (GRCm39) probably null Het
Nek3 A T 8: 22,622,243 (GRCm39) probably benign Het
Nes G A 3: 87,885,935 (GRCm39) G1398E probably damaging Het
Nf1 G T 11: 79,345,015 (GRCm39) V1323L probably damaging Het
Or5b96 T A 19: 12,867,801 (GRCm39) I47F probably benign Het
Or6c2 T C 10: 129,362,773 (GRCm39) F226L probably benign Het
Paqr8 G T 1: 21,005,482 (GRCm39) C212F probably benign Het
Pcdhb1 T C 18: 37,399,515 (GRCm39) Y489H probably damaging Het
Piwil2 T C 14: 70,629,966 (GRCm39) K683E probably damaging Het
Pjvk A C 2: 76,480,734 (GRCm39) probably null Het
Pkd1l3 A T 8: 110,359,823 (GRCm39) S893C probably damaging Het
Plxna2 A G 1: 194,471,207 (GRCm39) T993A probably benign Het
Ppp2r2b A T 18: 42,821,417 (GRCm39) I247N probably damaging Het
Rac2 T C 15: 78,449,654 (GRCm39) N92S probably damaging Het
Senp2 A T 16: 21,860,130 (GRCm39) H501L possibly damaging Het
Snx29 A T 16: 11,556,227 (GRCm39) I753F probably damaging Het
Tcf20 T A 15: 82,740,386 (GRCm39) H355L probably damaging Het
Tex2 T C 11: 106,437,666 (GRCm39) D668G unknown Het
Tlr12 G A 4: 128,510,502 (GRCm39) Q583* probably null Het
Tmem119 T C 5: 113,933,289 (GRCm39) I171V probably damaging Het
Ube2m C T 7: 12,770,249 (GRCm39) probably null Het
Vmn2r25 A T 6: 123,817,062 (GRCm39) I173N probably damaging Het
Whrn A T 4: 63,350,951 (GRCm39) V15E probably damaging Het
Zfp558 A C 9: 18,368,296 (GRCm39) V164G possibly damaging Het
Other mutations in Or6b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Or6b2 APN 1 92,407,746 (GRCm39) missense probably damaging 0.99
IGL00980:Or6b2 APN 1 92,407,402 (GRCm39) splice site probably null
IGL01540:Or6b2 APN 1 92,408,202 (GRCm39) missense probably damaging 0.96
BB007:Or6b2 UTSW 1 92,407,570 (GRCm39) missense probably benign 0.01
BB017:Or6b2 UTSW 1 92,407,570 (GRCm39) missense probably benign 0.01
R1146:Or6b2 UTSW 1 92,407,612 (GRCm39) missense probably damaging 1.00
R1146:Or6b2 UTSW 1 92,407,612 (GRCm39) missense probably damaging 1.00
R4751:Or6b2 UTSW 1 92,407,705 (GRCm39) missense probably benign 0.01
R5287:Or6b2 UTSW 1 92,408,019 (GRCm39) missense possibly damaging 0.88
R5403:Or6b2 UTSW 1 92,408,019 (GRCm39) missense possibly damaging 0.88
R6074:Or6b2 UTSW 1 92,407,497 (GRCm39) missense probably benign 0.45
R6232:Or6b2 UTSW 1 92,408,305 (GRCm39) missense probably benign 0.00
R6355:Or6b2 UTSW 1 92,407,702 (GRCm39) missense probably benign 0.21
R6378:Or6b2 UTSW 1 92,408,178 (GRCm39) missense probably damaging 1.00
R6901:Or6b2 UTSW 1 92,408,327 (GRCm39) missense probably damaging 1.00
R7930:Or6b2 UTSW 1 92,407,570 (GRCm39) missense probably benign 0.01
R8280:Or6b2 UTSW 1 92,407,729 (GRCm39) missense noncoding transcript
R8351:Or6b2 UTSW 1 92,407,660 (GRCm39) missense probably benign 0.09
R8437:Or6b2 UTSW 1 92,408,187 (GRCm39) missense probably benign 0.00
R8451:Or6b2 UTSW 1 92,407,660 (GRCm39) missense probably benign 0.09
X0065:Or6b2 UTSW 1 92,407,484 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAAAGTTCTTCTCACAGCATC -3'
(R):5'- GCTCCAATGTCTTGAACCAC -3'

Sequencing Primer
(F):5'- CACAGCATCCTTAAATTCAGTATTCC -3'
(R):5'- AGCTGGCCTGCACTGACTTC -3'
Posted On 2016-07-22