Incidental Mutation 'R5220:Ifi211'
ID 402254
Institutional Source Beutler Lab
Gene Symbol Ifi211
Ensembl Gene ENSMUSG00000026536
Gene Name interferon activated gene 211
Synonyms Ifi205b, Mnda
MMRRC Submission 042793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R5220 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173723911-173740612 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 173735262 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 56 (F56L)
Ref Sequence ENSEMBL: ENSMUSP00000009340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009340] [ENSMUST00000111210]
AlphaFold P0DOV1
PDB Structure Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205 [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000009340
AA Change: F56L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000009340
Gene: ENSMUSG00000026536
AA Change: F56L

DomainStartEndE-ValueType
PYRIN 6 84 1.94e-14 SMART
low complexity region 120 154 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:HIN 225 393 2.2e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111210
SMART Domains Protein: ENSMUSP00000106841
Gene: ENSMUSG00000090272

DomainStartEndE-ValueType
PYRIN 5 83 3.71e-20 SMART
internal_repeat_1 152 166 2.38e-7 PROSPERO
low complexity region 170 200 N/A INTRINSIC
internal_repeat_1 208 222 2.38e-7 PROSPERO
low complexity region 225 249 N/A INTRINSIC
low complexity region 276 292 N/A INTRINSIC
low complexity region 294 305 N/A INTRINSIC
Pfam:HIN 311 479 3.4e-76 PFAM
low complexity region 497 507 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A G 7: 78,738,045 (GRCm39) E250G probably damaging Het
Adgra1 A G 7: 139,455,512 (GRCm39) N380S probably benign Het
Ap3d1 G A 10: 80,563,001 (GRCm39) P160L probably damaging Het
Atg9a C T 1: 75,162,372 (GRCm39) V505M probably damaging Het
Chsy3 A T 18: 59,543,102 (GRCm39) I747F probably damaging Het
Clec2g A G 6: 128,958,269 (GRCm39) S100G probably benign Het
Cmya5 G T 13: 93,228,804 (GRCm39) P2095T probably damaging Het
Dcaf10 T C 4: 45,373,909 (GRCm39) W445R possibly damaging Het
Espl1 T A 15: 102,207,012 (GRCm39) L159M probably benign Het
Fbxw8 T C 5: 118,233,776 (GRCm39) D285G possibly damaging Het
Fras1 C T 5: 96,916,222 (GRCm39) R3419W probably damaging Het
Galc T A 12: 98,197,672 (GRCm39) probably null Het
Ghdc T C 11: 100,660,543 (GRCm39) E110G probably damaging Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
H2-T24 T C 17: 36,325,562 (GRCm39) T309A probably benign Het
Helb A C 10: 119,937,391 (GRCm39) F618V probably damaging Het
Hycc1 A C 5: 24,170,220 (GRCm39) S376R possibly damaging Het
Kntc1 T C 5: 123,950,160 (GRCm39) F1988L probably damaging Het
Mapk13 G A 17: 28,997,465 (GRCm39) S361N probably benign Het
Mapk3 A G 7: 126,363,408 (GRCm39) I146V probably benign Het
Megf6 G A 4: 154,338,295 (GRCm39) probably null Het
Mug1 G T 6: 121,838,092 (GRCm39) V441F probably benign Het
Mymk A G 2: 26,952,226 (GRCm39) S173P probably benign Het
Nox4 A G 7: 87,023,616 (GRCm39) T501A possibly damaging Het
Or13c7 C A 4: 43,854,624 (GRCm39) S105Y possibly damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or52n2 T C 7: 104,542,104 (GRCm39) T244A possibly damaging Het
Prkcb C A 7: 121,888,678 (GRCm39) H37Q probably damaging Het
Rabggtb A G 3: 153,615,024 (GRCm39) F189L probably damaging Het
Setd1b T C 5: 123,281,471 (GRCm39) I75T unknown Het
Slc10a5 T A 3: 10,400,148 (GRCm39) R171* probably null Het
Slc12a4 A G 8: 106,680,484 (GRCm39) F211L probably damaging Het
Slc1a5 T A 7: 16,527,759 (GRCm39) W352R probably damaging Het
Slc22a27 C G 19: 7,843,303 (GRCm39) A359P probably damaging Het
St8sia4 A G 1: 95,555,460 (GRCm39) M190T probably damaging Het
Tmeff2 A G 1: 51,018,476 (GRCm39) M153V probably benign Het
Trappc12 T C 12: 28,796,696 (GRCm39) T279A probably damaging Het
Ubn1 G T 16: 4,895,818 (GRCm39) A955S probably benign Het
Usp24 T A 4: 106,239,500 (GRCm39) H1147Q possibly damaging Het
Vrk1 T A 12: 106,039,865 (GRCm39) probably null Het
Zdhhc25 T A 15: 88,485,365 (GRCm39) Y233* probably null Het
Zfp109 A G 7: 23,928,179 (GRCm39) V418A probably benign Het
Other mutations in Ifi211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03258:Ifi211 APN 1 173,733,098 (GRCm39) missense probably benign 0.40
IGL03304:Ifi211 APN 1 173,735,273 (GRCm39) missense probably damaging 1.00
BB007:Ifi211 UTSW 1 173,733,769 (GRCm39) missense possibly damaging 0.91
BB017:Ifi211 UTSW 1 173,733,769 (GRCm39) missense possibly damaging 0.91
FR4548:Ifi211 UTSW 1 173,733,759 (GRCm39) missense possibly damaging 0.85
R1686:Ifi211 UTSW 1 173,726,969 (GRCm39) missense probably damaging 0.99
R2011:Ifi211 UTSW 1 173,735,169 (GRCm39) missense probably damaging 0.99
R4657:Ifi211 UTSW 1 173,735,226 (GRCm39) missense probably benign 0.03
R5410:Ifi211 UTSW 1 173,733,829 (GRCm39) missense probably benign 0.08
R6644:Ifi211 UTSW 1 173,733,118 (GRCm39) missense probably benign 0.42
R6953:Ifi211 UTSW 1 173,733,832 (GRCm39) missense probably damaging 1.00
R7451:Ifi211 UTSW 1 173,727,058 (GRCm39) missense probably damaging 1.00
R7567:Ifi211 UTSW 1 173,729,401 (GRCm39) missense probably damaging 1.00
R7667:Ifi211 UTSW 1 173,727,020 (GRCm39) missense probably damaging 1.00
R7930:Ifi211 UTSW 1 173,733,769 (GRCm39) missense possibly damaging 0.91
R8499:Ifi211 UTSW 1 173,733,086 (GRCm39) missense probably benign 0.40
R9002:Ifi211 UTSW 1 173,733,894 (GRCm39) missense possibly damaging 0.68
R9299:Ifi211 UTSW 1 173,735,288 (GRCm39) missense probably damaging 0.96
R9562:Ifi211 UTSW 1 173,733,052 (GRCm39) missense probably benign 0.43
Z1088:Ifi211 UTSW 1 173,735,226 (GRCm39) missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- GGCCTTTGAGATGCAAACTGG -3'
(R):5'- TTTCTTCCAGGCTCAGCAACAAC -3'

Sequencing Primer
(F):5'- ATGACAGCTATGTGTGGACTTCAAG -3'
(R):5'- TCAGCAACAACTTCAAAGATGGTG -3'
Posted On 2016-07-22