Incidental Mutation 'R5222:Dapk3'
ID 402371
Institutional Source Beutler Lab
Gene Symbol Dapk3
Ensembl Gene ENSMUSG00000034974
Gene Name death-associated protein kinase 3
Synonyms ZIP kinase
MMRRC Submission 042795-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5222 (G1)
Quality Score 97
Status Validated
Chromosome 10
Chromosomal Location 81018839-81029031 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 81028294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 288 (E288G)
Ref Sequence ENSEMBL: ENSMUSP00000151577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047665] [ENSMUST00000178422] [ENSMUST00000219850] [ENSMUST00000219133] [ENSMUST00000218157]
AlphaFold O54784
Predicted Effect probably damaging
Transcript: ENSMUST00000047665
AA Change: E288G

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000035962
Gene: ENSMUSG00000034974
AA Change: E288G

DomainStartEndE-ValueType
S_TKc 13 275 1.93e-98 SMART
low complexity region 288 299 N/A INTRINSIC
low complexity region 331 347 N/A INTRINSIC
low complexity region 349 411 N/A INTRINSIC
coiled coil region 419 444 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129834
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129950
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150782
Predicted Effect probably damaging
Transcript: ENSMUST00000178422
AA Change: E288G

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000137333
Gene: ENSMUSG00000034974
AA Change: E288G

DomainStartEndE-ValueType
S_TKc 13 275 1.93e-98 SMART
low complexity region 288 299 N/A INTRINSIC
low complexity region 331 347 N/A INTRINSIC
low complexity region 349 411 N/A INTRINSIC
coiled coil region 419 444 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217936
Predicted Effect unknown
Transcript: ENSMUST00000218227
AA Change: E98G
Predicted Effect probably damaging
Transcript: ENSMUST00000219850
AA Change: E288G

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably benign
Transcript: ENSMUST00000219133
Predicted Effect probably benign
Transcript: ENSMUST00000218157
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219944
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220076
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219329
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218698
Meta Mutation Damage Score 0.1080 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit embryonic lethality after blastocyst implantation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik C A 1: 159,872,178 (GRCm39) noncoding transcript Het
Acad11 G A 9: 103,974,576 (GRCm39) A515T probably damaging Het
Angpt1 T C 15: 42,539,730 (GRCm39) Y43C probably damaging Het
Arhgef33 A G 17: 80,644,743 (GRCm39) Y24C probably damaging Het
Cd40 G C 2: 164,908,464 (GRCm39) S180T probably benign Het
Cenpc1 A T 5: 86,185,606 (GRCm39) S302T possibly damaging Het
Cit C A 5: 116,090,602 (GRCm39) T932K probably benign Het
Col19a1 A C 1: 24,598,721 (GRCm39) probably null Het
Ddx60 T C 8: 62,437,192 (GRCm39) F1002S probably damaging Het
Dgke G T 11: 88,941,220 (GRCm39) T321K probably benign Het
Ebf2 T G 14: 67,551,043 (GRCm39) probably benign Het
Enpp7 A G 11: 118,881,788 (GRCm39) D311G probably benign Het
Epm2a A G 10: 11,324,493 (GRCm39) E194G probably damaging Het
Esf1 A G 2: 140,000,503 (GRCm39) Y428H possibly damaging Het
Esyt2 T C 12: 116,282,446 (GRCm39) F132S probably damaging Het
Gm5455 T C 13: 110,441,494 (GRCm39) noncoding transcript Het
Gria1 T A 11: 57,080,623 (GRCm39) V202E probably benign Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Mark1 A T 1: 184,660,288 (GRCm39) F123I probably damaging Het
Nectin4 T A 1: 171,212,825 (GRCm39) probably null Het
Obscn T A 11: 58,934,971 (GRCm39) T5220S possibly damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or2l13 A C 16: 19,305,680 (GRCm39) I31L probably benign Het
Or2p2 T A 13: 21,256,739 (GRCm39) H244L probably damaging Het
Pdcd1 A T 1: 93,980,175 (GRCm39) V14E probably damaging Het
Pmel A G 10: 128,554,853 (GRCm39) probably null Het
Pramel28 T A 4: 143,691,362 (GRCm39) I454F possibly damaging Het
Prrx1 C T 1: 163,089,542 (GRCm39) R95Q probably damaging Het
Pstpip2 T A 18: 77,962,032 (GRCm39) Y267* probably null Het
Ptprq A G 10: 107,498,425 (GRCm39) I884T probably damaging Het
Rad17 G A 13: 100,770,399 (GRCm39) T216I possibly damaging Het
Rif1 T C 2: 51,967,032 (GRCm39) I107T probably benign Het
Rpp14 T C 14: 8,087,513 (GRCm38) L69P probably damaging Het
Rtel1 G T 2: 180,988,776 (GRCm39) probably benign Het
Sap130 C T 18: 31,799,756 (GRCm39) T362M probably damaging Het
Scn11a A G 9: 119,644,268 (GRCm39) probably null Het
Sec31a G T 5: 100,530,754 (GRCm39) T243N probably benign Het
Slc5a9 T A 4: 111,755,808 (GRCm39) H30L possibly damaging Het
Slco6b1 T A 1: 96,925,216 (GRCm39) noncoding transcript Het
Smarca4 A G 9: 21,567,002 (GRCm39) D694G probably benign Het
Spaca6 A G 17: 18,058,367 (GRCm39) T213A probably benign Het
Tagap C A 17: 8,152,473 (GRCm39) Q553K possibly damaging Het
Tagap A T 17: 8,152,474 (GRCm39) Q553L possibly damaging Het
Tcf7l2 A G 19: 55,887,044 (GRCm39) Q19R probably benign Het
Ttn A G 2: 76,709,197 (GRCm39) probably benign Het
Ubr7 A T 12: 102,741,964 (GRCm39) R399S probably benign Het
Uspl1 C A 5: 149,150,911 (GRCm39) Q690K possibly damaging Het
Vps8 T A 16: 21,400,298 (GRCm39) Y853* probably null Het
Vrk3 A T 7: 44,409,220 (GRCm39) Q129L possibly damaging Het
Wapl T A 14: 34,458,642 (GRCm39) C901* probably null Het
Other mutations in Dapk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Dapk3 APN 10 81,019,910 (GRCm39) critical splice donor site probably null
IGL02076:Dapk3 APN 10 81,026,131 (GRCm39) missense probably damaging 1.00
IGL02329:Dapk3 APN 10 81,025,999 (GRCm39) missense probably benign 0.42
IGL02515:Dapk3 APN 10 81,025,763 (GRCm39) splice site probably benign
IGL03002:Dapk3 APN 10 81,026,437 (GRCm39) nonsense probably null
R0131:Dapk3 UTSW 10 81,028,141 (GRCm39) missense probably benign 0.05
R0727:Dapk3 UTSW 10 81,026,096 (GRCm39) missense probably damaging 1.00
R1628:Dapk3 UTSW 10 81,027,643 (GRCm39) missense possibly damaging 0.79
R5084:Dapk3 UTSW 10 81,026,152 (GRCm39) splice site probably null
R6112:Dapk3 UTSW 10 81,019,864 (GRCm39) missense probably benign 0.43
R6799:Dapk3 UTSW 10 81,026,096 (GRCm39) missense probably damaging 1.00
R6884:Dapk3 UTSW 10 81,027,588 (GRCm39) splice site probably null
R8683:Dapk3 UTSW 10 81,026,069 (GRCm39) missense probably damaging 1.00
R9016:Dapk3 UTSW 10 81,028,266 (GRCm39) missense probably damaging 0.96
R9453:Dapk3 UTSW 10 81,025,825 (GRCm39) missense probably damaging 1.00
R9745:Dapk3 UTSW 10 81,028,594 (GRCm39) missense unknown
Z1177:Dapk3 UTSW 10 81,027,603 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- CTGACATGGTTGCCTTGATG -3'
(R):5'- GGAAAGCAGCTTTATTCTGGGG -3'

Sequencing Primer
(F):5'- TCCCTTGGGTGGAGTGACC -3'
(R):5'- TAACGGTTCTCCAGGCGACAC -3'
Posted On 2016-07-22