Incidental Mutation 'R5225:Olfr98'
ID402591
Institutional Source Beutler Lab
Gene Symbol Olfr98
Ensembl Gene ENSMUSG00000063660
Gene Nameolfactory receptor 98
SynonymsGA_x6K02T2PSCP-1703582-1702653, MOR156-4
MMRRC Submission 042798-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #R5225 (G1)
Quality Score225
Status Validated
Chromosome17
Chromosomal Location37262711-37263749 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 37263028 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 212 (V212A)
Ref Sequence ENSEMBL: ENSMUSP00000094936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080759]
Predicted Effect probably benign
Transcript: ENSMUST00000080759
AA Change: V212A

PolyPhen 2 Score 0.298 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000094936
Gene: ENSMUSG00000063660
AA Change: V212A

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 9.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.9e-5 PFAM
Pfam:7tm_1 38 287 2.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122476
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174168
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency 100% (70/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik C T 17: 9,008,007 R465* probably null Het
Abcg3 A T 5: 104,966,783 D289E probably damaging Het
Ablim2 G T 5: 35,866,771 probably null Het
Acp1 A T 12: 30,905,079 V36D probably benign Het
Adgrb1 T A 15: 74,577,499 probably benign Het
Akap6 G A 12: 52,886,546 V274I probably damaging Het
Arhgap39 T C 15: 76,725,515 probably benign Het
Bmp1 G A 14: 70,480,165 R789W probably damaging Het
Cfhr2 T A 1: 139,821,782 Y154F possibly damaging Het
Cilp2 T C 8: 69,883,365 Y358C probably damaging Het
Cyp1a2 T A 9: 57,677,233 K513* probably null Het
Dennd4a G T 9: 64,888,928 K745N possibly damaging Het
Dlg1 T A 16: 31,836,267 S542T probably benign Het
Dmbt1 A T 7: 131,094,735 I893F possibly damaging Het
Dnhd1 A T 7: 105,703,923 E2761V possibly damaging Het
F11 T C 8: 45,255,304 T40A probably benign Het
Fam227a T C 15: 79,636,735 D296G possibly damaging Het
Fance C T 17: 28,315,615 probably benign Het
Gaa A G 11: 119,276,843 D149G probably damaging Het
Gapt A G 13: 110,353,988 M47T possibly damaging Het
Gm1110 T C 9: 26,902,478 N202D probably damaging Het
Gm16432 A T 1: 178,148,908 probably benign Het
Gm7535 T C 17: 17,911,547 probably benign Het
Gm973 T A 1: 59,562,700 M491K probably benign Het
Gmnc A G 16: 26,963,945 V27A probably benign Het
Kif27 T C 13: 58,293,101 T1167A possibly damaging Het
Klrg1 T A 6: 122,271,372 *189C probably null Het
Lime1 T A 2: 181,382,847 M98K probably benign Het
Lrp1 C A 10: 127,556,096 A2867S probably benign Het
Lrrd1 G A 5: 3,858,735 S669N probably benign Het
Mmel1 A G 4: 154,891,999 N520S probably damaging Het
Mrpl48 A C 7: 100,549,328 L206V probably damaging Het
Nagpa C T 16: 5,203,732 A52T probably benign Het
Olfr1264 T G 2: 90,021,184 D294A probably benign Het
Orai2 A G 5: 136,161,501 S71P probably damaging Het
Pcbp1 A T 6: 86,525,227 I230N probably damaging Het
Pcdh15 T C 10: 74,303,154 L349P probably damaging Het
Pcdhb16 T C 18: 37,479,958 V657A probably benign Het
Prdm15 G T 16: 97,808,675 H590N probably damaging Het
Psg18 T C 7: 18,345,949 I442M probably damaging Het
Pygm C A 19: 6,389,464 D279E probably benign Het
Rrn3 T A 16: 13,792,934 probably null Het
Sass6 T C 3: 116,614,053 S273P possibly damaging Het
Schip1 A G 3: 68,494,937 M116V probably benign Het
Sdc3 G A 4: 130,818,776 V55I unknown Het
Serpinb8 T A 1: 107,597,471 M1K probably null Het
Slc24a5 T C 2: 125,085,819 I346T probably damaging Het
Slc35f3 T A 8: 126,391,107 I335N probably damaging Het
Snapc2 T A 8: 4,255,299 V147E probably damaging Het
Snx2 T C 18: 53,189,712 S56P possibly damaging Het
Sptbn5 A G 2: 120,085,331 probably benign Het
Stk19 A T 17: 34,821,424 probably benign Het
Sulf1 A G 1: 12,841,478 E692G probably benign Het
Tet1 C T 10: 62,838,671 V1209I probably damaging Het
Tln1 T C 4: 43,539,406 T1639A probably benign Het
Tmem135 G T 7: 89,196,127 Y165* probably null Het
Tmprss6 T C 15: 78,452,507 T398A probably damaging Het
Ube4a C T 9: 44,939,960 probably null Het
Vmn1r227 T C 17: 20,735,237 noncoding transcript Het
Wdhd1 T C 14: 47,250,816 S745G probably benign Het
Xylt1 A G 7: 117,592,036 H353R probably damaging Het
Zfp788 A G 7: 41,649,556 T539A probably benign Het
Zfp866 A T 8: 69,765,441 F510I possibly damaging Het
Other mutations in Olfr98
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02402:Olfr98 APN 17 37263220 missense possibly damaging 0.46
PIT4495001:Olfr98 UTSW 17 37262830 missense possibly damaging 0.88
R0574:Olfr98 UTSW 17 37262881 missense probably damaging 1.00
R1490:Olfr98 UTSW 17 37262842 missense probably benign 0.00
R1633:Olfr98 UTSW 17 37263662 start codon destroyed probably benign 0.02
R2105:Olfr98 UTSW 17 37263073 missense probably benign 0.26
R4996:Olfr98 UTSW 17 37262867 missense probably benign 0.02
R5114:Olfr98 UTSW 17 37262839 missense probably damaging 1.00
R5338:Olfr98 UTSW 17 37263641 missense probably benign 0.00
R5995:Olfr98 UTSW 17 37263648 missense probably benign 0.01
R6190:Olfr98 UTSW 17 37262744 missense probably benign 0.00
R7006:Olfr98 UTSW 17 37262734 makesense probably null
R7246:Olfr98 UTSW 17 37263014 missense probably benign 0.00
R7261:Olfr98 UTSW 17 37263185 missense probably benign
R7611:Olfr98 UTSW 17 37262854 missense probably benign 0.02
R7642:Olfr98 UTSW 17 37263073 missense probably benign 0.26
Predicted Primers PCR Primer
(F):5'- CAGAGTGGGTGTTACCAGAG -3'
(R):5'- AGCTCATTGTGTGTCTCTGAC -3'

Sequencing Primer
(F):5'- TGGGTGTTACCAGAGTATACATGAC -3'
(R):5'- ATTGTGTGTCTCTGACCCATAC -3'
Posted On2016-07-22