Incidental Mutation 'R5283:Or6b9'
ID 402872
Institutional Source Beutler Lab
Gene Symbol Or6b9
Ensembl Gene ENSMUSG00000036647
Gene Name olfactory receptor family 6 subfamily B member 9
Synonyms MOR103-16, M50, GA_x6K02T2PBJ9-9337331-9336381, Olfr6
MMRRC Submission 042868-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R5283 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 106555191-106556141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 106555955 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 63 (T63S)
Ref Sequence ENSEMBL: ENSMUSP00000151272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040983] [ENSMUST00000213552] [ENSMUST00000213651] [ENSMUST00000219365]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040983
AA Change: T63S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000048740
Gene: ENSMUSG00000036647
AA Change: T63S

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.5e-58 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209125
Predicted Effect probably benign
Transcript: ENSMUST00000213552
AA Change: T63S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000213651
AA Change: T63S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000219365
AA Change: T63S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.9%
  • 20x: 96.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp C T 1: 74,323,165 (GRCm39) E53K possibly damaging Het
Amotl1 T C 9: 14,469,780 (GRCm39) E651G probably damaging Het
Ankrd11 A C 8: 123,610,921 (GRCm39) V2655G probably damaging Het
Apbb1ip G A 2: 22,757,683 (GRCm39) V434M probably benign Het
Atp5pd T C 11: 115,306,611 (GRCm39) Y150C probably damaging Het
Ccdc13 T A 9: 121,637,254 (GRCm39) D75V probably damaging Het
Col4a4 C T 1: 82,471,312 (GRCm39) G681E unknown Het
Crh T C 3: 19,748,171 (GRCm39) H157R probably damaging Het
Cstdc6 T C 16: 36,142,205 (GRCm39) D57G probably damaging Het
Dpp4 G A 2: 62,190,680 (GRCm39) T392I probably damaging Het
Ehd3 G T 17: 74,127,498 (GRCm39) A144S probably benign Het
Fnip2 A T 3: 79,373,015 (GRCm39) I1021N probably damaging Het
Fus T A 7: 127,584,719 (GRCm39) probably benign Het
Glo1 T C 17: 30,819,047 (GRCm39) T92A probably benign Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm15130 A C 2: 110,965,754 (GRCm39) M165R unknown Het
Gon4l T C 3: 88,794,897 (GRCm39) L700P probably damaging Het
Grm1 C A 10: 10,608,936 (GRCm39) D566Y possibly damaging Het
Guca1b T C 17: 47,702,195 (GRCm39) probably benign Het
Has3 A G 8: 107,600,747 (GRCm39) M70V probably damaging Het
Hydin G T 8: 111,178,612 (GRCm39) C1069F possibly damaging Het
Ints1 A C 5: 139,750,137 (GRCm39) L920R probably damaging Het
Kdm2a T C 19: 4,381,297 (GRCm39) I54V probably benign Het
Kpna2 G A 11: 106,881,658 (GRCm39) T324I probably damaging Het
Lrr1 T C 12: 69,221,428 (GRCm39) L190S probably damaging Het
Lrrc49 A T 9: 60,594,461 (GRCm39) H16Q probably benign Het
Mab21l4 C T 1: 93,087,575 (GRCm39) D93N probably benign Het
Mapkap1 A G 2: 34,334,360 (GRCm39) E147G probably damaging Het
Mrpl2 C T 17: 46,959,992 (GRCm39) R219W possibly damaging Het
Muc21 A G 17: 35,932,224 (GRCm39) probably benign Het
Ndc80 A G 17: 71,828,130 (GRCm39) S66P probably benign Het
Notch1 A G 2: 26,358,638 (GRCm39) Y1398H probably damaging Het
Olfml2b C T 1: 170,508,758 (GRCm39) R539* probably null Het
Pde7a T C 3: 19,314,420 (GRCm39) T59A probably damaging Het
Plekhg1 G A 10: 3,906,654 (GRCm39) V524I probably benign Het
Plin4 T A 17: 56,413,777 (GRCm39) M283L probably benign Het
Prp2 C T 6: 132,577,606 (GRCm39) P298S unknown Het
Rap1gap2 G A 11: 74,286,651 (GRCm39) R550C probably damaging Het
Reln G A 5: 22,216,161 (GRCm39) T1008I probably damaging Het
Rffl T C 11: 82,703,615 (GRCm39) K103E probably damaging Het
Rmnd5b A T 11: 51,517,887 (GRCm39) F156I probably damaging Het
Rtn4ip1 T C 10: 43,778,461 (GRCm39) I68T probably damaging Het
Samhd1 T C 2: 156,951,412 (GRCm39) I442V possibly damaging Het
Slc12a4 A T 8: 106,677,326 (GRCm39) probably null Het
Slc35b1 G T 11: 95,275,814 (GRCm39) probably benign Het
Ssh1 A G 5: 114,088,606 (GRCm39) V354A probably damaging Het
Stk33 T C 7: 108,935,334 (GRCm39) K153E possibly damaging Het
Stk4 C T 2: 163,952,199 (GRCm39) R19* probably null Het
Tas2r136 A T 6: 132,754,374 (GRCm39) I251N probably damaging Het
Tbr1 A T 2: 61,635,244 (GRCm39) T65S probably benign Het
Tkt C T 14: 30,282,575 (GRCm39) S124F probably damaging Het
Tll1 T C 8: 64,555,000 (GRCm39) I228V possibly damaging Het
Tmem236 A G 2: 14,179,644 (GRCm39) I82V probably benign Het
Vmn2r110 T C 17: 20,800,899 (GRCm39) Q511R probably benign Het
Vmn2r98 T C 17: 19,300,981 (GRCm39) M661T probably benign Het
Vps13a T A 19: 16,655,334 (GRCm39) K1898I probably damaging Het
Zc3h12a T C 4: 125,020,558 (GRCm39) E95G probably benign Het
Other mutations in Or6b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Or6b9 APN 7 106,555,634 (GRCm39) missense probably damaging 0.99
IGL02150:Or6b9 APN 7 106,555,763 (GRCm39) missense probably damaging 1.00
IGL02556:Or6b9 APN 7 106,555,598 (GRCm39) missense possibly damaging 0.82
R1550:Or6b9 UTSW 7 106,555,235 (GRCm39) missense probably benign
R1883:Or6b9 UTSW 7 106,555,981 (GRCm39) missense probably benign 0.42
R2069:Or6b9 UTSW 7 106,555,494 (GRCm39) nonsense probably null
R2250:Or6b9 UTSW 7 106,555,580 (GRCm39) missense probably benign 0.00
R2279:Or6b9 UTSW 7 106,555,834 (GRCm39) missense probably benign 0.00
R9700:Or6b9 UTSW 7 106,555,630 (GRCm39) missense probably benign 0.12
R9733:Or6b9 UTSW 7 106,555,846 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- ATCCTGTGGTCATCATGACTGG -3'
(R):5'- ACCAACATCAGTGAGTTCATCCTC -3'

Sequencing Primer
(F):5'- TGGCTACATAACGATCATAGGCCATG -3'
(R):5'- ACATCAGTGAGTTCATCCTCATGGG -3'
Posted On 2016-07-22