Mutagenetix > Incidental Mutations

Incidental Mutation 'R5283:Vmn2r98'

402896

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

042868-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R5283 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19080719 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 661 (M661T)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: M661T

PolyPhen 2 Score 0.050 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: M661T

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.9%
20x: 96.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310007B03Rik	C	T	1: 93,159,853	D93N	probably benign	Het
Aamp	C	T	1: 74,284,006	E53K	possibly damaging	Het
Amotl1	T	C	9: 14,558,484	E651G	probably damaging	Het
Ankrd11	A	C	8: 122,884,182	V2655G	probably damaging	Het
Apbb1ip	G	A	2: 22,867,671	V434M	probably benign	Het
Atp5h	T	C	11: 115,415,785	Y150C	probably damaging	Het
BC117090	T	C	16: 36,321,843	D57G	probably damaging	Het
Ccdc13	T	A	9: 121,808,188	D75V	probably damaging	Het
Col4a4	C	T	1: 82,493,591	G681E	unknown	Het
Crh	T	C	3: 19,694,007	H157R	probably damaging	Het
Dpp4	G	A	2: 62,360,336	T392I	probably damaging	Het
Ehd3	G	T	17: 73,820,503	A144S	probably benign	Het
Fnip2	A	T	3: 79,465,708	I1021N	probably damaging	Het
Fus	T	A	7: 127,985,547		probably benign	Het
Glo1	T	C	17: 30,600,073	T92A	probably benign	Het
Gm11595	G	A	11: 99,772,555	R100C	unknown	Het
Gm15130	A	C	2: 111,135,409	M165R	unknown	Het
Gm9573	A	G	17: 35,621,332		probably benign	Het
Gon4l	T	C	3: 88,887,590	L700P	probably damaging	Het
Grm1	C	A	10: 10,733,192	D566Y	possibly damaging	Het
Guca1b	T	C	17: 47,391,270		probably benign	Het
Has3	A	G	8: 106,874,115	M70V	probably damaging	Het
Hydin	G	T	8: 110,451,980	C1069F	possibly damaging	Het
Ints1	A	C	5: 139,764,382	L920R	probably damaging	Het
Kdm2a	T	C	19: 4,331,269	I54V	probably benign	Het
Kpna2	G	A	11: 106,990,832	T324I	probably damaging	Het
Lrr1	T	C	12: 69,174,654	L190S	probably damaging	Het
Lrrc49	A	T	9: 60,687,178	H16Q	probably benign	Het
Mapkap1	A	G	2: 34,444,348	E147G	probably damaging	Het
Mrpl2	C	T	17: 46,649,066	R219W	possibly damaging	Het
Ndc80	A	G	17: 71,521,135	S66P	probably benign	Het
Notch1	A	G	2: 26,468,626	Y1398H	probably damaging	Het
Olfml2b	C	T	1: 170,681,189	R539*	probably null	Het
Olfr6	T	A	7: 106,956,748	T63S	probably benign	Het
Pde7a	T	C	3: 19,260,256	T59A	probably damaging	Het
Plekhg1	G	A	10: 3,956,654	V524I	probably benign	Het
Plin4	T	A	17: 56,106,777	M283L	probably benign	Het
Prp2	C	T	6: 132,600,643	P298S	unknown	Het
Rap1gap2	G	A	11: 74,395,825	R550C	probably damaging	Het
Reln	G	A	5: 22,011,163	T1008I	probably damaging	Het
Rffl	T	C	11: 82,812,789	K103E	probably damaging	Het
Rmnd5b	A	T	11: 51,627,060	F156I	probably damaging	Het
Rtn4ip1	T	C	10: 43,902,465	I68T	probably damaging	Het
Samhd1	T	C	2: 157,109,492	I442V	possibly damaging	Het
Slc12a4	A	T	8: 105,950,694		probably null	Het
Slc35b1	G	T	11: 95,384,988		probably benign	Het
Ssh1	A	G	5: 113,950,545	V354A	probably damaging	Het
Stk33	T	C	7: 109,336,127	K153E	possibly damaging	Het
Stk4	C	T	2: 164,110,279	R19*	probably null	Het
Tas2r136	A	T	6: 132,777,411	I251N	probably damaging	Het
Tbr1	A	T	2: 61,804,900	T65S	probably benign	Het
Tkt	C	T	14: 30,560,618	S124F	probably damaging	Het
Tll1	T	C	8: 64,101,966	I228V	possibly damaging	Het
Tmem236	A	G	2: 14,174,833	I82V	probably benign	Het
Vmn2r110	T	C	17: 20,580,637	Q511R	probably benign	Het
Vps13a	T	A	19: 16,677,970	K1898I	probably damaging	Het
Zc3h12a	T	C	4: 125,126,765	E95G	probably benign	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19065745	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19065185	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19065758	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19065259	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19066451	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19066286	missense	probably benign
IGL02123:Vmn2r98	APN	17	19080679	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19065851	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19065821	missense	probably benign
IGL02650:Vmn2r98	APN	17	19080961	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19065259	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19066013	missense	probably benign
IGL02807:Vmn2r98	APN	17	19081021	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19065980	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19069845	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19080961	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19066400	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19065827	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19053613	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19080497	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19080520	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19080749	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19065948	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19065178	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19080908	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19066440	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19066418	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19065333	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19081291	missense	unknown
R2238:Vmn2r98	UTSW	17	19065951	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19080436	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19065819	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19081177	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19067402	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19080625	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19066092	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19069745	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19066340	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19066157	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19066044	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19053553	missense	probably benign	0.13
R5294:Vmn2r98	UTSW	17	19069754	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19069753	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19080899	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19065998	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19066074	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19065881	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19065801	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19065248	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19066268	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19080922	missense	probably benign
R7068:Vmn2r98	UTSW	17	19065313	missense	probably benign
R7607:Vmn2r98	UTSW	17	19067308	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19080535	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19067198	splice site	probably null
R7915:Vmn2r98	UTSW	17	19067231	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19053650	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19081163	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19080769	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19066270	missense	probably benign
R8952:Vmn2r98	UTSW	17	19065269	missense	possibly damaging	0.76
Z1177:Vmn2r98	UTSW	17	19065136	critical splice acceptor site	probably null
Z1177:Vmn2r98	UTSW	17	19067423	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GGCATCTTTGTGAAGCACAGAG -3'
(R):5'- TGCACAAAATGAGGATGTGTCC -3'

Sequencing Primer
(F):5'- TGTGAAGCACAGAGACACTCCTATTG -3'
(R):5'- GTCCATATTCAGTATGAGCATCTTGG -3'

Posted On

2016-07-22