Incidental Mutation 'R5285:Vmn2r120'
ID 403021
Institutional Source Beutler Lab
Gene Symbol Vmn2r120
Ensembl Gene ENSMUSG00000090655
Gene Name vomeronasal 2, receptor 120
Synonyms EG224916
MMRRC Submission 042869-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5285 (G1)
Quality Score 173
Status Validated
Chromosome 17
Chromosomal Location 57815783-57852314 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57843703 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 47 (L47P)
Ref Sequence ENSEMBL: ENSMUSP00000129296 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165781]
AlphaFold A0A3Q4EG79
Predicted Effect probably damaging
Transcript: ENSMUST00000165781
AA Change: L47P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: L47P

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 80 474 5.9e-42 PFAM
Pfam:NCD3G 517 570 7.5e-22 PFAM
Pfam:7tm_3 598 836 1.3e-54 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 98% (65/66)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A G 8: 106,435,097 (GRCm39) T12A probably benign Het
Acbd6 T A 1: 155,434,471 (GRCm39) S30T probably benign Het
Adcy8 G T 15: 64,639,706 (GRCm39) H685N possibly damaging Het
Aldh1l1 A T 6: 90,553,752 (GRCm39) K539* probably null Het
Ap1m2 G T 9: 21,216,933 (GRCm39) Y134* probably null Het
Apobr A G 7: 126,184,175 (GRCm39) probably benign Het
Atl1 A G 12: 70,001,273 (GRCm39) K345R probably benign Het
Avil T C 10: 126,854,328 (GRCm39) L765P probably damaging Het
Caps2 T A 10: 112,044,216 (GRCm39) Y472N probably benign Het
Catspere2 A G 1: 177,931,454 (GRCm39) K458E unknown Het
Cd177 A T 7: 24,445,674 (GRCm39) S590T probably benign Het
Cep295 T C 9: 15,233,887 (GRCm39) D2223G probably benign Het
Cfh T C 1: 140,028,636 (GRCm39) T493A probably benign Het
Chek1 T C 9: 36,625,748 (GRCm39) D299G probably benign Het
Cpox G A 16: 58,495,649 (GRCm39) G322D probably damaging Het
Crhr1 A T 11: 104,061,323 (GRCm39) I243F possibly damaging Het
Cyp3a11 A G 5: 145,791,893 (GRCm39) V500A probably benign Het
Dcdc5 A T 2: 106,198,500 (GRCm39) noncoding transcript Het
Ergic3 A G 2: 155,859,957 (GRCm39) probably benign Het
Fabp3-ps1 T G 10: 86,568,066 (GRCm39) probably benign Het
Gm6445 C A 19: 9,585,032 (GRCm39) noncoding transcript Het
Gucy2d C A 7: 98,107,474 (GRCm39) probably null Het
Ighv1-19-1 C A 12: 114,667,872 (GRCm39) probably benign Het
Igkv2-116 G T 6: 68,129,463 (GRCm39) R75L probably benign Het
Inhbc C A 10: 127,193,269 (GRCm39) R249L probably damaging Het
Lrrn2 T A 1: 132,866,983 (GRCm39) S683T possibly damaging Het
Lyst T C 13: 13,809,011 (GRCm39) V227A probably benign Het
Mroh5 TGGAG TG 15: 73,654,923 (GRCm39) probably benign Het
Msh4 T C 3: 153,579,350 (GRCm39) N587S probably benign Het
Mug1 G A 6: 121,818,066 (GRCm39) E126K probably benign Het
Nav2 T C 7: 49,197,982 (GRCm39) S1204P probably damaging Het
Ncor1 A G 11: 62,283,475 (GRCm39) I413T probably damaging Het
Nipa2 A T 7: 55,582,760 (GRCm39) Y328* probably null Het
Or1e25 T A 11: 73,493,767 (GRCm39) Y120* probably null Het
Or51a24 A G 7: 103,733,340 (GRCm39) *316R probably null Het
Or52s1 C T 7: 102,862,005 (GRCm39) R302* probably null Het
Or5k15 A T 16: 58,710,471 (GRCm39) Y37* probably null Het
Or5k3 T C 16: 58,969,633 (GRCm39) L140P probably damaging Het
Pla2g4e T C 2: 120,019,985 (GRCm39) D155G probably damaging Het
Plxnb1 C T 9: 108,937,527 (GRCm39) T1176I probably damaging Het
Polg A G 7: 79,114,973 (GRCm39) probably benign Het
Prl8a2 G A 13: 27,534,116 (GRCm39) probably null Het
Prmt7 G A 8: 106,974,991 (GRCm39) R529Q probably benign Het
Psg17 T A 7: 18,554,126 (GRCm39) L41F probably benign Het
Rad18 T C 6: 112,663,726 (GRCm39) R73G probably benign Het
Rhpn2 G T 7: 35,080,990 (GRCm39) probably benign Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Sarm1 A G 11: 78,388,265 (GRCm39) F7S probably benign Het
Sgip1 T A 4: 102,778,674 (GRCm39) probably benign Het
Sh3gl2 A G 4: 85,294,686 (GRCm39) K99R probably benign Het
Sorbs1 G A 19: 40,310,334 (GRCm39) T1018I probably damaging Het
Spns2 G A 11: 72,380,305 (GRCm39) A106V possibly damaging Het
Stab1 A G 14: 30,865,433 (GRCm39) probably benign Het
Steap3 T C 1: 120,169,610 (GRCm39) D191G probably damaging Het
Stxbp5 T C 10: 9,674,019 (GRCm39) probably null Het
Sycp2 A T 2: 178,034,191 (GRCm39) probably null Het
Tm6sf1 A G 7: 81,509,200 (GRCm39) S2G possibly damaging Het
Usp24 T A 4: 106,264,230 (GRCm39) D1720E probably benign Het
Vmn1r200 G A 13: 22,579,457 (GRCm39) E78K possibly damaging Het
Vmn2r14 T C 5: 109,365,442 (GRCm39) N544S probably damaging Het
Vwa1 C T 4: 155,855,352 (GRCm39) A254T probably benign Het
Zfp7 G A 15: 76,775,422 (GRCm39) R488Q probably damaging Het
Zfp940 A T 7: 29,545,025 (GRCm39) L294H probably damaging Het
Other mutations in Vmn2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r120 APN 17 57,832,732 (GRCm39) missense possibly damaging 0.86
IGL01346:Vmn2r120 APN 17 57,852,232 (GRCm39) missense probably benign 0.11
IGL01996:Vmn2r120 APN 17 57,832,222 (GRCm39) missense possibly damaging 0.92
IGL02503:Vmn2r120 APN 17 57,816,385 (GRCm39) missense probably benign 0.40
IGL02582:Vmn2r120 APN 17 57,831,724 (GRCm39) missense probably damaging 0.99
IGL02747:Vmn2r120 APN 17 57,831,719 (GRCm39) missense probably benign 0.19
IGL02896:Vmn2r120 APN 17 57,816,008 (GRCm39) missense probably damaging 1.00
IGL03139:Vmn2r120 APN 17 57,831,742 (GRCm39) missense probably benign 0.39
IGL03342:Vmn2r120 APN 17 57,816,372 (GRCm39) missense probably benign 0.03
A4554:Vmn2r120 UTSW 17 57,832,715 (GRCm39) missense probably benign 0.01
R0207:Vmn2r120 UTSW 17 57,832,052 (GRCm39) missense probably benign 0.17
R0472:Vmn2r120 UTSW 17 57,831,518 (GRCm39) missense probably benign 0.03
R0517:Vmn2r120 UTSW 17 57,815,949 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r120 UTSW 17 57,832,829 (GRCm39) missense probably benign 0.09
R1316:Vmn2r120 UTSW 17 57,832,939 (GRCm39) missense probably benign 0.28
R1543:Vmn2r120 UTSW 17 57,829,374 (GRCm39) missense probably benign 0.09
R1795:Vmn2r120 UTSW 17 57,832,038 (GRCm39) missense probably benign 0.35
R1850:Vmn2r120 UTSW 17 57,832,826 (GRCm39) missense probably benign 0.19
R1920:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1921:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1922:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R2063:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2064:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2065:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2067:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2286:Vmn2r120 UTSW 17 57,815,958 (GRCm39) missense probably damaging 1.00
R2291:Vmn2r120 UTSW 17 57,816,479 (GRCm39) missense probably damaging 1.00
R3416:Vmn2r120 UTSW 17 57,816,241 (GRCm39) missense possibly damaging 0.89
R3874:Vmn2r120 UTSW 17 57,831,954 (GRCm39) missense probably benign 0.40
R4023:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4024:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4348:Vmn2r120 UTSW 17 57,829,466 (GRCm39) missense possibly damaging 0.47
R4409:Vmn2r120 UTSW 17 57,816,477 (GRCm39) missense probably damaging 1.00
R4610:Vmn2r120 UTSW 17 57,816,120 (GRCm39) missense probably damaging 1.00
R4771:Vmn2r120 UTSW 17 57,831,887 (GRCm39) missense probably damaging 1.00
R4786:Vmn2r120 UTSW 17 57,829,048 (GRCm39) missense probably benign 0.14
R4927:Vmn2r120 UTSW 17 57,816,125 (GRCm39) missense probably damaging 1.00
R5566:Vmn2r120 UTSW 17 57,852,290 (GRCm39) missense possibly damaging 0.95
R5578:Vmn2r120 UTSW 17 57,829,514 (GRCm39) missense probably benign 0.01
R5643:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5644:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5781:Vmn2r120 UTSW 17 57,831,938 (GRCm39) missense probably benign 0.00
R6084:Vmn2r120 UTSW 17 57,832,721 (GRCm39) missense probably benign 0.15
R6120:Vmn2r120 UTSW 17 57,832,973 (GRCm39) missense probably benign 0.02
R6160:Vmn2r120 UTSW 17 57,816,418 (GRCm39) missense probably benign 0.03
R6248:Vmn2r120 UTSW 17 57,852,287 (GRCm39) missense probably benign 0.03
R6256:Vmn2r120 UTSW 17 57,831,700 (GRCm39) nonsense probably null
R6730:Vmn2r120 UTSW 17 57,832,012 (GRCm39) missense probably benign 0.03
R6821:Vmn2r120 UTSW 17 57,843,659 (GRCm39) missense probably benign 0.00
R6868:Vmn2r120 UTSW 17 57,852,218 (GRCm39) missense probably benign 0.00
R6880:Vmn2r120 UTSW 17 57,816,187 (GRCm39) missense probably damaging 1.00
R6986:Vmn2r120 UTSW 17 57,816,340 (GRCm39) missense probably damaging 1.00
R7276:Vmn2r120 UTSW 17 57,831,881 (GRCm39) missense probably benign 0.11
R7373:Vmn2r120 UTSW 17 57,816,406 (GRCm39) missense probably benign 0.35
R7653:Vmn2r120 UTSW 17 57,816,258 (GRCm39) missense possibly damaging 0.93
R7667:Vmn2r120 UTSW 17 57,843,657 (GRCm39) missense probably benign 0.04
R7775:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7778:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7797:Vmn2r120 UTSW 17 57,815,874 (GRCm39) missense probably damaging 1.00
R7824:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7902:Vmn2r120 UTSW 17 57,816,244 (GRCm39) missense possibly damaging 0.87
R7922:Vmn2r120 UTSW 17 57,831,683 (GRCm39) missense probably damaging 0.99
R8508:Vmn2r120 UTSW 17 57,832,843 (GRCm39) missense probably benign 0.03
R8847:Vmn2r120 UTSW 17 57,816,217 (GRCm39) missense probably benign 0.01
R8882:Vmn2r120 UTSW 17 57,852,229 (GRCm39) missense probably benign 0.01
R9134:Vmn2r120 UTSW 17 57,832,093 (GRCm39) missense probably damaging 1.00
R9161:Vmn2r120 UTSW 17 57,831,864 (GRCm39) missense
R9336:Vmn2r120 UTSW 17 57,832,201 (GRCm39) missense possibly damaging 0.91
RF005:Vmn2r120 UTSW 17 57,828,991 (GRCm39) missense possibly damaging 0.65
Z1177:Vmn2r120 UTSW 17 57,816,245 (GRCm39) missense probably benign 0.00
Z1188:Vmn2r120 UTSW 17 57,829,436 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCAACACATGGTGCTGGTT -3'
(R):5'- GCATCTGCTGTCACCTGAG -3'

Sequencing Primer
(F):5'- GTCGATGTGGATCAAAAGCCTCC -3'
(R):5'- AGGTGCTTCTAGACTCTCCATG -3'
Posted On 2016-07-22