Incidental Mutation 'R5210:Klra6'
ID 403091
Institutional Source Beutler Lab
Gene Symbol Klra6
Ensembl Gene ENSMUSG00000061769
Gene Name killer cell lectin-like receptor, subfamily A, member 6
Synonyms Ly49F, Ly49f
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R5210 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 129989996-130003917 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 129995855 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 168 (K168*)
Ref Sequence ENSEMBL: ENSMUSP00000073700 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074056]
AlphaFold Q60653
Predicted Effect probably null
Transcript: ENSMUST00000074056
AA Change: K168*
SMART Domains Protein: ENSMUSP00000073700
Gene: ENSMUSG00000061769
AA Change: K168*

DomainStartEndE-ValueType
Blast:CLECT 73 123 3e-9 BLAST
CLECT 143 258 8.42e-18 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: This gene belongs to the highly polymorphic family of C-type lectin-like Ly49 genes that are expressed in natural killer (NK) cells. The encoded protein is a homodimeric type II transmembrane receptor located at the cell surface and inhibits NK cell activation upon ligand binding. This gene is located in a cluster of several Klra paralogs on chromosome 6. Different strains of mice show variation in the number of paralogs, including strain specific duplications, deletions and pseudogene sequences. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim2 T A 5: 35,994,416 (GRCm39) V342E probably benign Het
Adgre4 T A 17: 56,092,029 (GRCm39) N96K probably damaging Het
Aopep A G 13: 63,215,924 (GRCm39) I399V probably benign Het
Bltp1 T C 3: 37,087,414 (GRCm39) V710A possibly damaging Het
Ccdc171 A G 4: 83,473,093 (GRCm39) E174G probably damaging Het
Col11a1 T C 3: 113,946,806 (GRCm39) F1026S probably damaging Het
Coro1c A G 5: 113,983,367 (GRCm39) L387P probably damaging Het
Dsg1c C T 18: 20,407,758 (GRCm39) T368I probably damaging Het
Exoc3l4 C A 12: 111,395,275 (GRCm39) probably benign Het
Extl1 T C 4: 134,087,895 (GRCm39) D453G probably benign Het
Gm21136 T C 7: 38,567,165 (GRCm39) noncoding transcript Het
H3c4 G T 13: 23,760,015 (GRCm39) G14C possibly damaging Het
Ifi208 T C 1: 173,510,831 (GRCm39) S329P probably benign Het
Iscu T A 5: 113,915,034 (GRCm39) L182* probably null Het
Map3k5 T C 10: 19,900,647 (GRCm39) S274P possibly damaging Het
Megf6 G T 4: 154,354,273 (GRCm39) probably benign Het
Mmp12 T A 9: 7,349,729 (GRCm39) Y53* probably null Het
Nucb2 T A 7: 116,128,222 (GRCm39) Y278N probably damaging Het
Numa1 C A 7: 101,649,188 (GRCm39) A973E probably benign Het
Or1o4 C A 17: 37,590,824 (GRCm39) K162N probably benign Het
Or2w1b A T 13: 21,300,222 (GRCm39) Y120F probably damaging Het
Or5b123 A G 19: 13,596,763 (GRCm39) K79R probably damaging Het
Or7g18 T A 9: 18,787,103 (GRCm39) L157Q probably damaging Het
Pcdhga3 C A 18: 37,808,963 (GRCm39) T472K probably benign Het
Pclo A G 5: 14,763,464 (GRCm39) D694G probably damaging Het
Plch1 A G 3: 63,607,199 (GRCm39) probably null Het
Pou3f2 C T 4: 22,487,324 (GRCm39) D270N probably damaging Het
Prrc2a G A 17: 35,372,596 (GRCm39) R1682W probably damaging Het
Rb1 A G 14: 73,436,751 (GRCm39) F838S probably damaging Het
Sec24c A G 14: 20,741,872 (GRCm39) E769G probably damaging Het
Slc45a2 C T 15: 11,027,871 (GRCm39) T480I probably damaging Het
Tmem63c A T 12: 87,136,172 (GRCm39) E796V probably benign Het
Tomm70a G A 16: 56,953,614 (GRCm39) probably null Het
Tpcn1 G A 5: 120,677,279 (GRCm39) T676I probably damaging Het
Vps51 T G 19: 6,121,063 (GRCm39) E283D probably benign Het
Other mutations in Klra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00861:Klra6 APN 6 130,000,663 (GRCm39) missense possibly damaging 0.77
IGL02037:Klra6 APN 6 129,990,439 (GRCm39) missense probably benign 0.02
IGL02319:Klra6 APN 6 130,002,177 (GRCm39) missense probably damaging 0.98
IGL02427:Klra6 APN 6 129,993,680 (GRCm39) missense possibly damaging 0.54
IGL02730:Klra6 APN 6 129,999,660 (GRCm39) missense probably benign
IGL02822:Klra6 APN 6 129,993,673 (GRCm39) nonsense probably null
R0485:Klra6 UTSW 6 130,000,601 (GRCm39) missense probably benign 0.12
R0697:Klra6 UTSW 6 129,993,687 (GRCm39) missense probably benign 0.18
R0731:Klra6 UTSW 6 129,999,668 (GRCm39) missense probably damaging 1.00
R1081:Klra6 UTSW 6 129,999,588 (GRCm39) missense probably damaging 0.96
R1708:Klra6 UTSW 6 129,999,677 (GRCm39) nonsense probably null
R1749:Klra6 UTSW 6 129,995,915 (GRCm39) missense probably damaging 1.00
R1842:Klra6 UTSW 6 129,999,573 (GRCm39) missense probably benign 0.14
R1944:Klra6 UTSW 6 129,995,908 (GRCm39) missense possibly damaging 0.92
R4214:Klra6 UTSW 6 129,995,885 (GRCm39) missense probably benign 0.10
R5286:Klra6 UTSW 6 129,995,932 (GRCm39) missense probably benign 0.02
R5418:Klra6 UTSW 6 129,990,393 (GRCm39) missense probably damaging 0.96
R5764:Klra6 UTSW 6 129,999,692 (GRCm39) missense possibly damaging 0.92
R6193:Klra6 UTSW 6 129,995,881 (GRCm39) missense probably benign 0.12
R6536:Klra6 UTSW 6 130,000,682 (GRCm39) missense probably benign 0.07
R6696:Klra6 UTSW 6 129,993,696 (GRCm39) missense probably benign
R7021:Klra6 UTSW 6 129,995,821 (GRCm39) missense possibly damaging 0.93
R7718:Klra6 UTSW 6 129,990,315 (GRCm39) frame shift probably null
R8500:Klra6 UTSW 6 129,999,660 (GRCm39) missense probably benign
R8910:Klra6 UTSW 6 129,993,647 (GRCm39) missense probably benign
R8983:Klra6 UTSW 6 129,999,573 (GRCm39) missense probably benign 0.14
R9164:Klra6 UTSW 6 129,993,687 (GRCm39) missense possibly damaging 0.95
R9775:Klra6 UTSW 6 129,999,639 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCCACAGTTTTGTTCACATTACAG -3'
(R):5'- CATAGATCATGAGTGTGCAGGG -3'

Sequencing Primer
(F):5'- AGTTTTGTTCACATTACAGGAAAATC -3'
(R):5'- TGAGAACTATGTGATTTTACCCCC -3'
Posted On 2016-07-22