Incidental Mutation 'IGL00327:Krt6b'
ID 4031
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Krt6b
Ensembl Gene ENSMUSG00000023041
Gene Name keratin 6B
Synonyms mK6[b], Krt2-6b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL00327
Quality Score
Status
Chromosome 15
Chromosomal Location 101584458-101588722 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 101588267 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Proline at position 131 (Q131P)
Ref Sequence ENSEMBL: ENSMUSP00000023786 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023786]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000023786
AA Change: Q131P

PolyPhen 2 Score 0.219 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000023786
Gene: ENSMUSG00000023041
AA Change: Q131P

DomainStartEndE-ValueType
Pfam:Keratin_2_head 15 148 1.3e-36 PFAM
Filament 151 464 2.79e-175 SMART
low complexity region 483 537 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198940
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg16l2 A G 7: 100,949,367 (GRCm39) L60S probably damaging Het
Aup1 A G 6: 83,033,390 (GRCm39) E267G probably damaging Het
Bpi T C 2: 158,116,764 (GRCm39) probably benign Het
Brinp2 A G 1: 158,074,670 (GRCm39) Y484H probably benign Het
Colq C T 14: 31,257,545 (GRCm39) probably null Het
Cubn T C 2: 13,431,867 (GRCm39) D1242G possibly damaging Het
Dclre1c T A 2: 3,434,821 (GRCm39) L95* probably null Het
Fry C T 5: 150,263,869 (GRCm39) R171* probably null Het
Krt23 T C 11: 99,383,610 (GRCm39) E94G probably damaging Het
Lonp1 A G 17: 56,926,265 (GRCm39) L414P probably damaging Het
Lrit2 T A 14: 36,793,920 (GRCm39) M328K probably benign Het
Lysmd3 C T 13: 81,813,197 (GRCm39) L22F probably benign Het
Map3k20 A G 2: 72,242,514 (GRCm39) D388G probably damaging Het
Mrpl44 C T 1: 79,758,721 (GRCm39) L290F probably benign Het
Nell1 A G 7: 49,770,421 (GRCm39) H160R probably damaging Het
Nlrc3 T C 16: 3,773,030 (GRCm39) N109S probably damaging Het
Prpf40a T C 2: 53,040,700 (GRCm39) T553A probably benign Het
Ptpn23 G T 9: 110,217,174 (GRCm39) T894K probably benign Het
Scgb2b27 A G 7: 33,712,771 (GRCm39) C24R probably damaging Het
Sipa1l3 G T 7: 29,053,558 (GRCm39) H140N probably damaging Het
Slc22a23 T G 13: 34,489,228 (GRCm39) D219A probably damaging Het
Slc9a7 T C X: 20,005,158 (GRCm39) Y557C probably damaging Het
Slco1a1 A T 6: 141,854,851 (GRCm39) I600N probably damaging Het
Tmx2 T C 2: 84,503,643 (GRCm39) N190S probably benign Het
Tpr T G 1: 150,299,447 (GRCm39) probably benign Het
Yme1l1 T C 2: 23,082,512 (GRCm39) V501A probably benign Het
Other mutations in Krt6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01653:Krt6b APN 15 101,587,549 (GRCm39) missense probably damaging 1.00
IGL01900:Krt6b APN 15 101,585,981 (GRCm39) missense possibly damaging 0.45
IGL03187:Krt6b APN 15 101,588,392 (GRCm39) missense probably benign
R0511:Krt6b UTSW 15 101,586,042 (GRCm39) splice site probably benign
R0788:Krt6b UTSW 15 101,585,954 (GRCm39) missense probably damaging 0.96
R1370:Krt6b UTSW 15 101,585,987 (GRCm39) missense probably damaging 0.96
R1481:Krt6b UTSW 15 101,586,809 (GRCm39) missense probably benign 0.05
R2007:Krt6b UTSW 15 101,586,562 (GRCm39) missense probably damaging 1.00
R2112:Krt6b UTSW 15 101,586,999 (GRCm39) missense possibly damaging 0.48
R2166:Krt6b UTSW 15 101,587,050 (GRCm39) critical splice acceptor site probably null
R2227:Krt6b UTSW 15 101,587,557 (GRCm39) missense probably damaging 0.96
R2495:Krt6b UTSW 15 101,586,757 (GRCm39) missense probably damaging 1.00
R2496:Krt6b UTSW 15 101,588,216 (GRCm39) missense probably damaging 1.00
R4726:Krt6b UTSW 15 101,586,520 (GRCm39) missense probably damaging 0.98
R4969:Krt6b UTSW 15 101,588,460 (GRCm39) missense possibly damaging 0.71
R6301:Krt6b UTSW 15 101,587,386 (GRCm39) missense probably damaging 1.00
R6646:Krt6b UTSW 15 101,585,649 (GRCm39) missense probably damaging 0.98
R7232:Krt6b UTSW 15 101,586,577 (GRCm39) missense probably damaging 1.00
R7406:Krt6b UTSW 15 101,587,513 (GRCm39) missense probably benign 0.04
R7414:Krt6b UTSW 15 101,587,449 (GRCm39) missense probably benign 0.05
R7849:Krt6b UTSW 15 101,587,009 (GRCm39) missense probably damaging 1.00
R8110:Krt6b UTSW 15 101,588,577 (GRCm39) missense probably damaging 0.96
R8348:Krt6b UTSW 15 101,586,455 (GRCm39) missense probably damaging 1.00
R8448:Krt6b UTSW 15 101,586,455 (GRCm39) missense probably damaging 1.00
R8736:Krt6b UTSW 15 101,587,047 (GRCm39) missense probably damaging 1.00
R9466:Krt6b UTSW 15 101,586,027 (GRCm39) missense probably damaging 1.00
R9633:Krt6b UTSW 15 101,586,996 (GRCm39) missense probably benign 0.00
R9720:Krt6b UTSW 15 101,588,226 (GRCm39) missense probably benign 0.40
Z1177:Krt6b UTSW 15 101,586,767 (GRCm39) missense probably damaging 1.00
Posted On 2012-04-20