Incidental Mutation 'R5213:Npr2'
ID 403247
Institutional Source Beutler Lab
Gene Symbol Npr2
Ensembl Gene ENSMUSG00000028469
Gene Name natriuretic peptide receptor 2
Synonyms pwe, guanylyl cyclase-B, cn
MMRRC Submission 042854-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.748) question?
Stock # R5213 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 43631935-43651244 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 43640673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030191] [ENSMUST00000107874]
AlphaFold Q6VVW5
Predicted Effect probably null
Transcript: ENSMUST00000030191
SMART Domains Protein: ENSMUSP00000030191
Gene: ENSMUSG00000028469

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 44 399 1.9e-45 PFAM
Pfam:Pkinase_Tyr 518 786 4.7e-39 PFAM
Pfam:Pkinase 535 785 1.2e-32 PFAM
CYCc 825 1019 3.28e-111 SMART
Predicted Effect probably null
Transcript: ENSMUST00000107874
SMART Domains Protein: ENSMUSP00000103506
Gene: ENSMUSG00000028469

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 44 399 5.7e-56 PFAM
Pfam:Pkinase_Tyr 518 786 4.1e-39 PFAM
Pfam:Pkinase 533 785 3.8e-34 PFAM
CYCc 825 989 4.37e-57 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123351
SMART Domains Protein: ENSMUSP00000117761
Gene: ENSMUSG00000028469

DomainStartEndE-ValueType
transmembrane domain 28 50 N/A INTRINSIC
Pfam:Pkinase_Tyr 71 173 1.3e-12 PFAM
Pfam:Pkinase 85 170 1.2e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123883
Predicted Effect probably benign
Transcript: ENSMUST00000128549
SMART Domains Protein: ENSMUSP00000114385
Gene: ENSMUSG00000028469

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Pfam:Pkinase_Tyr 84 352 1e-39 PFAM
Pfam:Pkinase 101 351 2.6e-33 PFAM
CYCc 391 585 3.28e-111 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137535
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144418
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145817
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in skeletal abnormalities, malocclusion, and reduced viability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 C A 4: 86,303,865 (GRCm39) H1342N possibly damaging Het
Adcy2 G T 13: 68,768,942 (GRCm39) T1062K possibly damaging Het
Aqr T C 2: 113,943,808 (GRCm39) N1110S probably damaging Het
Atp10a C T 7: 58,423,731 (GRCm39) T232I probably damaging Het
Atp5pb T A 3: 105,863,227 (GRCm39) K70* probably null Het
Atp8b4 A C 2: 126,231,329 (GRCm39) probably null Het
Atraid A C 5: 31,209,552 (GRCm39) Q72P probably damaging Het
Atxn2 G T 5: 121,952,543 (GRCm39) probably null Het
Best3 A T 10: 116,860,377 (GRCm39) T546S probably benign Het
Brd3 T C 2: 27,353,960 (GRCm39) K51E possibly damaging Het
Brip1 A G 11: 86,034,147 (GRCm39) S525P possibly damaging Het
Cenpf A G 1: 189,387,177 (GRCm39) I1701T probably benign Het
Chrna9 A T 5: 66,128,427 (GRCm39) K208* probably null Het
Clec2l T A 6: 38,657,127 (GRCm39) C197S probably damaging Het
Crp A G 1: 172,526,086 (GRCm39) H57R probably benign Het
Cyp27b1 C A 10: 126,887,964 (GRCm39) T492N probably damaging Het
Dock4 A T 12: 40,726,741 (GRCm39) I340F probably damaging Het
Dsg1b A T 18: 20,528,987 (GRCm39) D241V probably damaging Het
Epg5 G T 18: 78,058,049 (GRCm39) V1865L probably benign Het
Erap1 A G 13: 74,819,614 (GRCm39) probably null Het
Fat2 C T 11: 55,144,658 (GRCm39) C4072Y probably benign Het
Fat4 T A 3: 39,034,340 (GRCm39) I2664N possibly damaging Het
Gabrp A G 11: 33,517,211 (GRCm39) probably null Het
Glis2 G T 16: 4,431,946 (GRCm39) probably benign Het
Gm17654 A G 14: 43,816,559 (GRCm39) S15P probably damaging Het
Gm21836 A G 9: 124,252,736 (GRCm39) V14A unknown Het
Gon7 G A 12: 102,720,380 (GRCm39) T84I possibly damaging Het
Greb1 G T 12: 16,764,791 (GRCm39) Y447* probably null Het
Grip2 A T 6: 91,756,812 (GRCm39) D546E probably benign Het
Hectd1 A G 12: 51,849,316 (GRCm39) probably null Het
Il36a T A 2: 24,114,486 (GRCm39) F120L probably damaging Het
Itga4 T C 2: 79,150,920 (GRCm39) V842A probably benign Het
Khsrp G A 17: 57,331,366 (GRCm39) A404V probably benign Het
Map3k11 T C 19: 5,740,669 (GRCm39) V132A probably damaging Het
Mcub A C 3: 129,710,646 (GRCm39) F262C probably benign Het
Msantd5f6 G T 4: 73,319,571 (GRCm39) Q302K probably damaging Het
Mysm1 A T 4: 94,836,614 (GRCm39) V732E probably damaging Het
Or10d5 A C 9: 39,861,389 (GRCm39) I226S probably damaging Het
Or12d12 T C 17: 37,610,942 (GRCm39) I124V probably damaging Het
Or5k1b T C 16: 58,580,984 (GRCm39) Y185C probably damaging Het
Oxgr1 G T 14: 120,259,552 (GRCm39) Y218* probably null Het
Paf1 A G 7: 28,095,397 (GRCm39) Q161R possibly damaging Het
Pck1 A T 2: 172,997,878 (GRCm39) K316* probably null Het
Plac8 T A 5: 100,704,371 (GRCm39) M109L probably benign Het
Plagl2 A T 2: 153,074,239 (GRCm39) C221S probably damaging Het
Polg T C 7: 79,103,846 (GRCm39) D870G probably damaging Het
Polr2k T A 15: 36,175,143 (GRCm39) M1K probably null Het
Prdm9 T C 17: 15,775,416 (GRCm39) H276R probably damaging Het
Resf1 C A 6: 149,227,551 (GRCm39) P199Q possibly damaging Het
Rgs12 T A 5: 35,122,664 (GRCm39) I149N probably damaging Het
Serpina3i A G 12: 104,231,914 (GRCm39) I184V probably benign Het
Shank3 A G 15: 89,417,481 (GRCm39) E26G possibly damaging Het
Skil T C 3: 31,171,600 (GRCm39) S575P probably damaging Het
Slc13a1 A G 6: 24,108,158 (GRCm39) L306P probably damaging Het
Slc20a1 G T 2: 129,042,429 (GRCm39) W166L probably damaging Het
Slc45a2 C T 15: 11,027,871 (GRCm39) T480I probably damaging Het
Snrnp200 G T 2: 127,073,661 (GRCm39) G1353V probably damaging Het
Spata6l A T 19: 28,940,964 (GRCm39) V50E probably benign Het
Sphkap A G 1: 83,258,224 (GRCm39) I173T probably damaging Het
Stab2 A T 10: 86,743,061 (GRCm39) F1183I probably damaging Het
Stard9 A G 2: 120,529,707 (GRCm39) D1988G probably damaging Het
Tank T A 2: 61,480,292 (GRCm39) I276N probably benign Het
Tcaf3 A G 6: 42,568,401 (GRCm39) W652R probably damaging Het
Tgm2 G A 2: 157,984,980 (GRCm39) T42I possibly damaging Het
Tnni2 G T 7: 141,997,039 (GRCm39) probably null Het
Tns1 A G 1: 73,992,771 (GRCm39) S9P probably damaging Het
Tram1 T C 1: 13,649,966 (GRCm39) Y86C probably damaging Het
Trdv2-1 T C 14: 54,183,863 (GRCm39) S32P probably benign Het
Trim24 T C 6: 37,934,010 (GRCm39) I651T probably damaging Het
Trpm3 T G 19: 22,674,818 (GRCm39) Y72* probably null Het
Ube2o G A 11: 116,432,285 (GRCm39) P894S possibly damaging Het
Ubr4 C T 4: 139,129,877 (GRCm39) R666* probably null Het
Ugt1a8 T A 1: 88,015,845 (GRCm39) L86* probably null Het
Usp32 T A 11: 84,913,085 (GRCm39) N941I probably damaging Het
Utrn C T 10: 12,512,504 (GRCm39) V2322M probably damaging Het
Vmn1r184 A T 7: 25,967,136 (GRCm39) Y294F probably damaging Het
Vmn2r108 T C 17: 20,691,755 (GRCm39) N256S probably benign Het
Wdr7 T C 18: 63,888,197 (GRCm39) S557P probably damaging Het
Xrra1 C A 7: 99,547,690 (GRCm39) P293Q possibly damaging Het
Zc3h18 A G 8: 123,110,388 (GRCm39) D79G probably damaging Het
Zfp74 A T 7: 29,634,668 (GRCm39) Y347N probably damaging Het
Zfp740 T C 15: 102,121,082 (GRCm39) C169R possibly damaging Het
Other mutations in Npr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Npr2 APN 4 43,641,612 (GRCm39) missense possibly damaging 0.51
IGL01116:Npr2 APN 4 43,640,248 (GRCm39) missense probably damaging 0.99
IGL01447:Npr2 APN 4 43,640,554 (GRCm39) missense possibly damaging 0.93
IGL02412:Npr2 APN 4 43,647,005 (GRCm39) missense probably damaging 0.97
IGL02449:Npr2 APN 4 43,646,641 (GRCm39) missense probably damaging 1.00
IGL03120:Npr2 APN 4 43,643,133 (GRCm39) missense probably damaging 0.99
IGL03351:Npr2 APN 4 43,640,652 (GRCm39) missense probably benign 0.36
Anterior UTSW 4 43,643,622 (GRCm39) missense probably damaging 1.00
palmar UTSW 4 43,647,553 (GRCm39) missense probably damaging 1.00
Plantar UTSW 4 43,640,597 (GRCm39) missense probably damaging 1.00
Ventral UTSW 4 43,641,254 (GRCm39) missense probably damaging 1.00
R0066:Npr2 UTSW 4 43,632,329 (GRCm39) missense probably benign 0.00
R0201:Npr2 UTSW 4 43,641,617 (GRCm39) missense probably damaging 0.98
R0309:Npr2 UTSW 4 43,640,904 (GRCm39) unclassified probably benign
R0437:Npr2 UTSW 4 43,648,082 (GRCm39) missense probably damaging 1.00
R0440:Npr2 UTSW 4 43,650,315 (GRCm39) missense probably damaging 0.99
R0464:Npr2 UTSW 4 43,640,597 (GRCm39) splice site probably null
R0511:Npr2 UTSW 4 43,632,801 (GRCm39) missense probably benign 0.00
R0576:Npr2 UTSW 4 43,640,947 (GRCm39) missense probably benign 0.01
R0630:Npr2 UTSW 4 43,641,219 (GRCm39) missense probably benign 0.18
R0690:Npr2 UTSW 4 43,646,991 (GRCm39) missense probably damaging 0.98
R1079:Npr2 UTSW 4 43,643,654 (GRCm39) missense probably damaging 1.00
R1140:Npr2 UTSW 4 43,648,353 (GRCm39) missense possibly damaging 0.87
R1171:Npr2 UTSW 4 43,647,260 (GRCm39) missense possibly damaging 0.52
R1741:Npr2 UTSW 4 43,643,350 (GRCm39) missense probably damaging 1.00
R1848:Npr2 UTSW 4 43,632,384 (GRCm39) missense probably benign
R1864:Npr2 UTSW 4 43,641,258 (GRCm39) missense probably benign 0.30
R1919:Npr2 UTSW 4 43,640,578 (GRCm39) missense probably damaging 1.00
R2054:Npr2 UTSW 4 43,646,560 (GRCm39) missense probably damaging 0.99
R2106:Npr2 UTSW 4 43,644,329 (GRCm39) missense probably damaging 1.00
R2143:Npr2 UTSW 4 43,648,166 (GRCm39) missense probably damaging 1.00
R2306:Npr2 UTSW 4 43,633,609 (GRCm39) missense probably damaging 1.00
R2372:Npr2 UTSW 4 43,650,432 (GRCm39) missense probably damaging 1.00
R2889:Npr2 UTSW 4 43,641,600 (GRCm39) missense probably benign 0.26
R3076:Npr2 UTSW 4 43,640,182 (GRCm39) missense probably damaging 1.00
R3078:Npr2 UTSW 4 43,640,182 (GRCm39) missense probably damaging 1.00
R3711:Npr2 UTSW 4 43,643,378 (GRCm39) missense probably benign 0.00
R3730:Npr2 UTSW 4 43,640,999 (GRCm39) missense possibly damaging 0.93
R4301:Npr2 UTSW 4 43,641,332 (GRCm39) critical splice donor site probably null
R4352:Npr2 UTSW 4 43,646,592 (GRCm39) missense probably damaging 1.00
R4412:Npr2 UTSW 4 43,644,150 (GRCm39) missense probably damaging 0.99
R4583:Npr2 UTSW 4 43,633,522 (GRCm39) splice site probably null
R4593:Npr2 UTSW 4 43,647,323 (GRCm39) unclassified probably benign
R5042:Npr2 UTSW 4 43,647,002 (GRCm39) missense probably damaging 1.00
R5546:Npr2 UTSW 4 43,650,150 (GRCm39) missense probably damaging 1.00
R5784:Npr2 UTSW 4 43,632,801 (GRCm39) missense probably benign 0.00
R5787:Npr2 UTSW 4 43,633,593 (GRCm39) missense possibly damaging 0.69
R6364:Npr2 UTSW 4 43,643,622 (GRCm39) missense probably damaging 1.00
R6925:Npr2 UTSW 4 43,647,553 (GRCm39) missense probably damaging 1.00
R6949:Npr2 UTSW 4 43,640,597 (GRCm39) missense probably damaging 1.00
R7380:Npr2 UTSW 4 43,641,254 (GRCm39) missense probably damaging 1.00
R7432:Npr2 UTSW 4 43,647,155 (GRCm39) missense probably damaging 0.96
R7500:Npr2 UTSW 4 43,650,415 (GRCm39) missense probably damaging 1.00
R8235:Npr2 UTSW 4 43,641,603 (GRCm39) missense probably benign 0.09
R8292:Npr2 UTSW 4 43,643,086 (GRCm39) missense possibly damaging 0.70
R9310:Npr2 UTSW 4 43,632,404 (GRCm39) missense probably benign 0.01
R9684:Npr2 UTSW 4 43,632,491 (GRCm39) missense probably damaging 1.00
R9746:Npr2 UTSW 4 43,633,527 (GRCm39) missense possibly damaging 0.64
Z1176:Npr2 UTSW 4 43,650,720 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCTCAGGGGACATTTGGAGAG -3'
(R):5'- TTTGAGATCTAACCCTGGCCAC -3'

Sequencing Primer
(F):5'- ACATTTGGAGAGTGTTGCTGC -3'
(R):5'- AGTAGCTGTCTTCTGCCC -3'
Posted On 2016-07-22