|Institutional Source||Beutler Lab|
|Gene Name||kelch-like 20|
|Essential gene?||Possibly essential (E-score: 0.524)|
|Stock #||R5216 (G1)|
|Chromosomal Location||161088375-161131511 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 161093679 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000107238 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000111611] [ENSMUST00000117467] [ENSMUST00000195584]|
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a transgenic gene disruption may exhibit male sterility. Mice homozygous for a gene trap allele exhibit corneal vascularization and premature death. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Klhl20||
(F):5'- TTCCCCAGCAGGATATGACG -3'
(R):5'- CCTAGAGACTGTGAATTCCCC -3'
(F):5'- TTTAATCCCAGCACTCAGGAGG -3'
(R):5'- TGTGAATTCCCCGCGGC -3'