Mutagenetix > Incidental Mutations

Incidental Mutation 'R5216:Vmn1r67'

403478

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r67

Ensembl Gene

ENSMUSG00000046716

Gene Name

vomeronasal 1 receptor 67

Synonyms

V1re10

MMRRC Submission

042789-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R5216 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

10443331-10449202 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 10447163 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 57 (D57G)

Ref Sequence

ENSEMBL: ENSMUSP00000154237 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055964] [ENSMUST00000226237]

Predicted Effect

probably benign
Transcript: ENSMUST00000055964
AA Change: D118G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000060746
Gene: ENSMUSG00000046716
AA Change: D118G

Domain	Start	End	E-Value	Type
Pfam:V1R	34	292	4.3e-31	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226237
AA Change: D57G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.5%
20x: 95.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700097O09Rik	A	T	12: 55,061,162	V84D	probably damaging	Het
Abcb1b	T	C	5: 8,813,705	V220A	probably benign	Het
Actg1	A	T	11: 120,347,754	M82K	probably damaging	Het
Ahi1	T	C	10: 20,960,076	S103P	probably benign	Het
Aldh1b1	G	T	4: 45,803,652	G397C	probably damaging	Het
Arhgef3	A	G	14: 27,401,842	T507A	probably benign	Het
Atg7	A	G	6: 114,724,949	D682G	probably damaging	Het
Atp13a3	A	G	16: 30,340,284	I783T	probably damaging	Het
Atp9a	T	C	2: 168,674,888	I362V	probably benign	Het
BC067074	G	A	13: 113,342,413	C1497Y	probably benign	Het
Birc6	T	A	17: 74,613,470	I168K	probably damaging	Het
Brca2	T	A	5: 150,542,980	Y2070N	probably damaging	Het
Cabp7	A	G	11: 4,738,873	I199T	probably damaging	Het
Cacng5	A	G	11: 107,877,489	F231L	possibly damaging	Het
Cngb3	T	A	4: 19,415,729	V413D	possibly damaging	Het
Col24a1	G	A	3: 145,315,310	E481K	possibly damaging	Het
Ctr9	T	A	7: 111,045,458	I560N	possibly damaging	Het
Dip2b	C	T	15: 100,211,986	R1451C	probably damaging	Het
Fat3	T	C	9: 16,377,537	D230G	probably damaging	Het
Gramd4	G	A	15: 86,134,785		probably null	Het
Grb14	C	T	2: 64,917,309	V369I	probably benign	Het
Hoxd1	A	T	2: 74,764,351	N317Y	probably damaging	Het
Kcnc4	A	G	3: 107,439,441	S623P	probably benign	Het
Klhl20	A	G	1: 161,093,679		probably null	Het
Lamc1	C	A	1: 153,227,696	V1375L	probably damaging	Het
Lpin2	C	T	17: 71,242,760	S640L	probably damaging	Het
Ltbp4	AATTCAGGCCAAGGCTGGGATTCAGGCCGAGGCCGGGATTCAGGCCTAGGCTGGGATTCAGGC	AATTCAGGCCTAGGCTGGGATTCAGGC	7: 27,327,311		probably benign	Het
Mgll	T	A	6: 88,766,329	C110*	probably null	Het
Mmp14	A	G	14: 54,437,663	N251D	possibly damaging	Het
Olfr393	A	T	11: 73,847,436	S230T	probably damaging	Het
Olfr552	A	G	7: 102,604,821	T156A	probably benign	Het
Olfr857	T	A	9: 19,713,289	V154E	probably benign	Het
Pfkl	T	G	10: 78,009,670	D5A	probably damaging	Het
Pik3c3	A	G	18: 30,272,976	Y9C	probably damaging	Het
Pkhd1l1	T	A	15: 44,495,647	Y417*	probably null	Het
Rptor	G	A	11: 119,843,713	G514D	probably damaging	Het
Sulf1	T	A	1: 12,796,874	M94K	probably benign	Het
Synrg	A	G	11: 83,982,196	T157A	probably damaging	Het
Syt1	T	C	10: 108,642,257	N102S	probably benign	Het
Tnip2	C	T	5: 34,503,805	R101H	probably damaging	Het
Trmt2a	A	G	16: 18,252,184	D421G	probably benign	Het
Wnt2b	A	G	3: 104,961,345	L43P	possibly damaging	Het
Zfp113	C	T	5: 138,150,715	D56N	probably damaging	Het
Zfp184	C	T	13: 21,950,236	L69F	probably damaging	Het
Zyx	T	C	6: 42,356,532	V464A	probably damaging	Het

Other mutations in Vmn1r67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01690:Vmn1r67	APN	7	10446840	missense	possibly damaging	0.96
IGL02812:Vmn1r67	APN	7	10447018	missense	probably benign	0.01
IGL03121:Vmn1r67	APN	7	10447467	missense	probably benign	0.00
IGL03208:Vmn1r67	APN	7	10447098	missense	possibly damaging	0.94
PIT4142001:Vmn1r67	UTSW	7	10446950	missense	probably benign	0.13
R0048:Vmn1r67	UTSW	7	10446866	missense	probably damaging	1.00
R0549:Vmn1r67	UTSW	7	10447714	missense	probably damaging	1.00
R1595:Vmn1r67	UTSW	7	10447670	missense	probably benign	0.18
R1608:Vmn1r67	UTSW	7	10446980	missense	possibly damaging	0.82
R2284:Vmn1r67	UTSW	7	10447673	missense	probably damaging	0.97
R3614:Vmn1r67	UTSW	7	10447429	missense	probably damaging	0.98
R4399:Vmn1r67	UTSW	7	10447549	missense	possibly damaging	0.89
R4542:Vmn1r67	UTSW	7	10447430	missense	probably damaging	0.99
R5655:Vmn1r67	UTSW	7	10447388	missense	probably benign	0.43
R5837:Vmn1r67	UTSW	7	10447022	missense	probably benign	0.26
R6526:Vmn1r67	UTSW	7	10447671	missense	probably benign	0.05
R6735:Vmn1r67	UTSW	7	10447211	missense	probably damaging	1.00
R6846:Vmn1r67	UTSW	7	10446913	missense	probably benign	0.04
R7086:Vmn1r67	UTSW	7	10447117	missense	possibly damaging	0.93
R7227:Vmn1r67	UTSW	7	10447548	nonsense	probably null
R7594:Vmn1r67	UTSW	7	10447415	missense	possibly damaging	0.95
R7608:Vmn1r67	UTSW	7	10447363	missense	possibly damaging	0.89
R7797:Vmn1r67	UTSW	7	10446976	missense	probably benign	0.30

Predicted Primers

PCR Primer
(F):5'- TCTCATGCACCTAATGGCATCC -3'
(R):5'- AGTGAGGCATTGATGTCATCACC -3'

Sequencing Primer
(F):5'- GATAGTTCTCTTTACAGGAATGCCTC -3'
(R):5'- GATGTCATCACCCCCTCTAATTGAAC -3'

Posted On

2016-07-22