|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 26|
|Is this an essential gene?||Probably non essential (E-score: 0.070)|
|Stock #||R5229 (G1)|
|Chromosomal Location||131966460-131994405 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 131984247 bp|
|Amino Acid Change||Arginine to Serine at position 315 (R315S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000041664 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000045840] [ENSMUST00000124096]|
|Predicted Effect||probably damaging
AA Change: R315S
PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
AA Change: R315S
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.5054|
|Coding Region Coverage||
|Validation Efficiency||98% (62/63)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit increased anxiety- and depression-related behaviors and alcohol preference. Female mice homozygous for another allele display increased susceptibility to diet-induced obesity with increased food intake. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr26||
(F):5'- ACAGGCTGGTGGAACTCTTC -3'
(R):5'- TGACATCTACCCTGGAAGAGC -3'
(F):5'- GGTGGAACTCTTCTCCACAG -3'
(R):5'- TGTTCAGACGTCAGCATCACG -3'