Incidental Mutation 'R5273:Gm4841'
ID403792
Institutional Source Beutler Lab
Gene Symbol Gm4841
Ensembl Gene ENSMUSG00000068606
Gene Namepredicted gene 4841
Synonyms
MMRRC Submission 042862-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #R5273 (G1)
Quality Score225
Status Not validated
Chromosome18
Chromosomal Location60268301-60273267 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 60270743 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 93 (V93I)
Ref Sequence ENSEMBL: ENSMUSP00000087727 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090260]
Predicted Effect probably benign
Transcript: ENSMUST00000090260
AA Change: V93I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000087727
Gene: ENSMUSG00000068606
AA Change: V93I

DomainStartEndE-ValueType
Pfam:IIGP 36 409 1.2e-129 PFAM
Pfam:MMR_HSR1 72 185 2.2e-11 PFAM
Pfam:Roc 72 188 1.9e-8 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T C 15: 8,244,341 S2603P probably damaging Het
2410089E03Rik T C 15: 8,262,938 S3012P unknown Het
Abcc4 T C 14: 118,594,821 N799S possibly damaging Het
Arhgap20 A G 9: 51,848,616 N589S probably damaging Het
Armc10 C T 5: 21,653,428 A157V possibly damaging Het
Atp2b2 A G 6: 113,759,232 L958P probably damaging Het
Bhmt2 G A 13: 93,666,578 A149V possibly damaging Het
C77080 T C 4: 129,224,212 T208A possibly damaging Het
Ccdc7a CATCAGCTGATAT CAT 8: 129,061,609 probably null Het
Cntnap4 A G 8: 112,733,438 D141G probably damaging Het
Dis3 A G 14: 99,098,806 V88A probably benign Het
Dnajc21 A T 15: 10,454,807 C316S probably damaging Het
Dnhd1 A G 7: 105,714,482 T4084A probably damaging Het
Dock3 A C 9: 106,900,705 probably null Het
Eml5 T C 12: 98,790,688 H1894R probably damaging Het
Galc T C 12: 98,252,071 Y174C probably damaging Het
Gm7995 T C 14: 42,311,456 Y98H probably damaging Het
Gnrhr T A 5: 86,182,246 H305L possibly damaging Het
Gpr179 A T 11: 97,347,430 F323I probably damaging Het
Kdm6b G T 11: 69,404,201 P1080Q unknown Het
Man2a1 C T 17: 64,733,785 T126I probably damaging Het
Mdm4 G A 1: 132,994,582 T274M probably benign Het
Mug1 T A 6: 121,873,789 V748E probably damaging Het
Nav3 A T 10: 109,693,038 probably null Het
Olfr957 A G 9: 39,511,499 S74P possibly damaging Het
Olfr974 T C 9: 39,942,557 V99A probably benign Het
Pcdhb1 T C 18: 37,265,713 V239A probably benign Het
Ppic T A 18: 53,409,258 H126L probably damaging Het
Sdk1 T C 5: 141,998,828 F463L probably damaging Het
Shroom1 A G 11: 53,463,844 E197G possibly damaging Het
Slc22a14 A G 9: 119,170,638 S496P probably benign Het
Slc27a1 G A 8: 71,584,256 G379S probably benign Het
Slco1a5 T C 6: 142,242,098 E505G probably benign Het
Snrpe A C 1: 133,609,780 probably benign Het
Sp100 G T 1: 85,709,104 V299F possibly damaging Het
Stard9 A G 2: 120,705,087 S3942G possibly damaging Het
Ttn A G 2: 76,814,604 V12969A probably damaging Het
Txndc11 T C 16: 11,128,623 Q108R probably benign Het
Wnk4 A T 11: 101,263,869 I295F probably damaging Het
Other mutations in Gm4841
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01102:Gm4841 APN 18 60270052 missense probably damaging 1.00
IGL02043:Gm4841 APN 18 60270965 missense probably benign 0.05
IGL02751:Gm4841 APN 18 60271021 utr 5 prime probably benign
R0277:Gm4841 UTSW 18 60270646 missense possibly damaging 0.83
R0323:Gm4841 UTSW 18 60270646 missense possibly damaging 0.83
R0616:Gm4841 UTSW 18 60270937 missense probably benign 0.00
R0882:Gm4841 UTSW 18 60269780 missense possibly damaging 0.92
R1778:Gm4841 UTSW 18 60270948 nonsense probably null
R2035:Gm4841 UTSW 18 60269857 missense probably benign 0.29
R2513:Gm4841 UTSW 18 60270905 missense probably damaging 1.00
R4242:Gm4841 UTSW 18 60270683 missense probably benign 0.05
R4295:Gm4841 UTSW 18 60270190 missense probably benign 0.01
R4574:Gm4841 UTSW 18 60269926 missense probably benign 0.02
R4720:Gm4841 UTSW 18 60270063 missense probably benign 0.00
R5314:Gm4841 UTSW 18 60270292 missense probably benign 0.13
R5378:Gm4841 UTSW 18 60271041 critical splice acceptor site probably null
R5902:Gm4841 UTSW 18 60270796 missense probably damaging 1.00
R5908:Gm4841 UTSW 18 60270434 missense possibly damaging 0.89
R6361:Gm4841 UTSW 18 60270760 missense probably damaging 1.00
R6677:Gm4841 UTSW 18 60270580 missense probably damaging 1.00
R8155:Gm4841 UTSW 18 60270337 missense probably damaging 0.97
R8334:Gm4841 UTSW 18 60270982 missense probably benign 0.00
Predicted Primers
Posted On2016-07-22