Incidental Mutation 'R5274:Or5p64'
ID 403824
Institutional Source Beutler Lab
Gene Symbol Or5p64
Ensembl Gene ENSMUSG00000096465
Gene Name olfactory receptor family 5 subfamily P member 64
Synonyms Olfr488, MOR204-15, GA_x6K02T2PBJ9-10586187-10585243
MMRRC Submission 042837-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.258) question?
Stock # R5274 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 107854399-107855343 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 107854842 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 168 (F168I)
Ref Sequence ENSEMBL: ENSMUSP00000149427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072968] [ENSMUST00000211345] [ENSMUST00000211508] [ENSMUST00000215173]
AlphaFold Q8VG02
Predicted Effect probably benign
Transcript: ENSMUST00000072968
AA Change: F168I

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000072735
Gene: ENSMUSG00000096465
AA Change: F168I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.7e-53 PFAM
Pfam:7tm_1 44 293 2.6e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211345
AA Change: F168I
Predicted Effect probably benign
Transcript: ENSMUST00000211508
AA Change: F168I

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000215173
AA Change: F168I

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 98.0%
  • 20x: 96.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik C T 4: 103,092,856 (GRCm39) R155H probably benign Het
Ace T C 11: 105,858,863 (GRCm39) M19T probably benign Het
Agl A G 3: 116,566,135 (GRCm39) L995P probably damaging Het
AY761185 T C 8: 21,433,889 (GRCm39) N90S unknown Het
Brca2 T C 5: 150,463,154 (GRCm39) S973P probably benign Het
Cacna1e T C 1: 154,576,250 (GRCm39) T66A probably damaging Het
Cbarp T C 10: 79,967,649 (GRCm39) S531G possibly damaging Het
Cby2 A G 14: 75,820,666 (GRCm39) V362A probably benign Het
Cd96 G T 16: 45,890,066 (GRCm39) T319K possibly damaging Het
Ceacam23 T C 7: 17,649,642 (GRCm39) probably null Het
Chil5 A C 3: 105,936,169 (GRCm39) F41C probably damaging Het
Col24a1 A C 3: 145,190,433 (GRCm39) E1239D probably benign Het
Dip2b A G 15: 100,109,985 (GRCm39) E1490G possibly damaging Het
Dync1li1 T C 9: 114,544,273 (GRCm39) V315A possibly damaging Het
Dync2h1 T C 9: 7,116,540 (GRCm39) S99G probably benign Het
Dynlt5 A T 4: 102,859,768 (GRCm39) T103S possibly damaging Het
E2f8 C T 7: 48,516,925 (GRCm39) R818H probably damaging Het
Eomes T C 9: 118,309,597 (GRCm39) V250A probably damaging Het
Esyt3 T C 9: 99,200,350 (GRCm39) T615A probably benign Het
Fbxo38 A T 18: 62,648,140 (GRCm39) D799E probably damaging Het
Fdft1 A G 14: 63,389,792 (GRCm39) F288S probably damaging Het
Gm14325 G A 2: 177,474,777 (GRCm39) H102Y possibly damaging Het
Gm4871 C G 5: 144,967,180 (GRCm39) E185Q probably damaging Het
Gm5901 C A 7: 105,026,655 (GRCm39) P141Q probably damaging Het
Herc1 T A 9: 66,306,691 (GRCm39) I933N probably benign Het
Ifih1 T C 2: 62,442,062 (GRCm39) Q385R probably benign Het
Ighmbp2 T C 19: 3,315,518 (GRCm39) E634G probably damaging Het
Klk6 C G 7: 43,478,553 (GRCm39) probably null Het
Kmt2d A G 15: 98,752,111 (GRCm39) probably benign Het
Lig3 T A 11: 82,688,118 (GRCm39) probably null Het
Lrp1b T C 2: 41,234,456 (GRCm39) D310G probably null Het
Mroh6 A G 15: 75,756,849 (GRCm39) V571A possibly damaging Het
Olfm5 A G 7: 103,809,190 (GRCm39) S132P probably damaging Het
Or52n20 T C 7: 104,320,733 (GRCm39) S275P probably damaging Het
Pacc1 T C 1: 191,080,665 (GRCm39) V295A probably damaging Het
Patj G C 4: 98,407,218 (GRCm39) S4T probably damaging Het
Pcdhga12 T A 18: 37,899,475 (GRCm39) C102* probably null Het
Pik3ap1 T C 19: 41,270,391 (GRCm39) D766G possibly damaging Het
Plch2 A T 4: 155,083,411 (GRCm39) L408Q probably damaging Het
Pnma2 G T 14: 67,154,209 (GRCm39) R211L probably damaging Het
Prkg2 T A 5: 99,117,850 (GRCm39) H468L probably damaging Het
Rad1 T A 15: 10,488,059 (GRCm39) probably null Het
Rims3 A G 4: 120,748,571 (GRCm39) D264G probably damaging Het
Rnf123 AT ATT 9: 107,941,202 (GRCm39) probably null Het
Rrm2 T A 12: 24,760,406 (GRCm39) Y75* probably null Het
Sall3 T C 18: 81,013,052 (GRCm39) N1128S probably benign Het
Slc26a5 T C 5: 22,018,899 (GRCm39) T610A possibly damaging Het
Snx29 G T 16: 11,556,268 (GRCm39) E766D probably damaging Het
Sox17 A G 1: 4,562,111 (GRCm39) V298A possibly damaging Het
Ss18 G A 18: 14,774,106 (GRCm39) Q228* probably null Het
Tas2r121 A G 6: 132,677,811 (GRCm39) S54P probably damaging Het
Ttc21b T C 2: 66,066,627 (GRCm39) E342G possibly damaging Het
Ubap2l A G 3: 89,920,037 (GRCm39) Y818H probably damaging Het
Usp15 C A 10: 123,004,256 (GRCm39) R166I probably damaging Het
Vmn1r34 T G 6: 66,614,123 (GRCm39) H205P probably damaging Het
Vmn2r22 A T 6: 123,627,593 (GRCm39) M1K probably null Het
Vps51 T G 19: 6,121,063 (GRCm39) E283D probably benign Het
Zdhhc1 T C 8: 106,210,402 (GRCm39) N5S probably benign Het
Zfp758 T A 17: 22,594,836 (GRCm39) C441S probably benign Het
Zp2 T C 7: 119,737,315 (GRCm39) E291G possibly damaging Het
Other mutations in Or5p64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Or5p64 APN 7 107,854,742 (GRCm39) missense possibly damaging 0.89
IGL02510:Or5p64 APN 7 107,855,348 (GRCm39) utr 5 prime probably benign
IGL02943:Or5p64 APN 7 107,854,623 (GRCm39) missense possibly damaging 0.80
IGL02962:Or5p64 APN 7 107,854,910 (GRCm39) missense possibly damaging 0.78
PIT4472001:Or5p64 UTSW 7 107,855,310 (GRCm39) missense possibly damaging 0.46
R0980:Or5p64 UTSW 7 107,855,229 (GRCm39) small deletion probably benign
R0981:Or5p64 UTSW 7 107,855,229 (GRCm39) small deletion probably benign
R0981:Or5p64 UTSW 7 107,855,228 (GRCm39) small deletion probably benign
R1957:Or5p64 UTSW 7 107,854,403 (GRCm39) nonsense probably null
R3147:Or5p64 UTSW 7 107,854,883 (GRCm39) missense possibly damaging 0.89
R4163:Or5p64 UTSW 7 107,855,039 (GRCm39) missense probably benign 0.06
R4190:Or5p64 UTSW 7 107,855,330 (GRCm39) missense probably benign
R4911:Or5p64 UTSW 7 107,855,244 (GRCm39) missense possibly damaging 0.81
R5684:Or5p64 UTSW 7 107,855,246 (GRCm39) missense possibly damaging 0.75
R6394:Or5p64 UTSW 7 107,854,970 (GRCm39) missense possibly damaging 0.95
R6467:Or5p64 UTSW 7 107,855,109 (GRCm39) missense probably damaging 0.99
R7173:Or5p64 UTSW 7 107,854,955 (GRCm39) missense possibly damaging 0.78
R7317:Or5p64 UTSW 7 107,854,425 (GRCm39) missense probably benign 0.00
R7348:Or5p64 UTSW 7 107,855,330 (GRCm39) missense probably benign
R7485:Or5p64 UTSW 7 107,855,045 (GRCm39) missense probably damaging 1.00
R9358:Or5p64 UTSW 7 107,854,799 (GRCm39) missense probably damaging 0.99
R9715:Or5p64 UTSW 7 107,855,198 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- AGTGGAGCGCATCTTTAGG -3'
(R):5'- TGTGGCATTCAGCTCAGCTC -3'

Sequencing Primer
(F):5'- TCTTTAGGATGGTGATGAGGATATAG -3'
(R):5'- AGCTGCTCTCTTTGGGACAC -3'
Posted On 2016-07-22