|Institutional Source||Beutler Lab|
|Gene Name||exocyst complex component 5|
|Synonyms||Sec10l1, SEC10, PRO1912|
|Is this an essential gene?||Probably essential (E-score: 0.951)|
|Stock #||R4794 (G1)|
|Chromosomal Location||49004090-49066653 bp(-) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||T to C at 49048900 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000125434 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000161504] [ENSMUST00000162175]|
|Meta Mutation Damage Score||0.9502|
|Coding Region Coverage||
|Validation Efficiency||97% (75/77)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in all cells die prior to E8.5. Mice homozygous for a conditional allele activated in kidney cells exhibit ureteropelvic junction obstructions leading to neontal death. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Exoc5||
(F):5'- TGGCAATGCTTACCTTTTCAG -3'
(R):5'- GTGGTATCAAAGTTAGAAGCTTGG -3'
(F):5'- GGCAATGCTTACCTTTTCAGAATTTG -3'
(R):5'- TCAAAGTTAGAAGCTTGGTTAAGAG -3'