Incidental Mutation 'R5302:Il17rc'
ID 404297
Institutional Source Beutler Lab
Gene Symbol Il17rc
Ensembl Gene ENSMUSG00000030281
Gene Name interleukin 17 receptor C
Synonyms 1110025H02Rik, Il17rl, IL17-RL
MMRRC Submission 042885-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R5302 (G1)
Quality Score 200
Status Not validated
Chromosome 6
Chromosomal Location 113448416-113460124 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 113459997 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 648 (A648S)
Ref Sequence ENSEMBL: ENSMUSP00000055343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032422] [ENSMUST00000058300]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000032422
SMART Domains Protein: ENSMUSP00000032422
Gene: ENSMUSG00000030284

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Pfam:DUF3456 45 103 1.7e-9 PFAM
EGF 154 193 2.11e1 SMART
FU 208 255 1.66e-1 SMART
EGF 213 244 2.2e1 SMART
EGF_like 245 290 4.26e-3 SMART
FU 268 315 4.46e-2 SMART
EGF_CA 305 344 1.1e-7 SMART
transmembrane domain 363 382 N/A INTRINSIC
transmembrane domain 387 406 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000058300
AA Change: A648S

PolyPhen 2 Score 0.709 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000055343
Gene: ENSMUSG00000030281
AA Change: A648S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:IL17_R_N 71 190 2.8e-45 PFAM
Pfam:IL17_R_N 189 432 1.3e-93 PFAM
transmembrane domain 441 460 N/A INTRINSIC
Pfam:SEFIR 473 623 7.7e-41 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135852
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147932
Predicted Effect not run
Transcript: ENSMUST00000149899
AA Change: A552S
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156764
Predicted Effect probably benign
Transcript: ENSMUST00000205208
AA Change: A552S

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203668
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a reporter allele exhibit increased interleukin-17 secretion, reduced chemokine expression, and decreased susceptibility to experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,323,111 (GRCm39) V1657A possibly damaging Het
Abca8b C A 11: 109,868,639 (GRCm39) G175V probably damaging Het
Acot5 A G 12: 84,120,215 (GRCm39) Y190C probably damaging Het
Ascc3 T A 10: 50,583,873 (GRCm39) Y941N probably benign Het
BC035947 A T 1: 78,488,599 (GRCm39) M1K probably null Het
C2cd5 A G 6: 143,019,482 (GRCm39) C278R probably benign Het
Cd200r1 G T 16: 44,613,172 (GRCm39) L259F possibly damaging Het
Clcn4 A G 7: 7,297,050 (GRCm39) V136A possibly damaging Het
Cntnap5a T C 1: 116,085,300 (GRCm39) S413P probably benign Het
Corin T A 5: 72,473,441 (GRCm39) E748D probably benign Het
Crtc2 G T 3: 90,168,325 (GRCm39) G356V probably damaging Het
D1Pas1 T A 1: 186,701,642 (GRCm39) Y524N probably damaging Het
Dlgap4 T C 2: 156,602,818 (GRCm39) S147P probably damaging Het
Eif1ad16 T A 12: 87,985,316 (GRCm39) I76F probably damaging Het
Enpp1 A T 10: 24,527,288 (GRCm39) I633N probably benign Het
Gm3095 A G 14: 15,170,367 (GRCm39) D72G probably null Het
Gm5449 C T 13: 53,679,787 (GRCm39) noncoding transcript Het
Gpx7 T C 4: 108,258,111 (GRCm39) T161A probably benign Het
Grip1 T C 10: 119,855,982 (GRCm39) L236P probably damaging Het
H2-Q2 G T 17: 35,563,885 (GRCm39) R255S probably damaging Het
Klhl12 A G 1: 134,417,189 (GRCm39) E540G possibly damaging Het
Mcm10 T C 2: 5,012,181 (GRCm39) I135V probably benign Het
Mrps26 C A 2: 130,406,087 (GRCm39) T100K probably benign Het
Nid2 A G 14: 19,829,769 (GRCm39) T687A probably benign Het
Npas3 A T 12: 54,115,619 (GRCm39) D829V probably damaging Het
Ocln T C 13: 100,642,807 (GRCm39) D176G probably damaging Het
Or11h6 A G 14: 50,879,776 (GRCm39) probably null Het
Pax3 A C 1: 78,098,249 (GRCm39) M380R possibly damaging Het
Pcdha3 A G 18: 37,081,208 (GRCm39) E650G probably damaging Het
Pdcd11 C A 19: 47,096,083 (GRCm39) H668N probably damaging Het
Polr3b T C 10: 84,535,264 (GRCm39) Y858H possibly damaging Het
Pus10 T C 11: 23,617,416 (GRCm39) probably null Het
Raver1 T C 9: 20,986,677 (GRCm39) D739G probably damaging Het
Skic3 G A 13: 76,295,886 (GRCm39) E1050K possibly damaging Het
Slc26a11 T C 11: 119,254,276 (GRCm39) L198P probably damaging Het
Slc44a3 A G 3: 121,303,962 (GRCm39) V258A probably damaging Het
Socs7 T A 11: 97,280,025 (GRCm39) I524N probably damaging Het
Steap4 T A 5: 8,025,547 (GRCm39) L36* probably null Het
Svep1 G C 4: 58,096,183 (GRCm39) T1479S possibly damaging Het
Ttn C A 2: 76,547,619 (GRCm39) V32184F probably damaging Het
Vmn1r22 T C 6: 57,877,960 (GRCm39) N6D possibly damaging Het
Other mutations in Il17rc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00497:Il17rc APN 6 113,451,132 (GRCm39) missense probably damaging 0.96
IGL03192:Il17rc APN 6 113,449,846 (GRCm39) missense probably damaging 1.00
R1462:Il17rc UTSW 6 113,455,950 (GRCm39) missense probably damaging 1.00
R1462:Il17rc UTSW 6 113,455,950 (GRCm39) missense probably damaging 1.00
R4075:Il17rc UTSW 6 113,458,158 (GRCm39) missense possibly damaging 0.82
R5025:Il17rc UTSW 6 113,449,327 (GRCm39) missense possibly damaging 0.62
R5052:Il17rc UTSW 6 113,449,284 (GRCm39) missense probably damaging 1.00
R5148:Il17rc UTSW 6 113,459,958 (GRCm39) missense probably benign 0.19
R5977:Il17rc UTSW 6 113,459,692 (GRCm39) missense probably damaging 0.98
R6275:Il17rc UTSW 6 113,457,308 (GRCm39) missense probably benign 0.00
R7010:Il17rc UTSW 6 113,456,249 (GRCm39) missense possibly damaging 0.86
R8031:Il17rc UTSW 6 113,459,782 (GRCm39) missense probably damaging 1.00
R8138:Il17rc UTSW 6 113,459,500 (GRCm39) missense probably damaging 1.00
R8160:Il17rc UTSW 6 113,453,489 (GRCm39) missense possibly damaging 0.94
R8209:Il17rc UTSW 6 113,449,771 (GRCm39) missense probably benign 0.01
R8890:Il17rc UTSW 6 113,456,031 (GRCm39) missense probably damaging 1.00
R9310:Il17rc UTSW 6 113,451,210 (GRCm39) missense probably damaging 1.00
R9347:Il17rc UTSW 6 113,457,780 (GRCm39) critical splice donor site probably null
R9350:Il17rc UTSW 6 113,456,048 (GRCm39) missense probably damaging 0.96
R9369:Il17rc UTSW 6 113,449,641 (GRCm39) missense probably benign
R9495:Il17rc UTSW 6 113,449,741 (GRCm39) missense probably damaging 1.00
R9514:Il17rc UTSW 6 113,449,741 (GRCm39) missense probably damaging 1.00
R9794:Il17rc UTSW 6 113,453,726 (GRCm39) missense probably benign 0.14
Z1176:Il17rc UTSW 6 113,453,756 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TACCCGATTTCCTGCAAGG -3'
(R):5'- ACCTGTCCGGGCTTTAAAG -3'

Sequencing Primer
(F):5'- TACGTCGGGGTCTACTTCGAC -3'
(R):5'- TCCGGGCTTTAAAGGGCAG -3'
Posted On 2016-07-22