Incidental Mutation 'R5303:Zfp850'
ID 404349
Institutional Source Beutler Lab
Gene Symbol Zfp850
Ensembl Gene ENSMUSG00000096916
Gene Name zinc finger protein 850
Synonyms C130069I09Rik, Gm4636
MMRRC Submission 042886-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R5303 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 27684279-27713540 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 27707838 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 2 (A2T)
Ref Sequence ENSEMBL: ENSMUSP00000141063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000180024] [ENSMUST00000180502]
AlphaFold J3QPC5
Predicted Effect probably damaging
Transcript: ENSMUST00000180024
AA Change: A2T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000137192
Gene: ENSMUSG00000096916
AA Change: A2T

DomainStartEndE-ValueType
KRAB 14 75 1.56e-34 SMART
ZnF_C2H2 172 194 7.18e1 SMART
ZnF_C2H2 200 222 3.63e-3 SMART
ZnF_C2H2 228 250 8.94e-3 SMART
ZnF_C2H2 256 278 7.49e-5 SMART
ZnF_C2H2 313 335 1.01e-1 SMART
ZnF_C2H2 341 363 4.4e-2 SMART
ZnF_C2H2 369 391 7.37e-4 SMART
ZnF_C2H2 397 419 8.47e-4 SMART
ZnF_C2H2 425 447 1.92e-2 SMART
ZnF_C2H2 453 475 2.99e-4 SMART
ZnF_C2H2 481 503 7.78e-3 SMART
ZnF_C2H2 509 531 1.95e-3 SMART
ZnF_C2H2 537 559 1.92e-2 SMART
ZnF_C2H2 565 587 2.99e-4 SMART
ZnF_C2H2 593 615 1.79e-2 SMART
ZnF_C2H2 621 643 7.37e-4 SMART
ZnF_C2H2 649 671 4.4e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000180502
AA Change: A2T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000141063
Gene: ENSMUSG00000096916
AA Change: A2T

DomainStartEndE-ValueType
KRAB 14 75 6.5e-37 SMART
ZnF_C2H2 172 194 3e-1 SMART
ZnF_C2H2 200 222 1.5e-5 SMART
ZnF_C2H2 228 250 3.8e-5 SMART
ZnF_C2H2 256 274 2.5e-1 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C G 3: 124,199,999 (GRCm39) G531A probably damaging Het
4921504E06Rik A G 2: 19,521,110 (GRCm39) Y256H possibly damaging Het
Abcc12 C A 8: 87,236,415 (GRCm39) R1133L probably benign Het
Acss3 T A 10: 106,920,712 (GRCm39) T133S possibly damaging Het
Adra1d G A 2: 131,388,169 (GRCm39) P462L possibly damaging Het
Ank2 A T 3: 126,739,453 (GRCm39) probably benign Het
Arid2 G A 15: 96,290,349 (GRCm39) R1748Q probably damaging Het
B3glct C T 5: 149,677,488 (GRCm39) probably benign Het
C3ar1 A T 6: 122,826,794 (GRCm39) S474R probably damaging Het
Cd1d1 A G 3: 86,905,427 (GRCm39) F189L probably benign Het
Cd46 T C 1: 194,744,707 (GRCm39) I344V probably benign Het
Chrna1 T C 2: 73,396,618 (GRCm39) M426V probably benign Het
Cinp G A 12: 110,843,295 (GRCm39) T139M probably damaging Het
Cplane1 G A 15: 8,290,174 (GRCm39) probably null Het
Disp2 T C 2: 118,641,329 (GRCm39) probably benign Het
Dnaaf6rt G A 1: 31,262,537 (GRCm39) R173H probably damaging Het
Eapp G A 12: 54,739,703 (GRCm39) P38L probably damaging Het
Eif4g3 T C 4: 137,853,873 (GRCm39) S480P probably benign Het
Epb41l3 G C 17: 69,564,444 (GRCm39) E390Q probably damaging Het
Fermt1 T C 2: 132,753,259 (GRCm39) probably null Het
Foxf2 T A 13: 31,810,463 (GRCm39) F134Y possibly damaging Het
Foxp2 T A 6: 15,324,636 (GRCm39) C95S probably benign Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gria1 A G 11: 57,133,851 (GRCm39) T577A probably benign Het
Hal A G 10: 93,352,227 (GRCm39) probably benign Het
Hdac7 C A 15: 97,695,899 (GRCm39) E670D probably damaging Het
Islr2 A T 9: 58,115,558 (GRCm39) probably benign Het
Itpr3 T C 17: 27,335,663 (GRCm39) Y2258H probably benign Het
Mical3 G T 6: 120,936,941 (GRCm39) T1195K probably benign Het
Myh1 T C 11: 67,092,843 (GRCm39) S46P probably benign Het
Mylk3 T A 8: 86,077,105 (GRCm39) I444F probably damaging Het
Nlrc3 A T 16: 3,781,478 (GRCm39) C644S probably benign Het
Notch1 C T 2: 26,368,631 (GRCm39) V553M probably benign Het
Or10g9 A G 9: 39,911,884 (GRCm39) I213T probably damaging Het
Or4a72 T A 2: 89,405,345 (GRCm39) I242F possibly damaging Het
Or51a43 T C 7: 103,718,239 (GRCm39) probably benign Het
Or5b102 T A 19: 13,041,139 (GRCm39) Y121* probably null Het
Postn A G 3: 54,285,018 (GRCm39) T669A probably damaging Het
Ppp5c G T 7: 16,739,209 (GRCm39) Q472K probably benign Het
Qsox1 T C 1: 155,655,039 (GRCm39) H708R probably benign Het
Rhbdl2 A G 4: 123,704,014 (GRCm39) probably benign Het
Ryr1 C T 7: 28,767,907 (GRCm39) E2884K probably damaging Het
Saysd1 T C 14: 20,133,026 (GRCm39) T44A probably benign Het
Septin14 T A 5: 129,766,712 (GRCm39) M290L possibly damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Slc38a8 C A 8: 120,212,780 (GRCm39) V294L possibly damaging Het
Spdye4b C T 5: 143,188,158 (GRCm39) T217I probably benign Het
Sugp2 T A 8: 70,694,827 (GRCm39) probably benign Het
Syne1 T C 10: 5,370,464 (GRCm39) T232A probably benign Het
Tbc1d5 A T 17: 51,043,228 (GRCm39) D753E probably benign Het
Tmed1 G T 9: 21,421,343 (GRCm39) Q44K possibly damaging Het
Ttc6 T A 12: 57,622,606 (GRCm39) S2T possibly damaging Het
Ube4b T C 4: 149,468,260 (GRCm39) D172G probably damaging Het
Vmn1r235 C A 17: 21,482,268 (GRCm39) Q198K probably benign Het
Wdfy3 T C 5: 102,100,849 (GRCm39) H256R probably damaging Het
Zfat A T 15: 67,982,335 (GRCm39) H1059Q probably damaging Het
Zfp758 A G 17: 22,593,842 (GRCm39) I77M probably benign Het
Zfyve1 A T 12: 83,621,830 (GRCm39) N188K probably damaging Het
Zyg11a C T 4: 108,041,629 (GRCm39) probably null Het
Other mutations in Zfp850
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02278:Zfp850 APN 7 27,707,822 (GRCm39) missense probably damaging 0.96
R0610:Zfp850 UTSW 7 27,688,819 (GRCm39) missense probably damaging 0.99
R0690:Zfp850 UTSW 7 27,684,642 (GRCm39) missense possibly damaging 0.67
R0711:Zfp850 UTSW 7 27,689,698 (GRCm39) missense probably benign 0.00
R1310:Zfp850 UTSW 7 27,688,884 (GRCm39) missense probably benign 0.40
R1594:Zfp850 UTSW 7 27,688,816 (GRCm39) missense probably benign 0.00
R1771:Zfp850 UTSW 7 27,684,700 (GRCm39) nonsense probably null
R2189:Zfp850 UTSW 7 27,688,480 (GRCm39) missense probably benign 0.02
R2192:Zfp850 UTSW 7 27,684,620 (GRCm39) missense probably damaging 1.00
R2417:Zfp850 UTSW 7 27,688,608 (GRCm39) missense possibly damaging 0.54
R4321:Zfp850 UTSW 7 27,688,825 (GRCm39) missense probably damaging 0.99
R4770:Zfp850 UTSW 7 27,684,411 (GRCm39) splice site probably null
R4970:Zfp850 UTSW 7 27,689,658 (GRCm39) nonsense probably null
R5112:Zfp850 UTSW 7 27,689,658 (GRCm39) nonsense probably null
R5166:Zfp850 UTSW 7 27,689,781 (GRCm39) nonsense probably null
R5315:Zfp850 UTSW 7 27,689,743 (GRCm39) missense probably benign 0.02
R5496:Zfp850 UTSW 7 27,706,771 (GRCm39) missense probably damaging 0.98
R5547:Zfp850 UTSW 7 27,688,844 (GRCm39) missense probably damaging 1.00
R5677:Zfp850 UTSW 7 27,688,513 (GRCm39) missense probably damaging 1.00
R5927:Zfp850 UTSW 7 27,689,620 (GRCm39) missense probably benign 0.17
R6654:Zfp850 UTSW 7 27,684,640 (GRCm39) nonsense probably null
R6950:Zfp850 UTSW 7 27,689,939 (GRCm39) missense possibly damaging 0.86
R6987:Zfp850 UTSW 7 27,689,426 (GRCm39) missense probably damaging 1.00
R6990:Zfp850 UTSW 7 27,689,801 (GRCm39) missense probably benign 0.09
R7640:Zfp850 UTSW 7 27,688,634 (GRCm39) missense probably benign 0.05
R7856:Zfp850 UTSW 7 27,689,899 (GRCm39) missense probably benign 0.02
R9498:Zfp850 UTSW 7 27,689,275 (GRCm39) missense possibly damaging 0.88
R9506:Zfp850 UTSW 7 27,688,987 (GRCm39) missense possibly damaging 0.82
Z1186:Zfp850 UTSW 7 27,689,704 (GRCm39) missense probably benign 0.00
Z1186:Zfp850 UTSW 7 27,688,549 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CACAGACAGGAAGTGCTCAGAC -3'
(R):5'- AGCTTAGTTGATACAATCTACGCTG -3'

Sequencing Primer
(F):5'- AAGTGCTCAGACCTGCCAG -3'
(R):5'- CCAAGAGCTCTCTGCATTTGAGAATG -3'
Posted On 2016-07-22