Mutagenetix > Incidental Mutation

Incidental Mutation 'R5305:Gm7535'

404531

Institutional Source

Beutler Lab

Gene Symbol

Gm7535

Ensembl Gene

ENSMUSG00000090957

Gene Name

predicted gene 7535

Synonyms

MMRRC Submission

042888-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.307) question?

Stock #

R5305 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

17911039-17911947 bp(-) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to C at 17911799 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093316 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054871] [ENSMUST00000164167]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000054871

SMART Domains

Protein: ENSMUSP00000093316
Gene: ENSMUSG00000079700

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	302	2.2e-43	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000164167

SMART Domains

Protein: ENSMUSP00000125897
Gene: ENSMUSG00000090957

Domain	Start	End	E-Value	Type
Pfam:CNDH2_C	15	292	6.7e-90	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231820

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.4%

Validation Efficiency

99% (67/68)

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	G	A	15: 82,059,219	V11M	possibly damaging	Het
Acot8	A	G	2: 164,795,765	V179A	probably benign	Het
Actb	A	G	5: 142,904,230	I194T	probably benign	Het
Ap1g2	A	G	14: 55,099,076	V787A	probably benign	Het
Areg	G	T	5: 91,144,449	A203S	probably damaging	Het
Asb13	A	T	13: 3,643,479	D79V	probably damaging	Het
Atad2b	C	T	12: 4,965,855	T527I	probably damaging	Het
Auts2	T	G	5: 131,443,794		probably benign	Het
Ceacam3	T	A	7: 17,151,576	S35T	probably damaging	Het
Crebzf	T	C	7: 90,444,134		probably benign	Het
Cttnbp2	G	T	6: 18,381,098	N1366K	probably benign	Het
Cubn	C	A	2: 13,388,939	C1417F	probably damaging	Het
Dot1l	C	T	10: 80,790,793	P162S	probably benign	Het
Epc1	G	A	18: 6,490,690		probably benign	Het
Eps8l1	A	G	7: 4,477,896	S613G	possibly damaging	Het
Erich6	T	G	3: 58,625,116	I357L	probably benign	Het
Foxj3	T	A	4: 119,619,958	S288T	possibly damaging	Het
Gls2	T	G	10: 128,204,709	Y326*	probably null	Het
Gm11595	G	A	11: 99,772,555	R100C	unknown	Het
Gxylt2	T	G	6: 100,787,218	L288R	probably damaging	Het
Kdm4a	T	C	4: 118,160,501	Y456C	probably damaging	Het
Mgat4c	T	A	10: 102,389,279	F451L	possibly damaging	Het
Mrpl20	G	A	4: 155,803,705	R17H	probably damaging	Het
Mtf2	A	G	5: 108,104,499	T465A	possibly damaging	Het
Mycbp2	A	C	14: 103,346,321	L66R	probably benign	Het
Nos1ap	T	A	1: 170,349,399	K145M	probably damaging	Het
Nr2e1	A	T	10: 42,571,487	Y176*	probably null	Het
Obscn	T	C	11: 59,012,715	T7628A	possibly damaging	Het
Olfr1353	A	T	10: 78,970,556	K302N	possibly damaging	Het
Pitx2	T	G	3: 129,215,840	V129G	probably damaging	Het
Polr2e	A	G	10: 80,038,063		probably benign	Het
Ppard	A	G	17: 28,298,858	D300G	probably damaging	Het
Ppp1r27	A	G	11: 120,550,917	V46A	probably benign	Het
Prex2	T	A	1: 11,107,678	V332E	probably damaging	Het
Prss30	T	G	17: 23,972,776	Y257S	probably benign	Het
Ptprd	T	C	4: 75,982,626	E1082G	probably damaging	Het
Rab3c	T	A	13: 110,181,077	R89S	probably damaging	Het
Rimbp2	A	G	5: 128,797,381	V389A	possibly damaging	Het
Rims1	T	A	1: 22,596,542	R119S	probably damaging	Het
Sema3b	T	C	9: 107,603,337	H137R	probably null	Het
Sf3b4	G	C	3: 96,173,642	A89P	probably damaging	Het
Sgta	T	A	10: 81,046,247	Q298L	probably damaging	Het
Spag9	C	A	11: 94,069,012	D342E	probably damaging	Het
Sry	T	A	Y: 2,662,982	D226V	unknown	Het
Sv2a	A	G	3: 96,185,458	E158G	possibly damaging	Het
Sytl2	A	G	7: 90,381,863		probably benign	Het
Thbs3	T	A	3: 89,217,976		probably benign	Het
Top3a	A	T	11: 60,762,539	N56K	possibly damaging	Het
Ttc37	G	A	13: 76,147,767	E1050K	possibly damaging	Het
Tyk2	T	C	9: 21,109,381	D918G	probably damaging	Het
Uqcrh	A	G	4: 116,067,284		probably benign	Het
Vmn1r61	A	G	7: 5,610,815	S167P	probably damaging	Het
Wdr25	C	A	12: 109,026,440	H74N	probably damaging	Het
Zfp458	T	C	13: 67,256,318	N686D	probably benign	Het
Zfp574	T	A	7: 25,081,090	H512Q		Het
Zfp976	A	T	7: 42,613,478	Y312N	probably benign	Het
Zscan4c	G	A	7: 11,009,535	V354I	probably benign	Het

Other mutations in Gm7535

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00422:Gm7535	APN	17	17911888	intron	probably benign
IGL01663:Gm7535	APN	17	17911357	intron	probably benign
R0165:Gm7535	UTSW	17	17911175	intron	probably benign
R0335:Gm7535	UTSW	17	17911112	intron	probably benign
R1985:Gm7535	UTSW	17	17911538	intron	probably benign
R2217:Gm7535	UTSW	17	17911674	intron	probably benign
R2218:Gm7535	UTSW	17	17911674	intron	probably benign
R4464:Gm7535	UTSW	17	17911662	intron	probably benign
R4581:Gm7535	UTSW	17	17911083	intron	probably benign
R4887:Gm7535	UTSW	17	17911071	intron	probably benign
R5225:Gm7535	UTSW	17	17911547	intron	probably benign
R5641:Gm7535	UTSW	17	17911526	intron	probably benign
R5658:Gm7535	UTSW	17	17911320	intron	probably benign
R5760:Gm7535	UTSW	17	17911818	intron	probably benign

Predicted Primers

PCR Primer
(F):5'- TAGGCCACAGATCCTGCTTG -3'
(R):5'- ATCTTGCCAAGGAGATACATGC -3'

Sequencing Primer
(F):5'- GCCCCAGGTAGCCATCTCTTG -3'
(R):5'- AGATACATGCTAAGGGGCCCC -3'

Posted On

2016-07-22