Incidental Mutation 'R5306:Vmn2r52'
ID 404559
Institutional Source Beutler Lab
Gene Symbol Vmn2r52
Ensembl Gene ENSMUSG00000091930
Gene Name vomeronasal 2, receptor 52
Synonyms EG384534
MMRRC Submission 042889-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5306 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 9892579-9910213 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 9904672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Arginine at position 389 (I389R)
Ref Sequence ENSEMBL: ENSMUSP00000129352 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164918]
AlphaFold L7N2B2
Predicted Effect possibly damaging
Transcript: ENSMUST00000164918
AA Change: I389R

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000129352
Gene: ENSMUSG00000091930
AA Change: I389R

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 8.1e-29 PFAM
Pfam:NCD3G 512 565 1.5e-19 PFAM
Pfam:7tm_3 596 833 1.1e-55 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 97% (64/66)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam29 T A 8: 56,324,792 (GRCm39) D554V probably damaging Het
Ankrd44 G A 1: 54,965,362 (GRCm39) probably benign Het
Api5 A T 2: 94,253,811 (GRCm39) C297* probably null Het
Asb14 G A 14: 26,633,866 (GRCm39) C357Y probably damaging Het
Brd10 A G 19: 29,707,230 (GRCm39) probably benign Het
Brdt T A 5: 107,493,010 (GRCm39) D112E probably damaging Het
Capsl C A 15: 9,457,876 (GRCm39) Q32K probably benign Het
Ccdc106 A G 7: 5,061,096 (GRCm39) D81G probably damaging Het
Ccdc121rt3 T C 5: 112,502,910 (GRCm39) R265G probably benign Het
Cep104 C A 4: 154,090,699 (GRCm39) T884K probably benign Het
Cmbl T C 15: 31,582,215 (GRCm39) Y71H probably damaging Het
Crybg3 A T 16: 59,380,356 (GRCm39) probably benign Het
Dynlt1c T C 17: 6,869,210 (GRCm39) M1T probably null Het
Erbb2 T C 11: 98,319,032 (GRCm39) S574P probably benign Het
Exosc10 T C 4: 148,646,849 (GRCm39) V153A probably benign Het
Faxc G T 4: 21,931,557 (GRCm39) probably benign Het
Fcgbp A G 7: 27,791,243 (GRCm39) T835A probably damaging Het
Fmo5 G T 3: 97,549,076 (GRCm39) M241I probably benign Het
Gabra1 A C 11: 42,024,379 (GRCm39) I432S probably benign Het
Gfap A G 11: 102,786,574 (GRCm39) probably null Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm12185 T A 11: 48,806,382 (GRCm39) M270L probably benign Het
Gm14443 T C 2: 175,011,372 (GRCm39) N358S possibly damaging Het
Gpr3 C T 4: 132,938,490 (GRCm39) V61M probably damaging Het
Herc2 C T 7: 55,834,709 (GRCm39) T3229M probably damaging Het
Ifit3 A G 19: 34,565,207 (GRCm39) Y251C probably damaging Het
Inf2 G A 12: 112,567,987 (GRCm39) V180I probably benign Het
Ints11 T C 4: 155,959,665 (GRCm39) Y91H probably damaging Het
Ints4 A C 7: 97,158,885 (GRCm39) D419A probably damaging Het
Kmt2e T C 5: 23,704,331 (GRCm39) S1175P probably damaging Het
Mki67 A T 7: 135,315,730 (GRCm39) V44E probably damaging Het
Mrgprb13 A T 7: 47,961,940 (GRCm39) noncoding transcript Het
Myh2 T C 11: 67,077,382 (GRCm39) L839P probably damaging Het
Nos1ap T A 1: 170,176,968 (GRCm39) K145M probably damaging Het
Or4l1 A G 14: 50,167,007 (GRCm39) probably benign Het
Or6c70 A C 10: 129,709,810 (GRCm39) I272R probably damaging Het
Pced1a T A 2: 130,261,091 (GRCm39) H422L probably benign Het
Plpp1 G T 13: 112,988,089 (GRCm39) probably null Het
Plxna4 T C 6: 32,183,056 (GRCm39) Y949C probably damaging Het
Polg2 G A 11: 106,669,796 (GRCm39) T158I probably damaging Het
Prss38 A T 11: 59,263,821 (GRCm39) I297K probably benign Het
Psph A G 5: 129,846,431 (GRCm39) L98P probably damaging Het
Rab11b G A 17: 33,979,243 (GRCm39) probably benign Het
Rsf1 CGGCGGC CGGCGGCGGGGGCGGC 7: 97,229,136 (GRCm39) probably benign Het
Serpine3 G A 14: 62,908,382 (GRCm39) A137T probably damaging Het
Sh3bp4 T C 1: 89,071,997 (GRCm39) F282L probably damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Skic3 G A 13: 76,295,886 (GRCm39) E1050K possibly damaging Het
Slco2b1 T A 7: 99,338,198 (GRCm39) Y109F possibly damaging Het
Slfn10-ps T A 11: 82,926,355 (GRCm39) noncoding transcript Het
Smc5 A G 19: 23,237,009 (GRCm39) probably null Het
Smyd4 A G 11: 75,292,984 (GRCm39) N638S probably benign Het
Stxbp5 T C 10: 9,675,735 (GRCm39) E628G probably damaging Het
Tmem236 A T 2: 14,223,975 (GRCm39) K255* probably null Het
Ttc29 T A 8: 78,978,539 (GRCm39) probably null Het
Tyr A G 7: 87,087,222 (GRCm39) I430T probably damaging Het
Uckl1 A G 2: 181,216,160 (GRCm39) probably null Het
Wdr62 A T 7: 29,964,688 (GRCm39) F352Y possibly damaging Het
Wdr70 T C 15: 7,953,754 (GRCm39) D379G probably benign Het
Zfp408 T A 2: 91,476,690 (GRCm39) M155L probably benign Het
Zfp459 T A 13: 67,561,249 (GRCm39) Q66H probably damaging Het
Zfp870 C A 17: 33,102,627 (GRCm39) G234V probably damaging Het
Other mutations in Vmn2r52
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Vmn2r52 APN 7 9,903,023 (GRCm39) missense probably benign 0.30
IGL00328:Vmn2r52 APN 7 9,905,344 (GRCm39) missense probably benign 0.12
IGL00980:Vmn2r52 APN 7 9,905,017 (GRCm39) missense probably damaging 1.00
IGL01468:Vmn2r52 APN 7 9,892,868 (GRCm39) missense probably damaging 1.00
IGL01660:Vmn2r52 APN 7 9,893,107 (GRCm39) missense probably damaging 0.97
IGL02215:Vmn2r52 APN 7 9,905,029 (GRCm39) missense probably damaging 0.97
IGL03030:Vmn2r52 APN 7 9,892,799 (GRCm39) missense probably benign 0.12
IGL03212:Vmn2r52 APN 7 9,893,474 (GRCm39) missense possibly damaging 0.47
FR4589:Vmn2r52 UTSW 7 9,892,947 (GRCm39) missense probably damaging 0.97
PIT4283001:Vmn2r52 UTSW 7 9,904,756 (GRCm39) missense possibly damaging 0.89
R0184:Vmn2r52 UTSW 7 9,893,265 (GRCm39) missense probably damaging 1.00
R0190:Vmn2r52 UTSW 7 9,905,315 (GRCm39) missense probably benign 0.00
R0240:Vmn2r52 UTSW 7 9,893,327 (GRCm39) missense probably damaging 0.99
R0240:Vmn2r52 UTSW 7 9,893,327 (GRCm39) missense probably damaging 0.99
R0257:Vmn2r52 UTSW 7 9,904,982 (GRCm39) nonsense probably null
R0310:Vmn2r52 UTSW 7 9,893,393 (GRCm39) missense probably damaging 1.00
R1831:Vmn2r52 UTSW 7 9,893,415 (GRCm39) missense probably damaging 1.00
R1862:Vmn2r52 UTSW 7 9,907,333 (GRCm39) missense possibly damaging 0.94
R2484:Vmn2r52 UTSW 7 9,903,058 (GRCm39) missense probably damaging 0.96
R2510:Vmn2r52 UTSW 7 9,904,795 (GRCm39) missense probably benign
R3625:Vmn2r52 UTSW 7 9,893,105 (GRCm39) missense probably damaging 1.00
R3803:Vmn2r52 UTSW 7 9,907,439 (GRCm39) missense probably damaging 1.00
R4013:Vmn2r52 UTSW 7 9,904,603 (GRCm39) missense probably benign 0.00
R4283:Vmn2r52 UTSW 7 9,904,565 (GRCm39) missense possibly damaging 0.60
R4324:Vmn2r52 UTSW 7 9,904,940 (GRCm39) missense possibly damaging 0.94
R4578:Vmn2r52 UTSW 7 9,904,617 (GRCm39) missense probably damaging 1.00
R4806:Vmn2r52 UTSW 7 9,893,169 (GRCm39) missense probably damaging 1.00
R5083:Vmn2r52 UTSW 7 9,893,392 (GRCm39) nonsense probably null
R5249:Vmn2r52 UTSW 7 9,910,197 (GRCm39) missense probably benign
R5332:Vmn2r52 UTSW 7 9,903,052 (GRCm39) missense probably benign 0.17
R5617:Vmn2r52 UTSW 7 9,904,861 (GRCm39) missense probably damaging 0.99
R5643:Vmn2r52 UTSW 7 9,905,059 (GRCm39) missense probably damaging 1.00
R5749:Vmn2r52 UTSW 7 9,892,959 (GRCm39) missense probably damaging 1.00
R5763:Vmn2r52 UTSW 7 9,905,231 (GRCm39) missense probably benign 0.01
R6103:Vmn2r52 UTSW 7 9,905,327 (GRCm39) missense probably benign 0.36
R6148:Vmn2r52 UTSW 7 9,905,090 (GRCm39) missense probably benign 0.00
R6356:Vmn2r52 UTSW 7 9,902,926 (GRCm39) missense probably benign 0.01
R6412:Vmn2r52 UTSW 7 9,904,936 (GRCm39) missense probably benign
R6657:Vmn2r52 UTSW 7 9,893,090 (GRCm39) missense probably damaging 0.99
R6997:Vmn2r52 UTSW 7 9,902,998 (GRCm39) missense probably benign 0.06
R7395:Vmn2r52 UTSW 7 9,904,744 (GRCm39) missense probably benign 0.00
R7621:Vmn2r52 UTSW 7 9,907,274 (GRCm39) missense probably benign 0.00
R7691:Vmn2r52 UTSW 7 9,893,109 (GRCm39) missense probably damaging 0.97
R7852:Vmn2r52 UTSW 7 9,892,895 (GRCm39) missense probably damaging 1.00
R7908:Vmn2r52 UTSW 7 9,896,877 (GRCm39) missense probably benign
R7909:Vmn2r52 UTSW 7 9,896,877 (GRCm39) missense probably benign
R7912:Vmn2r52 UTSW 7 9,896,877 (GRCm39) missense probably benign
R7913:Vmn2r52 UTSW 7 9,896,877 (GRCm39) missense probably benign
R7938:Vmn2r52 UTSW 7 9,893,300 (GRCm39) missense probably benign 0.12
R8884:Vmn2r52 UTSW 7 9,892,734 (GRCm39) missense probably damaging 1.00
R9003:Vmn2r52 UTSW 7 9,905,181 (GRCm39) missense probably benign 0.07
R9140:Vmn2r52 UTSW 7 9,892,643 (GRCm39) missense probably damaging 0.99
R9141:Vmn2r52 UTSW 7 9,905,331 (GRCm39) nonsense probably null
R9500:Vmn2r52 UTSW 7 9,905,281 (GRCm39) missense probably damaging 1.00
R9562:Vmn2r52 UTSW 7 9,893,476 (GRCm39) missense probably benign 0.22
R9564:Vmn2r52 UTSW 7 9,905,182 (GRCm39) missense probably benign 0.15
R9565:Vmn2r52 UTSW 7 9,893,476 (GRCm39) missense probably benign 0.22
R9597:Vmn2r52 UTSW 7 9,904,719 (GRCm39) nonsense probably null
R9743:Vmn2r52 UTSW 7 9,904,606 (GRCm39) missense possibly damaging 0.81
Z1176:Vmn2r52 UTSW 7 9,905,127 (GRCm39) missense probably damaging 0.97
Z1177:Vmn2r52 UTSW 7 9,903,117 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GCTATGCTATTGAAGACACCAAAC -3'
(R):5'- AAAGACTTAACTCATGGCCCATTC -3'

Sequencing Primer
(F):5'- TGCTATTGAAGACACCAAACACCATC -3'
(R):5'- ACCATGGTGAGATTTCTGGC -3'
Posted On 2016-07-22