Incidental Mutation 'R5306:Zfp870'
ID 404596
Institutional Source Beutler Lab
Gene Symbol Zfp870
Ensembl Gene ENSMUSG00000095325
Gene Name zinc finger protein 870
Synonyms
MMRRC Submission 042889-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R5306 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 33098193-33110616 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 33102627 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Valine at position 234 (G234V)
Ref Sequence ENSEMBL: ENSMUSP00000136197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178401] [ENSMUST00000228075]
AlphaFold Q6NZJ3
Predicted Effect probably damaging
Transcript: ENSMUST00000178401
AA Change: G234V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000136197
Gene: ENSMUSG00000095325
AA Change: G234V

DomainStartEndE-ValueType
KRAB 3 60 1.01e-19 SMART
ZnF_C2H2 193 215 4.5e1 SMART
ZnF_C2H2 221 241 6.4e0 SMART
ZnF_C2H2 277 299 2.24e-3 SMART
ZnF_C2H2 305 327 9.58e-3 SMART
ZnF_C2H2 333 355 2.86e-1 SMART
ZnF_C2H2 361 383 6.42e-4 SMART
ZnF_C2H2 389 411 1.18e-2 SMART
ZnF_C2H2 417 439 3.89e-3 SMART
ZnF_C2H2 445 467 5.5e-3 SMART
ZnF_C2H2 473 495 4.47e-3 SMART
ZnF_C2H2 501 523 5.9e-3 SMART
ZnF_C2H2 529 551 3.11e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000228075
AA Change: G235V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228410
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 97% (64/66)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam29 T A 8: 56,324,792 (GRCm39) D554V probably damaging Het
Ankrd44 G A 1: 54,965,362 (GRCm39) probably benign Het
Api5 A T 2: 94,253,811 (GRCm39) C297* probably null Het
Asb14 G A 14: 26,633,866 (GRCm39) C357Y probably damaging Het
Brd10 A G 19: 29,707,230 (GRCm39) probably benign Het
Brdt T A 5: 107,493,010 (GRCm39) D112E probably damaging Het
Capsl C A 15: 9,457,876 (GRCm39) Q32K probably benign Het
Ccdc106 A G 7: 5,061,096 (GRCm39) D81G probably damaging Het
Ccdc121rt3 T C 5: 112,502,910 (GRCm39) R265G probably benign Het
Cep104 C A 4: 154,090,699 (GRCm39) T884K probably benign Het
Cmbl T C 15: 31,582,215 (GRCm39) Y71H probably damaging Het
Crybg3 A T 16: 59,380,356 (GRCm39) probably benign Het
Dynlt1c T C 17: 6,869,210 (GRCm39) M1T probably null Het
Erbb2 T C 11: 98,319,032 (GRCm39) S574P probably benign Het
Exosc10 T C 4: 148,646,849 (GRCm39) V153A probably benign Het
Faxc G T 4: 21,931,557 (GRCm39) probably benign Het
Fcgbp A G 7: 27,791,243 (GRCm39) T835A probably damaging Het
Fmo5 G T 3: 97,549,076 (GRCm39) M241I probably benign Het
Gabra1 A C 11: 42,024,379 (GRCm39) I432S probably benign Het
Gfap A G 11: 102,786,574 (GRCm39) probably null Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm12185 T A 11: 48,806,382 (GRCm39) M270L probably benign Het
Gm14443 T C 2: 175,011,372 (GRCm39) N358S possibly damaging Het
Gpr3 C T 4: 132,938,490 (GRCm39) V61M probably damaging Het
Herc2 C T 7: 55,834,709 (GRCm39) T3229M probably damaging Het
Ifit3 A G 19: 34,565,207 (GRCm39) Y251C probably damaging Het
Inf2 G A 12: 112,567,987 (GRCm39) V180I probably benign Het
Ints11 T C 4: 155,959,665 (GRCm39) Y91H probably damaging Het
Ints4 A C 7: 97,158,885 (GRCm39) D419A probably damaging Het
Kmt2e T C 5: 23,704,331 (GRCm39) S1175P probably damaging Het
Mki67 A T 7: 135,315,730 (GRCm39) V44E probably damaging Het
Mrgprb13 A T 7: 47,961,940 (GRCm39) noncoding transcript Het
Myh2 T C 11: 67,077,382 (GRCm39) L839P probably damaging Het
Nos1ap T A 1: 170,176,968 (GRCm39) K145M probably damaging Het
Or4l1 A G 14: 50,167,007 (GRCm39) probably benign Het
Or6c70 A C 10: 129,709,810 (GRCm39) I272R probably damaging Het
Pced1a T A 2: 130,261,091 (GRCm39) H422L probably benign Het
Plpp1 G T 13: 112,988,089 (GRCm39) probably null Het
Plxna4 T C 6: 32,183,056 (GRCm39) Y949C probably damaging Het
Polg2 G A 11: 106,669,796 (GRCm39) T158I probably damaging Het
Prss38 A T 11: 59,263,821 (GRCm39) I297K probably benign Het
Psph A G 5: 129,846,431 (GRCm39) L98P probably damaging Het
Rab11b G A 17: 33,979,243 (GRCm39) probably benign Het
Rsf1 CGGCGGC CGGCGGCGGGGGCGGC 7: 97,229,136 (GRCm39) probably benign Het
Serpine3 G A 14: 62,908,382 (GRCm39) A137T probably damaging Het
Sh3bp4 T C 1: 89,071,997 (GRCm39) F282L probably damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Skic3 G A 13: 76,295,886 (GRCm39) E1050K possibly damaging Het
Slco2b1 T A 7: 99,338,198 (GRCm39) Y109F possibly damaging Het
Slfn10-ps T A 11: 82,926,355 (GRCm39) noncoding transcript Het
Smc5 A G 19: 23,237,009 (GRCm39) probably null Het
Smyd4 A G 11: 75,292,984 (GRCm39) N638S probably benign Het
Stxbp5 T C 10: 9,675,735 (GRCm39) E628G probably damaging Het
Tmem236 A T 2: 14,223,975 (GRCm39) K255* probably null Het
Ttc29 T A 8: 78,978,539 (GRCm39) probably null Het
Tyr A G 7: 87,087,222 (GRCm39) I430T probably damaging Het
Uckl1 A G 2: 181,216,160 (GRCm39) probably null Het
Vmn2r52 A C 7: 9,904,672 (GRCm39) I389R possibly damaging Het
Wdr62 A T 7: 29,964,688 (GRCm39) F352Y possibly damaging Het
Wdr70 T C 15: 7,953,754 (GRCm39) D379G probably benign Het
Zfp408 T A 2: 91,476,690 (GRCm39) M155L probably benign Het
Zfp459 T A 13: 67,561,249 (GRCm39) Q66H probably damaging Het
Other mutations in Zfp870
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01304:Zfp870 APN 17 33,101,980 (GRCm39) missense possibly damaging 0.72
R1591:Zfp870 UTSW 17 33,102,990 (GRCm39) missense probably damaging 1.00
R1892:Zfp870 UTSW 17 33,102,863 (GRCm39) missense possibly damaging 0.66
R1941:Zfp870 UTSW 17 33,101,778 (GRCm39) missense possibly damaging 0.71
R1997:Zfp870 UTSW 17 33,103,027 (GRCm39) missense possibly damaging 0.66
R2289:Zfp870 UTSW 17 33,102,334 (GRCm39) missense probably benign 0.27
R4240:Zfp870 UTSW 17 33,104,710 (GRCm39) missense probably benign 0.00
R4860:Zfp870 UTSW 17 33,102,314 (GRCm39) nonsense probably null
R4860:Zfp870 UTSW 17 33,102,314 (GRCm39) nonsense probably null
R6425:Zfp870 UTSW 17 33,102,045 (GRCm39) missense possibly damaging 0.66
R6736:Zfp870 UTSW 17 33,102,570 (GRCm39) missense probably benign
R7054:Zfp870 UTSW 17 33,102,456 (GRCm39) missense probably damaging 0.97
R7291:Zfp870 UTSW 17 33,102,828 (GRCm39) missense probably damaging 0.97
R7466:Zfp870 UTSW 17 33,102,736 (GRCm39) missense possibly damaging 0.66
R7681:Zfp870 UTSW 17 33,101,664 (GRCm39) missense probably benign
R8230:Zfp870 UTSW 17 33,102,663 (GRCm39) missense possibly damaging 0.46
R8346:Zfp870 UTSW 17 33,102,843 (GRCm39) missense possibly damaging 0.92
R8673:Zfp870 UTSW 17 33,101,904 (GRCm39) missense probably damaging 0.97
R8695:Zfp870 UTSW 17 33,102,679 (GRCm39) missense possibly damaging 0.46
R8736:Zfp870 UTSW 17 33,104,966 (GRCm39) missense possibly damaging 0.92
R9057:Zfp870 UTSW 17 33,102,793 (GRCm39) missense probably benign 0.27
Predicted Primers PCR Primer
(F):5'- TTACAGACATAGGGTTTCACACC -3'
(R):5'- TCCTTGTGTCAGATCTGGCC -3'

Sequencing Primer
(F):5'- ACACCAGTGTGAATCCTCCTGTG -3'
(R):5'- CTTGTGTCAGATCTGGCCAAACG -3'
Posted On 2016-07-22