Incidental Mutation 'R0009:Magi2'
| ID |
40463 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi2
|
| Ensembl Gene |
ENSMUSG00000040003 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| Synonyms |
Magi-2, S-SCAM, Acvrinp1 |
| MMRRC Submission |
038304-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0009 (G1)
|
| Quality Score |
200 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
19227036-20704792 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20611055 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 747
(Y747F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146769
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088516]
[ENSMUST00000101558]
[ENSMUST00000115267]
[ENSMUST00000197354]
[ENSMUST00000197443]
[ENSMUST00000197553]
[ENSMUST00000208219]
|
| AlphaFold |
Q9WVQ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088516
AA Change: Y1137F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000085872
Gene: ENSMUSG00000040003
AA Change: Y1137F
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
5.26e-9 |
SMART |
|
GuKc
|
107 |
290 |
2.76e-45 |
SMART |
|
WW
|
302 |
334 |
7.43e-12 |
SMART |
|
WW
|
348 |
380 |
2.4e-6 |
SMART |
|
PDZ
|
433 |
509 |
3.51e-19 |
SMART |
|
PDZ
|
612 |
682 |
2.3e-14 |
SMART |
|
PDZ
|
785 |
861 |
4.04e-19 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
5.05e-20 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
3.88e-21 |
SMART |
|
low complexity region
|
1257 |
1270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101558
AA Change: Y960F
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000099094
Gene: ENSMUSG00000040003
AA Change: Y960F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
608 |
684 |
4.04e-19 |
SMART |
|
low complexity region
|
716 |
730 |
N/A |
INTRINSIC |
|
PDZ
|
751 |
832 |
5.05e-20 |
SMART |
|
low complexity region
|
875 |
886 |
N/A |
INTRINSIC |
|
PDZ
|
970 |
1044 |
3.88e-21 |
SMART |
|
low complexity region
|
1080 |
1093 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115267
AA Change: Y974F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000110922
Gene: ENSMUSG00000040003
AA Change: Y974F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
66 |
74 |
N/A |
INTRINSIC |
|
WW
|
139 |
171 |
7.43e-12 |
SMART |
|
WW
|
185 |
217 |
2.4e-6 |
SMART |
|
PDZ
|
270 |
346 |
3.51e-19 |
SMART |
|
PDZ
|
449 |
519 |
2.3e-14 |
SMART |
|
PDZ
|
622 |
698 |
4.04e-19 |
SMART |
|
low complexity region
|
730 |
744 |
N/A |
INTRINSIC |
|
PDZ
|
765 |
846 |
5.05e-20 |
SMART |
|
low complexity region
|
889 |
900 |
N/A |
INTRINSIC |
|
PDZ
|
984 |
1058 |
3.88e-21 |
SMART |
|
low complexity region
|
1094 |
1107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197354
AA Change: Y1137F
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000142576
Gene: ENSMUSG00000040003
AA Change: Y1137F
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
785 |
861 |
2e-21 |
SMART |
|
low complexity region
|
893 |
907 |
N/A |
INTRINSIC |
|
PDZ
|
928 |
1009 |
2.4e-22 |
SMART |
|
low complexity region
|
1052 |
1063 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1221 |
1.9e-23 |
SMART |
|
low complexity region
|
1255 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1304 |
1319 |
N/A |
INTRINSIC |
|
low complexity region
|
1344 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197443
AA Change: Y1123F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000142764
Gene: ENSMUSG00000040003
AA Change: Y1123F
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
101 |
2.5e-11 |
SMART |
|
GuKc
|
107 |
290 |
1.4e-47 |
SMART |
|
WW
|
302 |
334 |
4.3e-14 |
SMART |
|
WW
|
348 |
380 |
1.4e-8 |
SMART |
|
PDZ
|
433 |
509 |
1.7e-21 |
SMART |
|
PDZ
|
612 |
682 |
1.1e-16 |
SMART |
|
PDZ
|
771 |
847 |
2e-21 |
SMART |
|
low complexity region
|
879 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
914 |
995 |
2.4e-22 |
SMART |
|
low complexity region
|
1038 |
1049 |
N/A |
INTRINSIC |
|
PDZ
|
1133 |
1207 |
1.9e-23 |
SMART |
|
low complexity region
|
1241 |
1255 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1349 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1370 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197553
AA Change: Y747F
PolyPhen 2
Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000199514
AA Change: Y77F
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000208219
AA Change: Y731F
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| Meta Mutation Damage Score |
0.0584 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
100% (68/68) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show neonatal death and hippocampal neurons with altered dendritic spine morphology. Homozygotes for a different null allele die neonatally due to anuria and podocyte anomalies. Mice lacking all three isoforms develop proteinuria, podocytopathy and die of renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1bg |
T |
G |
15: 60,919,633 (GRCm38) |
|
probably benign |
Het |
| Abcg4 |
T |
G |
9: 44,277,649 (GRCm38) |
|
probably benign |
Het |
| Afm |
C |
A |
5: 90,545,384 (GRCm38) |
|
probably benign |
Het |
| Ahrr |
G |
A |
13: 74,283,024 (GRCm38) |
|
probably benign |
Het |
| Aplnr |
T |
A |
2: 85,137,276 (GRCm38) |
|
probably null |
Het |
| Arih2 |
T |
A |
9: 108,611,727 (GRCm38) |
H264L |
probably damaging |
Het |
| Atp1a1 |
A |
T |
3: 101,579,835 (GRCm38) |
I886N |
possibly damaging |
Het |
| Bmf |
A |
T |
2: 118,549,622 (GRCm38) |
V14E |
probably damaging |
Het |
| Ccdc116 |
T |
C |
16: 17,144,039 (GRCm38) |
E15G |
probably damaging |
Het |
| Ccdc175 |
T |
C |
12: 72,135,965 (GRCm38) |
N427D |
possibly damaging |
Het |
| Cfap53 |
A |
G |
18: 74,299,176 (GRCm38) |
H45R |
probably benign |
Het |
| Chd3 |
A |
G |
11: 69,349,906 (GRCm38) |
L1569P |
probably damaging |
Het |
| Cntn2 |
G |
A |
1: 132,516,180 (GRCm38) |
Q457* |
probably null |
Het |
| Coro1a |
A |
T |
7: 126,701,413 (GRCm38) |
|
probably benign |
Het |
| Cracr2b |
T |
A |
7: 141,463,759 (GRCm38) |
L91Q |
probably damaging |
Het |
| Ctdspl |
T |
C |
9: 119,020,046 (GRCm38) |
|
probably null |
Het |
| Dip2b |
T |
A |
15: 100,169,312 (GRCm38) |
L565Q |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,621,903 (GRCm38) |
C1004S |
probably damaging |
Het |
| Dnah11 |
A |
T |
12: 118,045,522 (GRCm38) |
I2135N |
possibly damaging |
Het |
| Dnah14 |
A |
G |
1: 181,769,407 (GRCm38) |
|
probably benign |
Het |
| Dnase1 |
T |
C |
16: 4,038,946 (GRCm38) |
V147A |
probably damaging |
Het |
| Dusp8 |
T |
C |
7: 142,082,054 (GRCm38) |
|
probably benign |
Het |
| Fer1l6 |
T |
C |
15: 58,662,787 (GRCm38) |
Y1828H |
probably damaging |
Het |
| Flvcr1 |
A |
G |
1: 191,008,191 (GRCm38) |
V544A |
probably benign |
Het |
| Fsd1l |
T |
C |
4: 53,687,209 (GRCm38) |
V311A |
probably benign |
Het |
| Glud1 |
G |
A |
14: 34,334,268 (GRCm38) |
G300S |
probably benign |
Het |
| Gm4847 |
C |
T |
1: 166,630,486 (GRCm38) |
V433I |
probably benign |
Het |
| Gstm3 |
T |
G |
3: 107,967,840 (GRCm38) |
Y62S |
probably damaging |
Het |
| Gtse1 |
C |
T |
15: 85,862,435 (GRCm38) |
P151S |
probably benign |
Het |
| Herc2 |
T |
C |
7: 56,207,812 (GRCm38) |
S4048P |
probably benign |
Het |
| Hp1bp3 |
T |
A |
4: 138,221,683 (GRCm38) |
I19K |
probably benign |
Het |
| Htr7 |
C |
A |
19: 36,041,540 (GRCm38) |
|
probably benign |
Het |
| Il1a |
C |
T |
2: 129,309,074 (GRCm38) |
D10N |
probably damaging |
Het |
| Il22ra2 |
A |
T |
10: 19,624,458 (GRCm38) |
N39I |
probably damaging |
Het |
| Kcnn4 |
T |
C |
7: 24,379,255 (GRCm38) |
C267R |
possibly damaging |
Het |
| Larp1 |
A |
G |
11: 58,055,473 (GRCm38) |
K879R |
possibly damaging |
Het |
| Lcn5 |
T |
A |
2: 25,661,405 (GRCm38) |
|
probably benign |
Het |
| Lep |
T |
A |
6: 29,068,972 (GRCm38) |
C7* |
probably null |
Het |
| Mast4 |
T |
C |
13: 102,742,058 (GRCm38) |
T1223A |
probably damaging |
Het |
| Mcc |
C |
T |
18: 44,445,933 (GRCm38) |
E803K |
probably damaging |
Het |
| Mtmr4 |
T |
C |
11: 87,611,508 (GRCm38) |
I796T |
probably benign |
Het |
| Myef2 |
A |
T |
2: 125,108,978 (GRCm38) |
D312E |
probably benign |
Het |
| Myl3 |
A |
C |
9: 110,767,929 (GRCm38) |
D119A |
probably damaging |
Het |
| Myo19 |
T |
A |
11: 84,888,169 (GRCm38) |
|
probably null |
Het |
| Naa15 |
T |
G |
3: 51,470,219 (GRCm38) |
H763Q |
probably damaging |
Het |
| Pde5a |
C |
T |
3: 122,824,902 (GRCm38) |
|
probably benign |
Het |
| Plpp2 |
C |
T |
10: 79,527,244 (GRCm38) |
R184H |
probably benign |
Het |
| Rab19 |
T |
G |
6: 39,389,687 (GRCm38) |
L179V |
probably damaging |
Het |
| Rims2 |
T |
A |
15: 39,534,966 (GRCm38) |
M1087K |
probably damaging |
Het |
| Riox2 |
C |
A |
16: 59,489,367 (GRCm38) |
D361E |
probably benign |
Het |
| Sh3rf1 |
T |
A |
8: 61,226,293 (GRCm38) |
V123E |
probably damaging |
Het |
| Slc35e1 |
A |
T |
8: 72,484,709 (GRCm38) |
N318K |
probably damaging |
Het |
| Slc9a2 |
A |
T |
1: 40,763,602 (GRCm38) |
E604V |
probably benign |
Het |
| Srp72 |
T |
C |
5: 76,987,885 (GRCm38) |
S221P |
probably damaging |
Het |
| Tbx19 |
A |
T |
1: 165,160,520 (GRCm38) |
S15T |
possibly damaging |
Het |
| Tcea2 |
A |
G |
2: 181,685,817 (GRCm38) |
T112A |
probably benign |
Het |
| Tesk1 |
T |
A |
4: 43,445,368 (GRCm38) |
D230E |
probably damaging |
Het |
| Tm4sf5 |
C |
T |
11: 70,510,712 (GRCm38) |
A179V |
probably damaging |
Het |
| Tnr |
G |
T |
1: 159,852,416 (GRCm38) |
G320V |
probably damaging |
Het |
| Trappc11 |
A |
T |
8: 47,503,320 (GRCm38) |
C874S |
possibly damaging |
Het |
| Trpm3 |
T |
A |
19: 22,914,446 (GRCm38) |
Y885N |
probably damaging |
Het |
| Unc5a |
T |
A |
13: 55,002,879 (GRCm38) |
C505S |
probably damaging |
Het |
| Vmn1r28 |
G |
A |
6: 58,265,717 (GRCm38) |
A182T |
probably benign |
Het |
| Xpo5 |
T |
C |
17: 46,204,786 (GRCm38) |
|
probably benign |
Het |
| Zfp637 |
C |
A |
6: 117,845,668 (GRCm38) |
H252Q |
probably damaging |
Het |
| Zfp646 |
T |
A |
7: 127,880,731 (GRCm38) |
D693E |
probably damaging |
Het |
|
| Other mutations in Magi2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00908:Magi2
|
APN |
5 |
20,391,301 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02120:Magi2
|
APN |
5 |
20,228,453 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02341:Magi2
|
APN |
5 |
20,466,203 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02411:Magi2
|
APN |
5 |
19,678,709 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02657:Magi2
|
APN |
5 |
19,227,583 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02976:Magi2
|
APN |
5 |
20,534,475 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03105:Magi2
|
APN |
5 |
20,543,618 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL03246:Magi2
|
APN |
5 |
20,358,950 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03329:Magi2
|
APN |
5 |
20,466,128 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
LCD18:Magi2
|
UTSW |
5 |
19,954,511 (GRCm38) |
intron |
probably benign |
|
|
PIT4519001:Magi2
|
UTSW |
5 |
20,661,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0009:Magi2
|
UTSW |
5 |
20,611,055 (GRCm38) |
missense |
probably benign |
0.15 |
|
R0352:Magi2
|
UTSW |
5 |
20,065,666 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0362:Magi2
|
UTSW |
5 |
19,227,575 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0496:Magi2
|
UTSW |
5 |
20,661,359 (GRCm38) |
splice site |
probably benign |
|
|
R1103:Magi2
|
UTSW |
5 |
20,611,103 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1435:Magi2
|
UTSW |
5 |
20,358,945 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1583:Magi2
|
UTSW |
5 |
19,227,332 (GRCm38) |
missense |
probably benign |
0.30 |
|
R1616:Magi2
|
UTSW |
5 |
20,609,326 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1643:Magi2
|
UTSW |
5 |
20,705,506 (GRCm38) |
unclassified |
probably benign |
|
|
R1707:Magi2
|
UTSW |
5 |
20,215,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1833:Magi2
|
UTSW |
5 |
19,227,457 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1837:Magi2
|
UTSW |
5 |
20,465,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1838:Magi2
|
UTSW |
5 |
20,465,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1839:Magi2
|
UTSW |
5 |
20,465,827 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1847:Magi2
|
UTSW |
5 |
20,602,460 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2223:Magi2
|
UTSW |
5 |
20,465,672 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2496:Magi2
|
UTSW |
5 |
19,678,752 (GRCm38) |
missense |
probably benign |
0.42 |
|
R2504:Magi2
|
UTSW |
5 |
20,358,936 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2848:Magi2
|
UTSW |
5 |
20,602,461 (GRCm38) |
frame shift |
probably null |
|
|
R2879:Magi2
|
UTSW |
5 |
20,602,461 (GRCm38) |
frame shift |
probably null |
|
|
R2935:Magi2
|
UTSW |
5 |
20,602,461 (GRCm38) |
frame shift |
probably null |
|
|
R2936:Magi2
|
UTSW |
5 |
20,602,461 (GRCm38) |
frame shift |
probably null |
|
|
R3694:Magi2
|
UTSW |
5 |
20,602,461 (GRCm38) |
frame shift |
probably null |
|
|
R3783:Magi2
|
UTSW |
5 |
20,465,909 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3786:Magi2
|
UTSW |
5 |
20,465,909 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3787:Magi2
|
UTSW |
5 |
20,465,909 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3837:Magi2
|
UTSW |
5 |
20,215,468 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4151:Magi2
|
UTSW |
5 |
19,227,292 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4721:Magi2
|
UTSW |
5 |
20,534,469 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5005:Magi2
|
UTSW |
5 |
20,534,446 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5012:Magi2
|
UTSW |
5 |
20,465,620 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5193:Magi2
|
UTSW |
5 |
20,358,972 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5298:Magi2
|
UTSW |
5 |
20,569,162 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5372:Magi2
|
UTSW |
5 |
20,702,110 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R5580:Magi2
|
UTSW |
5 |
20,215,424 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5806:Magi2
|
UTSW |
5 |
20,651,204 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5924:Magi2
|
UTSW |
5 |
20,611,069 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5992:Magi2
|
UTSW |
5 |
19,227,291 (GRCm38) |
start codon destroyed |
probably null |
0.42 |
|
R6014:Magi2
|
UTSW |
5 |
20,611,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6073:Magi2
|
UTSW |
5 |
20,569,288 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6500:Magi2
|
UTSW |
5 |
20,602,347 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6664:Magi2
|
UTSW |
5 |
20,702,397 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7229:Magi2
|
UTSW |
5 |
20,465,588 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7344:Magi2
|
UTSW |
5 |
20,550,240 (GRCm38) |
missense |
probably benign |
0.19 |
|
R7448:Magi2
|
UTSW |
5 |
20,358,956 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7605:Magi2
|
UTSW |
5 |
20,228,385 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7712:Magi2
|
UTSW |
5 |
20,550,282 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R7808:Magi2
|
UTSW |
5 |
20,465,840 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7955:Magi2
|
UTSW |
5 |
20,389,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8134:Magi2
|
UTSW |
5 |
20,391,394 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8134:Magi2
|
UTSW |
5 |
20,391,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8253:Magi2
|
UTSW |
5 |
20,609,307 (GRCm38) |
missense |
probably benign |
0.44 |
|
R8481:Magi2
|
UTSW |
5 |
20,389,154 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R8553:Magi2
|
UTSW |
5 |
20,651,200 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8751:Magi2
|
UTSW |
5 |
20,534,464 (GRCm38) |
missense |
probably benign |
|
|
R8766:Magi2
|
UTSW |
5 |
20,195,125 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8851:Magi2
|
UTSW |
5 |
20,065,620 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8876:Magi2
|
UTSW |
5 |
20,651,192 (GRCm38) |
nonsense |
probably null |
|
|
R9120:Magi2
|
UTSW |
5 |
20,528,307 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R9335:Magi2
|
UTSW |
5 |
20,661,265 (GRCm38) |
missense |
|
|
|
R9367:Magi2
|
UTSW |
5 |
20,561,310 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9454:Magi2
|
UTSW |
5 |
20,466,178 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9474:Magi2
|
UTSW |
5 |
20,195,021 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9577:Magi2
|
UTSW |
5 |
20,609,284 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9673:Magi2
|
UTSW |
5 |
20,465,584 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R9696:Magi2
|
UTSW |
5 |
20,465,866 (GRCm38) |
missense |
probably benign |
0.35 |
|
X0065:Magi2
|
UTSW |
5 |
20,569,178 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
Z1176:Magi2
|
UTSW |
5 |
20,702,109 (GRCm38) |
missense |
probably benign |
0.32 |
|
Z1177:Magi2
|
UTSW |
5 |
20,702,412 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGACCTACTTGAGCCTTTGGAGC -3'
(R):5'- TTGTCTGAGAGCACGCCTTAGC -3'
Sequencing Primer
(F):5'- AGCCTTTGGAGCTATGCC -3'
(R):5'- AGAGCACGCCTTAGCATCTTC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation