Incidental Mutation 'R5309:Or6c66b'
ID 404731
Institutional Source Beutler Lab
Gene Symbol Or6c66b
Ensembl Gene ENSMUSG00000094496
Gene Name olfactory receptor family 6 subfamily C member 66B
Synonyms Olfr792, MOR108-2, GA_x6K02T2PULF-11219415-11220350
MMRRC Submission 042892-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R5309 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 129376408-129377343 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 129377134 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 243 (M243L)
Ref Sequence ENSEMBL: ENSMUSP00000149872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076575] [ENSMUST00000215436]
AlphaFold Q7TRH9
Predicted Effect probably benign
Transcript: ENSMUST00000076575
AA Change: M243L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000096707
Gene: ENSMUSG00000094496
AA Change: M243L

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.9e-53 PFAM
Pfam:7tm_1 39 288 4.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215436
AA Change: M243L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630073D07Rik T C 6: 132,603,540 (GRCm39) Q72R unknown Het
Abca15 T C 7: 119,944,592 (GRCm39) V409A probably damaging Het
Abcg3 A C 5: 105,084,465 (GRCm39) C577G possibly damaging Het
Adamtsl5 A T 10: 80,180,982 (GRCm39) probably benign Het
Adgrg3 G A 8: 95,766,492 (GRCm39) V388I probably benign Het
Ank2 T C 3: 126,753,417 (GRCm39) Q288R probably damaging Het
Cdc45 C T 16: 18,614,647 (GRCm39) R205H probably damaging Het
Cdh3 A G 8: 107,265,652 (GRCm39) T232A probably damaging Het
Cfap210 T C 2: 69,617,602 (GRCm39) T60A possibly damaging Het
Cntnap5c A T 17: 58,666,249 (GRCm39) E1093V probably benign Het
Cplx3 A T 9: 57,518,360 (GRCm39) L343Q probably damaging Het
Cwh43 A G 5: 73,574,110 (GRCm39) H258R probably benign Het
Cyp2j6 T A 4: 96,423,793 (GRCm39) I192F probably damaging Het
Dnaaf5 T A 5: 139,138,617 (GRCm39) V266E probably damaging Het
Egfr G A 11: 16,861,703 (GRCm39) G1161S probably benign Het
Ehmt1 A G 2: 24,774,207 (GRCm39) V201A probably damaging Het
Exoc7 C A 11: 116,195,853 (GRCm39) E28* probably null Het
Fam118a C T 15: 84,934,956 (GRCm39) T195M probably damaging Het
Fancg A G 4: 43,003,019 (GRCm39) F613L probably benign Het
Fbxo10 A T 4: 45,042,036 (GRCm39) I731N possibly damaging Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Gfm2 G A 13: 97,299,659 (GRCm39) A406T probably damaging Het
Gnal G A 18: 67,346,178 (GRCm39) R219K possibly damaging Het
Helz2 T A 2: 180,876,639 (GRCm39) E1285V probably benign Het
Ighv1-74 A G 12: 115,766,501 (GRCm39) S39P probably damaging Het
Ipo11 T C 13: 106,970,481 (GRCm39) probably benign Het
Klc1 A G 12: 111,762,055 (GRCm39) K575R possibly damaging Het
Larp1 T C 11: 57,941,634 (GRCm39) V689A possibly damaging Het
Mki67 A T 7: 135,302,559 (GRCm39) V825E probably damaging Het
Mmp9 T A 2: 164,792,715 (GRCm39) probably benign Het
Myog A G 1: 134,218,064 (GRCm39) K91E probably damaging Het
Nfil3 A T 13: 53,121,656 (GRCm39) V416E probably damaging Het
Nup160 G T 2: 90,563,176 (GRCm39) E1314* probably null Het
Or4g17 T C 2: 111,210,179 (GRCm39) V278A possibly damaging Het
Or4k35 T G 2: 111,100,655 (GRCm39) D19A probably benign Het
Or6c75 T A 10: 129,337,383 (GRCm39) V210E probably damaging Het
Osbpl8 T A 10: 111,106,418 (GRCm39) V275E probably benign Het
Osbpl9 A G 4: 108,923,352 (GRCm39) S520P probably damaging Het
Ppp4r4 T A 12: 103,573,147 (GRCm39) probably null Het
Proz T C 8: 13,111,049 (GRCm39) L7P probably damaging Het
Ptpn13 G A 5: 103,688,919 (GRCm39) S904N probably damaging Het
Rap1gds1 A G 3: 138,664,389 (GRCm39) L322P probably damaging Het
Rnf5 A G 17: 34,820,562 (GRCm39) F175S probably benign Het
Sema4a G A 3: 88,344,343 (GRCm39) S636F probably damaging Het
Sfrp2 A G 3: 83,676,708 (GRCm39) D193G probably damaging Het
Shoc2 T C 19: 53,976,164 (GRCm39) V18A probably benign Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Slc10a6 A T 5: 103,756,958 (GRCm39) C269S probably damaging Het
Slc34a2 A G 5: 53,226,830 (GRCm39) E651G probably damaging Het
Snx13 C T 12: 35,194,324 (GRCm39) Q956* probably null Het
Spg21 A G 9: 65,376,084 (GRCm39) I31V probably benign Het
Srpk2 T C 5: 23,730,716 (GRCm39) K268E probably damaging Het
Supt16 T C 14: 52,400,155 (GRCm39) E996G probably damaging Het
Syf2 A G 4: 134,663,380 (GRCm39) D184G probably benign Het
Tmem45a2 T C 16: 56,859,370 (GRCm39) D287G possibly damaging Het
Utrn A T 10: 12,603,513 (GRCm39) D627E probably damaging Het
Vmn1r170 T A 7: 23,305,880 (GRCm39) I94N probably damaging Het
Vmn2r103 A T 17: 20,013,296 (GRCm39) N139I probably benign Het
Vmn2r15 T A 5: 109,440,956 (GRCm39) I301F probably damaging Het
Vps35l T C 7: 118,412,799 (GRCm39) I629T probably damaging Het
Zfp949 A C 9: 88,449,236 (GRCm39) T14P possibly damaging Het
Other mutations in Or6c66b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or6c66b APN 10 129,376,711 (GRCm39) missense probably benign 0.07
IGL01459:Or6c66b APN 10 129,376,410 (GRCm39) start codon destroyed probably null 1.00
IGL02090:Or6c66b APN 10 129,377,176 (GRCm39) missense probably damaging 1.00
IGL03338:Or6c66b APN 10 129,376,925 (GRCm39) missense probably damaging 0.99
R0382:Or6c66b UTSW 10 129,376,883 (GRCm39) missense probably benign 0.01
R1672:Or6c66b UTSW 10 129,376,561 (GRCm39) missense probably benign 0.00
R2285:Or6c66b UTSW 10 129,376,537 (GRCm39) missense probably benign 0.22
R2938:Or6c66b UTSW 10 129,376,484 (GRCm39) missense probably damaging 1.00
R3498:Or6c66b UTSW 10 129,376,778 (GRCm39) missense probably damaging 1.00
R5312:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R6004:Or6c66b UTSW 10 129,376,759 (GRCm39) missense probably benign 0.31
R6800:Or6c66b UTSW 10 129,377,132 (GRCm39) missense probably damaging 1.00
R7127:Or6c66b UTSW 10 129,376,936 (GRCm39) missense probably damaging 1.00
R7167:Or6c66b UTSW 10 129,376,607 (GRCm39) missense possibly damaging 0.88
R7763:Or6c66b UTSW 10 129,377,324 (GRCm39) missense probably benign
R7819:Or6c66b UTSW 10 129,376,562 (GRCm39) missense probably benign 0.01
R8104:Or6c66b UTSW 10 129,376,826 (GRCm39) missense probably benign
R8189:Or6c66b UTSW 10 129,377,122 (GRCm39) missense probably damaging 0.99
R8672:Or6c66b UTSW 10 129,376,596 (GRCm39) missense probably damaging 0.99
Z1189:Or6c66b UTSW 10 129,377,246 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- GCTCATCTCTTGCACAGACAC -3'
(R):5'- GGAAGTACACATCACATACAATGTTCC -3'

Sequencing Primer
(F):5'- TTGCACAGACACAGCCTTCCTAG -3'
(R):5'- TGAGCACTGCTATACCCT -3'
Posted On 2016-07-22