Incidental Mutation 'R5310:Or5p5'
ID 404787
Institutional Source Beutler Lab
Gene Symbol Or5p5
Ensembl Gene ENSMUSG00000066242
Gene Name olfactory receptor family 5 subfamily P member 5
Synonyms MOR204-33P, Olfr467, GA_x6K02T2PBJ9-10144091-10145011
MMRRC Submission 042893-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5310 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107413793-107414713 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107414171 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 129 (C129R)
Ref Sequence ENSEMBL: ENSMUSP00000081811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084756] [ENSMUST00000208563] [ENSMUST00000214253]
AlphaFold L7N455
Predicted Effect probably damaging
Transcript: ENSMUST00000084756
AA Change: C129R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000081811
Gene: ENSMUSG00000066242
AA Change: C129R

DomainStartEndE-ValueType
Pfam:7tm_4 33 308 5.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 37 307 8.3e-7 PFAM
Pfam:7tm_1 43 292 2.2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207203
Predicted Effect probably damaging
Transcript: ENSMUST00000208563
AA Change: C127R

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000214253
AA Change: C127R

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.9%
  • 20x: 96.7%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 A T 7: 119,931,839 (GRCm39) I31L possibly damaging Het
Abca17 T C 17: 24,500,204 (GRCm39) K1329R probably benign Het
Acap2 A G 16: 30,952,427 (GRCm39) Y197H probably benign Het
Adgrv1 A G 13: 81,624,809 (GRCm39) V3720A possibly damaging Het
Alms1 T A 6: 85,592,350 (GRCm39) S870T possibly damaging Het
Anapc4 A G 5: 53,016,501 (GRCm39) E493G probably benign Het
Ap2a1 A G 7: 44,555,489 (GRCm39) probably null Het
Arhgef38 A G 3: 132,822,227 (GRCm39) L179P probably damaging Het
Bicral T C 17: 47,124,909 (GRCm39) D630G possibly damaging Het
Ccdc97 A T 7: 25,415,201 (GRCm39) L154Q probably damaging Het
Cd40 T C 2: 164,905,483 (GRCm39) probably null Het
Celsr1 T A 15: 85,810,423 (GRCm39) N2155I possibly damaging Het
Cemip A T 7: 83,641,241 (GRCm39) L261H probably damaging Het
Cep57 G A 9: 13,730,164 (GRCm39) H98Y probably damaging Het
Chrna7 A T 7: 62,755,805 (GRCm39) L247Q probably damaging Het
Cyp2c40 T A 19: 39,766,474 (GRCm39) M374L probably damaging Het
Cyp4f13 T C 17: 33,144,795 (GRCm39) D372G probably damaging Het
Dazl C A 17: 50,588,311 (GRCm39) S288I probably damaging Het
Dnah5 T C 15: 28,311,474 (GRCm39) F1818L probably damaging Het
Echdc1 T C 10: 29,210,204 (GRCm39) V143A possibly damaging Het
Eif4enif1 T A 11: 3,192,687 (GRCm39) H838Q probably damaging Het
Erich3 A T 3: 154,469,217 (GRCm39) D1223V probably damaging Het
Fbxl2 A G 9: 113,815,576 (GRCm39) I229T possibly damaging Het
Gfm2 G A 13: 97,299,659 (GRCm39) A406T probably damaging Het
Ggnbp2 A G 11: 84,760,794 (GRCm39) M1T probably null Het
Glb1l2 C T 9: 26,708,162 (GRCm39) probably benign Het
Gnl2 A G 4: 124,946,633 (GRCm39) K618R probably benign Het
Greb1 A T 12: 16,766,760 (GRCm39) I346K probably benign Het
Greb1l G A 18: 10,542,427 (GRCm39) E1341K probably damaging Het
Gtse1 A G 15: 85,757,993 (GRCm39) Q533R probably benign Het
Hemgn A G 4: 46,403,927 (GRCm39) S23P possibly damaging Het
Htr6 G T 4: 138,788,977 (GRCm39) H359Q probably damaging Het
Ifit1 T C 19: 34,626,204 (GRCm39) F447L probably benign Het
Kansl1 T C 11: 104,315,684 (GRCm39) Y118C possibly damaging Het
Khk G A 5: 31,084,373 (GRCm39) V118M probably benign Het
Klra17 T A 6: 129,845,671 (GRCm39) K181M probably damaging Het
Lbh T C 17: 73,228,287 (GRCm39) probably null Het
Lmo2 T C 2: 103,806,445 (GRCm39) I108T probably damaging Het
Maco1 T C 4: 134,564,330 (GRCm39) probably benign Het
Mgat5 T A 1: 127,315,251 (GRCm39) probably null Het
Mink1 T C 11: 70,498,169 (GRCm39) V525A probably benign Het
Myo10 C A 15: 25,778,164 (GRCm39) probably null Het
Nlrp2 T C 7: 5,328,007 (GRCm39) N682S probably benign Het
Nr2e3 G A 9: 59,856,617 (GRCm39) probably benign Het
Or6b2b T C 1: 92,418,758 (GRCm39) T240A probably damaging Het
Pabpc4l T C 3: 46,401,276 (GRCm39) T123A probably benign Het
Pfas G A 11: 68,878,847 (GRCm39) S1319F probably damaging Het
Phf3 T C 1: 30,842,887 (GRCm39) K2024R probably damaging Het
Pld4 G A 12: 112,735,046 (GRCm39) C501Y probably damaging Het
Psg16 C T 7: 16,824,560 (GRCm39) R115W probably damaging Het
Rab3gap1 G A 1: 127,870,110 (GRCm39) probably null Het
Rimkla C A 4: 119,335,049 (GRCm39) K111N probably damaging Het
Rrm2b T C 15: 37,927,571 (GRCm39) E113G probably damaging Het
Rspry1 C T 8: 95,349,813 (GRCm39) T67I probably benign Het
Skint6 C A 4: 113,041,965 (GRCm39) E292* probably null Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Slc13a1 A G 6: 24,134,373 (GRCm39) M170T probably benign Het
Slc15a5 T C 6: 138,050,034 (GRCm39) N127S probably benign Het
Slc39a10 G A 1: 46,875,285 (GRCm39) H6Y probably damaging Het
Spata31e2 A C 1: 26,724,169 (GRCm39) V337G probably benign Het
Sugct A T 13: 17,427,145 (GRCm39) C338* probably null Het
Tbk1 A T 10: 121,391,956 (GRCm39) M486K probably benign Het
Terf1 A T 1: 15,875,909 (GRCm39) E3V probably damaging Het
Thoc5 T A 11: 4,860,648 (GRCm39) Y246N probably damaging Het
Tmem167b G A 3: 108,469,415 (GRCm39) probably benign Het
Tmtc1 T A 6: 148,256,910 (GRCm39) probably benign Het
Zfp322a A T 13: 23,541,532 (GRCm39) M70K possibly damaging Het
Zfp979 A T 4: 147,698,375 (GRCm39) H111Q possibly damaging Het
Other mutations in Or5p5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0110:Or5p5 UTSW 7 107,413,895 (GRCm39) missense probably damaging 1.00
R0450:Or5p5 UTSW 7 107,413,895 (GRCm39) missense probably damaging 1.00
R0707:Or5p5 UTSW 7 107,414,331 (GRCm39) missense probably damaging 0.99
R0918:Or5p5 UTSW 7 107,414,418 (GRCm39) missense probably benign 0.03
R1416:Or5p5 UTSW 7 107,414,469 (GRCm39) missense probably damaging 1.00
R1988:Or5p5 UTSW 7 107,413,907 (GRCm39) missense probably benign
R1989:Or5p5 UTSW 7 107,413,907 (GRCm39) missense probably benign
R2219:Or5p5 UTSW 7 107,414,429 (GRCm39) missense probably benign
R2241:Or5p5 UTSW 7 107,414,040 (GRCm39) missense possibly damaging 0.62
R2866:Or5p5 UTSW 7 107,414,126 (GRCm39) missense probably benign 0.06
R4946:Or5p5 UTSW 7 107,414,589 (GRCm39) missense possibly damaging 0.90
R4972:Or5p5 UTSW 7 107,413,953 (GRCm39) missense probably benign 0.10
R5099:Or5p5 UTSW 7 107,413,809 (GRCm39) missense probably benign 0.00
R5323:Or5p5 UTSW 7 107,413,883 (GRCm39) missense possibly damaging 0.96
R5531:Or5p5 UTSW 7 107,414,451 (GRCm39) missense probably benign 0.03
R5672:Or5p5 UTSW 7 107,413,844 (GRCm39) missense probably damaging 1.00
R5758:Or5p5 UTSW 7 107,414,022 (GRCm39) missense probably damaging 0.99
R5891:Or5p5 UTSW 7 107,414,387 (GRCm39) missense probably damaging 1.00
R6016:Or5p5 UTSW 7 107,414,219 (GRCm39) missense probably benign 0.01
R6399:Or5p5 UTSW 7 107,413,961 (GRCm39) missense possibly damaging 0.78
R6466:Or5p5 UTSW 7 107,413,901 (GRCm39) missense probably benign
R6894:Or5p5 UTSW 7 107,414,271 (GRCm39) missense probably benign 0.25
R7543:Or5p5 UTSW 7 107,414,308 (GRCm39) missense probably damaging 1.00
R8316:Or5p5 UTSW 7 107,414,030 (GRCm39) missense possibly damaging 0.81
R9285:Or5p5 UTSW 7 107,413,821 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTGTGGACATTGGGTACTCC -3'
(R):5'- AGATGGCAGGAGACATTTCAGC -3'

Sequencing Primer
(F):5'- TGGGTACTCCAGCTCAGTCAC -3'
(R):5'- ACATGGGTACAGGACAGCTCC -3'
Posted On 2016-07-22